Browsing by Author "Sacks, Frank"
Now showing items 21-40 of 75
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Discovery of HDL Subspecies and Investigation of Their Associations With Insulin Sensitivity and Early Carotid Atherosclerosis
Yamamoto, Rain (2016-05-03)Recent findings from genome-wide association studies and pharmaceutical trials of CETP inhibitors suggest that HDL cholesterol might not fully capture the anti-atherogenic functions of HDL. The protein component of HDL ... -
Distinct patterns of lipoproteins with apoB defined by presence of apoE or apoC-III in hypercholesterolemia and hypertriglyceridemia.
Campos, Hannia; Perlov, Dan; Khoo, Christina; Sacks, Frank Martin (American Society for Biochemistry and Molecular Biology, 2001)Apolipoprotein (apo) E and apoC-III concentrations in VLDL and LDL are associated with coronary heart disease. We studied the relationship between apoE and apoC-III and the abnormal concentrations and distribution of apoB ... -
Early behavioral adherence predicts short and long-term weight loss in the POUNDS LOST study
Williamson, Donald A.; Anton, Stephen D.; Han, Hongmei; Champagne, Catherine M.; Allen, Ray; LeBlanc, Eric; Ryan, Donna H.; Rood, Jennifer Evelyn; McManus, Katherine; Laranjo, Nancy M; Carey, Vincent James; Loria, Catherine M.; Bray, George A.; Sacks, Frank Martin (Springer Nature, 2010)The primary aim of this study was to test the association of early (first 6 months) adherence related to diet, self-monitoring, and attendance with changes in adiposity and cardiovascular risk factors. This study used data ... -
Effect of diet composition and weight loss on resting energy expenditure in the POUNDS LOST study
de Jonge, Lilian; Bray, George A.; Smith, Steven R.; Ryan, Donna H.; de Souza, Russell; Loria, Catherine M.; Champagne, Catherine M.; Williamson, Donald; Sacks, Frank M. (2012)Weight loss reduces energy expenditure, but it is unclear whether dietary macronutrient composition affects this reduction. We hypothesized that energy expenditure might be modulated by macronutrient composition of the ... -
Effect of Dietary Composition of Weight Loss Diets on High Sensitivity C-Reactive Protein: The Randomized POUNDS LOST Trial
Nicklas, Jacinda M.; Sacks, Frank M.; Smith, Steven R.; LeBoff, Meryl S.; Rood, Jennifer C.; Bray, George A.; Ridker, Paul M (2012)Overweight and obesity are associated with increased high sensitivity C-reactive protein (hsCRP) levels. The purpose of this study was to determine if weight loss diets differing in fat, protein, or carbohydrate composition ... -
Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III: results from the OmniHeart Trial.
Furtado, Jeremy Daniel; Campos, Hannia; Appel, Lawrence; Miller, Edgar; Laranjo, Nancy M; Carey, Vincent James; Sacks, Frank Martin (American Society for Nutrition, 2008) -
Effect of type and amount of dietary carbohydrate on biomarkers of glucose homeostasis and C reactive protein in overweight or obese adults: results from the OmniCarb trial
Juraschek, Stephen P; Miller, Edgar R; Selvin, Elizabeth; Carey, Vincent J; Appel, Lawrence J; Christenson, Robert H; Sacks, Frank M (BMJ Publishing Group, 2016)Objective: The glycemic index (GI) of dietary carbohydrate is thought to affect glucose homeostasis. Recently, the Effect of Amount and Type of Dietary Carbohydrates on Risk for Cardiovascular Heart Disease and Diabetes ... -
Effect on Blood Pressure of Potassium, Calcium, and Magnesium in Women With Low Habitual Intake
Sacks, Frank; Willett, Walter C.; Smith, A.; Brown, L. E.; Rosner, Bernard Alfred; Moore, Thomas Burton (Ovid Technologies (Wolters Kluwer Health), 1998)In populations, dietary intakes of potassium, calcium, and magnesium each have been inversely associated with blood pressure. However, most clinical trials in normotensive populations have not found that dietary supplements ... -
The Effects of Carbohydrate, Unsaturated Fat, and Protein Intake on Measures of Insulin Sensitivity: Results from the OmniHeart Trial
Gadgil, Meghana D.; Appel, Lawrence J.; Yeung, Edwina; Anderson, Cheryl A.M.; Sacks, Frank M.; Miller, Edgar R. (American Diabetes Association, 2013)OBJECTIVE Impaired insulin sensitivity increases the risk of cardiovascular disease. Although calorie restriction and weight loss increase insulin sensitivity, the effects of modifying macronutrient composition on insulin ... -
The Effects of Dietary Patterns on Urinary Albumin Excretion: Results of the Dietary Approaches to Stop Hypertension (DASH) Trial
Jacobs, David R.; Gross, Myron D.; Steffen, Lyn; Steffes, Michael W.; Yu, Xinhua; Svetkey, Laura P.; Appel, Lawrence J.; Vollmer, William M.; Bray, George A.; Moore, Thomas Burton; Conlin, Paul Richard; Sacks, Frank (Elsevier BV, 2009)Dietary studies designed to decrease the urinary albumin excretion rate (AER) typically reduce protein by increasing lower protein plant foods and decreasing higher protein animal products. STUDY DESIGN: We evaluated AER ... -
Effects of estrogenic oral contraceptives on the lipoprotein B particle system defined by apolipoproteins E and C-III content.
