Now showing items 21-40 of 46

    • MAFG-Driven Astrocytes Promote CNS Inflammation 

      Wheeler, Michael; Clark, Iain; Tjon, Emily; Li, Zhaorong; Zandee, Stephanie E. J.; Couturier, Charles P.; Watson, Brianna; Scalisi, Giulia; Alkwai, Sarah; Rothhammer, Veit; Rotem, Assaf; Heyman, John; Thaploo, Shravan; Sanmarco, Liliana; Ragoussis, Jiannis; Weitz, David; Petrecca, Kevin; Moffitt, Jeffrey; Becher, Burkhard; Antel, Jack P.; Prat, Alexandre; Quintana, Francisco (Springer Science and Business Media LLC, 2020-02-12)
    • Magnetic Spheres in Viscous Flows and at Interfaces: Sorting, Coating, and Interfacial Deformation 

      Tsai, Scott (2013-02-11)
      Magnetic microparticles are often used in laboratory settings for the separation of biological material. These microparticles can also be useful in microfluidic settings because of their small size and the possibility of ...
    • Mechanical Failure in Colloidal Gels 

      Kodger, Thomas Edward (2015-01-16)
      When colloidal particles in a dispersion are made attractive, they aggregate into fractal clusters which grow to form a space-spanning network, or gel, even at low volume fractions. These gels are crucial to the rheological ...
    • Mechanics and Dynamics of Biopolymer Networks 

      Morris, Eliza (2014-06-06)
      The three major mechanical components of cells are the biopolymers actin, microtubules, and intermediate filaments. Cellular processes are all highly reliant on the mechanics of the specific biopolymers and the networks ...
    • The Mechanics of Fibrin Networks and Their Alterations by Platelets 

      Jawerth, Louise Marie (2013-09-04)
      Fibrin is a biopolymer that assembles into a network during blood coagulation to become the structural scaffold of a blood clot. The precise mechanics of this network are crucial for a blood clot to properly stem the flow ...
    • Microfluidic Methods for High-Throughput Biological Screening 

      Ung, Warren Lloyd (2015-09-23)
      Often in biology, rare individuals within a population dominate the population’s overall behavior, and we wish to extract those individuals for further analysis. We design a sorting instrument as a flexible platform for ...
    • Microfluidic Platform for the Detection of Single Cell Immune Activity and Tag-Free Selection of Individual Target-Cell Responsive Effector Cells 

      Sun, Li (2016-05-19)
      Adoptive Immunotherapy has long been explored as a possible cure for challenging diseases including cancer and HIV infection. The key step in such therapies is to identify and select disease-specific effector cells, which ...
    • Microwave dielectric heating of non-aqueous droplets in a microfluidic device for nanoparticle synthesis 

      Koziej, Dorota; Floryan, Caspar; Sperling, Ralph A.; Ehrlicher, Allen; Issadore, David; Westervelt, Robert M.; Weitz, David A. (Royal Society of Chemistry (RSC), 2013)
      We describe a microfluidic device with an integrated microwave heater specifically designed to dielectrically heat non-aqueous droplets using time-varying electrical fields with the frequency range between 700 and 900 MHz. ...
    • A mix-and-read drop-based in vitro two-hybrid method for screening high-affinity peptide binders 

      Cui, Naiwen; Zhang, Huidan; Schneider, Nils; Tao, Ye; Asahara, Haruichi; Sun, Zhiyi; Cai, Yamei; Koehler, Stephan A.; de Greef, Tom F. A.; Abbaspourrad, Alireza; Weitz, David A.; Chong, Shaorong (Nature Publishing Group, 2016)
      Drop-based microfluidics have recently become a novel tool by providing a stable linkage between phenotype and genotype for high throughput screening. However, use of drop-based microfluidics for screening high-affinity ...
    • Molecular Basis of Filamin A-FilGAP Interaction and Its Impairment in Congenital Disorders Associated with Filamin A Mutations 

