Now showing items 21-37 of 37

    • Nanowired three-dimensional cardiac patches 

      Dvir, Tal; Timko, Brian Paul; Brigham, Mark Daniel; Naik, Shreesh R.; Karajanagi, Sandeep Sidram; Levy, Oren; Jin, Hongwei; Parker, Kevin Kit; Langer, Robert S.; Kohane, Daniel Solomon (Springer Nature, 2011)
      Engineered cardiac patches for treating damaged heart tissues after a heart attack are normally produced by seeding heart cells within three-dimensional porous biomaterial scaffolds. These biomaterials, which are usually ...
    • Neutrophil Responses to Sterile Implant Materials 

      Jhunjhunwala, Siddharth; Aresta-DaSilva, Stephanie; Tang, Katherine; Alvarez, David; Webber, Matthew J.; Tang, Benjamin C.; Lavin, Danya M.; Veiseh, Omid; Doloff, Joshua C.; Bose, Suman; Vegas, Arturo; Ma, Minglin; Sahay, Gaurav; Chiu, Alan; Bader, Andrew; Langan, Erin; Siebert, Sean; Li, Jie; Greiner, Dale L.; Newburger, Peter E.; von Andrian, Ulrich H.; Langer, Robert; Anderson, Daniel G. (Public Library of Science, 2015)
      In vivo implantation of sterile materials and devices results in a foreign body immune response leading to fibrosis of implanted material. Neutrophils, one of the first immune cells to be recruited to implantation sites, ...
    • Parallel microfluidic synthesis of size-tunable polymeric nanoparticles using 3D flow focusing towards in vivo study 

      Lim, Jong-Min; Bertrand, Nicolas; Valencia, Pedro M.; Rhee, Minsoung; Langer, Robert S.; Jon, Sangyong; Farokhzad, Omid Cameron; Karnik, Rohit (Elsevier BV, 2014)
      Microfluidic synthesis of nanoparticles (NPs) can enhance the controllability and reproducibility in physicochemical properties of NPs compared to bulk synthesis methods. However, applications of microfluidic synthesis are ...
    • pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices 

      Zhang, Shiyi; Bellinger, Andrew M.; Glettig, Dean L.; Barman, Ross; Lee, Young-Ah Lucy; Zhu, Jiahua; Cleveland, Cody; Montgomery, Veronica A; Gu, Li; Nash, Landon D.; Maitland, Duncan J.; Langer, Robert; Traverso, Giovanni (2015)
      Devices resident in the stomach -- which are used for a variety of clinical applications including nutritional modulation for bariatrics, ingestible electronics for diagnosis and monitoring, and gastric retentive dosage ...
    • Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery 

      Tong, Rong; Hemmati, Houman D.; Langer, Robert S.; Kohane, Daniel Solomon (American Chemical Society, 2012)
      We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, ...
    • Poly(ethylene glycol) with Observable Shedding 

      Gao, Weiwei; Langer, Robert S.; Farokhzad, Omid Cameron (Wiley-Blackwell, 2010)
      A novel FRET-bearing poly(ethylene glycol) (PEG) conjugate fluoresces at 520 nm when it is cleaved off from nanoparticles (NPs). When the NPs were targeted to cancer cell lines, the reducing redox of the endosomal compartment ...
    • Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates 

      Veiseh, Omid; Doloff, Joshua C.; Ma, Minglin; Vegas, Arturo J.; Tam, Hok Hei; Bader, Andrew R.; Li, Jie; Langan, Erin; Wyckoff, Jeffrey; Loo, Whitney S.; Jhunjhunwala, Siddharth; Chiu, Alan; Siebert, Sean; Tang, Katherine; Hollister-Lock, Jennifer; Aresta-Dasilva, Stephanie; Bochenek, Matthew; Mendoza-Elias, Joshua; Wang, Yong; Qi, Merigeng; Lavin, Danya M.; Chen, Michael; Dholakia, Nimit; Thakrar, Raj; Lacík, Igor; Weir, Gordon C.; Oberholzer, Jose; Greiner, Dale L.; Langer, Robert; Anderson, Daniel G. (2015)
      The efficacy of implanted biomedical devices is often compromised by host recognition and subsequent foreign body responses. Here, we demonstrate the role of the geometry of implanted materials on their biocompatibility ...
    • Superparamagnetic Iron Oxide Nanoparticle-Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy 

      Wang, Andrew Z.; Bagalkot, Vaishali; Vasilliou, Christophoros C.; Gu, Frank; Alexis, Frank; Zhang, Liangfang; Shaikh, Mariam; Yuet, Kai; Cima, Michael J.; Langer, Robert S.; Kantoff, Philip Wayne; Bander, Neil H.; Jon, Sangyong; Farokhzad, Omid Cameron (Wiley-Blackwell, 2008)
    • Surface Charge-Switching Polymeric Nanoparticles for Bacterial Cell Wall-Targeted Delivery of Antibiotics 

