Now showing items 21-27 of 27

    • Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice* 

      Nishida, Takefumi; De Yu, Jia; Minamishima, Shizuka; Sips, Patrick; Searles, Robert J.; Buys, Emmanuel; Janssens, Stefan; Brouckaert, Peter; Bloch, Kenneth Daniel; Ichinose, Fumito (Ovid Technologies (Wolters Kluwer Health), 2009)
      Objectives: Despite advances in resuscitation methods, survival after out-of-hospital cardiac arrest remains low, at least in part, due to postcardiac arrest circulatory and neurologic failure. To elucidate the role of ...
    • sGC\(\alpha_1 \beta_1\) Attenuates Cardiac Dysfunction and Mortality in Murine Inflammatory Shock Models 

      Cauwels, Anje; Raher, Michael J; Rauwerdink, Kristen M; Thibault, Helene; Thoonen, Robrecht; Brouckaert, Peter; Buys, Emmanuel; Passeri, Jonathan James; Hobai, Ion; Cawley, Sharon M.; Sips, Patrick; Scherrer-Crosbie, Marielle; Ichinose, Fumito; Bloch, Kenneth Daniel (BioMed Central, 2009)
    • Soluble Guanylate Cyclase  1 1 Limits Stroke Size and Attenuates Neurological Injury 

      Atochin, Dmitriy N.; Yuzawa, Izumi; Li, Qian; Rauwerdink, Kristen M.; Malhotra, Rajeev; Chang, Junlei; Brouckaert, Peter; Ayata, Cenk; Moskowitz, Michael Arthur; Bloch, Kenneth Daniel; Huang, Paul Lee; Buys, Emmanuel (Ovid Technologies (Wolters Kluwer Health), 2010)
      Background and Purpose— Nitric oxide mediates endothelium-dependent vasodilation, modulates cerebral blood flow, and determines stroke outcome. Nitric oxide signals in part by stimulating soluble guanylate cyclase (sGC) ...
    • Soluble Guanylate Cyclase α1–Deficient Mice: A Novel Murine Model for Primary Open Angle Glaucoma 

      Ko, Yu-Chieh; Hayton, Sarah R.; Jones, Alexander; Tainsh, Laurel T.; Ren, Ruiyi; Giani, Andrea; Clerté, Maeva; Abernathy, Emma; de Waard, Nadine; Turcotte, Raphael; Nathan, Daniel; Loomis, Stephanie J.; Gong, Haiyan; Brouckaert, Peter; Buys, Emmanuel; Alt, Clemens; Tainsh, Robert Edward Tillinghast; Oh, Dong-Jin; Malhotra, Rajeev; Arora, Pankaj; Yu, Binglan; Scherrer-Crosbie, Marielle; Kang, Jae Hee Hee; Lin, Charles P.; Rhee, Douglas J; Wiggs, Janey Lee; Gregory, Meredith S.; Pasquale, Louis; Bloch, Kenneth Daniel; Ksander, Bruce R. (Public Library of Science, 2013)
      Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown. Here, we report that mice lacking the \(α_1\) subunit of the nitric ...
    • Soluble Guanylate Cyclase-alpha1 Deficiency Selectively Inhibits the Pulmonary Vasodilator Response to Nitric Oxide and Increases the Pulmonary Vascular Remodeling Response to Chronic Hypoxia 

      Vermeersch, Pieter; Buys, Emmanuel; Pokreisz, Peter; Marsboom, Glenn; Ichinose, Fumito; Sips, Patrick; Pellens, Marijke; Gillijns, Hilde; Swinnen, Marc; Graveline, Amanda R; Collen, Desire; Dewerchin, Mieke; Brouckaert, Peter; Bloch, Kenneth; Janssens, Stefan (Ovid Technologies (Wolters Kluwer Health), 2007)
      BACKGROUND: Nitric oxide (NO) activates soluble guanylate cyclase (sGC), a heterodimer composed of alpha- and beta-subunits, to produce cGMP. NO reduces pulmonary vascular remodeling, but the role of sGC in vascular responses ...
    • Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation 

      Beppu, H; Mwizerwa, O N; Beppu, Y; Dattwyler, M P; Lauwers, Gregory Y.; Bloch, Kenneth Daniel; Goldstein, Allan Moises (Springer Nature, 2007)
      Stromal–epithelial interactions play a central role in development and tumorigenesis. Bone morphogenetic protein (BMP) signaling in the intestine is involved in both of these processes. Inactivation of BMP pathway genes ...
    • Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice 

      Pokreisz, Peter; Vandenwijngaert, Sara; Bito, Virginie; Van den Bergh, An; Lenaerts, Ilse; Busch, Cornelius; Marsboom, Glenn; Gheysens, Olivier; Vermeersch, Pieter; Biesmans, Liesbeth; Liu, Xiaoshun; Gillijns, Hilde; Pellens, Marijke; Van Lommel, Alfons; Buys, Emmanuel; Schoonjans, Luc; Vanhaecke, Johan; Verbeken, Erik; Sipido, Karin; Herijgers, Paul; Bloch, Kenneth Daniel; Janssens, Stefan P. (Ovid Technologies (Wolters Kluwer Health), 2009)
      Background— Ventricular expression of phosphodiesterase-5 (PDE5), an enzyme responsible for cGMP catabolism, is increased in human right ventricular hypertrophy, but its role in left ventricular (LV) failure remains ...