Now showing items 21-31 of 31

    • A Mechanosensitive Transcriptional Mechanism That Controls Angiogenesis 

      Mammoto, Akiko; Connor, Kip; Mammoto, Tadanori; Yung, Chong W.; Huh, Dongeun; Aderman, Christopher Michael; Mostoslavsky, Gustavo; Smith, Lois Elaine Hodgson; Ingber, Donald Elliott (Nature Publishing Group, 2009)
      Angiogenesis is controlled by physical interactions between cells and extracellular matrix as well as soluble angiogenic factors, such as VEGF. However, the mechanism by which mechanical signals integrate with other ...
    • A multi-modular tensegrity model of an actin stress fiber 

      Luo, Yaozhi; Xu, Xiang; Lele, Tanmay; Kumar, Sanjay; Ingber, Donald Elliot (Elsevier, 2008)
      Stress fibers are contractile bundles in the cytoskeleton that stabilize cell structure by exerting traction forces on the extracellular matrix. Individual stress fibers are molecular bundles composed of parallel actin ...
    • Multistable and Multistep Dynamics in Neutrophil Differentiation 

      Chang, Hannah H.; Oh, Philmo Y; Ingber, Donald Elliott; Huang, Sui (BioMed Central, 2006)
      Background Cell differentiation has long been theorized to represent a switch in a bistable system, and recent experimental work in micro-organisms has revealed bistable dynamics in small gene regulatory circuits. However, ...
    • Multizone Paper Platform for 3D Cell Cultures 

      Derda, Ratmir; Tang, Sindy K. Y.; Laromaine, Anna; Mosadegh, Bobak; Hong, Estrella; Mwangi, Martin; Mammoto, Akiko; Ingber, Donald Elliot; Whitesides, George McClelland (Public Library of Science (PLoS), 2011)
      In vitro 3D culture is an important model for tissues in vivo. Cells in different locations of 3D tissues are physiologically different, because they are exposed to different concentrations of oxygen, nutrients, and signaling ...
    • Noise-Driven Stem Cell and Progenitor Population Dynamics 

      Hoffmann, Martin; Chang, Hannah Han-Chun; Hang, Sui; Ingber, Donald Elliott; Loeffler, Markus; Galle, Joerg (Public Library of Science, 2008)
      BACKGROUND: The balance between maintenance of the stem cell state and terminal differentiation is influenced by the cellular environment. The switching between these states has long been understood as a transition between ...
    • Platform for High-Throughput Testing of the Effect of Soluble Compounds on 3D Cell Cultures 

      Deiss, Frédérique; Mazzeo, Aaron; Hong, Estrella; Ingber, Donald Elliott; Derda, Ratmir; Whitesides, George McClelland (American Chemical Society (ACS), 2013)
      In vitro 3D culture could provide an important model of tissues in vivo, but assessing the effects of chemical compounds on cells in specific regions of 3D culture requires physical isolation of cells and thus currently ...
    • A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function 

      Jain, Abhishek; Graveline, Amanda; Waterhouse, Anna; Vernet, Andyna; Flaumenhaft, Robert; Ingber, Donald E. (Nature Publishing Group, 2016)
      Accurate assessment of blood haemostasis is essential for the management of patients who use extracorporeal devices, receive anticoagulation therapy or experience coagulopathies. However, current monitoring devices do not ...
    • Silencing HoxA1 by Intraductal Injection of siRNA Lipidoid Nanoparticles Prevents Mammary Tumor Progression in Mice 

      Brock, Amy; Krause, Silva; Li, Hu; Kowalski, Marek; Goldberg, Michael; Collins, James J.; Ingber, Donald Elliot (American Association for the Advancement of Science (AAAS), 2014)
      With advances in screening, the incidence of detection of premalignant breast lesions has increased in recent decades; however, treatment options remain limited to surveillance or surgical removal by lumpectomy or mastectomy. ...
    • Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro 

      Benam, Kambez H; Villenave, Remi; Lucchesi, Carolina; Varone, Antonio; Hubeau, Cedric; Lee, Hyun-Hee; Alves, Stephen E; Salmon, Michael; Ferrante, Thomas Charles; Weaver, James C.; Bahinski, Anthony; Hamilton, Geraldine A; Ingber, Donald Elliot (Nature Publishing Group, 2015)
      Here we describe development of a human ‘lung small airway-on-a-chip’ containing a differentiated, mucociliary, bronchiolar epithelium and an underlying microvascular endothelium that experiences fluid flow, which enables ...
    • Stability of Surface-Immobilized Lubricant Interfaces under Flow 

      Howell, Caitlin; Vu, Thy L.; Johnson, Christopher; Hou, Xu; Ahanotu, Onyemaechi; Alvarenga, Jack; Leslie, Daniel; Uzun, Oktay; Waterhouse, Anna; Kim, Philseok; Super, Michael; Aizenberg, Michael; Ingber, Donald Elliot; Aizenberg, Joanna (American Chemical Society (ACS), 2015)
      The stability and longevity of surface-stabilized lubricant layers is a critical question in their application as low- and nonfouling slippery surface treatments in both industry and medicine. Here, we investigate lubricant ...
    • Towards a Holistic, Yet Gene-Centered Analysis of Gene Expression Profiles: A Case Study of Human Lung Cancers 

      Guo, Yuchun; Eichler, Gabriel S.; Feng, Ying; Ingber, Donald Elliott; Huang, Sui (Hindawi Publishing Corporation, 2006)
      Genome-wide gene expression profile studies encompass increasingly large number of samples, posing a challenge to their presentation and interpretation without losing the notion that each transcriptome constitutes a complex ...