Now showing items 21-36 of 36

    • A murine model of myocardial microvascular thrombosis 

      Christie, Patricia D.; Edelberg, Jay M.; Picard, Michael Howard; Foulkes, Andrea S.; Mamuya, Wilfred; Weiler-Guettler, Hartmut; Rubin, Robert Harold; Gilbert, Peter; Rosenberg, Robert D. (American Society for Clinical Investigation, 1999)
      Disorders of hemostasis lead to vascular pathology. Endothelium-derived gene products play a critical role in the formation and degradation of fibrin. We sought to characterize the importance of these locally produced ...
    • Mutant Mouse Models Reveal the Relative Roles of E2F1 and E2F3 In Vivo 

      Cloud, J. E.; Rogers, Catherine; Reza, Tammi; Ziebold, U.; Stone, James Robert; Picard, Michael Howard; Caron, A. M.; Bronson, Roderick Terry; Lees, J. A. (American Society for Microbiology, 2002)
      The E2F1, -2, and -3 transcription factors are key downstream targets of the retinoblastoma protein (pRB) tumor suppressor that drive expression of proliferation-associated genes. Here we use mutant mouse strains to ...
    • Myocardial Alterations in Senescent Mice and Effect of Exercise Training: A Strain Rate Imaging Study 

      Derumeaux, G.; Ichinose, Fumito; Raher, M. J.; Morgan, J. G.; Coman, T.; Lee, C.; Cuesta, J. M.; Thibault, H.; Bloch, K. D.; Picard, Michael Howard; Scherrer-Crosbie, Marielle (Ovid Technologies (Wolters Kluwer Health), 2008)
      Background: Aging is accompanied by an alteration in myocardial contractility. However, its noninvasive detection is difficult. The effect of chronic exercise on this decrease is unknown. Murine models of senescence are ...
    • One-Year Survival Following Early Revascularization for Cardiogenic Shock 

      Hochman, Judith S.; Sleeper, Lynn A.; White, Harvey D.; Dzavik, Vladimir; Wong, S. Chiu; Menon, Venu; Webb, John G.; Steingart, Richard; Picard, Michael Howard; Menegus, Mark A.; Boland, Jean; Sanborn, Timothy; Buller, Christopher E.; Modur, Sharada; Forman, Robert; Desvigne-Nickens, Patrice; Jacobs, Alice K.; Slater, James N.; LeJemtel, Thierry H. (American Medical Association (AMA), 2001)
      Context Cardiogenic shock (CS) is the leading cause of death for patients hospitalized with acute myocardial infarction (AMI). Objective To assess the effect of early revascularization (ERV) on 1-year survival for ...
    • Outcomes of Anatomical versus Functional Testing for Coronary Artery Disease 

      Douglas, Pamela S.; Hoffmann, Udo; Patel, Manesh R.; Mark, Daniel B.; Al-Khalidi, Hussein R.; Cavanaugh, Brendan; Cole, Jason; Dolor, Rowena J.; Fordyce, Christopher B.; Huang, Megan Jinyu; Khan, Muhammad Akram; Kosinski, Andrzej S.; Krucoff, Mitchell W.; Malhotra, Vinay; Picard, Michael Howard; Udelson, James E.; Velazquez, Eric J.; Yow, Eric; Cooper, Lawton S.; Lee, Kerry L. (New England Journal of Medicine (NEJM/MMS), 2015)
      BACKGROUND: Many patients have symptoms suggestive of coronary artery disease (CAD) and are often evaluated with the use of diagnostic testing, although there are limited data from randomized trials to guide care. METHODS: ...
    • Phenotypic Spectrum Caused by Transgenic Overexpression of Activated Akt in the Heart 

      Matsui, Takashi; Li, Ling; Wu, Justina C.; Cook, Stuart; Nagoshi, Tomohisa; Picard, Michael Howard; Liao, Ronglih; Rosenzweig, Anthony (American Society for Biochemistry & Molecular Biology (ASBMB), 2002)
      The serine-threonine kinase, Akt, inhibits cardiomyocyte apoptosis acutely both in vitro and in vivo. However, the effects of chronic Akt activation in the heart are unknown. To address this issue, we generated transgenic ...
    • Predictors of Sustained Ventricular Arrhythmias in Cardiac Resynchronization Therapy 

      Friedman, D. J.; Altman, R. K.; Orencole, M.; Picard, Michael Howard; Ruskin, Jeremy Neil; Singh, Jagmeet P.; Heist, Edwin Kevin (Ovid Technologies (Wolters Kluwer Health), 2012)
      Background: Patients undergoing cardiac resynchronization therapy (CRT) are at high risk for ventricular arrhythmias and risk stratification in this population remains poor. Methods and Results: This study followed 269 ...
    • Preload Dependency of Left Ventricular Torsion: The Impact of Normal Saline Infusion 

      Weiner, Rory Brett; Weyman, Arthur Edward; Khan, A. M.; Reingold, J. S.; Chen-Tournoux, A. A.; Scherrer-Crosbie, Marielle; Picard, Michael Howard; Wang, T. J.; Baggish, Aaron L. (Ovid Technologies (Wolters Kluwer Health), 2010)
      Background: Left ventricular (LV) rotation results from contraction of obliquely oriented myocardial fibers. The net difference between systolic apical counterclockwise rotation and basal clockwise rotation is left ventricular ...
    • Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouse 