      Heikkinen, Outi; Pentikäinen, Olli T.; Kasza, Karen E.; Kupiainen, Olga; Permi, Perttu; Kilpeläinen, Ilkka; Ylänne, Jari; Nakamura, Fumihiko; Osborn, Teresia M.; Weitz, David A.; Hartwig, John Henry; Stossel, Thomas Peter (Public Library of Science, 2009)
      Background: Mutations in filamin A (FLNa), an essential cytoskeletal protein with multiple binding partners, cause developmental anomalies in humans. Methodology/principal findings: We determined the structure of the 23rd ...
    • Optimal vein density in artificial and real leaves 

      Noblin, X.; Mahadevan, Lakshminarayanan; Coomaraswamy, I. A.; Weitz, David A.; Holbrook, Noel Michele; Zwieniecki, Maciej A. (Proceedings of the National Academy of Sciences, 2008)
      The long evolution of vascular plants has resulted in a tremendous variety of natural networks responsible for the evaporatively driven transport of water. Nevertheless, little is known about the physical principles that ...
    • Osmotic-pressure-controlled concentration of colloidal particles in thin-shelled capsules 

      Kim, Shin-Hyun; Park, Jin-Gyu; Choi, Tae Min; Manoharan, Vinothan N.; Weitz, David A. (Nature Publishing Group, 2014)
      Colloidal crystals are promising structures for photonic applications requiring dynamic control over optical properties. However, for ease of processing and reconfigurability, the crystals should be encapsulated to form ...
    • Perfluoroalkyl-Functionalized Hyperbranched Polyglycerol as Pore Forming Agents and Supramolecular Hosts in Polymer Microspheres 

      Wagner, Olaf; Zieringer, Maximilian; Duncanson, Wynter J.; Weitz, David A.; Haag, Rainer (MDPI, 2015)
      Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres. In a previously-presented work a dendrimer with a ...
    • Perfluoroalkyl-Functionalized Hyperbranched Polyglycerol as Pore Forming Agents and Supramolecular Hosts in Polymer Microspheres 

      Wagner, Olaf; Zieringer, Maximilian; Duncanson, Wynter J.; Weitz, David A.; Haag, Rainer (MDPI, 2015)
      Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres. In a previously-presented work a dendrimer with a ...
    • Physical Nature of Cytoplasm 

      Guo, Ming (2014-10-22)
      Forces are increasingly recognized as major regulators of cell physiology and function, and the mechanical properties of cells are essential to the mechanisms by which cells sense forces, transmit them to the cell interior ...
    • Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state 

      Rotem, Assaf; Ram, Oren; Shoresh, Noam; Sperling, Ralph A.; Goren, Alon; Weitz, David A.; Bernstein, Bradley E. (2015)
      Chromatin profiling provides a versatile means to investigate functional genomic elements and their regulation. However, current methods yield ensemble profiles that are insensitive to cell-to-cell variation. Here we combine ...
    • Soft Colloids from p(NIPAm-co-AAc): Packing Dynamics and Structure 

      Muluneh, Melaku (2012-08-03)
      Traditionally, the experimental model of choice for studying the structure and dynamics of glasses or crystals are hard-sphere colloids. An analogy with molecular or atomic materials is often drawn, in which each colloidal ...
    • Stiffness of the Crystal-Liquid Interface in a Hard-Sphere Colloidal System Measured from Capillary Fluctuations 

      Ramsteiner, I. B.; Weitz, David A.; Spaepen, Frans A. (American Physical Society (APS), 2010)
      Face-centered cubic single crystals of \(σ=1.55 μm\) diameter hard-sphere silica colloidal particles were prepared by sedimentation onto (100) and (110) oriented templates. The crystals had a wide interface with the ...
    • Strain-Induced Alignment in Collagen Gels 

      Vader, David; Kabla, Alexandre; Weitz, David A.; Mahadevan, Lakshminarayanan (Public Library of Science, 2009)
      Collagen is the most abundant extracellular-network-forming protein in animal biology and is important in both natural and artificial tissues, where it serves as a material of great mechanical versatility. This versatility ...
    • Structure and Defects of Hard-Sphere Colloidal Crystals and Glasses 

      Jensen, Katharine Estelle (2013-08-21)
      Colloidal particles provide convenient and useful building blocks for creating ordered and disordered structures with length scales on the order of a micrometer. These structures are useful materials in their own right, ...