Now showing items 21-40 of 58

    • Exposure to persistent organic pollutants and sperm sex chromosome ratio in men from the Faroe Islands 

      Kvist, L.; Giwercman, A.; Weihe, Pal; Kold Jensen, T.; Grandjean, Philippe; Halling, J.; Skaalum Petersen, M.; Lundberg Giwercman, Y. (Elsevier BV, 2014)
      People in the Arctic as well as fishermen on the polluted Swedish east coast are highly exposed to persistent organic pollutants (POPs). These compounds have been shown to affect the sperm Y:X chromosome ratio. In present ...
    • Functional MRI approach to developmental methylmercury and polychlorinated biphenyl neurotoxicity 

      White, Roberta F; Palumbo, Carole L.; Yurgelun-Todd, Deborah; Heaton, Kristin J.; Weihe, Pal; Debes, Frodi; Grandjean, Philippe (Elsevier BV, 2011)
      Prenatal and early childhood exposure to methylmercury (MeHg) or polychlorinated biphenyls (PCBs) are associated with deficits in cognitive, sensory, motor and other functions measured by neurobehavioral tests. The main ...
    • Gestational diabetes and offspring birth size at elevated environmental pollutant exposures 

      Valvi, Damaskini; Oulhote, Youssef; Weihe, Pal; Dalgård, Christine; Bjerve, Kristian S.; Steuerwald, Ulrike; Grandjean, Philippe (Elsevier BV, 2017)
      BACKGROUND: Gestational diabetes mellitus (GDM) is associated with increased availability of glucose and macronutrients in fetal circulation and macrosomia. Therefore, the role of GDM in the association between ...
    • High latitude and marine diet: vitamin D status in elderly Faroese 

      Dalgård, Christine; Petersen, Maria Skaalum; Schmedes, Anne V.; Brandslund, Ivan; Weihe, Pal; Grandjean, Philippe (Cambridge University Press (CUP), 2010)
      Human subjects obtain their vitamin D from the diet, especially from marine food, and from endogenous synthesis following cutaneous sun exposure. The risk of an insufficient vitamin D synthesis is increased in northern ...
    • Human Milk as a Source of Methylmercury Exposure in Infants 

      Grandjean, Philippe; Jørgensen, PJ; Weihe, Pal (Environmental Health Perspectives, 1994)
      As methylmercury is excreted in human milk and infants are particularly susceptible to toxicity due to this compound, the purpose of this study was to evaluate the possible transfer of methylmercury to infants via ...
    • Hydroxylated PCB Metabolites and PCBs in Serum from Pregnant Faroese Women 

      Fängström, Britta; Athanasiadou, Maria; Grandjean, Philippe; Weihe, Pal; Bergman, Åke (Environmental Health Perspectives, 2002)
      In the Faroe Islands in the North Atlantic, the traditional diet includes pilot whale meat and blubber and other marine food. Fatty fish and blubber of mammals may contain high concentrations of organohalogen substances ...
    • Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years 

      Debes, Frodi; Budtz-Jørgensen, Esben; Weihe, Pal; White, Roberta F; Grandjean, Philippe (Elsevier BV, 2006)
      A cohort of 1022 consecutive singleton births was generated during 1987–1988 in the Faroe Islands, where increased methylmercury exposure occurs from traditional seafood diets that include pilot whale meat. The prenatal ...
    • Marine Food Pollutants as a Risk Factor for Hypoinsulinemia and Type 2 Diabetes 

      Grandjean, Philippe; Henriksen, Jan Erik; Choi, Anna Lai; Petersen, Maria Skaalum; Dalgård, Christine; Nielsen, Flemming; Weihe, Pal (Ovid Technologies (Wolters Kluwer Health), 2011)
      Background: Some persistent environmental chemicals are suspected of causing an increased risk of type 2 diabetes mellitus, a disease particularly common after the age of 70. This concern was examined in a cross-sectional ...
    • Maternal seafood diet, methylmercury exposure, and neonatal neurologic function 

      Steuerwald, Ulrike; Weihe, Pal; Jørgensen, Poul J.; Bjerve, Kristian; Brock, John; Heinzow, Birger; Budtz-Jørgensen, Esben; Grandjean, Philippe (Elsevier BV, 2000)
      Objective: To determine whether neonatal neurologic function is adversely affected by seafood contaminants from maternal diet during pregnancy. Study design: One hundred eighty-two singleton term births were evaluated in ...
    • Mercury in the Umbilical Cord: Implications for Risk Assessment for Minamata Disease 

      Dalgard, C; Grandjean, Philippe; Jorgensen, PJ; Weihe, Pal (Environmental Health Perspectives, 1994)
      Umbilical cord tissue was obtained from 50 births in the Faroe Islands, where high mercury intake is due to ingestion of pilot whale meat. The mercury concentration correlated significantly with the frequency of maternal ...
    • Methylmercury Exposure and Adverse Cardiovascular Effects in Faroese Whaling Men 

      Choi, Anna Lai; Weihe, Pal; Budtz-Jørgensen, Esben; Jørgensen, Poul J.; Salonen, Jukka T.; Tuomainen, Tomi-Pekka; Murata, Katsuyuki; Nielsen, Hans Petur; Petersen, Maria Skaalum; Askham, Jórun; Grandjean, Philippe (National Institute of Environmental Health Sciences, 2008)
      Background: Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality. Objective: We examined 42 Faroese whaling men (30–70 years of age) to ...
    • Methylmercury: significance of intrauterine and postnatal exposures. 

