Now showing items 21-29 of 29

    • Prominin-1 (CD133) Defines Both Stem and Non-Stem Cell Populations in CNS Development and Gliomas 

      Holmberg Olausson, Karl; Maire, Cecile L.; Haidar, Sam; Ling, Jason; Learner, Emily; Nistér, Monica; Ligon, Keith L. (Public Library of Science, 2014)
      Prominin-1 (CD133) is a commonly used cancer stem cell marker in central nervous system (CNS) tumors including glioblastoma (GBM). Expression of Prom1 in cancer is thought to parallel expression and function in normal stem ...
    • Rapid Intraoperative Molecular Characterization of Glioma 

      Shankar, Ganesh Mani; Francis, Joshua M.; Rinne, Mikael Lee; Ramkissoon, Shakti; Huang, Franklin W; Venteicher, Andrew S; Akama-Garren, Elliot H.; Kang, Yun Jee; Lelic, Nina; Kim, James C.; Brown, Loreal E.; Charbonneau, Sarah K; Golby, Alexandra Jacqueline; Sekhar Pedamallu, Chandra; Hoang, Mai P; Sullivan, Ryan Joseph; Cherniack, Andrew D.; Garraway, Levi Alexander; Stemmer-Rachamimov, Anat; Reardon, David Allen; Wen, Patrick Yung Chih; Brastianos, Priscilla Kalliope; Curry, William Thomas; Barker, Frederick George; Hahn, William Chun; Nahed, Brian Vala; Ligon, Keith Lloyd; Louis, David N.; Cahill, Daniel P.; Meyerson, Matthew Langer (American Medical Association (AMA), 2015)
      IMPORTANCE: Conclusive intraoperative pathologic confirmation of diffuse infiltrative glioma guides the decision to pursue definitive neurosurgical resection. Establishing the intraoperative diagnosis by histologic analysis ...
    • Rapid, Label-Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy 

      Ji, Minbiao; Orringer, Daniel A.; Freudiger, Christian Wilhelm; Ramkissoon, Shakti; Liu, Xiaohui; Lau, Darryl; Golby, Alexandra Jacqueline; Norton, Isaiah Hakim; Hayashi, Marika; Agar, Nathalie Marie Yvonne Rachel; Young, Geoffrey; Spino, Cathie; Santagata, Sandro; Camelo-Piragua, Sandra; Ligon, Keith Lloyd; Sagher, Oren; Xie, Xiaoliang Sunney (American Association for the Advancement of Science (AAAS), 2013)
      Surgery is an essential component in the treatment of brain tumors. However, delineating tumor from normal brain remains a major challenge. We describe the use of stimulated Raman scattering (SRS) microscopy for ...
    • SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance 

      Kim, Dohoon; Fiske, Brian P.; Birsoy, Kivanc; Freinkman, Elizaveta; Kami, Kenjiro; Possemato, Richard; Chudnovsky, Yakov; Pacold, Michael E.; Chen, Walter W.; Cantor, Jason R.; Shelton, Laura M.; Gui, Dan Y.; Kwon, Manjae; Ramkissoon, Shakti H.; Ligon, Keith L.; Kang, Seong Woo; Snuderl, Matija; Heiden, Matthew G. Vander; Sabatini, David M. (2015)
      SUMMARY Cancer cells adapt their metabolic processes to support rapid proliferation, but less is known about how cancer cells alter metabolism to promote cell survival in a poorly vascularized tumor microenvironment1–3. ...
    • Somatic mutations associated with MRI-derived volumetric features in glioblastoma 

      Gutman, David A.; Dunn, William D.; Grossmann, Patrick; Cooper, Lee A. D.; Holder, Chad A.; Ligon, Keith L.; Alexander, Brian M.; Aerts, Hugo J. W. L. (Springer Berlin Heidelberg, 2015)
      Introduction: MR imaging can noninvasively visualize tumor phenotype characteristics at the macroscopic level. Here, we investigated whether somatic mutations are associated with and can be predicted by MRI-derived tumor ...
    • Somatic Mutations of PIK3R1 Promote Gliomagenesis 

      Quayle, Steven N.; Cheung, Lydia W T.; Wiedemeyer, Ruprecht; Dewan, Robert W.; Huang-Hobbs, Emmet; Zhuang, Li; Mills, Gordon B.; Chin, Lynda; Lee, Jennifer Y.; Ding, Li; Wilson, Richard K.; Ligon, Keith Lloyd; Cantley, Lewis C. (Public Library of Science, 2012)
      The phosphoinositide 3-kinase (PI3K) pathway is targeted for frequent alteration in glioblastoma (GBM) and is one of the core GBM pathways defined by The Cancer Genome Atlas. Somatic mutations of PIK3R1 are observed in ...
    • Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas 

      Bechet, Denise; Gielen, Gerrit G. H.; Korshunov, Andrey; Pfister, Stefan M.; Rousso, Caterina; Faury, Damien; Fiset, Pierre-Olivier; Benlimane, Naciba; Lewis, Peter W.; Lu, Chao; David Allis, C.; Kieran, Mark W.; Ligon, Keith L.; Pietsch, Torsten; Ellezam, Benjamin; Albrecht, Steffen; Jabado, Nada (Springer Berlin Heidelberg, 2014)
      Studies in pediatric high-grade astrocytomas (HGA) by our group and others have uncovered recurrent somatic mutations affecting highly conserved residues in histone 3 (H3) variants. One of these mutations leads to analogous ...
    • Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level 

      Munoz, Jessian L.; Rodriguez-Cruz, Vivian; Ramkissoon, Shakti H.; Ligon, Keith L.; Greco, Steven J.; Rameshwar, Pranela (Impact Journals LLC, 2015)
      Glioblastoma Multiforme (GBM), the most common and lethal adult primary tumor of the brain, showed a link between Sonic Hedgehog (SHH) pathway in the resistance to temozolomide (TMZ). PTCH1, the SHH receptor, can tonically ...
    • Transformation by the R Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation 

      Koivunen, Peppi; Lee, Sungwoo; Duncan, Christopher G.; Lopez, Giselle; Lu, Gang; Ramkissoon, Shakti; Losman, Julie-Aurore; Joensuu, Päivi; Bergmann, Ulrich; Gross, Stefan; Travins, Jeremy; Weiss, Samuel; Looper, Ryan; Ligon, Keith Lloyd; Verhaak, Roel G.W.; Yan, Hai; Kaelin, William George (2013)
      The identification of succinate dehydrogenase (SDH), fumarate hydratase (FH), and isocitrate dehydrogenase (IDH) mutations in human cancers has rekindled the idea that altered cellular metabolism can transform cells. ...