      Braun, A.; Zhang, S.; Miettinen, H. E.; Ebrahim, S.; Holm, T. M.; Vasile, E.; Post, M. J.; Yoerger, D. M.; Picard, Michael Howard; Krieger, J. L.; Andrews, N. C.; Simons, M.; Krieger, M. (Proceedings of the National Academy of Sciences, 2003)
      Mice with homozygous null mutations in the high-density lipoprotein receptor SR-BI (scavenger receptor class B, type I) and apolipoprotein E genes fed a low-fat diet exhibit a constellation of pathologies shared with human ...
    • PROspective Multicenter Imaging Study for Evaluation of chest pain: Rationale and design of the PROMISE trial 

      Douglas, Pamela S.; Hoffmann, Udo; Lee, Kerry L.; Mark, Daniel B.; Al-Khalidi, Hussein R.; Anstrom, Kevin; Dolor, Rowena J.; Kosinski, Andrzej; Krucoff, Mitchell W.; Mudrick, Daniel W.; Patel, Manesh R.; Picard, Michael Howard; Udelson, James E.; Velazquez, Eric J.; Cooper, Lawton (Elsevier BV, 2014)
      Background: Suspected coronary artery disease (CAD) is one of the most common, potentially life threatening diagnostic problems clinicians encounter. However, no large outcome-based randomized trials have been performed ...
    • Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH2-terminal kinases 

      Choukroun, Gabriel; Hajjar, Roger; Fry, Stefanie; Del Monte, Federica; Haq, Syed; Guerrero, J. Luis; Picard, Michael Howard; Rosenzweig, Anthony; Force, Thomas (American Society for Clinical Investigation, 1999)
      Cardiac hypertrophy often presages the development of heart failure. Numerous cytosolic signaling pathways have been implicated in the hypertrophic response in cardiomyocytes in culture, but their roles in the hypertrophic ...
    • Risk Prediction in Aortic Valve Replacement: Incremental Value of the Preoperative Echocardiogram 

      Tan, Timothy C.; Flynn, Aidan W.; Chen‐Tournoux, Annabel; Rudski, Lawrence G.; Mehrotra, Praveen; Nunes, Maria C.; Rincon, Luis M.; Shahian, David M.; Picard, Michael H.; Afilalo, Jonathan (John Wiley and Sons Inc., 2015)
      Background: Risk prediction is a critical step in patient selection for aortic valve replacement (AVR), yet existing risk scores incorporate very few echocardiographic parameters. We sought to evaluate the incremental ...
    • Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. 

      Steudel, W; Scherrer-Crosbie, Marielle; Bloch, K D; Weimann, J; Huang, P L; Jones, R C; Picard, Michael Howard; Zapol, Warren Myron (American Society for Clinical Investigation, 1998)
      Chronic hypoxia induces pulmonary hypertension and right ventricular (RV) hypertrophy. Nitric oxide (NO) has been proposed to modulate the pulmonary vascular response to hypoxia. We investigated the effects of congenital ...
    • Usefulness of Hemoglobin A1c to Predict Outcome After Cardiac Resynchronization Therapy in Patients With Diabetes Mellitus and Heart Failure 

      Shah, Ravi Vikram; Altman, Robert K.; Park, Mi Young; Zilinski, Jodi; Leyton-Mange, Jordan Stewart; Orencole, Mary; Picard, Michael Howard; Barrett, Conor D.; Heist, Edwin Kevin; Upadhyay, Gaurav; Das, Ranendra; Singh, Jagmeet P.; Das, Saumya (Elsevier BV, 2012)
      Patients with diabetes and heart failure (HF) have worse clinical outcomes compared to patients with HF without diabetes after cardiac resynchronization therapy (CRT). Patients with HF and diabetes represent a growing ...
    • Validation of Noninvasive Measurements of Cardiac Output in Mice Using Echocardiography 

      Tournoux, François; Petersen, Bodil; Thibault, Hélène; Zou, Lin; Raher, Michael J.; Kurtz, Baptiste; Halpern, Elkan; Chaput, Miguel; Chao, Wei; Picard, Michael Howard; Scherrer-Crosbie, Marielle (Elsevier BV, 2011)
      Although multiple echocardiographic methods exist to calculate cardiac output (CO), they have not been validated in mice using a reference method. Echocardiographic and flow probe measurements of CO were obtained in mice ...
    • The value of core lab stress echocardiography interpretations: observations from the ISCHEMIA Trial 

      Kataoka, Akihisa; Scherrer-Crosbie, Marielle; Senior, Roxy; Gosselin, Gilbert; Phaneuf, Denis; Guzman, Gabriela; Perna, Gian; Lara, Alfonso; Kedev, Sasko; Mortara, Andrea; El-Hajjar, Mohammad; Shaw, Leslee J.; Reynolds, Harmony R.; Picard, Michael H. (BioMed Central, 2015)
      Background: Stress echocardiography (SE) is dependent on subjective interpretations. As a prelude to the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) Trial, potential ...