Browsing by Author "Sparrow, David"
Now showing items 21-28 of 28
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Long-Term Exposure to Ambient Fine Particulate Matter and Renal Function in Older Men: The Veterans Administration Normative Aging Study
Mehta, Amar J.; Zanobetti, Antonella; Bind, Marie-Abele C.; Kloog, Itai; Koutrakis, Petros; Sparrow, David; Vokonas, Pantel S.; Schwartz, Joel D. (National Institute of Environmental Health Sciences, 2016)Background: It is unknown if ambient fine particulate matter (PM2.5) is associated with lower renal function, a cardiovascular risk factor. Objective: We investigated whether long-term PM2.5 exposure was associated with ... -
Low-Level Lead Exposure, Metabolic Syndrome, and Heart Rate Variability: The VA Normative Aging Study
Park, Sung Kyun; Schwartz, Joel David; Weisskopf, Marc G.; Sparrow, David; Vokonas, Pantel S; Wright, Robert O.; Coull, Brent Andrew; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2006)Background: Altered heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with sudden cardiac death and heart failure. Objective: We examined the association of low-level lead ... -
Medium-Term Exposure to Traffic-Related Air Pollution and Markers of Inflammation and Endothelial Function
Alexeeff, Stacey E.; Coull, Brent Andrew; Gryparis, Alexandros; Suh, Helen; Sparrow, David; Vokonas, Pantel S.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2011)Background: Exposure to traffic-related air pollution (TRAP) contributes to increased cardiovascular risk. Land-use regression models can improve exposure assessment for TRAP. Objectives: We examined the association between ... -
Modifying Effects of the HFE Polymorphisms on the Association Between Lead Burden and Cognitive Decline
Wang, Florence T.; Hu, Howard; Schwartz, Joel David; Weuve, Jennifer Lynn; Spiro, Avron S.; Sparrow, David; Nie, Huiling; Silverman, Edwin Kepner; Weiss, Scott Tillman; Wright, Robert O. (National Institute of Environmental Health Sciences, 2007)Background: As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship. Objective: ... -
Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort
Chahine, Teresa; Baccarelli, Andrea; Litonjua, Augusto Ampil; Wright, Robert O.; Suh MacIntosh, Helen H.; Gold, Diane R.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2007)Background and Objectives: We have previously shown that reduced defenses against oxidative stress due to glutathione S-transferase M1 (GSTM1) deletion modify the effects of PM[2.5] (fine-particulate air pollution of < 2.5 ... -
Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter
Wilker, Elissa Hope; Mittleman, Murray A.; Litonjua, Augusto Ampil; Poon, Audrey; Baccarelli, Andrea; Suh, Helen; Wright, Robert O.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2009)Background: Fine particulate matter [aerodynamic diameter ≤ 2.5 μm (PM2.5)] has been associated with autonomic dysregulation.Objective We hypothesized that PM2.5 influences postural changes in systolic blood pressure (ΔSBP) ... -
Proton Magnetic Resonance Spectroscopic Evidence of Glial Effects of Cumulative Lead Exposure in the Adult Human Hippocampus
Weisskopf, Marc G.; Hu, Howard; Sparrow, David; Lenkinski, Robert E.; Wright, Robert O. (National Institute of Environmental Health Sciences, 2007)Background: Exposure to lead is known to have adverse effects on cognition in several different populations. Little is known about the underlying structural and functional correlates of such exposure in humans. Objectives: ... -
Stress as a Potential Modifier of the Impact of Lead Levels on Blood Pressure: The Normative Aging Study
Peters, Junenette L.; Kubzansky, Laura Diane; McNeely, Eileen; Schwartz, Joel David; Spiro, Avron; Sparrow, David; Wright, Robert O.; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007)Background: Lead exposure and psychological stress have been independently associated with hypertension in various populations, and animal studies suggest that when they co-occur, their effects may be exacerbated. Objectives: ...