      Radovic-Moreno, Aleksandar F.; Lu, Timothy K.; Puscasu, Vlad A.; Yoon, Christopher J.; Langer, Robert S.; Farokhzad, Omid Cameron (American Chemical Society (ACS), 2012)
      Bacteria have shown a remarkable ability to overcome drug therapy if there is a failure to achieve sustained bactericidal concentration or if there is a reduction in activity in situ. The latter can be caused by localized ...
    • Synergistic cytotoxicity of irinotecan and cisplatin in dual-drug targeted polymeric nanoparticles 

      Valencia, Pedro M; Pridgen, Eric M; Perea, Brian; Gadde, Suresh; Sweeney, Christopher; Kantoff, Philip Wayne; Bander, Neil H; Lippard, Stephen J; Langer, Robert S.; Karnik, Rohit; Farokhzad, Omid Cameron (Future Medicine Ltd, 2013)
      Aim: Two unexplored aspects for irinotecan and cisplatin (I&C) combination chemotherapy are (1) actively targeting both drugs to a specific diseased cell type and (2) delivering both drugs on the same vehicle to ensure ...
    • Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform 

      Gianella, Anita; Mieszawska, Aneta J.; Hoeben, Freek J. M.; Janssen, Henk M.; Jarzyna, Peter A.; Cormode, David P.; Costa, Kevin D.; Rao, Satish; Farokhzad, Omid Cameron; Langer, Robert S.; Fayad, Zahi A.; Mulder, Willem J. M. (Royal Society of Chemistry (RSC), 2013)
      We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and ...
    • Synthesis of Polymer–Lipid Nanoparticles for Image-Guided Delivery of Dual Modality Therapy 

      Mieszawska, Aneta J.; Kim, YongTae; Gianella, Anita; van Rooy, Inge; Priem, Bram; Labarre, Matthew P.; Ozcan, Canturk; Cormode, David P.; Petrov, Artiom; Langer, Robert S.; Farokhzad, Omid Cameron; Fayad, Zahi A.; Mulder, Willem J. M. (American Chemical Society (ACS), 2013)
      For advanced treatment of diseases such as cancer, multi component, multi functional nanoparticles hold great promise. In the current study we report the synthesis of a complex nanoparticle (NP) system with dual drug loading ...
    • Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels 

      Rhee, Minsoung; Valencia, Pedro M.; Rodriguez, Maria I.; Langer, Robert S.; Farokhzad, Omid Cameron; Karnik, Rohit (Wiley-Blackwell, 2011)
      A versatile microfluidic platform to synthesize NPs by nanoprecipitation using 3D hydrodynamic flow focusing isolates the precipitating precursors from channel walls, eliminating fouling of the channels. It is shown that ...
    • Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells 

      Novobrantseva, Tatiana I; Borodovsky, Anna; Wong, Jamie; Klebanov, Boris; Zafari, Mohammad; Yucius, Kristina; Querbes, William; Ge, Pei; Ruda, Vera M.; Milstein, Stuart; Speciner, Lauren; Duncan, Rick; Barros, Scott; Basha, Genc; Cullis, Pieter; Akinc, Akin; Donahoe, Jessica S; Narayanannair Jayaprakash, K; Jayaraman, Muthusamy; Bogorad, Roman L; Love, Kevin; Whitehead, Katie; Levins, Chris; Manoharan, Muthiah; Swirski, Filip K.; Weissleder, Ralph; Langer, Robert S.; Anderson, Daniel Griffith; de Fougerolles, Antonin; Nahrendorf, Matthias; Koteliansky, Victor (Nature Publishing Group, 2012)
      Leukocytes are central regulators of inflammation and the target cells of therapies for key diseases, including autoimmune, cardiovascular, and malignant disorders. Efficient in vivo delivery of small interfering RNA (siRNA) ...
    • Transepithelial Transport of Fc-Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery 

      Pridgen, E. M.; Alexis, F.; Kuo, T; Levy-Nissenbaum, E.; Karnik, R.; Blumberg, Richard Steven; Langer, Robert S.; Farokhzad, Omid Cameron (American Association for the Advancement of Science (AAAS), 2013)
      Nanoparticles are poised to have a tremendous impact on the treatment of many diseases, but their broad application is limited because currently they can only be administered by parenteral methods. Oral administration of ...
    • The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules 

      Teply, Benjamin A.; Tong, Rong; Jeong, Seok Y.; Luther, Gaurav; Sherifi, Ines; Yim, Christopher H.; Khademhosseini, Ali; Farokhzad, Omid Cameron; Langer, Robert S.; Cheng, Jianjun (Elsevier BV, 2008)
      Protein drugs have low bioavailability after oral administration, which is due in part to fast transit of the drugs or drug delivery vehicles through the gastrointestinal tract. Increasing the time that the drugs spend in ...
    • YY1 Regulates Melanocyte Development and Function by Cooperating with MITF 

      Li, Juying; Bell, Robert J. A.; Liu, Huifei; Love, Kevin T.; Larue, Lionel; Song, Jun S.; Tran, Thanh-Nga Trinh; Haq, Rizwan; Langer, Robert S.; Anderson, Daniel Griffith; Fisher, David Erich (Public Library of Science, 2012)
      Studies of coat color mutants have greatly contributed to the discovery of genes that regulate melanocyte development and function. Here, we generated Yy1 conditional knockout mice in the melanocyte-lineage and observed ...