Browsing by Author "Tanzi, Rudolph"

Now showing items 21-24 of 24

    • Synaptotagmins interact with APP and promote Aβ generation 

      Gautam, Vivek; D’Avanzo, Carla; Berezovska, Oksana; Tanzi, Rudolph E.; Kovacs, Dora M. (BioMed Central, 2015)
      Background: Accumulation of the β-amyloid peptide (Aβ) is a major pathological hallmark of Alzheimer’s disease (AD). Recent studies have shown that synaptic Aβ toxicity may directly impair synaptic function. However, ...

    • A three-dimensional human neural cell culture model of Alzheimer’s disease 

      Choi, Se Hoon; Kim, Young Hye; Hebisch, Matthias; Sliwinski, Christopher; Lee, Seungkyu; D'Avanzo, Carla; Chen, Jennifer; Hooli, Basavaraj; Asselin, Caroline; Muffat, Julien; Klee, Justin B.; Zhang, Can; Wainger, Brian Jason; Peitz, Michael; Kovacs, Dora M.; Woolf, Clifford; Wagner, Steven L.; Tanzi, Rudolph Emile; Kim, Doo Yeon (Nature Publishing Group, 2014)
      Alzheimer’s disease (AD) is the most common form of dementia, characterized by two pathological hallmarks: β-amyloid plaques and neurofibrillary tangles1. The amyloid hypothesis of AD posits that excessive accumulation of ...

    • Two Mutations in the SARS-CoV-2 Spike Protein and RNA Polymerase Complex Are Associated With COVID-19 Mortality Risk 

      Hahn, Georg; Wu, Chloe M.; Lee, Sanghun; Hecker, Julian; Lutz, Sharon; Haneuse, Sebastien; Qiao, Dandi; Demeo, Dawn; Tanzi, Rudolph; Choudhary, Manish; Etemad, Behzad; Mohammadi, Abbas; Esmaeilzadeh, Elmira; Cho, Michael M.; Li, Jonathan; Randolph, Adrienne; Laird, Nan; Weiss, Scott; Silverman, Edwin; Ribbeck, Katharina; Lange, Christoph (2021)
      SARS-CoV-2 mortality has been extensively studied in relation to host susceptibility. How sequence variations in the SARS-CoV-2 genome affect pathogenicity is poorly understood. Association between whole-genome sequencing ...

    • Zinc-induced Alzheimer's Aβ1–40 Aggregation Is Mediated by Conformational Factors 

      Atwood, Craig S.; Hartshorn, Mariana A.; Vonsattel, Jean-Paul; Huang, Xudong; Moir, Robert; Tanzi, Rudolph; Bush, Ashley (American Society for Biochemistry & Molecular Biology (ASBMB), 1997-10-17)
      The heterogeneous precipitates of Aβ that accumulate in the brain cortex in Alzheimer's disease possess varying degrees of resistance to resolubilization. We previously found that Aβ1–40 is rapidly precipitated in vitro ...