Browsing by Author "Grandjean, Philippe"
Now showing items 21-40 of 174
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Benchmark Dose Calculations for Methylmercury-Associated Delays on Evoked Potential Latencies in Two Cohorts of Children
Murata, Katsuyuki; Budtz-Jorgensen, Esben; Grandjean, Philippe (Wiley-Blackwell, 2002)Delays in evoked potential latencies were observed at increased exposures to methylmercury from seafood in two cohorts of children. Because this outcome parameter appeared to be virtually independent of confounders, including ... -
Benchmark dose calculations of methylmercury-associated neurobehavioural deficits
Budtz-Jørgensen, Esben; Grandjean, Philippe; Keiding, Niels; White, Roberta F; Weihe, Pal (Elsevier BV, 2000)Prenatal methylmercury exposure is associated with neuropsychological deficits in Faroese children at age 7 years. Lower confidence bounds of benchmark doses (BMDLs) have now been calculated. With the cord-blood mercury ... -
Benefits of Regulating Hazardous Air Pollutants from Coal and Oil-Fired Utilities in the United States
Sunderland, Elsie M; Driscoll, Charles T.; Hammitt, James K.; Grandjean, Philippe; Evans, John S.; Blum, Joel D.; Chen, Celia Y.; Evers, David C.; Jaffe, Daniel A.; Mason, Robert P.; Goho, Shaun Alaric; Jacobs, Wendy B (American Chemical Society (ACS), 2016) -
Biomarkers in environmental toxicology: state of the art.
Grandjean, Philippe; Brown, SS; Reavey, P; Young, DS (American Association for Clinical Chemistry, 1995) -
Biomarkers in epidemiology
Grandjean, Philippe (American Association for Clinical Chemistry, 1995) -
Biomarkers of chemical exposure: state of the art.
Grandjean, Philippe; Brown, SS; Reavey, P; Young, DS (American Association for Clinical Chemistry, 1994)Establishing associations between environmental agents and disease presents challenges to both epidemiologists and toxicologists, particularly in cases of complex gene-environment interactions and when there is a long ... -
Birthweight in a fishing community: significance of essential fatty acids and marine food contaminants
Grandjean, Philippe; Bjerve, Kristian S; Weihe, Pal; Steuerwald, Ulrike (Oxford University Press (OUP), 2001)Background Marine food provides essential fatty acids that are important during pregnancy, but the benefits may be limited at high intakes and by seafood contaminants. Methods In the fishing community of the Faroe Islands, ... -
Breastfeeding as an Exposure Pathway for Perfluorinated Alkylates
Mogensen, Ulla B.; Grandjean, Philippe; Nielsen, Flemming; Weihe, Pal; Budtz-Jørgensen, Esben (American Chemical Society (ACS), 2015)Perfluorinated alkylate substances (PFASs) are widely used and have resulted in human exposures worldwide. PFASs occur in breast milk, and the duration of breastfeeding is associated with serum-PFAS concentrations in ... -
Burden of disease and costs of exposure to endocrine disrupting chemicals in the European Union: an updated analysis
Trasande, L.; Zoeller, R. T.; Hass, U.; Kortenkamp, A.; Grandjean, Philippe; Myers, J. P.; DiGangi, J.; Hunt, P. M.; Rudel, R.; Sathyanarayana, S.; Bellanger, M.; Hauser, R.; Legler, J.; Skakkebaek, N. E.; Heindel, J. J. (Wiley-Blackwell, 2016)A previous report documented that endocrine disrupting chemicals contribute substantially to certain forms of disease and disability. In the present analysis, our main objective was to update a range of health and economic ... -
Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls
Petersen, Maria Skaalum; Halling, Jónrit; Damkier, Per; Nielsen, Flemming; Grandjean, Philippe; Weihe, Pal; Brøsen, Kim (Springer Nature, 2006)Objective To investigate the CYP1A2 phenotype distribution in a population with an increased exposure to polychlorinated biphenyls (PCBs) that would likely induce an increased activity of this enzyme. Further, to ... -
Calculation of Mercury's Effects on Neurodevelopment
Grandjean, Philippe; Pichery, Celine; Bellanger, Martine; Budtz-Jørgensen, Esben (National Institute of Environmental Health Sciences, 2012) -
Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth cohort
