Browsing by Author "Baccarelli, Andrea"

Now showing items 21-40 of 65

    • DNA methylation age of blood predicts all-cause mortality in later life 

      Marioni, Riccardo E; Shah, Sonia; McRae, Allan F; Chen, Brian H; Colicino, Elena; Harris, Sarah E; Gibson, Jude; Henders, Anjali K; Redmond, Paul; Cox, Simon R; Pattie, Alison; Corley, Janie; Murphy, Lee; Martin, Nicholas G; Montgomery, Grant W; Feinberg, Andrew P; Fallin, M Daniele; Multhaup, Michael L; Jaffe, Andrew E; Joehanes, Roby; Schwartz, Joel; Just, Allan C; Lunetta, Kathryn L; Murabito, Joanne M; Starr, John M; Horvath, Steve; Baccarelli, Andrea A; Levy, Daniel; Visscher, Peter M; Wray, Naomi R; Deary, Ian J (BioMed Central, 2015)
      Background: DNA methylation levels change with age. Recent studies have identified biomarkers of chronological age based on DNA methylation levels. It is not yet known whether DNA methylation age captures aspects of ...

    • DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases 

      Ligthart, Symen; Marzi, Carola; Aslibekyan, Stella; Mendelson, Michael M.; Conneely, Karen N.; Tanaka, Toshiko; Colicino, Elena; Waite, Lindsay L.; Joehanes, Roby; Guan, Weihua; Brody, Jennifer A.; Elks, Cathy; Marioni, Riccardo; Jhun, Min A.; Agha, Golareh; Bressler, Jan; Ward-Caviness, Cavin K.; Chen, Brian H.; Huan, Tianxiao; Bakulski, Kelly; Salfati, Elias L.; Fiorito, Giovanni; Wahl, Simone; Schramm, Katharina; Sha, Jin; Hernandez, Dena G.; Just, Allan C.; Smith, Jennifer A.; Sotoodehnia, Nona; Pilling, Luke C.; Pankow, James S.; Tsao, Phil S.; Liu, Chunyu; Zhao, Wei; Guarrera, Simonetta; Michopoulos, Vasiliki J.; Smith, Alicia K.; Peters, Marjolein J.; Melzer, David; Vokonas, Pantel; Fornage, Myriam; Prokisch, Holger; Bis, Joshua C.; Chu, Audrey Y.; Herder, Christian; Grallert, Harald; Yao, Chen; Shah, Sonia; McRae, Allan F.; Lin, Honghuang; Horvath, Steve; Fallin, Daniele; Hofman, Albert; Wareham, Nicholas J.; Wiggins, Kerri L.; Feinberg, Andrew P.; Starr, John M.; Visscher, Peter M.; Murabito, Joanne M.; Kardia, Sharon L. R.; Absher, Devin M.; Binder, Elisabeth B.; Singleton, Andrew B.; Bandinelli, Stefania; Peters, Annette; Waldenberger, Melanie; Matullo, Giuseppe; Schwartz, Joel D.; Demerath, Ellen W.; Uitterlinden, André G.; van Meurs, Joyce B. J.; Franco, Oscar H.; Chen, Yii-Der Ida; Levy, Daniel; Turner, Stephen T.; Deary, Ian J.; Ressler, Kerry J.; Dupuis, Josée; Ferrucci, Luigi; Ong, Ken K.; Assimes, Themistocles L.; Boerwinkle, Eric; Koenig, Wolfgang; Arnett, Donna K.; Baccarelli, Andrea A.; Benjamin, Emelia J.; Dehghan, Abbas (BioMed Central, 2016)
      Background: Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade ...

    • DNA methylation-based measures of biological age: meta-analysis predicting time to death 

