Browsing by Author "Spiegelman, Donna"
Now showing items 21-40 of 60
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Gender-Related Differences in the Prevalence of Cardiovascular Disease Risk Factors and their Correlates in Urban Tanzania
Njelekela, Marina A; Mpembeni, Rose; Mligiliche, Nuru L; Mtabaji, Jacob; Muhihi, Alfa; Spiegelman, Donna Lynn; Hertzmark, Ellen; Liu, Enju; Finkelstein, Julia Leigh; Fawzi, Wafaie W.; Willett, Walter C. (BioMed Central, 2009)Background: Urban areas in Africa suffer a serious problem with dual burden of infectious diseases and emerging chronic diseases such as cardiovascular diseases (CVD) and diabetes which pose a serious threat to population ... -
Home endotoxin exposure and wheeze in infants: correction for bias due to exposure measurement error
Horick, Nora; Weller, Edie A.; Milton, Donald Kirby; Gold, Diane R.; Li, Ruifeng; Spiegelman, Donna Lynn (National Institute of Environmental Health Sciences, 2005)Exposure to elevated levels of endotoxin in family-room dust was previously observed to be significantly associated with increased wheeze in the first year of life among a cohort of 404 children in the Boston, Massachusetts, ... -
Incident tuberculosis and risk factors among HIV-infected children in Tanzania
Li, Nan; Manji, Karim P.; Spiegelman, Donna Lynn; Muya, Aisa; Mwiru, Ramadhani S.; Liu, Enju; Chalamilla, Guerino; Fawzi, Wafaie W.; Duggan, Christopher Paul (Ovid Technologies (Wolters Kluwer Health), 2013)Objective To describe the burden of pediatric tuberculosis (TB) in a human immunodeficiency virus (HIV)-infected population and explore the demographic and clinical factors associated with the occurrence of pediatric ... -
Infant Infections and Respiratory Symptoms in Relation to in Utero Arsenic Exposure in a U.S. Cohort
Farzan, Shohreh F.; Li, Zhigang; Korrick, Susan A.; Spiegelman, Donna; Enelow, Richard; Nadeau, Kari; Baker, Emily; Karagas, Margaret R. (National Institute of Environmental Health Sciences, 2015)Background: Arsenic has been linked to disrupted immune function and greater infection susceptibility in highly exposed populations. Well arsenic levels above the U.S. EPA limit occur in our U.S. study area and are of ... -
Iron Status Predicts Treatment Failure and Mortality in Tuberculosis Patients: A Prospective Cohort Study from Dar es Salaam, Tanzania
Isanaka, Sheila; Aboud, Said; Mugusi, Ferdinand; Bosch, Ronald J.; Willett, Walter C.; Spiegelman, Donna Lynn; Duggan, Christopher Paul; Fawzi, Wafaie W. (Public Library of Science, 2012)Background: Experimental data suggest a role for iron in the course of tuberculosis (TB) infection, but there is limited evidence on the potential effects of iron deficiency or iron overload on the progression of TB disease ... -
Iron supplementation and paediatric HIV disease progression: a cohort study among children receiving routine HIV care in Dar es Salaam, Tanzania
Andersen, Christopher; Duggan, Christopher; Manji, Karim; Seage, George; Spiegelman, Donna; Perumal, Nandita; Ulenga, Nzovu; Fawzi, Wafaie (Oxford University Press (OUP), 2022-02-15)Abstract Background Anaemia is common among HIV-infected children and iron supplementation is prescribed routinely for the prevention and management of anaemia among children. Limited evidence suggests iron supplementation ... -
Making the Case for Better Integration of Cervical Cancer Screening and Treatment for HIV-Infected Women Attending Care and Treatment Clinics in Dar es Salaam, Tanzania
McCree-Hale, Renicha; Aris, Eric; Chalamilla, Guerino; Andrew, Irene; Mwaiselage, Julius; Spiegelman, Donna Lynn; Hirschorn, Lisa; Fawzi, Wafaie W. (BioMed Central, 2012) -
Malaria Parasitemia and CD4 T Cell Count, Viral Load, and Adverse HIV Outcomes Among HIV-Infected Pregnant Women in Tanzania
Franke, Molly Forrest; Spiegelman, Donna Lynn; Ezeamama, A.; Aboud, S.; Msamanga, G. I.; Mehta, S.; Fawzi, Wafaie W. (American Society of Tropical Medicine and Hygiene, 2010)We examined the cross-sectional relationships between malaria parasitemia and CD4 T cell count and viral load among human immunodeficiency virus (HIV)-infected pregnant women. We then followed women to investigate whether ... -
Maternal hyperglycemia and adverse pregnancy outcomes in Dar es Salaam, Tanzania
Darling, Anne Marie; Liu, Enju; Aboud, Said; Urassa, Willy; Spiegelman, Donna Lynn; Fawzi, Wafaie W. (Elsevier BV, 2014)Objective To evaluate maternal glucose levels during pregnancy as a predictor of adverse perinatal outcomes in Dar es Salaam, Tanzania. Methods Random blood glucose measurements were analyzed from 3833 pregnant ... -
Maternal Vitamin D Status and Child Morbidity, Anemia, and Growth in Human Immunodeficiency Virus-exposed Children in Tanzania
Finkelstein, Julia; Mehta, Saurabh; Duggan, Christopher Paul; Manji, Karim P.; Mugusi, Ferdinand M.; Aboud, Said; Spiegelman, Donna Lynn; Msamanga, Gernard I.; Fawzi, Wafaie W. (Ovid Technologies (Wolters Kluwer Health), 2012)Background Vitamin D may help prevent adverse pediatric outcomes, including infectious diseases and growth failure, based on its role in immune and metabolic functions. We examined the association of maternal vitamin D ... -
