Browsing by Author "Serhan, Charles"
Now showing items 21-34 of 34
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Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study
Frediani, Jennifer K.; Jones, Dean P.; Tukvadze, Nestan; Uppal, Karan; Sanikidze, Eka; Kipiani, Maia; Tran, ViLinh T.; Hebbar, Gautam; Walker, Douglas I.; Kempker, Russell R.; Kurani, Shaheen S.; Colas, Romain A.; Dalli, Jesmond; Tangpricha, Vin; Serhan, Charles N.; Blumberg, Henry M.; Ziegler, Thomas R. (Public Library of Science, 2014)We aimed to characterize metabolites during tuberculosis (TB) disease and identify new pathophysiologic pathways involved in infection as well as biomarkers of TB onset, progression and resolution. Such data may inform ... -
Pro-Resolving Lipid Mediators (SPMs) and Their Actions in Regulating miRNA in Novel Resolution Circuits in Inflammation
Recchiuti, Antonio; Serhan, Charles Nicholas (Frontiers Media S.A., 2012)Unresolved inflammation is associated with several widely occurring diseases such as arthritis, periodontal diseases, cancer, and atherosclerosis. Endogenous mechanisms that curtail excessive inflammation and prompt its ... -
Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis
Norling, Lucy V.; Headland, Sarah E.; Dalli, Jesmond; Arnardottir, Hildur H.; Haworth, Oliver; Jones, Hefin R.; Irimia, Daniel; Serhan, Charles N.; Perretti, Mauro (2016)Rheumatoid arthritis (RA) is a debilitating disease characterized by persistent accumulation of leukocytes within the articular cavity and synovial tissue. Metabololipidomic profiling of arthritic joints from omega-3 ... -
Protectin D1 Is Generated in Asthma and Dampens Airway Inflammation and Hyperresponsiveness
Levy, Bruce; Kohli, Payal; Gotlinger, Katherine; Haworth, Oliver; Hong, Song; Kazani, Shamsah; Israel, Elliot; Haley, Kathleen; Serhan, Charles (American Association of Immunologists, 2007-01-01)Protectins are newly identified natural chemical mediators that counter leukocyte activation to promote resolution of inflammation. In this study, we provide the first evidence for protectin D1 (PD1, 10R,17S-dihydroxy-do ... -
The Resolvin D1 Analogue Controls Maturation of Dendritic Cells and Suppresses Alloimmunity in Corneal Transplantation
Hua, Jing; Jin, Yiping; Chen, Yihe; Inomata, Takenori; Lee, HyunSoo; Chauhan, Sunil Kumar; Petasis, Nicos A.; Serhan, Charles Nicholas; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2014)Purpose. To analyze the effect of a resolvin D1 (RvD1) analogue (RvD1a) on dendritic cell maturation, T-cell sensitization, and allograft rejection in corneal allotransplantation. Methods. The receptor expression ... -
Resolvin D1 and Aspirin-Triggered Resolvin D1 Regulate Histamine-stimulated Conjunctival Goblet Cell Secretion
Li, Dayu; Hodges, Robin R.; Jiao, Jianwei; Carozza, Richard B.; Shatos, Marie A.; Chiang, Nan; Serhan, Charles N.; Dartt, Darlene A. (2013)Resolution of inflammation is an active process mediated by pro-resolution lipid mediators. Since resolvin (Rv) D1 is produced in the cornea, pro-resolution mediators could be effective in regulating inflammatory responses ... -
Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance
Winkler, Jeremy W.; Orr, Sarah K.; Dalli, Jesmond; Cheng, Chien-Yee C.; Sanger, Julia M.; Chiang, Nan; Petasis, Nicos A.; Serhan, Charles N. (Nature Publishing Group, 2016)Resolvins of the D-series are specialized pro-resolving lipid mediators that regulate cellular response by orchestrating resolution networks involved in host responses to injury and infection. Here, endogenous resolvin D4 ... -
