Now showing items 21-24 of 24

    • ROS1 Immunohistochemistry for Detection of ROS1-Rearranged Lung Adenocarcinomas 

      Sholl, Lynette Marie; Sun, Heather; Butaney, Mohit; Zhang, Chengsheng; Lee, Charles; Janne, Pasi Antero; Rodig, Scott J. (Ovid Technologies (Wolters Kluwer Health), 2013)
      ROS1 gene rearrangements are reported in 1–2% of lung adenocarcinomas (ACA) and are associated with response to the multitargeted tyrosine kinase inhibitor, crizotinib. ROS1 rearrangements can be detected using fluorescence ...
    • Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes 

      Dada, Shirine; Wong, Masie; Law, Kenneth; Wu, Erxi; Dunussi-Joannopoulos, Kyri; Bluestone, Jeffrey; Fiorina, Paolo; Vergani, Andrea; Jurewicz, Mollie; Tian, Ze; Abdi, Reza; Guleria, Indira; Rodig, Scott J.; Sayegh, Mohamed Hassan (American Diabetes Association, 2008)
      OBJECTIVES—To investigate a B-cell–depleting strategy to reverse diabetes in naïve NOD mice. RESEARCH DESIGN AND METHODS—We targeted the CD22 receptor on B-cells of naïve NOD mice to deplete and reprogram B-cells to ...
    • Taxonomy of breast cancer based on normal cell phenotype predicts outcome 

      Santagata, Sandro; Thakkar, Ankita; Ergonul, Ayse; Wang, Bin; Woo, Terri; Hu, Rong; Harrell, J. Chuck; McNamara, George; Schwede, Matthew; Culhane, Aedin; Kindelberger, David; Rodig, Scott J.; Richardson, Andrea; Schnitt, Stuart Jay; Tamimi, Rulla May; Ince, Tan A. (American Society for Clinical Investigation, 2014)
      Accurate classification is essential for understanding the pathophysiology of a disease and can inform therapeutic choices. For hematopoietic malignancies, a classification scheme based on the phenotypic similarity between ...
    • Unique Clinicopathologic Features Characterize ALK-Rearranged Lung Adenocarcinoma in the Western Population 

      Rodig, Scott; Mino-Kenudson, Mari; Dacic, Sanja; Yeap, Beow; Shaw, Alice; Barletta, Justine; Stubbs, Hannah; Law, Kenny; Lindeman, Neal; Mark, Eugene; Janne, Pasi; Lynch, Thomas; Johnson, Bruce; Iafrate, Anthony; Chirieac, Lucian (American Association for Cancer Research (AACR), 2009-08-15)
      Purpose The anaplastic large cell kinase gene (ALK) is rearranged in approximately 5% of lung adenocarcinomas within the Asian population. We evaluated the incidence and the characteristics of ALK-rearranged lung ...