Now showing items 21-40 of 150

    • Cerebral white matter abnormalities and their associations with negative but not positive symptoms of schizophrenia 

      Asami, Takeshi; Hyuk Lee, Sang; Bouix, Sylvain; Rathi, Yogesh; Whitford, Thomas; Niznikiewicz, Margaret A.; Nestor, Paul Gerard; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Elsevier BV, 2014)
      Although diffusion tensor imaging (DTI) studies have reported fractional anisotropy (FA) abnormalities in multiple white matter (WM) regions in schizophrenia, relationship between abnormal FA and negative symptoms has not ...
    • Chronic Ketamine Reduces the Peak Frequency of Gamma Oscillations in Mouse Prefrontal Cortex Ex vivo 

      McNally, James M.; McCarley, Robert W.; Brown, Ritchie E. (Frontiers Media S.A., 2013)
      Abnormalities in EEG gamma band oscillations (GBO, 30–80 Hz) serve as a prominent biomarker of schizophrenia (Sz), associated with positive, negative, and cognitive symptoms. Chronic, subanesthetic administration of ...
    • Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study 

      Kubicki, Marek R.; Westin, Carl-Fredrik; Nestor, Paul Gerard; Wible, Cynthia Gayle; Frumin, Melissa; Maier, Stephan Ernst; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2003)
      Background: Evidence suggests that a disruption in limbic system network integrity and, in particular, the cingulate gyrus (CG), may play a role in the pathophysiology of schizophrenia; however, the cingulum bundle (CB), ...
    • Cingulum bundle integrity associated with delusions of control in schizophrenia: Preliminary evidence from diffusion-tensor tractography 

      Whitford, Thomas; Kubicki, Marek R.; Pelavin, Paula E.; Lucia, Diandra; Schneiderman, Jason S.; Pantelis, Christos; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2015)
      Background—Delusions of control are among the most distinctive and characteristic symptoms of schizophrenia. Several theories have been proposed that implicate aberrant communication between spatially disparate brain regions ...
    • Clinical high risk and first episode schizophrenia: Auditory event-related potentials 

      Del Re, Elisabetta; Spencer, Kevin M.; Oribe, Naoya; Mesholam-Gately, Raquelle; Goldstein, Jill M.; Shenton, Martha Elizabeth; Petryshen, Tracey Lynn; Seidman, Larry Joel; McCarley, Robert William; Niznikiewicz, Margaret A. (Elsevier BV, 2015)
      The clinical high risk (CHR) period is a phase denoting a risk for overt psychosis during which subacute symptoms often appear, and cognitive functions may deteriorate. To compare biological indices during this phase with ...
    • Clinical, cognitive, and social characteristics of a sample of neuroleptic-naive persons with schizotypal personality disorder 

      Dickey, Chandlee C.; McCarley, Robert William; Niznikiewicz, Margaret A.; Voglmaier, Martina M.; Seidman, Larry Joel; Kim, Sunnie; Shenton, Martha Elizabeth (Elsevier BV, 2005)
      Introduction: Schizotypal personality disorder (SPD) shares with schizophrenia many biological features, yet little is known about the clinical characteristics of persons diagnosed with this disorder. This report describes ...
    • Cognitive dysfunction in schizophrenia: unifying basic research and clinical aspects 

      McCarley, Robert William; Niznikiewicz, Margaret A.; Salisbury, Dean F.; Nestor, Paul Gerard; O’Donnell, Brian F.; Hirayasu, Yoshio; Grunze, Heinz; Greene, Robert W.; Shenton, Martha Elizabeth (Springer Science + Business Media, 1999)
      Seeking to unite psychological and biological approaches, this paper links cognitive and cellular hypotheses and data about thought and language abnormalities in schizophrenia. The common thread, it is proposed, is a ...
    • Combining ERP and Structural MRI Information in First Episode Schizophrenia and Bipolar Disorder 

      McCarley, Robert William; Nakamura, M.; Shenton, Martha Elizabeth; Salisbury, D. F. (SAGE Publications, 2008)
      The electrical activity in the electroencephalogram (EEG) and the event-related potentials extracted from the EEG provide the greatest temporal resolution for examining brain function. When coupled with the high spatial ...
    • A comparative profile analysis of neuropsychological function in men and women with schizotypal personality disorder 

      Voglmaier, Martina M.; Seidman, Larry Joel; Niznikiewicz, Margaret A.; Dickey, Chandlee C.; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2005)
      The purpose of this study was to compare the cognitive profiles of men and women with clinically defined schizotypal personality disorder (SPD). We examined the neuropsychological profile of SPD in 26 right-handed females ...
    • Comparing prefrontal gray and white matter contributions to intelligence and decision making in schizophrenia and healthy controls. 