      Chen, Brian H.; Marioni, Riccardo E.; Colicino, Elena; Peters, Marjolein J.; Ward-Caviness, Cavin K.; Tsai, Pei-Chien; Roetker, Nicholas S.; Just, Allan C.; Demerath, Ellen W.; Guan, Weihua; Bressler, Jan; Fornage, Myriam; Studenski, Stephanie; Vandiver, Amy R.; Moore, Ann Zenobia; Tanaka, Toshiko; Kiel, Douglas P.; Liang, Liming; Vokonas, Pantel; Schwartz, Joel; Lunetta, Kathryn L.; Murabito, Joanne M.; Bandinelli, Stefania; Hernandez, Dena G.; Melzer, David; Nalls, Michael; Pilling, Luke C.; Price, Timothy R.; Singleton, Andrew B.; Gieger, Christian; Holle, Rolf; Kretschmer, Anja; Kronenberg, Florian; Kunze, Sonja; Linseisen, Jakob; Meisinger, Christine; Rathmann, Wolfgang; Waldenberger, Melanie; Visscher, Peter M.; Shah, Sonia; Wray, Naomi R.; McRae, Allan F.; Franco, Oscar H.; Hofman, Albert; Uitterlinden, André G.; Absher, Devin; Assimes, Themistocles; Levine, Morgan E.; Lu, Ake T.; Tsao, Philip S.; Hou, Lifang; Manson, JoAnn E.; Carty, Cara L.; LaCroix, Andrea Z.; Reiner, Alexander P.; Spector, Tim D.; Feinberg, Andrew P.; Levy, Daniel; Baccarelli, Andrea; van Meurs, Joyce; Bell, Jordana T.; Peters, Annette; Deary, Ian J.; Pankow, James S.; Ferrucci, Luigi; Horvath, Steve (Impact Journals LLC, 2016)
      Estimates of biological age based on DNA methylation patterns, often referred to as “epigenetic age”, “DNAm age”, have been shown to be robust biomarkers of age in humans. We previously demonstrated that independent of ...

    • Do Nutrients Counteract the Acute Cardiovascular Effects of Air Particles? The Role of Immuno-Epigenetics in Observational and Intervention Studies 

      Zhong, Jia (2016-05-03)
      Background: Fine particulate matter (PM2.5) pollution is a major risk factor for cardiovascular diseases. Identifying modifiable factors and preventative strategies to mitigate the cardiovascular effect of PM2.5 is essential ...

    • Effects of Air Pollution and Blood Mitochondrial DNA Methylation on Markers of Heart Rate Variability 

      Byun, Hyang‐Min; Colicino, Elena; Trevisi, Letizia; Fan, Tianteng; Christiani, David C.; Baccarelli, Andrea A. (Wiley-Blackwell, 2016)
      Background: The mitochondrion is the primary target of oxidative stress in response to exogenous environments. Mitochondrial DNA (mtDNA) is independent from nuclear DNA and uses separate epigenetic machinery to regulate ...

    • Effects of airborne pollutants on mitochondrial DNA Methylation 

      Byun, Hyang-Min; Panni, Tommaso; Motta, Valeria; Hou, Lifang; Nordio, Francesco; Apostoli, Pietro; Bertazzi, Pier Alberto; Baccarelli, Andrea (BioMed Central, 2013)
      Background: Mitochondria have small mitochondrial DNA (mtDNA) molecules independent from the nuclear DNA, a separate epigenetic machinery that generates mtDNA methylation, and are primary sources of oxidative-stress ...

    • Effects of Particulate Air Pollution on Blood Pressure in a Highly Exposed Population in Beijing, China: A Repeated-Measure Study 

      Baccarelli, Andrea; Barretta, Francesco; Dou, Chang; Zhang, Xiao; McCracken, John Patrick; Díaz, Anaité; Bertazzi, Pier Alberto; Schwartz, Joel David; Wang, Sheng; Hou, Lifang (BioMed Central, 2011)
      Background: Particulate Matter (PM) exposure is critical in Beijing due to high population density and rapid increase in vehicular traffic. PM effects on blood pressure (BP) have been investigated as a mechanism mediating ...

    • Effects of particulate matter exposure on blood 5-hydroxymethylation: results from the Beijing truck driver air pollution study 

      Sanchez-Guerra, Marco; Zheng, Yinan; Osorio-Yanez, Citlalli; Zhong, Jia; Chervona, Yana; Wang, Sheng; Chang, Dou; McCracken, John P; Díaz, Anaite; Bertazzi, Pier Alberto; Koutrakis, Petros; Kang, Choong-Min; Zhang, Xiao; Zhang, Wei; Byun, Hyang-Min; Schwartz, Joel; Hou, Lifang; Baccarelli, Andrea A (Taylor & Francis, 2015)
      Previous studies have reported epigenetic changes induced by environmental exposures. However, previous investigations did not distinguish 5-methylcytosine (5mC) from a similar oxidative form with opposite functions, ...

    • Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation 

      Tarantini, Letizia; Bonzini, Matteo; Apostoli, Pietro; Pegoraro, Valeria; Bollati, Valentina; Marinelli, Barbara; Cantone, Laura; Rizzo, Giovanna; Hou, Lifang; Bertazzi, Pier Alberto; Schwartz, Joel David; Baccarelli, Andrea (National Institute of Environmental Health Sciences, 2008)
      Background: Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined.Objectives We aimed at ...

