Browsing by Author "Seaman, Michael"
Now showing items 21-30 of 30
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P03-07. Autologous Neutralizing Antibodies That Select Viral Escape Variants Emerge Late After SIV Infection of Rhesus Monkeys
Rahman, I; Hraber, P; Giri, A; Nevidomskyte, D; Coffey, RT; Miljkovic, S; Keele, BF; Shaw, GM; Korber, BT; Yeh, Wendy Wen-Li; Asmal, Mohammed; Whitney, James B.; Seaman, Michael S.; Letvin, Norman Lee (BioMed Central, 2009) -
P04-41. Kinetics of Antibody Neutralization and Viral Evolution Following Envelope Vaccination in SIV-infected Rhesus Monkeys
Basavapathruni, A; Coffey, R; Hraber, P; Giri, A; Mascola, J; Nabel, G; Korber, B; Yeh, Wendy Wen-Li; Whitney, James B.; Rao, Sowmya R.; Seaman, Michael S.; Letvin, Norman Lee (BioMed Central, 2009)Poster presentation. Conclusion: Our results indicate that env vaccination is associated with an accelerated development of autologous neutralizing antibodies. These antibodies were focused at least in part on the V1 region ... -
P04-54 LB. Genetic Signature Analysis Identifies the CD4i Region of gp120 as a Determinant of Broadly NAb Responses in HIV-1-Infected Individuals
Gnanakaran, G; Bhattacharya, T; Lapedes, A; Gao, F; Haynes, BF; Montefiori, DC; Korber, BT; Daniels, M.; Kumar, A.; Li, M.; Tang, H.; Greene, K.; Gao, H.; Seaman, Michael S. (BioMed Central, 2009) -
P17-09. Immunization with a Single HIV-1 Envelope Sequence Can Generate CD8+ T lymphocytes Capable of Recognizing Multiple Variant Forms of Envelope
Hulot, SL; Seaman, Michael S.; Dorosh, LA; Korber, BT; Letvin, Norman Lee (BioMed Central, 2009)Background: The ability of CD8+ T lymphocytes to recognize a diversity of mutant forms of an HIV epitope is of central importance in the immune containment of this virus. The present studies were pursued to determine the ... -
Potent and Broad Neutralization of HIV-1 by a Llama Antibody Elicited by Immunization
McCoy, Laura E.; Quigley, Anna Forsman; Strokappe, Nika M.; Bulmer-Thomas, Bianca; Mortier, Daniella; Rutten, Lucy; Chander, Nikita; Edwards, Carolyn J.; Ketteler, Robin; Verrips, Theo; Weiss, Robin A.; Seaman, Michael S.; Davis, David (The Rockefeller University Press, 2012)Llamas (Lama glama) naturally produce heavy chain–only antibodies (Abs) in addition to conventional Abs. The variable regions (VHH) in these heavy chain–only Abs demonstrate comparable affinity and specificity for antigens ... -
Production of Mucosally Transmissible SHIV Challenge Stocks from HIV-1 Circulating Recombinant Form 01_AE env Sequences
Tartaglia, Lawrence J.; Chang, Hui-Wen; Lee, Benjamin C.; Abbink, Peter; Ng’ang’a, David; Boyd, Michael; Lavine, Christy L.; Lim, So-Yon; Sanisetty, Srisowmya; Whitney, James B.; Seaman, Michael S.; Rolland, Morgane; Tovanabutra, Sodsai; Ananworanich, Jintanat; Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.; Barouch, Dan H. (Public Library of Science, 2016)Simian-human immunodeficiency virus (SHIV) challenge stocks are critical for preclinical testing of vaccines, antibodies, and other interventions aimed to prevent HIV-1. A major unmet need for the field has been the lack ... -
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice
McGuire, Andrew T.; Gray, Matthew D.; Dosenovic, Pia; Gitlin, Alexander D.; Freund, Natalia T.; Petersen, John; Correnti, Colin; Johnsen, William; Kegel, Robert; Stuart, Andrew B.; Glenn, Jolene; Seaman, Michael S.; Schief, William R.; Strong, Roland K.; Nussenzweig, Michel C.; Stamatatos, Leonidas (Nature Publishing Group, 2016)VRC01-class broadly neutralizing HIV-1 antibodies protect animals from experimental infection and could contribute to an effective vaccine response. Their predicted germline forms (gl) bind Env inefficiently, which may ... -
Strategic addition of an N-linked glycan to a monoclonal antibody improves its HIV-1-neutralizing activity
Song, Ruijiang; Oren, Deena A.; Franco, David; Seaman, Michael S.; Ho, David D. (2013)Ibalizumab is a humanized monoclonal antibody that binds human CD4—a key receptor for HIV—and blocks HIV-1 infection. However, HIV-1 strains with mutations resulting in loss of an N-linked glycan from the V5 loop of the ... -
Therapeutic Efficacy of Potent Neutralizing HIV-1-Specific Monoclonal Antibodies in SHIV-Infected Rhesus Monkeys
Barouch, Dan H.; Whitney, James B.; Moldt, Brian; Klein, Florian; Oliveira, Thiago Y.; Liu, Jinyan; Stephenson, Kathryn E.; Chang, Hui-Wen; Shekhar, Karthik; Gupta, Sanjana; Nkolola, Joseph P.; Seaman, Michael S.; Smith, Kaitlin M.; Borducchi, Erica N.; Cabral, Crystal; Smith, Jeffrey Y.; Blackmore, Stephen; Sanisetty, Srisowmya; Perry, James R.; Beck, Matthew; Lewis, Mark G.; Rinaldi, William; Chakraborty, Arup K.; Poignard, Pascal; Nussenzweig, Michel C.; Burton, Dennis R. (2014)HIV-1-specific monoclonal antibodies (mAbs) with extraordinary potency and breadth have recently been described. In humanized mice, combinations of mAbs have been shown to suppress viremia, but the therapeutic potential ... -
Transient CD4+ T Cell Depletion Results in Delayed Development of Functional Vaccine-Elicited Antibody Responses
Provine, Nicholas M.; Badamchi-Zadeh, Alexander; Bricault, Christine A.; Penaloza-MacMaster, Pablo; Larocca, Rafael A.; Borducchi, Erica N.; Seaman, Michael S.; Barouch, Dan H. (American Society for Microbiology, 2016)ABSTRACT We have recently demonstrated that CD4+ T cell help is required at the time of adenovirus (Ad) vector immunization for the development of functional CD8+ T cell responses, but the temporal requirement for CD4+ T ...