Browsing by Author "Luster, Andrew"

Now showing items 21-25 of 25

    • The scavenger receptor SCARF1 mediates apoptotic cell clearance and prevents autoimmunity 

      Ramirez-Ortiz, Zaida G.; Pendergraft, William F.; Prasad, Amit; Byrne, Michael H.; Iram, Tal; Blanchette, Christopher J.; Luster, Andrew D.; Hacohen, Nir; Khoury, Joseph El; Means, Terry K. (2013)
      Clearance of apoptotic cells is critical for control of tissue homeostasis however the full range of receptor(s) on phagocytes responsible for recognition of apoptotic cells remains to be identified. Here we show that ...

    • Splenic differentiation and emergence of CCR5+CXCL9+CXCL10+ monocyte-derived dendritic cells in the brain during cerebral malaria 

      Hirako, Isabella C.; Ataide, Marco A.; Faustino, Lucas; Assis, Patricia A.; Sorensen, Elizabeth W.; Ueta, Hisashi; Araújo, Natalia M.; Menezes, Gustavo B.; Luster, Andrew D.; Gazzinelli, Ricardo T. (Nature Publishing Group, 2016)
      Dendritic cells have an important role in immune surveillance. After being exposed to microbial components, they migrate to secondary lymphoid organs and activate T lymphocytes. Here we show that during mouse malaria, ...

    • Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine 

      Woodruff, Matthew C.; Heesters, Balthasar A.; Herndon, Caroline N.; Groom, Joanna R.; Thomas, Paul G.; Luster, Andrew D.; Turley, Shannon J.; Carroll, Michael C. (The Rockefeller University Press, 2014)
      Dendritic cells (DCs) are well established as potent antigen-presenting cells critical to adaptive immunity. In vaccination approaches, appropriately stimulating lymph node–resident DCs (LNDCs) is highly relevant to effective ...

    • TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity 

      Ramirez-Ortiz, Zaida G.; Prasad, Amit; Griffith, Jason W.; Pendergraft, William F.; Cowley, Glenn S.; Root, David E.; Tai, Melissa; Luster, Andrew D.; Khoury, Joseph El; Hacohen, Nir; Means, Terry K. (2015)
      The genes and pathways that fine-tune TLR7-mediated innate inflammatory responses remain to be fully elucidated. Using an unbiased genome-scale shRNA screen, we identified the receptor TREML4 as an essential positive ...

    • Unlocking tumor vascular barriers with CXCR3: Implications for cancer immunotherapy 

      Mikucki, Maryann E.; Skitzki, Joseph J.; Frelinger, John G.; Odunsi, Kunle; Gajewski, Thomas F.; Luster, Andrew D.; Evans, Sharon S. (Taylor & Francis, 2016)
      ABSTRACT Promising cancer immunotherapeutics depend on mobilization of cytotoxic T cells across tumor vascular barriers through mechanisms that are poorly understood. Recently, we discovered that the CXCR3 chemokine receptor ...