Browsing by Author "Novitsky, Vladimir"

Now showing items 21-28 of 28

    • Response to Antiretroviral Therapy after a Single, Peripartum Dose of Nevirapine 

      Lockman, Shahin; Shapiro, Roger L.; Smeaton, Laura Marie; Wester, Carolyn; Thior, Ibou; Stevens, Lisa; Chand, Fatima; Makhema, Joseph Moeketsi; Moffat, Claire; Asmelash, Aida; Ndase, Patrick; van Widenfelt, Peter Arimim Eri; Mazhani, Loeto; Novitsky, Vladimir A.; Lagakos, Stephen; Essex, Myron Elmer (New England Journal of Medicine (NEJM/MMS), 2007)
      BACKGROUND: A single dose of nevirapine during labor reduces perinatal transmission of human immunodeficiency virus type 1 (HIV-1) but often leads to viral nevirapine resistance mutations in mothers and infants. METHODS: ...

    • Risk Factors for Symptomatic Hyperlactatemia and Lactic Acidosis Among Combination Antiretroviral Therapy-Treated Adults in Botswana: Results from a Clinical Trial 

      Wester, C William; Eden, Svetlana K.; Shepherd, Bryan E.; Bussmann, Hermann; Novitsky, Vladimir A.; Samuels, David C.; Hendrickson, Sher L.; Winkler, Cheryl A.; O, Stephen J.; Essex, Myron Elmer; D, Richard T.; De Gruttola, Victor Gerard; Marlink, Richard G. (Mary Ann Liebert Inc., 2012)
      Nucleoside analogue reverse transcriptase inhibitors are an integral component of combination antiretroviral treatment regimens. However, their ability to inhibit polymerase-γ has been associated with several mitochondrial ...

    • Short Communication: Effect of Short-Course Antenatal Zidovudine and Single-Dose Nevirapine on the BED Capture Enzyme Immunoassay Levels in HIV Type 1 Subtype C Infection 

      Wang, Rui; Weng, Jia; Moyo, Sikhulile; Pain, Debanjan; Barr, Christopher D.; Maruapula, Dorcas; Mongwato, Dineo; Makhema, Joseph Moeketsi; Novitsky, Vladimir A.; Essex, Myron Elmer (Mary Ann Liebert Inc., 2013)
      Cross-sectional prevalence studies based on immunoassays that discriminate between recent and long-term infections, such as the BED assay, have been widely used to estimate HIV incidence. However, individuals receiving ...

    • tat Exon 1 Exhibits Functional Diversity during HIV-1 Subtype C Primary Infection 

      Rossenkhan, R.; MacLeod, Iain James; Sebunya, T. K.; Castro-Nallar, E.; McLane, Mary Frances; Musonda, Rosemary Mubanga; Gashe, B. A.; Novitsky, Vladimir A.; Essex, Myron Elmer (American Society for Microbiology, 2013)
      Human immunodeficiency virus type 1 (HIV-1) Tat is a mediator of viral transcription and is involved in the control of virus replication. However, associations between HIV-1 Tat diversity and functional effects during ...

    • Timing Constraints of In Vivo Gag Mutations during Primary HIV-1 Subtype C Infection 

      Kebaabetswe, Lemme; Rossenkhan, Raabya; Bonney, Caitlin; Herzig, Michaela; Nkwe, David; Woldegabriel, Elias; van Widenfelt, Erik; Lagakos, Stephen; Zhang, Linqi; Novitsky, Vladimir A.; Wang, Rui; Margolin, Lauren; Baca, Jeannie; Moyo, Sikhulile; Musonda, Rosemary Mubanga; Makhema, Joseph Moeketsi; Essex, Myron Elmer (Public Library of Science, 2009)
      Background: Aiming to answer the broad question “When does mutation occur?” this study examined the time of appearance, dominance, and completeness of in vivo Gag mutations in primary HIV-1 subtype C infection. Methods: A ...

    • Transmission of Single and Multiple Viral Variants in Primary HIV-1 Subtype C Infection 

      Moyo, Sikhulile; van Widenfelt, Erik; Vartanian, Jean-Pierre; Novitsky, Vladimir A.; Wang, Rui; Margolin, Lauren; Baca, Jeannie; Rossenkhan, Raabya; Essex, Myron Elmer (Public Library of Science, 2011)
      To address whether sequences of viral gag and env quasispecies collected during the early post-acute period can be utilized to determine multiplicity of transmitted HIV's, recently developed approaches for analysis of viral ...

    • Viral Diversity and Diversification of Major Non-Structural Genes vif, vpr, vpu, tat exon 1 and rev exon 1 during Primary HIV-1 Subtype C Infection 

      Rossenkhan, Raabya; Novitsky, Vladimir A.; Sebunya, Theresa K.; Musonda, Rosemary Mubanga; Gashe, Berhanu A.; Essex, Myron Elmer (Public Library of Science, 2012)
      To assess the level of intra-patient diversity and evolution of HIV-1C non-structural genes in primary infection, viral quasispecies obtained by single genome amplification (SGA) at multiple sampling timepoints up to 500 ...

    • Viral Genetic Linkage Analysis in the Presence of Missing Data 

      Liu, Shelley H.; Erion, Gabriel; Novitsky, Vladimir; Gruttola, Victor De (Public Library of Science, 2015)
      Analyses of viral genetic linkage can provide insight into HIV transmission dynamics and the impact of prevention interventions. For example, such analyses have the potential to determine whether recently-infected individuals ...