Browsing by Author "Seidman, Larry Joel"

Now showing items 21-40 of 45

    • Is There an Association between Advanced Paternal Age and Endophenotype Deficit Levels in Schizophrenia? 

      Tsuang, Debby; Esterberg, Michelle; Braff, David; Calkins, Monica; Cadenhead, Kristin; Dobie, Dorcas; Freedman, Robert; Green, Michael F.; Greenwood, Tiffany; Gur, Raquel; Gur, Ruben; Horan, William; Lazzeroni, Laura C.; Light, Gregory A.; Millard, Steven P.; Olincy, Ann; Nuechterlein, Keith; Seidman, Larry; Siever, Larry; Silverman, Jeremy; Stone, William; Sprock, Joyce; Sugar, Catherine; Swerdlow, Neal; Tsuang, Ming; Turetsky, Bruce; Radant, Allen (Public Library of Science, 2014)
      The children of older fathers have increased risks of developing schizophrenia spectrum disorders, and among those who develop these disorders, those with older fathers present with more severe clinical symptoms. However, ...

    • Large CSF Volume Not Attributable to Ventricular Volume in Schizotypal Personality Disorder 

      Dickey, Chandlee C.; Shenton, Martha Elizabeth; Hirayasu, Yoshio; Fischer, Iris; Voglmaier, Martina M.; Niznikiewicz, Margaret A.; Seidman, Larry Joel; Fraone, Stephanie; McCarley, Robert William (American Psychiatric Publishing, 2000)
      Objective: The purpose of this study was to determine whether schizotypal personality disorder, which has the same genetic diathesis as schizophrenia, manifests abnormalities in whole-brain and CSF volumes. Method: Sixteen ...

    • Lateralized P3 deficit in schizotypal personality disorder 

      Niznikiewicz, Margaret A.; Voglmaier, Martina M.; Shenton, Martha Elizabeth; Dickey, Chandlee C.; Seidman, Larry Joel; Teh, EngKeat; Van Rhoads, Richard; McCarley, Robert William (Elsevier BV, 2000)
      Background: Reduced, left-lateralized P3 amplitude has been reported in several studies focusing on electrophysiologic function in schizophrenia. Also, several lines of evidence suggest a similarity between schizophrenia ...

    • Molecular Profiles of Parvalbumin-Immunoreactive Neurons in the Superior Temporal Cortex in Schizophrenia 

      Pietersen, Charmaine Y.; Mauney, Sarah A.; Kim, Susie S.; Passeri, Eleonora; Lim, Maribel P.; Rooney, Robert J.; Goldstein, Jill M.; Petreyshen, Tracey L.; Seidman, Larry Joel; Shenton, Martha Elizabeth; McCarley, Robert William; Sonntag, Kai-Christian; Woo, Tsung-Ung Wilson (Informa Healthcare, 2014)
      Dysregulation of pyramidal cell network function by the soma- and axon-targeting inhibitory neurons that contain the calcium-binding protein parvalbumin (PV) represents a core pathophysiological feature of schizophrenia. ...

    • Molecular Profiles of Pyramidal Neurons in the Superior Temporal Cortex in Schizophrenia 

      Pietersen, Charmaine Y.; Mauney, Sarah A.; Kim, Susie S.; Lim, Maribel P.; Rooney, Robert J.; Goldstein, Jill M.; Petryshen, Tracey L.; Seidman, Larry J.; Shenton, Martha E.; McCarley, Robert W.; Sonntag, Kai-C.; Woo, Tsung-Ung W. (Informa Healthcare, 2014)
      Disrupted synchronized oscillatory firing of pyramidal neuronal networks in the cerebral cortex in the gamma frequency band (i.e., 30–100 Hz) mediates many of the cognitive deficits and symptoms of schizophrenia. In fact, ...

    • MRI abnormalities of the hippocampus and cavum septi pellucidi in females with schizotypal personality disorder 

      Dickey, Chandlee C.; McCarley, Robert William; Xu, Mina L.; Seidman, Larry Joel; Voglmaier, Martina M.; Niznikiewicz, Margaret A.; Connor, Erin; Shenton, Martha Elizabeth (Elsevier BV, 2007)
      Objective: This study examined MRI hippocampal volume and cavum septi pellucidi (CSP) in female subjects with schizotypal personality disorder (SPD) and comparison subjects. Method: MRI was performed on 20 SPD and 29 ...

