Now showing items 21-33 of 33

    • The Impact of Lesion In-Painting and Registration Methods on Voxel-Based Morphometry in Detecting Regional Cerebral Gray Matter Atrophy in Multiple Sclerosis 

      Ceccarelli, A.; Jackson, J. S.; Tauhid, S.; Arora, A; Gorky, J.; Dell, E.; Bakshi, A.; Chitnis, Tanuja; Khoury, Samia Joseph; Weiner, Howard Lee; Guttmann, Charles R.G.; Bakshi, Rohit; Neema, Mohit (American Society of Neuroradiology (ASNR), 2012)
      Background and Purpose: VBM has been widely used to study GM atrophy in MS. MS lesions lead to segmentation and registration errors that may affect the reliability of VBM results. Improved segmentation and registration ...
    • Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium 

      Laurent, Louise C.; Abdel-Mageed, Asim B.; Adelson, P. David; Arango, Jorge; Balaj, Leonora; Breakefield, Xandra; Carlson, Elizabeth; Carter, Bob S.; Majem, Blanca; Chen, Clark C.; Cocucci, Emanuele; Danielson, Kirsty; Courtright, Amanda; Das, Saumya; Elmageed, Zakaria Y. Abd; Enderle, Daniel; Ezrin, Alan; Ferrer, Marc; Freedman, Jane; Galas, David; Gandhi, Roopali; Huentelman, Matthew J.; Van Keuren-Jensen, Kendall; Kalani, Yashar; Kim, Yong; Krichevsky, Anna M.; Lai, Charles; Lal-Nag, Madhu; Laurent, Clara D.; Leonardo, Trevor; Li, Feng; Malenica, Ivana; Mondal, Debasis; Nejad, Parham; Patel, Tushar; Raffai, Robert L.; Rubio, Renee; Skog, Johan; Spetzler, Robert; Sun, Jie; Tanriverdi, Kahraman; Vickers, Kasey; Wang, Liang; Wang, Yaoyu; Wei, Zhiyun; Weiner, Howard L.; Wong, David; Yan, Irene K.; Yeri, Ashish; Gould, Stephen (Co-Action Publishing, 2015)
      Extracellular RNAs (exRNAs) have been identified in all tested biofluids and have been associated with a variety of extracellular vesicles, ribonucleoprotein complexes and lipoprotein complexes. Much of the interest in ...
    • Modeling Disease Severity in Multiple Sclerosis Using Electronic Health Records 

      Xia, Zongqi; Secor, Elizabeth; Chibnik, Lori B.; Bove, Riley M.; Cheng, Suchun; Chitnis, Tanuja; Cagan, Andrew; Gainer, Vivian S.; Chen, Pei J.; Liao, Katherine P.; Shaw, Stanley Y.; Ananthakrishnan, Ashwin N.; Szolovits, Peter; Weiner, Howard L.; Karlson, Elizabeth W.; Murphy, Shawn N.; Savova, Guergana K.; Cai, Tianxi; Churchill, Susanne E.; Plenge, Robert M.; Kohane, Isaac S.; De Jager, Philip L. (Public Library of Science, 2013)
      Objective: To optimally leverage the scalability and unique features of the electronic health records (EHR) for research that would ultimately improve patient care, we need to accurately identify patients and extract ...
    • MRI phenotypes based on cerebral lesions and atrophy in patients with multiple sclerosis 

      Tauhid, Shahamat Syed; Neema, Mohit; Healy, Brian Curran; Weiner, Howard Lee; Bakshi, Rohit (Elsevier BV, 2014)
      Background: While disease categories (i.e. clinical phenotypes) of multiple sclerosis (MS) are established, there remains MRI heterogeneity among patients within those definitions. MRI-defined lesions and atrophy show only ...
    • Platelets Recognize Brain-Specific Glycolipid Structures, Respond to Neurovascular Damage and Promote Neuroinflammation 

      Sotnikov, Ilya; Veremeyko, Tatyana; Starossom, Sarah Christin; Barteneva, Natalia; Weiner, Howard Lee; Ponomarev, Eugene D. (Public Library of Science, 2013)
      Platelets respond to vascular damage and contribute to inflammation, but their role in the neurodegenerative diseases is unknown. We found that the systemic administration of brain lipid rafts induced a massive platelet ...
    • A Putative Alzheimer's Disease Risk Allele in PCK1 Influences Brain Atrophy in Multiple Sclerosis 

      Xia, Zongqi; Chibnik, Lori; Glanz, Bonnie; Liguori, Maria; Shulman, Joshua M.; Tran, Dong; Khoury, Samia; Chitnis, Tanuja; Holyoak, Todd; Weiner, Howard; Guttmann, Charles; De Jager, Philip L. (Public Library of Science (PLoS), 2010-11-30)
      Background Brain atrophy and cognitive dysfunction are neurodegenerative features of Multiple Sclerosis (MS). We used a candidate gene approach to address whether genetic variants implicated in susceptibility to late onset ...
    • Quantitative MRI Phenotypes in Longitudinal Population of MS Patients. 