Grandjean, Philippe; Murata, Katsuyuki; Budtz-Jørgensen, Esben; Weihe, Pal (Elsevier BV, 2004)Objective To determine whether heart function in childhood is affected by exposure to methylmercury (MeHg) from seafood. Study design Prospective study of a Faroese birth cohort (N = 1022). Examinations at ages 7 ... -
Childhood Lead Exposure in France: Benefit Estimation and Partial Cost-Benefit Analysis of Lead Hazard Control
Pichery, Céline; Bellanger, Martine; Zmirou-Navier, Denis; Glorennec, Philippe; Hartemann, Philippe; Grandjean, Philippe (BioMed Central, 2011)Background: Lead exposure remains a public health concern due to its serious adverse effects, such as cognitive and behavioral impairment: children younger than six years of age being the most vulnerable population. In ... -
Children’s white blood cell counts in relation to developmental exposures to methylmercury and persistent organic pollutants
Oulhote, Youssef; Shamim, Z.; Kielsen, K.; Weihe, Pal; Grandjean, Philippe; Ryder, L.P.; Heilmann, C. (Elsevier BV, 2017)Background: To explore possible markers of developmental immunotoxicity, we prospectively examined 56 children to determine associations between exposures to mercury and persistent organic pollutants since birth and the ... -
Cognitive deficits at age 22 years associated with prenatal exposure to methylmercury
Debes, Frodi; Weihe, Pal; Grandjean, Philippe (Elsevier BV, 2016)Prenatal exposure to mercury has been associated with adverse effects on child neurodevelopment. The present study aims to determine the extent to which methylmercury-associated cognitive deficits persist into adult age. ... -
Comparison of Polychlorinated Biphenyl Levels across Studies of Human Neurodevelopment
Longnecker, Matthew P.; Wolff, Mary S.; Gladen, Beth C.; Brock, John W.; Grandjean, Philippe; Jacobson, Joseph L.; Korrick, Susan Abigail; Rogan, Walter J.; Weisglas-Kuperus, Nynke; Hertz-Picciotto, Irva; Ayotte, Pierre; Stewart, Paul; Winneke, Gerhard; Charles, M. Judith; Jacobson, Sandra W.; Dewailly, Éric; Boersma, E. Rudy; Altshul, Larisa M.; Heinzow, Birger; Pagano, James J.; Jensen, Allan A. (Environmental Health Perspectives, 2002)Polychlorinated biphenyls (PCBs) are persistent pollutants that are ubiquitous in the food chain, and detectable amounts are in the blood of almost every person in most populations that have been examined. Extensive evidence ... -
A computational approach to chemical etiologies of diabetes
Audouze, Karine; Brunak, Søren; Grandjean, Philippe (Nature Publishing Group, 2013)Computational meta-analysis can link environmental chemicals to genes and proteins involved in human diseases, thereby elucidating possible etiologies and pathogeneses of non-communicable diseases. We used an integrated ... -
Concentrations of Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Polychlorobiphenylols in Serum from Pregnant Faroese Women and Their Children 7 Years Later
Fängström, Britta; Hovander, Lotta; Bignert, Anders; Athanassiadis, Ioannis; Linderholm, Linda; Grandjean, Philippe; Weihe, Pal; Bergman, Åke (American Chemical Society (ACS), 2005)The objective of this study was to assess blood concentrations of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs), and their polychlorobiphenylol (OH-PCB) metabolites in humans with a high seafood ... -
Conference Report: Advancing the Science of Developmental Neurotoxicity (DNT): Testing for Better Safety Evaluation.
Bal-Price, Anna K.; Coecke, Sandra; Costa, Lucio; Crofton, Kevin M.; Fritsche, Ellen; Goldberg, Alan; Grandjean, Philippe; Lein, Pamela J.; Li, Abby; Lucchini, Roberto; Mundy, William R.; Padilla, Stephanie; Persico, Antonio M.; Seiler, Andrea E. M.; Kreysa, Joachim (Springer Verlag, 2012) -
Consensus Statement: Atlantic Coast Contaminants Workshop 2000
Guise, Sylvain De; Shaw, Susan D.; Barclay, John S.; Brock, John; Brouwer, Abraham; Dewailly, Eric; Fair, Patricia A.; Fournier, Michel; Grandjean, Philippe; Guillette, Louis J.; Hahn, Mark E.; Koopman-Esseboom, Corine; Letcher, Robert J.; Matz, Angela; Norstrom, Ross J.; Perkins, Christopher R.; Schwacke, Lori; Skaare, Janneche Utne; Sowles, John; Aubin, David J. St.; Stegeman, John; Whaley, Janet E. (JSTOR, 2001)