Browsing by Author "Fuchs, Charles"

Now showing items 21-33 of 33

    • Neoadjuvant irinotecan, cisplatin, and concurrent radiation therapy with celecoxib for patients with locally advanced esophageal cancer 

      Cleary, James M.; Mamon, Harvey J.; Szymonifka, Jackie; Bueno, Raphael; Choi, Noah; Donahue, Dean M.; Fidias, Panos M.; Gaissert, Henning A.; Jaklitsch, Michael T.; Kulke, Matthew H.; Lynch, Thomas P.; Mentzer, Steven J.; Meyerhardt, Jeffrey A.; Swanson, Richard S.; Wain, John; Fuchs, Charles S.; Enzinger, Peter C. (BioMed Central, 2016)
      Background: Patients with locally advanced esophageal cancer who are treated with trimodality therapy have a high recurrence rate. Preclinical evidence suggests that inhibition of cyclooxygenase 2 (COX2) increases the ...

    • Nut consumption and risk of colorectal cancer in women 

      Yang, Meng; Hu, Frank B.; Giovannucci, Edward L.; Stampfer, Meir; Willett, Walter C.; Fuchs, Charles Stewart; Wu, Kana; Bao, Ying (Nature Publishing Group, 2015)
      Background/Objectives: Increasing nut consumption has been associated with reduced risk of obesity and type II diabetes, which are risk factors for colorectal cancer. However, the association between nut consumption and ...

    • Oral Contraceptive Use and Colorectal Cancer in the Nurses' Health Study I and II 

      Charlton, Brittany Michelle; Wu, Kana; Zhang, Xuehong; Giovannucci, Edward L.; Fuchs, Charles Stewart; Missmer, Stacey Ann; Rosner, Bernard Alfred; Hankinson, Susan Elizabeth; Willett, Walter C.; Michels, Karin B. (American Association for Cancer Research (AACR), 2015)
      Background—It remains unclear if oral contraceptive (OC) use is associated with the incidence of colorectal cancer. Few studies have examined this association by duration of OC use, time since last OC use, and different ...

    • Physical activity and risk of inflammatory bowel disease: prospective study from the Nurses’ Health Study cohorts 

      Khalili, Hamed; Ananthakrishnan, Ashwin N; Konijeti, Gauree G; Liao, Xiaomei; Higuchi, Leslie M; Fuchs, Charles S; Spiegelman, Donna; Richter, James M; Korzenik, Joshua R; Chan, Andrew T (BMJ Publishing Group Ltd., 2013)
      Objective: To examine the association between physical activity and risk of ulcerative colitis and Crohn’s disease. Design: Prospective cohort study. Setting: Nurses’ Health Study and Nurses’ Health Study II. Participants: ...

    • Post Diagnosis Diet Quality and Colorectal Cancer Survival in Women 

      Fung, Teresa T.; Kashambwa, Rutendo; Sato, Kaori; Chiuve, Stephanie E.; Fuchs, Charles S.; Wu, Kana; Giovannucci, Edward; Ogino, Shuji; Hu, Frank B.; Meyerhardt, Jeffrey A. (Public Library of Science, 2014)
      Background: Dietary factors are known to influence colorectal cancer (CRC) risk, however, their association with CRC survival is unclear. Therefore, we prospectively examined the association between diet quality scores, ...

    • Pre-Diagnostic Leukocyte Genomic DNA Methylation and the Risk of Colorectal Cancer in Women 

      Nan, Hongmei; Giovannucci, Edward L.; Wu, Kana; Selhub, Jacob; Paul, Ligi; Rosner, Bernard Alfred; Fuchs, Charles Stewart; Cho, Eunyoung (Public Library of Science, 2013)
      Background: Abnormal one-carbon metabolism may lead to general genomic (global) hypomethylation, which may predispose an individual to the development of colorectal neoplasia. Methods: We evaluated the association between ...

    • Processed and Unprocessed Red Meat and Risk of Colorectal Cancer: Analysis by Tumor Location and Modification by Time 

      Bernstein, Adam M.; Song, Mingyang; Zhang, Xuehong; Pan, An; Wang, Molin; Fuchs, Charles S.; Le, Ngoan; Chan, Andrew T.; Willett, Walter C.; Ogino, Shuji; Giovannucci, Edward L.; Wu, Kana (Public Library of Science, 2015)
      Although the association between red meat consumption and colorectal cancer (CRC) is well established, the association across subsites of the colon and rectum remains uncertain, as does time of consumption in relation to ...