      Egorova, Svetlana; Polgar-Turcsanyi, Mariann; Anderson, Mark Allen; Healy, Brian Curran; Weiner, Howard Lee (2014)
    • Quantitative MRI study of Pineal Gland in MS. 

      Egorova, Svetlana; Denes, Palma; Polgar-Turcsanyi, Mariann; Anderson, Mark Allen; Cavallari, Michele; Guttmann, Charles R.G.; Glanz, Bonnie; Chitnis, Tanuja; Bove, Riley; Buckle, Guy; De Jager, Philip Lawrence; Severson, Cristopher; Stankiewicz, James; Houtchens, Maria K.; Quintana, Francisco Javier; Gandhi, Roopali; Webb, Pia; Meier, Dominik; Healy, Brian Curran; Weiner, Howard Lee (2016)
    • Restoring immune tolerance in neuromyelitis optica: Part I 

      Steinman, Larry; Bar-Or, Amit; Behne, Jacinta M.; Benitez-Ribas, Daniel; Chin, Peter S.; Clare-Salzler, Michael; Healey, Donald; Kim, James I.; Kranz, David M.; Lutterotti, Andreas; Martin, Roland; Schippling, Sven; Villoslada, Pablo; Wei, Cheng-Hong; Weiner, Howard L.; Zamvil, Scott S.; Yeaman, Michael R.; Smith, Terry J. (Lippincott Williams & Wilkins, 2016)
      Neuromyelitis optica (NMO) and spectrum disorder (NMO/SD) represent a vexing process and its clinical variants appear to have at their pathogenic core the loss of immune tolerance to the aquaporin-4 water channel protein. ...
    • Restoring immune tolerance in neuromyelitis optica: Part II 

      Bar-Or, Amit; Steinman, Larry; Behne, Jacinta M.; Benitez-Ribas, Daniel; Chin, Peter S.; Clare-Salzler, Michael; Healey, Donald; Kim, James I.; Kranz, David M.; Lutterotti, Andreas; Martin, Roland; Schippling, Sven; Villoslada, Pablo; Wei, Cheng-Hong; Weiner, Howard L.; Zamvil, Scott S.; Smith, Terry J.; Yeaman, Michael R. (Lippincott Williams & Wilkins, 2016)
      Neuromyelitis optica spectrum disorder (NMO/SD) and its clinical variants have at their core the loss of immune tolerance to aquaporin-4 and perhaps other autoantigens. The characteristic phenotype is disruption of astrocyte ...
    • Scara1 deficiency impairs clearance of soluble Amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression 

      Frenkel, Dan; Wilkinson, Kim; Zhao, Lingzhi; Hickman, Suzanne E.; Means, Terry K.; Puckett, Lindsey; Farfara, Dorit; Kingery, Nathan D.; Weiner, Howard L.; El Khoury, Joseph (2013)
      In Alzheimer’s disease soluble amyloid beta (sAβ) causes synaptic dysfunction and neuronal loss. Receptors involved in clearance of sAβ are not known. Here we use shRNA screening and identify the scavenger receptor Scara1 ...
    • Serum lipid antibodies are associated with cerebral tissue damage in multiple sclerosis 

      Bakshi, Rohit; Yeste, A; Patel, B.; Tauhid, Shahamat Syed; Tummala, Subhash; Rahbari, R.; Chu, Renxin; Regev, Keren; Kivisakk, Pia; Weiner, Howard Lee; Quintana, Francisco Javier (Ovid Technologies (Wolters Kluwer Health), 2016)
      Objective: To determine whether peripheral immune responses as measured by serum antigen arrays are linked to cerebral MRI measures of disease severity in multiple sclerosis (MS). Methods: In this cross-sectional study, ...
    • Systems biology approaches for the study of multiple sclerosis 

      Quintana, Francisco J; Farez, Mauricio F; Weiner, Howard L (Blackwell Publishing Ltd, 2008)
      Multiple sclerosis (MS) is a progressive neurological disease caused by an autoimmune attack to the central nervous system (CNS). MS is thought to result from a complex interaction between genetic and environmental factors. ...