Now showing items 21-31 of 31

    • Nanowired three-dimensional cardiac patches 

      Dvir, Tal; Timko, Brian Paul; Brigham, Mark Daniel; Naik, Shreesh R.; Karajanagi, Sandeep Sidram; Levy, Oren; Jin, Hongwei; Parker, Kevin Kit; Langer, Robert S.; Kohane, Daniel Solomon (Springer Nature, 2011)
      Engineered cardiac patches for treating damaged heart tissues after a heart attack are normally produced by seeding heart cells within three-dimensional porous biomaterial scaffolds. These biomaterials, which are usually ...
    • Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury 

      Grevesse, Thomas; Dabiri, Borna E.; Parker, Kevin Kit; Gabriele, Sylvain (Nature Publishing Group, 2015)
      Although pathological changes in axonal morphology have emerged as important features of traumatic brain injury (TBI), the mechanical vulnerability of the axonal microcompartment relative to the cell body is not well ...
    • A Possible Role for Integrin Signaling in Diffuse Axonal Injury 

      Hemphill, Matthew Allen; Dabiri, Borna Esfahani; Gabriele, Sylvain; Kerscher, Lucas; Franck, Christian; Goss, Josue; Alford, Patrick W.; Parker, Kevin Kit (Public Library of Science (PLoS), 2011)
      Over the past decade, investigators have attempted to establish the pathophysiological mechanisms by which non-penetrating injuries damage the brain. Several studies have implicated either membrane poration or ion channel ...
    • Protein-Based Textiles: Bio-Inspired and Bio-Derived Materials for Medical and Non-Medical Applications 

      Deravi, Leila F.; Golecki, Holly M.; Parker, Kevin Kit (American Scientific Publishers, 2013)
      The hierarchical structure-dependent function of self-assembling proteins regulates the biochemical and mechanical functions of cells, tissues, and organs. These multi-scale properties make proteins desirable candidates ...
    • Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip 

      McCain, M. L.; Sheehy, Sean Paul; Grosberg, A.; Goss, J. A.; Parker, Kevin Kit (Proceedings of the National Academy of Sciences, 2013)
      The lack of a robust pipeline of medical therapeutic agents for the treatment of heart disease may be partially attributed to the lack of in vitro models that recapitulate the essential structure–function relationships of ...
    • A Role for Focal Adhesions and Extracellular Matrix in Traumatic Axonal Injury 

      Hemphill, Matthew Allen (2014-10-21)
      Traumatic Brain Injury (TBI) is linked to a diverse range of diffuse pathological damage for which there is a severe lack of therapeutic options. A major limitation to drug development is the inability to identify causal ...
    • The Role of Microenvironmental Cues in Cardiomyogenesis and Pathogenesis 

      Horton, Renita Elillian (2014-06-06)
      The cellular microenvironment consists of soluble and insoluble factors that provide signals that dictate cell behavior and cell fate. Limited characterization has hindered our ability to mimic the physiological or ...
    • Self-Organization of Muscle Cell Structure and Function 

      Grosberg, Anna; Kuo, Po-Ling; Guo, Chin-Lin; Geisse, Nicholas A.; Bray, Mark-Anthony; Adams, William J.; Sheehy, Sean Paul; Parker, Kevin Kit (Public Library of Science (PLoS), 2011)
      The organization of muscle is the product of functional adaptation over several length scales spanning from the sarcomere to the muscle bundle. One possible strategy for solving this multiscale coupling problem is to ...
    • A Simple Model for Nanofiber Formation by Rotary Jet-Spinning 

      Mellado, Paula; McIlwee, Holly Alice; Badrossamay, Mohammad R.; Goss, Josue; Mahadevan, Lakshminarayanan; Parker, Kevin Kit (AIP Publishing, 2011)
      Nanofibers are microstructured materials that span a broad range of applications from tissue engineering scaffolds to polymer transistors. An efficient method of nanofiber production is rotary jet-spinning (RJS), consisting ...
    • Three-Dimensional Paper-Based Model for Cardiac Ischemia 

      Mosadegh, Bobak; Dabiri, Borna; Lockett, Matthew; Derda, Ratmir; Campbell, Patrick Healy; Parker, Kevin Kit; Whitesides, George McClelland (Wiley-Blackwell, 2014)
      In vitro models of ischemia have not historically recapitulated the cellular interactions and gradients of molecules that occur in a 3D tissue. This work demonstrates a paper-based 3D culture system that mimics some of the ...
    • Vascular smooth muscle contractility depends on cell shape 

      Alford, Patrick W.; Nesmith, Alexander Peyton; Seywerd, Johannes N.; Grosberg, Anna; Parker, Kevin Kit (Royal Society of Chemistry (RSC), 2011)
      The physiologic role of smooth muscle structure in defining arterial function is poorly understood. We aimed to elucidate the relationship between vascular smooth muscle architecture and functional contractile output. Using ...