      Grandjean, Philippe; Weihe, Pal; Nielsen, JB (American Association for Clinical Chemistry, 1994)
      Outbreaks of methylmercury poisoning in Japan and Iraq have demonstrated the sensitivity of the fetus to neurotoxic effects. Based on toxicokinetics and considerations of practicability, the optimal biomarker of methylmercury ...
    • Negative confounding by essential fatty acids in methylmercury neurotoxicity associations 

      Choi, Anna; Mogensen, Ulla B.; Bjerve, Kristian S.; Debes, Frodi; Weihe, Pal; Grandjean, Philippe; Budtz-Jørgensen, Esben (Elsevier BV, 2014)
      Background Methylmercury, a worldwide contaminant of fish and seafood, can cause adverse effects on the developing nervous system. However, long-chain n-3 polyunsaturated fatty acids in seafood provide beneficial effects ...
    • Negative Confounding in the Evaluation of Toxicity: The Case of Methylmercury in Fish and Seafood 

      Choi, Anna L.; Cordier, Sylvaine; Weihe, Pal; Grandjean, Philippe (Informa UK Limited, 2008)
      In observational studies, the presence of confounding can distort the true association between an exposure and a toxic effect outcome if the confounding variable is not controlled either in the study design or the analysis ...
    • Neurobehavioral deficits at age 7years associated with prenatal exposure to toxicants from maternal seafood diet 

      Grandjean, Philippe; Weihe, Pal; Nielsen, Flemming; Heinzow, Birger; Debes, Frodi; Budtz-Jørgensen, Esben (Elsevier BV, 2012)
      To determine the possible neurotoxic impact of prenatal exposure to polychlorinated biphenyls (PCBs), we analyzed banked cord blood from a Faroese birth cohort for PCBs. The subjects were born in 1986–1987, and 917 cohort ...
    • Neurobehavioral epidemiology: application in risk assessment 

      Grandjean, Philippe; White, RF; Weihe, Pal (National Institute of Environmental Health Sciences, 1996)
      Neurobehavioral epidemiology may contribute information to risk assessment in relation to a) characterization of neurotoxicity and its time course; b) the dose-effect relationship; c) the dose-response relationship; and ...
    • Neurobehavioral performance of Inuit children with increased prenatal exposure to methylmercury 

      Weihe, Pal; Hansen, Jens C.; Murata, Katsuyuki; Debes, Frodi; Jorgensen, Poul J.; Steuerwald, Ulrike; White, Roberta F; Grandjean, Philippe (Taylor & Francis Open, 2002)
      Exposure to methylmercury from marine mammals and other seafood may affect the development of the central nervous system. In a traditional Inuit community in Qaanaaq, Greenland, mercury concentrations in cord blood and ...
    • Neurotoxic Risk Caused by Stable and Variable Exposure to Methylmercury From Seafood 

      Grandjean, Philippe; White, Roberta F; Weihe, Pal; Jørgensen, Poul J. (Elsevier, 2003)
      Objectives.—To examine whether the dose-effect relationship for developmental mercury neurotoxicity is affected by variable mercury exposure during pregnancy. Methods.—The study was based on a birth cohort of 1022 children ...
    • Neurotoxicity from prenatal and postnatal exposure to methylmercury 

      Grandjean, Philippe; Weihe, Pal; Debes, Frodi; Choi, Anna; Budtz-Jørgensen, Esben (Elsevier BV, 2014)
      The extent to which postnatal methylmercury exposure contributes to neurobehavioral delays is uncertain. Confounding may occur because the child's dietary exposure likely correlates with the mother's. This conundrum was ...
    • No changes in lymphocyte muscarinic receptors and platelet monoamine oxidase-B examined as surrogate central nervous system biomarkers in a Faroese children cohort prenatally exposed to methylmercury and polychlorinated biphenyls 

      Coccini, Teresa; Manzo, Luigi; Debes, Frodi; Steuerwald, Ulrike; Weihe, Pal; Grandjean, Philippe (Informa UK Limited, 2009)
      Experimental evidence suggests that monoamine oxidase B (MAO-B) and muscarinic cholinergic receptors (mAChRs) are involved in the pathogenesis of neurotoxicity caused by methylmercury and polychlorinated biphenyls (PCBs). ...