Mercury Exposure and Risk of Cardiovascular Disease in Two U.S. Cohorts
Mozaffarian, Dariush; Shi, Peilin; Morris, J. Steven; Spiegelman, Donna Lynn; Grandjean, Philippe; Siscovick, David S.; Willett, Walter C.; Rimm, Eric Bruce (New England Journal of Medicine (NEJM/MMS), 2011)BACKGROUND: Exposure to methylmercury from fish consumption has been linked to a potentially increased risk of cardiovascular disease, but evidence from prior studies is equivocal. Beneficial effects of the ingestion of ... -
Mercury Exposure and Risk of Hypertension in US Men and Women in 2 Prospective Cohorts
Mozaffarian, D.; Shi, Peilin; Morris, J. Steven; Grandjean, Philippe; Siscovick, D. S.; Spiegelman, Donna Lynn; Willett, Walter C.; Rimm, Eric Bruce; Curhan, Gary Craig; Forman, John Phillip (Ovid Technologies (Wolters Kluwer Health), 2012)Cross-sectional studies and animal-experiments suggest that methylmercury exposure could increase risk of hypertension. This relationship has not been evaluated in large prospective studies. Using data from prior nested ... -
Methylmercury Exposure and Incident Diabetes in U.S. Men and Women in Two Prospective Cohorts
Mozaffarian, Dariush; Shi, Peilin; Morris, J. S.; Grandjean, Philippe; Siscovick, D. S.; Spiegelman, Donna Lynn; Hu, Frank B. (American Diabetes Association, 2013)OBJECTIVE Emerging in vitro and animal evidence suggests that methylmercury could increase type 2 diabetes, but little evidence exists in humans. We aimed to prospectively determine associations of mercury exposure, as ... -
Multivitamin supplementation in HIV infected adults initiating antiretroviral therapy in Uganda: the protocol for a randomized double blinded placebo controlled efficacy trial
Guwatudde, David; Ezeamama, Amara E; Bagenda, Danstan; Kyeyune, Rachel; Wabwire-Mangen, Fred; Wamani, Henry; Mugusi, Ferdinand; Spiegelman, Donna; Wang, Molin; Manabe, Yukari C; Fawzi, Wafaie W (BioMed Central, 2012)Background: Use of multivitamin supplements during the pre-HAART era has been found to reduce viral load, enhance immune response, and generally improve clinical outcomes among HIV-infected adults. However, immune ... -
Nutritional Status and Other Baseline Predictors of Mortality among HIV-Infected Children Initiating Antiretroviral Therapy in Tanzania
Mwiru, R. S.; Spiegelman, Donna Lynn; Duggan, Christopher Paul; Seage, George R.; Semu, H.; Chalamilla, G; Kisenge, R.; Fawzi, Wafaie W. (SAGE Publications, 2013)BACKGROUND: We assembled a prospective cohort of 3144 children less than 15 years of age initiating antiretroviral therapy (ART) in Dar es Salaam, Tanzania. METHODS: The relationships of nutritional status and other ... -
Obesity epidemic has emerged among Nigerians
Akarolo-Anthony, Sally N; Willett, Walter C; Spiegelman, Donna; Adebamowo, Clement A (BioMed Central, 2014)Background: Data from the WHO shows that the prevalence of overweight and obesity increased by ~20% between 2002 and 2010 in Nigeria. We conducted this study to examine the correlates of this fast growing epidemic. Methods: ... -
Perinatal Outcomes, Including Mother‐to‐Child Transmission of HIV, and Child Mortality and Their Association with Maternal Vitamin D Status in Tanzania
Mehta, Saurabh; Hunter, David J.; Mugusi, Ferdinand M.; Spiegelman, Donna Lynn; Manji, Karim P.; Giovannucci, Edward L.; Hertzmark, Ellen; Msamanga, Gernard I.; Fawzi, Wafaie W. (Oxford University Press (OUP), 2009)Background Vitamin D is a strong immunomodulator and may protect against adverse pregnancy outcomes, mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV), and child mortality. Methods A total ... -
Physical activity and risk of inflammatory bowel disease: prospective study from the Nurses’ Health Study cohorts
Khalili, Hamed; Ananthakrishnan, Ashwin N; Konijeti, Gauree G; Liao, Xiaomei; Higuchi, Leslie M; Fuchs, Charles S; Spiegelman, Donna; Richter, James M; Korzenik, Joshua R; Chan, Andrew T (BMJ Publishing Group Ltd., 2013)Objective: To examine the association between physical activity and risk of ulcerative colitis and Crohn’s disease. Design: Prospective cohort study. Setting: Nurses’ Health Study and Nurses’ Health Study II. Participants: ... -
Plasma Phospholipid Saturated Fatty Acids and Incident Atrial Fibrillation: The Cardiovascular Health Study
Fretts, Amanda M.; Mozaffarian, Dariush; Siscovick, David S.; Djousse, Luc; Heckbert, Susan R.; King, Irena B.; McKnight, Barbara; Sitlani, Colleen; Sacks, Frank M.; Song, Xiaoling; Sotoodehnia, Nona; Spiegelman, Donna; Wallace, Erin R.; Lemaitre, Rozenn N. (Blackwell Publishing Ltd, 2014)Background: Prior studies suggest that circulating fatty acids may influence the risk of atrial fibrillation (AF), but little is known about the associations of circulating saturated fatty acids with risk of AF. Methods ... -
Polymorphic repeat in AIB1 does not alter breast cancer risk
Haiman, Christopher A; Hankinson, Susan Elizabeth; Spiegelman, Donna Lynn; Colditz, Graham A.; Willett, Walter C.; Speizer, Frank Erwin; Brown, Myles Avery; Hunter, David J. (BioMed Central, 2000)We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no association ...