Now showing items 21-27 of 27

    • Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions 

      Tang, E. H. C.; Shimizu, K.; Christen, T.; Rocha, V. Z.; Shvartz, E.; Tesmenitsky, Y.; Sukhova, Galina K.; Shi, Guo-Ping; Libby, Peter (Oxford University Press (OUP), 2010)
      Aim: Prostaglandin E2, by ligation of its receptor EP4, suppresses the production of inflammatory cytokines and chemokines in macrophages in vitro. Thus, activation of EP4 may constitute an endogenous anti-inflammatory ...
    • Local proliferation dominates lesional macrophage accumulation in atherosclerosis 

      Robbins, Clinton S.; Hilgendorf, Ingo; Weber, Georg F.; Theurl, Igor; Iwamoto, Yoshiko; Figueiredo, Jose-Luiz; Gorbatov, Rostic; Sukhova, Galina K.; Gerhardt, Louisa M.S.; Smyth, David; Zavitz, Caleb C. J.; Shikatani, Eric A.; Parsons, Michael; van Rooijen, Nico; Lin, Herbert Y.; Husain, Mansoor; Libby, Peter; Nahrendorf, Matthias; Weissleder, Ralph; Swirski, Filip K. (2013)
      During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall1,2. The observation that circulating monocytes give rise to lesional macrophages3–9 has ...
    • Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice 

      Sun, Jiusong; Sukhova, Galina K.; Yang, Min; Wolters, Paul J.; MacFarlane, Lindsey Adair; Libby, Peter; Sun, Chongxiu; Zhang, Yadong; Liu, Jianming; Ennis, Terri L.; Knispel, Rebecca; Xiong, Wanfen; Thompson, Robert W.; Baxter, B. Timothy; Shi, Guo-Ping (American Society for Clinical Investigation, 2007)
      Abdominal aortic aneurysm (AAA), an inflammatory disease, involves leukocyte recruitment, immune responses, inflammatory cytokine production, vascular remodeling, neovascularization, and vascular cell apoptosis, all of ...
    • Redundancy of IL-1 Isoform Signaling and Its Implications for Arterial Remodeling 

      Beltrami-Moreira, Marina; Vromman, Amélie; Sukhova, Galina K.; Folco, Eduardo J.; Libby, Peter (Public Library of Science, 2016)
      Aims Mice deficient in IL-1 receptor 1 (hence unresponsive to both IL-1 isoforms α and β) have impaired expansive arterial remodeling due to diminished expression of matrix-degrading enzymes, especially MMP-3. Emergence ...
    • Selective Inhibition of Matrix Metalloproteinase-13 Increases Collagen Content of Established Mouse Atherosclerosis 

      Quillard, T.; Tesmenitsky, Y.; Croce, Kevin James; Travers, R.; Shvartz, E.; Koskinas, K. C.; Sukhova, Galina K.; Aikawa, Elena; Aikawa, Masanori; Libby, Peter (Ovid Technologies (Wolters Kluwer Health), 2011)
      Objective—Evidence has linked collagen loss with the onset of acute coronary events. This study tested the hypothesis that selective matrix metalloproteinase-13 (MMP-13) collagenase inhibition increases collagen content ...
    • Thin-Capped Atheromata With Reduced Collagen Content in Pigs Develop in Coronary Arterial Regions Exposed to Persistently Low Endothelial Shear Stress 

      Koskinas, K. C.; Sukhova, Galina K.; Baker, A. B.; Papafaklis, M. I.; Chatzizisis, Y. S.; Coskun, A. U.; Quillard, T.; Jonas, M.; Maynard, C.; Antoniadis, Antonios; Shi, Guo-Ping; Libby, Peter; Edelman, Elazer Reuven; Feldman, Charles Lawrence; Stone, Peter Howard (Ovid Technologies (Wolters Kluwer Health), 2013)
      Objective—The mechanisms promoting the focal formation of rupture-prone coronary plaques in vivo remain incompletely understood. This study tested the hypothesis that coronary regions exposed to low endothelial shear stress ...
    • Tissue factor pathway inhibitor-2 is a novel inhibitor of matrix metalloproteinases with implications for atherosclerosis 

      Herman, Michael P.; Sukhova, Galina K.; Kisiel, Walter; Foster, Don; Kehry, Marilyn R.; Libby, Peter; Schönbeck, Uwe (American Society for Clinical Investigation, 2001)
      Degradation of ECM, particularly interstitial collagen, promotes plaque instability, rendering atheroma prone to rupture. Previous studies implicated matrix metalloproteinases (MMPs) in these processes, suggesting that ...