    • Epigenetic and Mitochondrial Biomarkers Linking Air Pollution and Temperature on Human Health: The Normative Aging Study 

      Peng, Cheng (2016-09-30)
      Fine particulate matter (particulate matter with aerodynamic diameter ≤2.5 micron or PM2.5) exposure, as well as changes in ambient meteorological conditions are associated with adverse health consequences. However, the ...

    • Epigenetic Influences on Associations between Air Pollutants and Lung Function in Elderly Men: The Normative Aging Study 

      Lepeule, Johanna; Bind, Marie-Abele Catherine; Baccarelli, Andrea A.; Koutrakis, Petros; Tarantini, Letizia; Litonjua, Augusto; Sparrow, David; Vokonas, Pantel; Schwartz, Joel D. (NLM-Export, 2014)
      Background: Few studies have been performed on pulmonary effects of air pollution in the elderly—a vulnerable population with low reserve capacity—and mechanisms and susceptibility factors for potential effects are unclear. ...

    • Epigenetics—a potential mediator between air pollution and preterm birth 

      Lin, Vania W.; Baccarelli, Andrea A.; Burris, Heather H. (2016)
      Preterm birth is a major cause of infant morbidity and mortality and a potential risk factor for adult chronic disease. With over 15 million infants born preterm worldwide each year, preterm birth poses a global health ...

    • Exposure to Metal-rich Particulate Matter Modifies the Expression of Candidate Micrornas in Peripheral Blood Leukocytes 

      Bollati, Valentina; Marinelli, Barbara; Apostoli, Pietro; Bonzini, Matteo; Nordio, Francesco; Hoxha, Mirjam; Pegoraro, Valeria; Tarantini, Letizia; Cantone, Laura; Bertazzi, Pier Alberto; Motta, Valeria; Schwartz, Joel David; Baccarelli, Andrea (National Institute of Environmental Health Sciences, 2010)
      Background: Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined. MicroRNAs (miRNAs) are ...

    • Folate Network Genetic Variation, Plasma Homocysteine, and Global Genomic Methylation Content: A Genetic Association Study 

      Wernimont, Susan M; Stover, Patrick J; Wells, Martin T; Tucker, Katherine L; Bollati, Valentina; Cassano, Patricia A; Clark, Andrew G.; Litonjua, Augusto Ampil; Weiss, Scott Tillman; Gaziano, John Michael; Baccarelli, Andrea; Schwartz, Joel David (BioMed Central, 2011)
      Background: Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of ...

    • GDM Women’s Pre-Pregnancy Overweight/Obesity and Gestational Weight Gain on Offspring Overweight Status 

      Leng, Junhong; Li, Weiqin; Zhang, Shuang; Liu, Huikun; Wang, Leishen; Liu, Gongshu; Li, Nan; Redman, Leanne M.; Baccarelli, Andrea A.; Hou, Lifang; Hu, Gang (Public Library of Science, 2015)
      Objectives: To examine the association of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with anthropometry in the offspring of mothers with gestational diabetes mellitus (GDM). Methods: We ...

    • Heart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders: a repeated-measures panel study 

      Fan, Tianteng; Fang, Shona C; Cavallari, Jennifer M; Barnett, Ian J; Wang, Zhaoxi; Su, Li; Byun, Hyang-Min; Lin, Xihong; Baccarelli, Andrea A; Christiani, David C (BioMed Central, 2014)
      Background: In occupational settings, boilermakers are exposed to high levels of metallic fine particulate matter (PM2.5) generated during the welding process. The effect of welding PM2.5 on heart rate variability (HRV) ...

    • IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans 

      Pearce, Neil; Blair, Aaron; Vineis, Paolo; Ahrens, Wolfgang; Andersen, Aage; Anto, Josep M.; Armstrong, Bruce K.; Baccarelli, Andrea A.; Beland, Frederick A.; Berrington, Amy; Bertazzi, Pier Alberto; Birnbaum, Linda S.; Brownson, Ross C.; Bucher, John R.; Cantor, Kenneth P.; Cardis, Elisabeth; Cherrie, John W.; Christiani, David C.; Cocco, Pierluigi; Coggon, David; Comba, Pietro; Demers, Paul A.; Dement, John M.; Douwes, Jeroen; Eisen, Ellen A.; Engel, Lawrence S.; Fenske, Richard A.; Fleming, Lora E.; Fletcher, Tony; Fontham, Elizabeth; Forastiere, Francesco; Frentzel-Beyme, Rainer; Fritschi, Lin; Gerin, Michel; Goldberg, Marcel; Grandjean, Philippe; Grimsrud, Tom K.; Gustavsson, Per; Haines, Andy; Hartge, Patricia; Hansen, Johnni; Hauptmann, Michael; Heederik, Dick; Hemminki, Kari; Hemon, Denis; Hertz-Picciotto, Irva; Hoppin, Jane A.; Huff, James; Jarvholm, Bengt; Kang, Daehee; Karagas, Margaret R.; Kjaerheim, Kristina; Kjuus, Helge; Kogevinas, Manolis; Kriebel, David; Kristensen, Petter; Kromhout, Hans; Laden, Francine; Lebailly, Pierre; LeMasters, Grace; Lubin, Jay H.; Lynch, Charles F.; Lynge, Elsebeth; ‘t Mannetje, Andrea; McMichael, Anthony J.; McLaughlin, John R.; Marrett, Loraine; Martuzzi, Marco; Merchant, James A.; Merler, Enzo; Merletti, Franco; Miller, Anthony; Mirer, Franklin E.; Monson, Richard; Nordby, Karl-Cristian; Olshan, Andrew F.; Parent, Marie-Elise; Perera, Frederica P.; Perry, Melissa J.; Pesatori, Angela Cecilia; Pirastu, Roberta; Porta, Miquel; Pukkala, Eero; Rice, Carol; Richardson, David B.; Ritter, Leonard; Ritz, Beate; Ronckers, Cecile M.; Rushton, Lesley; Rusiecki, Jennifer A.; Rusyn, Ivan; Samet, Jonathan M.; Sandler, Dale P.; de Sanjose, Silvia; Schernhammer, Eva; Costantini, Adele Seniori; Seixas, Noah; Shy, Carl; Siemiatycki, Jack; Silverman, Debra T.; Simonato, Lorenzo; Smith, Allan H.; Smith, Martyn T.; Spinelli, John J.; Spitz, Margaret R.; Stallones, Lorann; Stayner, Leslie T.; Steenland, Kyle; Stenzel, Mark; Stewart, Bernard W.; Stewart, Patricia A.; Symanski, Elaine; Terracini, Benedetto; Tolbert, Paige E.; Vainio, Harri; Vena, John; Vermeulen, Roel; Victora, Cesar G.; Ward, Elizabeth M.; Weinberg, Clarice R.; Weisenburger, Dennis; Wesseling, Catharina; Weiderpass, Elisabete; Zahm, Shelia Hoar (NLM-Export, 2015)
      Background: Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used ...

    • Increased Mitochondrial DNA Copy Number in Occupations Associated with Low-Dose Benzene Exposure 

      Carugno, Michele; Pesatori, Angela Cecilia; Dioni, Laura; Hoxha, Mirjam; Bollati, Valentina; Albetti, Benedetta; Bonzini, Matteo; Fustinoni, Silvia; Cocco, Pierluigi; Satta, Giannina; Zucca, Mariagrazia; Merlo, Domenico Franco; Cipolla, Massimo; Bertazzi, Pier Alberto; Byun, Hyang-Min; Baccarelli, Andrea (National Institute of Environmental Health Sciences, 2011)
      Background: Benzene is an established leukemogen at high exposure levels. Although low-level benzene exposure is widespread and may induce oxidative damage, no mechanistic biomarkers are available to detect biological ...

    • Inhalable particulate matter and mitochondrial DNA copy number in highly exposed individuals in Beijing, China: a repeated-measure study 

      Hou, Lifang; Zhang, Xiao; Dioni, Laura; Barretta, Francesco; Dou, Chang; Zheng, Yinan; Hoxha, Mirjam; Bertazzi, Pier Alberto; Schwartz, Joel David; Wu, Shanshan; Wang, Sheng; Baccarelli, Andrea (BioMed Central, 2013)
      Background: Mitochondria are both a sensitive target and a primary source of oxidative stress, a key pathway of air particulate matter (PM)-associated diseases. Mitochondrial DNA copy number (MtDNAcn) is a marker of ...

    • Lifetime Pesticide Use and Telomere Shortening among Male Pesticide Applicators in the Agricultural Health Study 

      Hou, Lifang; Andreotti, Gabriella; Baccarelli, Andrea A.; Savage, Sharon; Hoppin, Jane A.; Sandler, Dale P.; Barker, Joseph; Zhu, Zhong-Zheng; Hoxha, Mirjam; Dioni, Laura; Zhang, Xiao; Koutros, Stella; Freeman, Laura E. Beane; Alavanja, Michael C. (National Institute of Environmental Health Sciences, 2013)
      Background: Telomere length (TL) in surrogate tissues may be influenced by environmental exposures. Objective: We aimed to determine whether lifetime pesticides use is associated with buccal cell TL. Methods: We examined ...