    • MRI Study of Caudate Nucleus Volume and Its Cognitive Correlates in Neuroleptic-Naive Patients With Schizotypal Personality Disorder 

      Levitt, James Jonathan; McCarley, Robert William; Dickey, Chandlee C.; Voglmaier, Martina M.; Niznikiewicz, Margaret A.; Seidman, Larry Joel; Hirayasu, Yoshio; Ciszewski, Aleksandra A.; Kikinis, Ron; Jolesz, Ferenc A.; Shenton, Martha Elizabeth (American Psychiatric Publishing, 2002)
      Objective: “Cognitive” circuits anatomically link the frontal lobe to subcortical structures; therefore, pathology in any of the core components of these circuits, such as in the caudate nucleus, may result in neurobehavioral ...

    • A MRI study of fusiform gyrus in schizotypal personality disorder 

      Dickey, Chandlee C.; McCarley, Robert William; Voglmaier, Martina M.; Niznikiewicz, Margaret A.; Seidman, Larry Joel; Frumin, Melissa; Toner, Sarah; Demeo, Susan; Shenton, Martha Elizabeth (Elsevier BV, 2003)
      The fusiform gyrus is important for face and object recognition, is abnormal in schizophrenia, but has not been studied in schizotypal personality disorder (SPD). Thin-slice MR images showed no differences, either in right, ...

    • An MRI Study of Superior Temporal Gyrus Volume in Women With Schizotypal Personality Disorder 

      Dickey, Chandlee C.; McCarley, Robert William; Voglmaier, Martina M.; Niznikiewicz, Margaret A.; Seidman, Larry Joel; Demeo, Susan; Frumin, Melissa; Shenton, Martha Elizabeth (American Psychiatric Publishing, 2003)
      Objective: An abnormal superior temporal gyrus has figured prominently in schizophrenia research, and left superior temporal gyrus volume has been shown to be smaller in male subjects with schizotypal personality disorder. ...

    • N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth 

      Gonzalez-Heydrich, Joseph; Bosquet Enlow, Michelle; D'Angelo, Eugene; Seidman, Larry J.; Gumlak, Sarah; Kim, April; Woodberry, Kristen A.; Rober, Ashley; Tembulkar, Sahil; O'Donnell, Kyle; Hamoda, Hesham M.; Kimball, Kara; Rotenberg, Alexander; Oberman, Lindsay M.; Pascual-Leone, Alvaro; Keshavan, Matcheri S.; Duffy, Frank H. (Hindawi Publishing Corporation, 2016)
      Highly penetrant mutations leading to schizophrenia are enriched for genes coding for N-methyl-D-aspartate receptor signaling complex (NMDAR-SC), implicating plasticity defects in the disease's pathogenesis. The importance ...

    • The Neural Basis of Social Cognition and Its Relationship to Social Functioning in Young People at Risk for Schizophrenia 

      Lincoln, Sarah Hope (2015-08-12)
      These three studies seek to contribute to the neurological characterization of the development of schizophrenia as well as begin to branch into understanding how neuroanatomical structure and function may relate to specific ...

    • Neuropsychological Impairment in Prodromal, First-Episode, and Chronic Psychosis: Assessing RBANS Performance 

      Zhang, TianHong; Li, HuiJun; Stone, William S.; Woodberry, Kristen A.; Seidman, Larry J.; Tang, YingYing; Guo, Qian; Zhuo, KaiMing; Qian, ZhenYing; Cui, HuiRu; Zhu, YiKang; Jiang, LiJuan; Chow, Annabelle; Tang, YunXiang; Li, ChunBo; Jiang, KaiDa; Yi, ZhengHui; Xiao, ZePing; Wang, JiJun (Public Library of Science, 2015)
      Background: Cognitive deficits are observed throughout all developmental phases of psychosis. However, prior studies have usually focused on a limited illness period and used a wide variety of cognitive instruments. ...

    • Prenatal Exposure to Lead, δ-Aminolevulinic Acid, and Schizophrenia: Further Evidence 

      Opler, Mark G.A.; Groeger, Justina; McKeague, Ian; Wei, Catherine; Factor-Litvak, Pam; Bresnahan, Michaeline; Graziano, Joseph; Brown, Alan S.; Susser, Ezra S.; Buka, Stephen L.; Goldstein, Jill M.; Seidman, Larry Joel (National Institute of Environmental Health Sciences, 2008)
      Background: A previously conducted study of prenatal lead exposure and schizophrenia using δ-aminolevulinic acid, a biologic marker of Pb exposure, in archived maternal serum samples collected from subjects enrolled in the ...

