Now showing items 21-25 of 25

    • Tissue-Specific Alternative Splicing of TCF7L2 

      Prokunina-Olsson, Ludmila; Welch, Cullan; Hansson, Ola; Adhikari, Neeta; Usher, Nicolle; Tong, Maurine; Sprau, Andrew; Swift, Amy; Bonnycastle, Lori L.; Erdos, Michael R.; Harmon, Brennan; Kotova, Olga; Hoffman, Eric P.; Groop, Leif; Boehnke, Michael; Collins, Francis S.; Hall, Jennifer L.; Scott, Laura J.; He, Zhi; Saxena, Richa; Altshuler, David Matthew (Oxford University Press, 2009)
      Common variants in the transcription factor 7-like 2 (TCF7L2) gene have been identified as the strongest genetic risk factors for type 2 diabetes (T2D). However, the mechanisms by which these non-coding variants increase ...
    • Transferability and Fine Mapping of Type 2 Diabetes Loci in African Americans: The Candidate Gene Association Resource Plus Study 

      Ng, Maggie C.Y.; Saxena, Richa; Li, Jiang; Palmer, Nicholette D.; Dimitrov, Latchezar; Xu, Jianzhao; Rasmussen-Torvik, Laura J.; Zmuda, Joseph M.; Siscovick, David S.; Patel, Sanjay R.; Crook, Errol D.; Sims, Mario; Chen, Yii-Der I.; Bertoni, Alain G.; Li, Mingyao; Grant, Struan F.A.; Dupuis, Josée; Meigs, James B.; Psaty, Bruce M.; Pankow, James S.; Langefeld, Carl D.; Freedman, Barry I.; Rotter, Jerome I.; Wilson, James G.; Bowden, Donald W. (American Diabetes Association, 2013)
      Type 2 diabetes (T2D) disproportionally affects African Americans (AfA) but, to date, genetic variants identified from genome-wide association studies (GWAS) are primarily from European and Asian populations. We examined ...
    • Two Variants of the C-Reactive Protein Gene Are Associated with Risk of Pre-Eclampsia in an American Indian Population 

      Best, Lyle G.; Saxena, Richa; Anderson, Cindy M.; Barnes, Michael R.; Hakonarson, Hakon; Falcon, Gilbert; Martin, Candelaria; Castillo, Berta Almoguera; Karumanchi, Ananth; Keplin, Kylie; Pearson, Nichole; Lamb, Felicia; Bercier, Shellee; Keating, Brendan J. (Public Library of Science, 2013)
      Background: The etiology of pre-eclampsia (PE) is unknown; but it is accepted that normal pregnancy represents a distinctive challenge to the maternal immune system. C-reactive protein is a prominent component of the innate ...
    • TXNIP Regulates Peripheral Glucose Metabolism in Humans 

      Parikh, Hemang; Carlsson, Emma; Johansson, Lovisa E; Storgaard, Heidi; Poulsen, Pernille; Ladd, Christine; Schulze, P. Christian; Mazzini, Michael J; Jensen, Christine Bjørn; Krook, Anna; Björnholm, Marie; Tornqvist, Hans; Zierath, Juleen R; Ridderstråle, Martin; Vaag, Allan; Groop, Leif C; Chutkow, William Alexander; Saxena, Richa; Altshuler, David Matthew; Lee, Richard Theodore; Mootha, Vamsi Krishna (Public Library of Science, 2007)
      Background: Type 2 diabetes mellitus (T2DM) is characterized by defects in insulin secretion and action. Impaired glucose uptake in skeletal muscle is believed to be one of the earliest features in the natural history of ...
    • Updated Genetic Score Based on 34 Confirmed Type 2 Diabetes Loci Is Associated With Diabetes Incidence and Regression to Normoglycemia in the Diabetes Prevention Program 

      Hivert, Marie-France; Jablonski, Kathleen A.; Perreault, Leigh; McAteer, Jarred B.; Franks, Paul W.; Hamman, Richard F.; Kahn, Steven E.; Haffner, Steven; Knowler, William C.; Saxena, Richa; Meigs, James Benjamin; Altshuler, David Matthew; Florez, Jose Carlos (American Diabetes Association, 2011)
      Objective: Over 30 loci have been associated with risk of type 2 diabetes at genome-wide statistical significance. Genetic risk scores (GRSs) developed from these loci predict diabetes in the general population. We tested ...