      Nestor, Paul Gerard; Kubicki, Marek R.; Nakamura, Motoaki; Niznikiewicz, Margaret A.; McCarley, Robert William; Shenton, Martha Elizabeth (American Psychological Association (APA), 2010)
      We examined the relationship between neuropsychological performance and magnetic resonance imaging (MRI) of the orbital frontal cortex (OFC) and diffusion tensor imaging (DTI) of the cingulum bundle (CB) within groups of ...
    • Comparison of Single-Shot Echo-Planar and Line Scan Protocols for Diffusion Tensor Imaging 

      Kubicki, Marek R.; Maier, Stephan Ernst; Westin, Carl-Fredrik; Mamata, Hatsuho; Ersner-Hershfield, Hal; Estepar, Raul; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier, 2004)
      Rationale and Objectives: Both single-shot diffusion-weighted echo-planar imaging (EPI) and line scan diffusion imaging (LSDI) can be used to obtain magnetic resonance diffusion tensor data and to calculate directionally ...
    • Corpus Callosum Abnormalities and Their Association with Psychotic Symptoms in Patients with Schizophrenia 

      Whitford, Thomas; Kubicki, Marek R.; Schneiderman, Jason S.; O, Lauren J.; King, Rebecca; Alvarado, Jorge L.; Khan, Usman; Markant, Douglas; Nestor, Paul Gerard; Niznikiewicz, Margaret A.; McCarley, Robert William; Westin, Carl-Fredrik; Shenton, Martha Elizabeth (Elsevier BV, 2010)
      Background—Whilst the neuroanatomical underpinnings of the functional brain disconnectivity observed in patients with schizophrenia remain elusive, white matter fiber bundles of the brain are a likely candidate given that ...
    • A Cross-Sectional and Longitudinal Magnetic Resonance Imaging Study of Cingulate Gyrus Gray Matter Volume Abnormalities in First-Episode Schizophrenia and First-Episode Affective Psychosis 

      Koo, Min-Seong; Levitt, James Jonathan; Salisbury, Dean F.; Nakamura, Motoaki; Shenton, Martha Elizabeth; McCarley, Robert William (American Medical Association (AMA), 2008)
      Context: Previous magnetic resonance imaging (MRI) findings have demonstrated psychopathological symptom–related smaller gray matter volumes in various cingulate gyrus subregions in schizophrenia and bipolar disorder. ...
    • Dichotic listening in schizotypal personality disorder: Evidence for gender and laterality effects 

      Voglmaier, Martina M.; Seidman, Larry Joel; Niznikiewicz, Margaret A.; Madan, Anita; Dickey, Chandlee C.; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2009)
      Verbal dichotic listening performance was examined in 42 right-handed men and women with DSM-IV-defined schizotypal personality disorder (SPD) and 68 right-handed controls. As expected, both male and female control groups ...
    • Diffusion Tensor Imaging and Its Application to Neuropsychiatric Disorders 

      Kubicki, Marek R.; Westin, Carl-Fredrik; Maier, Stephan Ernst; Mamata, Hatsuho; Frumin, Melissa; Ersner-Hershfield, Hal; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Ovid Technologies (Wolters Kluwer Health), 2002)
      Magnetic resonance diffusion tensor imaging (DTI) is a new technique that can be used to visualize and measure the diffusion of water in brain tissue; it is particularly useful for evaluating white matter abnormalities. ...
    • A diffusion tensor imaging study of the anterior limb of the internal capsule in schizophrenia 

      Levitt, James Jonathan; Kubicki, Marek R.; Nestor, Paul Gerard; Ersner-Hershfield, Hal; Westin, C-F; Alvarado, Jorge L.; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2010)
      Introduction—Frontal-subcortical cognitive and limbic feedback loops modulate higher cognitive functioning. The final step in these feedback loops is the thalamo-cortical projection through the anterior limb of the internal ...
    • Diffusion tractography of the fornix in schizophrenia 

      Fitzsimmons, Jennifer J; Kubicki, Marek R.; Smith, K.; Bushell, G.; Estepar, R. San Jose; Westin, Carl-Fredrik; Nestor, Paul Gerard; Niznikiewicz, Margaret A.; Kikinis, Ron; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2009)
      Background: White matter fiber tracts, especially those interconnecting the frontal and temporal lobes, are likely implicated in pathophysiology of schizophrenia. Very few studies, however, have focused on the fornix, a ...
    • Disruption of function–structure coupling in brain regions sub-serving self monitoring in schizophrenia 

      Araki, Tsuyoshi; Niznikiewicz, Margaret A.; Kawashima, Toshiro; Nestor, Paul Gerard; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2013)
      Deficits in self monitoring are a core feature of cognitive dysfunction in schizophrenia, and may be the basis for disturbances of self and lack of insight, ultimately impacting social functioning. However, the functional ...
    • Dissociable contributions of MRI volume reductions of superior temporal and fusiform gyri to symptoms and neuropsychology in schizophrenia 

      Nestor, Paul Gerard; Onitsuka, Toshiaki; Gurrera, Ronald Joseph; Niznikiewicz, Margaret A.; Frumin, Melissa; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2007)
      We sought to identify the functional correlates of reduced magnetic resonance imaging (MRI) volumes of the superior temporal gyrus (STG) and the fusiform gyrus (FG) in patients with chronic schizophrenia. MRI volumes, ...
    • DTI and MTR abnormalities in schizophrenia: Analysis of white matter integrity 

      Kubicki, Marek R.; Park, H.; Westin, Carl-Fredrik; Nestor, Paul Gerard; Mulkern, Robert Vincent; Maier, Stephan Ernst; Niznikiewicz, Margaret A.; Connor, E.E.; Levitt, James Jonathan; Frumin, Melissa; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2005)
      Diffusion tensor imaging (DTI) studies in schizophrenia demonstrate lower anisotropic diffusion within white matter due either to loss of coherence of white matter fiber tracts, to changes in the number and/or density of ...