Self-Limited versus Delayed Resolution of Acute Inflammation: Temporal Regulation of Pro-Resolving Mediators and MicroRNA
Fredman, Gabrielle; Li, Yongsheng; Dalli, Jesmond P; Chiang, Nan; Serhan, Charles Nicholas (Nature Publishing Group, 2012)Mechanisms underlying delays in resolution programs of inflammation are of interest for many diseases. Here, we addressed delayed resolution of inflammation and identified specific microRNA (miR)-metabolipidomic signatures. ... -
Small-Molecule Screen Identifies Reactive Oxygen Species as Key Regulators of Neutrophil Chemotaxis
Hattori, Hidenori; Subramanian, Kulandayan K.; Sakai, Jiro; Jia, Yonghui; Li, Yitang; Porter, Timothy F.; Loison, Fabien; Sarraj, Bara; Kasorn, Anongnard; Jo, Hakryul; Blanchard, Catlyn; Zirkle, Dorothy; McDonald, Douglas Ray; Pai, Sung-Yun; Serhan, Charles Nicholas; Luo, Hongbo (Proceedings of the National Academy of Sciences, 2010)Neutrophil chemotaxis plays an essential role in innate immunity, but the underlying cellular mechanism is still not fully characterized. Here, using a small-molecule functional screening, we identified NADPH oxidase–dependent ... -
Synthesis and Anti-inflammatory and Pro-resolving Activities of 22-OH-PD1, a Monohydroxylated Metabolite of Protectin D1
Tungen, Jørn E.; Aursnes, Marius; Vik, Anders; Ramon, Sesquile; Colas, Romain A.; Dalli, Jesmond; Serhan, Charles N.; Hansen, Trond V. (American Chemical Society and American Society of Pharmacognosy, 2014)Protectin D1 (PD1 (3)), a C22-dihydroxylated polyunsaturated fatty acid biosynthesized from all-Z-docosahexaenoic acid, belongs to the new family of endogenous mediators referred to as specialized pro-resolving lipid ... -
Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins
Primdahl, Karoline G.; Aursnes, Marius; Walker, Mary E.; Colas, Romain A.; Serhan, Charles N.; Dalli, Jesmond; Hansen, Trond V.; Vik, Anders (American Chemical Society and American Society of Pharmacognosy, 2016)Specialized pro-resolving lipid mediators are biosynthesized during the resolution phase of acute inflammation from n-3 polyunsaturated fatty acids. Recently, the isolation and identification of the four novel mediators ... -
Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation
Koltsida, Ourania; Karamnov, Sergey; Pyrillou, Katerina; Vickery, Thad; Chairakaki, Aikaterini-Dimitra; Tamvakopoulos, Constantin; Sideras, Paschalis; Serhan, Charles Nicholas; Andreakos, Evangelos (WILEY-VCH Verlag, 2013)Although specialized pro-resolving mediators (SPMs) biosynthesized from polyunsaturated fatty acids are critical for the resolution of acute inflammation, the molecules and pathways that induce their production remain ... -
Total Synthesis of the Lipid Mediator PD1n-3 DPA: Configurational Assignments and Anti-inflammatory and Pro-resolving Actions
Aursnes, Marius; Tungen, Jørn E.; Vik, Anders; Colas, Romain; Cheng, Chien-Yee C.; Dalli, Jesmond; Serhan, Charles N.; Hansen, Trond V. (American Chemical Society and American Society of Pharmacognosy, 2014)The polyunsaturated lipid mediator PD1n-3 DPA (5) was recently isolated from self-resolving inflammatory exudates of 5 and human macrophages. Herein, the first total synthesis of PD1n-3 DPA (5) is reported in 10 steps and ... -
Vagus nerve controls resolution and pro-resolving mediators of inflammation
Mirakaj, Valbona; Dalli, Jesmond; Granja, Tiago; Rosenberger, Peter; Serhan, Charles N. (The Rockefeller University Press, 2014)Resolution of inflammation is now recognized as a biosynthetically active process involving pro-resolving mediators. Here, we show in zymosan-initiated peritoneal inflammation that the vagus nerve regulates local expression ...