    • Processing sentence context in women with schizotypal personality disorder: An ERP study 

      Niznikiewicz, Margaret A.; Friedman, Michelle; Shenton, Martha Elizabeth; Voglmaier, Martina M.; Nestor, Paul Gerard; Frumin, Melissa; Seidman, Larry Joel; Sutton, Johnathan; McCarley, Robert William (Wiley-Blackwell, 2004)
      Accumulating evidence suggests that schizophrenic patients do not use context efficiently. Also, studies suggest similarities in clinical and cognitive profiles between schizophrenic and schizotypal personality disorder ...

    • Reducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study 

      Srihari, Vinod H; Tek, Cenk; Pollard, Jessica; Zimmet, Suzannah; Keat, Jane; Cahill, John D; Kucukgoncu, Suat; Walsh, Barbara C; Li, Fangyong; Gueorguieva, Ralitza; Levine, Nina; Mesholam-Gately, Raquelle I; Friedman-Yakoobian, Michelle; Seidman, Larry J; Keshavan, Matcheri S; McGlashan, Thomas H; Woods, Scott W (BioMed Central, 2014)
      Background: Early intervention services for psychotic disorders optimally interlock strategies to deliver: (i) Early Detection (ED) to shorten the time between onset of psychotic symptoms and effective treatment (i.e. ...

    • Reduction of Caudate Nucleus Volumes in Neuroleptic-Naïve Female Subjects with Schizotypal Personality Disorder 

      Koo, Min-Seong; Levitt, James Jonathan; McCarley, Robert William; Seidman, Larry Joel; Dickey, Chandlee C.; Niznikiewicz, Margaret A.; Voglmaier, Martina M.; Zamani, Payman; Long, Katherine R.; Kim, Sunnie S.; Shenton, Martha Elizabeth (Elsevier BV, 2006)
      Background: The caudate nucleus might contribute to the psychopathological and cognitive deficits observed in schizotypal personality disorder (SPD), a schizophrenia spectrum disorder. Here we focused on female patients, ...

    • Schizotypal personality disorder and MRI abnormalities of temporal lobe gray matter 

      Dickey, Chandlee C.; McCarley, Robert William; Voglmaier, Martina M.; Niznikiewicz, Margaret A.; Seidman, Larry Joel; Hirayasu, Yoshio; Fischer, Iris; Teh, Eng Kaet; Van Rhoads, Richard; Jakab, Marianna; Kikinis, Ron; Jolesz, Ferenc A.; Shenton, Martha Elizabeth (Elsevier BV, 1999)
      Background: Structural MRI data indicate schizophrenics have reduced left-sided temporal lobe gray matter volumes, especially in the superior temporal gyrus (STG) and medial temporal lobe. Our data further suggest a ...

    • Semantic Dysfunction in Women With Schizotypal Personality Disorder 

      Niznikiewicz, Margaret A.; Shenton, Martha Elizabeth; Voglmaier, Martina M.; Nestor, Paul Gerard; Dickey, Chandlee C.; Frumin, Melissa; Seidman, Larry Joel; Allen, Christopher G.; McCarley, Robert William (American Psychiatric Publishing, 2002)
      Objective: This study examined whether early or late processes in semantic networks were abnormal in women with a diagnosis of schizotypal personality disorder. The N400 component of the EEG event-related potentials was ...

    • Shape of caudate nucleus and its cognitive correlates in neuroleptic-naive schizotypal personality disorder 

      Levitt, James Jonathan; Westin, Carl-Fredrik; Nestor, Paul Gerard; Estepar, Raul S.J; Dickey, Chandlee C.; Voglmaier, Martina M.; Seidman, Larry Joel; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2004)
      Background: We measured the shape of the head of the caudate nucleus with a new approach based on magnetic resonance imaging (MRI) in schizotypal personality disorder (SPD) subjects in whom we previously reported decreased ...

    • Smaller Left Heschl’s Gyrus Volume in Patients With Schizotypal Personality Disorder 

      Dickey, Chandlee C.; McCarley, Robert William; Voglmaier, Martina M.; Frumin, Melissa; Niznikiewicz, Margaret A.; Hirayasu, Yoshio; Fraone, Stephanie; Seidman, Larry Joel; Shenton, Martha Elizabeth (American Psychiatric Publishing, 2002)
      Objective: Individuals with schizophrenia spectrum disorders evince similar genetic, neurotransmitter, neuropsychological, electrophysiological, and structural abnormalities. Magnetic resonance imaging (MRI) studies have ...