Now showing items 21-40 of 45

• #### Magnetic Spheres in Viscous Flows and at Interfaces: Sorting, Coating, and Interfacial Deformation ﻿

(2013-02-11)
Magnetic microparticles are often used in laboratory settings for the separation of biological material. These microparticles can also be useful in microfluidic settings because of their small size and the possibility of ...
• #### Mechanical Failure in Colloidal Gels ﻿

(2015-01-16)
When colloidal particles in a dispersion are made attractive, they aggregate into fractal clusters which grow to form a space-spanning network, or gel, even at low volume fractions. These gels are crucial to the rheological ...
• #### Mechanics and Dynamics of Biopolymer Networks ﻿

(2014-06-06)
The three major mechanical components of cells are the biopolymers actin, microtubules, and intermediate filaments. Cellular processes are all highly reliant on the mechanics of the specific biopolymers and the networks ...
• #### The Mechanics of Fibrin Networks and Their Alterations by Platelets ﻿

(2013-09-04)
Fibrin is a biopolymer that assembles into a network during blood coagulation to become the structural scaffold of a blood clot. The precise mechanics of this network are crucial for a blood clot to properly stem the flow ...
• #### Microfluidic Methods for High-Throughput Biological Screening ﻿

(2015-09-23)
Often in biology, rare individuals within a population dominate the population’s overall behavior, and we wish to extract those individuals for further analysis. We design a sorting instrument as a flexible platform for ...
• #### Microfluidic Platform for the Detection of Single Cell Immune Activity and Tag-Free Selection of Individual Target-Cell Responsive Effector Cells ﻿

(2016-05-19)
Adoptive Immunotherapy has long been explored as a possible cure for challenging diseases including cancer and HIV infection. The key step in such therapies is to identify and select disease-specific effector cells, which ...
• #### Microwave dielectric heating of non-aqueous droplets in a microfluidic device for nanoparticle synthesis ﻿

(Royal Society of Chemistry (RSC), 2013)
We describe a microfluidic device with an integrated microwave heater specifically designed to dielectrically heat non-aqueous droplets using time-varying electrical fields with the frequency range between 700 and 900 MHz. ...
• #### A mix-and-read drop-based in vitro two-hybrid method for screening high-affinity peptide binders ﻿

(Nature Publishing Group, 2016)
Drop-based microfluidics have recently become a novel tool by providing a stable linkage between phenotype and genotype for high throughput screening. However, use of drop-based microfluidics for screening high-affinity ...
• #### Molecular Basis of Filamin A-FilGAP Interaction and Its Impairment in Congenital Disorders Associated with Filamin A Mutations ﻿

(Public Library of Science, 2009)
Background: Mutations in filamin A (FLNa), an essential cytoskeletal protein with multiple binding partners, cause developmental anomalies in humans. Methodology/principal findings: We determined the structure of the 23rd ...
• #### Optimal vein density in artificial and real leaves ﻿

(Proceedings of the National Academy of Sciences, 2008)
The long evolution of vascular plants has resulted in a tremendous variety of natural networks responsible for the evaporatively driven transport of water. Nevertheless, little is known about the physical principles that ...
• #### Osmotic-pressure-controlled concentration of colloidal particles in thin-shelled capsules ﻿

(Nature Publishing Group, 2014)
Colloidal crystals are promising structures for photonic applications requiring dynamic control over optical properties. However, for ease of processing and reconfigurability, the crystals should be encapsulated to form ...
• #### Perfluoroalkyl-Functionalized Hyperbranched Polyglycerol as Pore Forming Agents and Supramolecular Hosts in Polymer Microspheres ﻿

(MDPI, 2015)
Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres. In a previously-presented work a dendrimer with a ...
• #### Perfluoroalkyl-Functionalized Hyperbranched Polyglycerol as Pore Forming Agents and Supramolecular Hosts in Polymer Microspheres ﻿

(MDPI, 2015)
Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres. In a previously-presented work a dendrimer with a ...
• #### Physical Nature of Cytoplasm ﻿

(2014-10-22)
Forces are increasingly recognized as major regulators of cell physiology and function, and the mechanical properties of cells are essential to the mechanisms by which cells sense forces, transmit them to the cell interior ...
• #### Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state ﻿

(2015)
Chromatin profiling provides a versatile means to investigate functional genomic elements and their regulation. However, current methods yield ensemble profiles that are insensitive to cell-to-cell variation. Here we combine ...
• #### Soft Colloids from p(NIPAm-co-AAc): Packing Dynamics and Structure ﻿

(2012-08-03)
Traditionally, the experimental model of choice for studying the structure and dynamics of glasses or crystals are hard-sphere colloids. An analogy with molecular or atomic materials is often drawn, in which each colloidal ...
• #### Stiffness of the Crystal-Liquid Interface in a Hard-Sphere Colloidal System Measured from Capillary Fluctuations ﻿

(American Physical Society (APS), 2010)
Face-centered cubic single crystals of $σ=1.55 μm$ diameter hard-sphere silica colloidal particles were prepared by sedimentation onto (100) and (110) oriented templates. The crystals had a wide interface with the ...
• #### Strain-Induced Alignment in Collagen Gels ﻿

(Public Library of Science, 2009)
Collagen is the most abundant extracellular-network-forming protein in animal biology and is important in both natural and artificial tissues, where it serves as a material of great mechanical versatility. This versatility ...
• #### Structure and Defects of Hard-Sphere Colloidal Crystals and Glasses ﻿

(2013-08-21)
Colloidal particles provide convenient and useful building blocks for creating ordered and disordered structures with length scales on the order of a micrometer. These structures are useful materials in their own right, ...
• #### Structure and Properties of Charged Colloidal Systems ﻿

(2014-06-06)
This dissertation explores the changes in structure of colloidal systems on the introduction of repulsive interactions. Colloidal gels are well understood when all particle interactions are attractive, but their structure ...