    • A Prospective Analysis of Meat Mutagens and Colorectal Cancer in the Nurses’ Health Study and Health Professionals Follow-up Study 

      Le, Ngoan Tran; Michels, Fernanda Alessandra Silva; Song, Mingyang; Zhang, Xuehong; Bernstein, Adam M.; Giovannucci, Edward L.; Fuchs, Charles S.; Ogino, Shuji; Chan, Andrew T.; Sinha, Rashmi; Willett, Walter C.; Wu, Kana (National Institute of Environmental Health Sciences, 2016)
      Background: Heterocyclic amines (HCAs) in cooked meats may play a role in colorectal cancer (CRC) development. Objectives: We aimed to prospectively examine the association between estimated intakes of HCAs and meat-derived ...

    • A prospective study of oral contraceptive use and colorectal adenomas 

      Charlton, Brittany Michelle; Giovannucci, Edward L.; Fuchs, Charles Stewart; Chan, Andrew Tan; Lee, Jung; Cao, Yin; Missmer, Stacey Ann; Rosner, Bernard Alfred; Hankinson, Susan Elizabeth; Willett, Walter C.; Wu, Kana; Michels, Karin B. (Springer Nature, 2016)
      Purpose—The influence of reproductive factors on colorectal cancer, including oral contraceptive (OC) use, has been examined, but less research is available on OC use and adenomas. Methods—Participants of the Nurses' ...

    • Restriction of intestinal stem cell expansion and the regenerative response by YAP 

      Barry, Evan R.; Morikawa, Teppei; Butler, Brian L.; Shrestha, Kriti; de la Rosa, Rosemarie; Yan, Kelley S.; Fuchs, Charles S.; Magness, Scott T.; Smits, Ron; Ogino, Shuji; Kuo, Calvin J.; Camargo, Fernando D. (2012)
      A remarkable feature of regenerative processes is their ability to halt proliferation once an organ’s structure has been restored. The Wnt signaling pathway is the major driving force for homeostatic self-renewal and ...

    • Risk of a Second Primary Cancer after Non-melanoma Skin Cancer in White Men and Women: A Prospective Cohort Study 

      Song, Fengju; Qureshi, Abrar A.; Giovannucci, Edward L.; Fuchs, Charles Stewart; Chen, Wendy Yvonne; Stampfer, Meir; Han, Jiali (Public Library of Science, 2013)
      Background: Previous studies suggest a positive association between history of non-melanoma skin cancer (NMSC) and risk of subsequent cancer at other sites. The purpose of this study is to prospectively examine the risk ...

    • The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth 

      Firestein, Ron; Blander, Gil; Michan, Shaday; Oberdoerffer, Philipp; Luikenhuis, Sandra; de Cabo, Rafael; Guarente, Leonard P.; Ogino, Shuji; Campbell, Jennifer; Bhimavarapu, Anupama; Fuchs, Charles Stewart; Hahn, William C.; Sinclair, David Andrew (Public Library of Science, 2008)
      Numerous longevity genes have been discovered in model organisms and altering their function results in prolonged lifespan. In mammals, some have speculated that any health benefits derived from manipulating these same ...

    • Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer 

      Hanyuda, Akiko; Kim, Sun A.; Martinez-Fernandez, Alejandro; Qian, Zhi Rong; Yamauchi, Mai; Nakashima, Reiko; Morikawa, Teppei; Liao, Xiaoyun; Inamura, Kentaro; Mima, Kosuke; Cao, Yin; Zhang, Xuehong; Wu, Kana; Chan, Andrew T.; Ogino, Shuji; Giovannucci, Edward; Meyerhardt, Jeffrey; Fuchs, Charles; Shivdasani, Ramesh (Springer Nature, 2015-11-17)
      Background. High-level physical activity is associated with lower colorectal cancer (CRC) mortality, likely through insulin sensitization. Insulin receptor substrate 1 (IRS1) is a mediator of insulin and insulin-like growth ...