Khoo, Christina; Campos, Hannia; Judge, Helena; Sacks, Frank Martin (American Society for Biochemistry and Molecular Biology, 1999)Apolipoproteins E and C-III are modulators of lipoprotein metabolism that could affect development of atherosclerosis. The prevalence in plasma of apoB-containing particles (LpB) that contain either apoE or apoC-III, both ... -
Effects of High vs Low Glycemic Index of Dietary Carbohydrate on Cardiovascular Disease Risk Factors and Insulin Sensitivity
Sacks, Frank Martin; Carey, Vincent James; Anderson, Cheryl A. M.; Miller, Edgar R.; Copeland, Trisha; Charleston, Jeanne; Harshfield, Benjamin J.; Laranjo, Nancy M; McCarron, Phyllis; Swain, Janis; White, Karen; Yee, Karen; Appel, Lawrence J. (American Medical Association (AMA), 2014)Importance Foods that have similar carbohydrate content can differ in the amount they raise blood glucose. The effects of this property, called the glycemic index, on risk factors for cardiovascular disease and diabetes ... -
Effects of low dose oral contraceptives on very low density and low density lipoprotein metabolism.
Walsh, Barent W; Sacks, Frank Martin (American Society for Clinical Investigation, 1993)Oral contraceptives (OC) raise plasma triglyceride and VLDL levels, which may be of concern, since some conditions characterized by elevated triglycerides are associated with atherosclerosis. To identify the responsible ... -
Effects of Lowering Glycemic Index of Dietary Carbohydrate on Plasma Uric Acid: The OmniCarb Randomized Clinical Trial
Juraschek, Stephen P; McAdams-Demarco, Mara; Gelber, Allan C; Sacks, Frank Martin; Appel, Lawrence J.; White, Karen; Miller, Edgar R (Wiley-Blackwell, 2015)OBJECTIVE: The effects of carbohydrates on plasma uric acid levels are a subject of controversy. We determined the individual and combined effects of carbohydrate quality (the glycemic index) and quantity (the proportion ... -
Effects of Postmenopausal Estrogen Replacement on the Concentrations and Metabolism of Plasma Lipoproteins
Walsh, Brian; Schiff, Isaac; Rosner, Bernard; Greenberg, Louise; Ravnikar, Veronica; Sacks, Frank (Massachusetts Medical Society, 1991-10-24)BACKGROUND. Postmenopausal estrogen-replacement therapy may reduce the risk of cardiovascular disease, and this beneficial effect may be mediated in part by favorable changes in plasma lipid levels. However, the effects ... -
Effects of postmenopausal hormone replacement with oral and transdermal estrogen on high density lipoprotein metabolism
Walsh, Brian; Li, Helena; Sacks, Frank Martin (ASBMB, 1994)Estrogen treatment raises plasma high density lipoprotein (HDL) levels, which may reduce cardiovascular risk. To identify the responsible mechanisms as well as the importance of the route of administration, we treated eight ... -
Effects of Protein, Monounsaturated Fat, and Carbohydrate Intake on Blood Pressure and Serum Lipids
Appel, Lawrence J.; Sacks, Frank Martin; Carey, Vincent James; Obarzanek, Eva; Swain, Janis F.; Miller, Edgar R.; Conlin, Paul Richard; Erlinger, Thomas P.; Rosner, Bernard Alfred; Laranjo, Nancy M; Charleston, Jeanne; McCarron, Phyllis; Bishop, Louise M.; OmniHeart Collaborative Research Group, for the (American Medical Association (AMA), 2005) -
Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) Diet
Sacks, Frank; Svetkey, Laura P.; Vollmer, William M.; Appel, Lawrence J.; Bray, George A.; Harsha, David; Obarzanek, Eva; Conlin, Paul; Miller, Edgar R.; Simons-Morton, Denise G.; Karanja, Njeri; Lin, Pao-Hwa; Aickin, Mikel; Most-Windhauser, Marlene M.; Moore, Thomas J.; Proschan, Michael A.; Cutler, Jeffrey A. (Massachusetts Medical Society, 2001-01-04)Background: The effect of dietary composition on blood pressure is a subject of public health importance. We studied the effect of different levels of dietary sodium, in conjunction with the Dietary Approaches to Stop ... -
FTO Genotype and 2-Year Change in Body Composition and Fat Distribution in Response to Weight-Loss Diets: The POUNDS LOST Trial
Zhang, Xiaomin; Qi, Qibin; Zhang, Cuilin; Hu, Frank B.; Sacks, Frank M.; Qi, Lu (American Diabetes Association, 2012)Recent evidence suggests that the fat mass and obesity-associated gene (FTO) genotype may interact with dietary intakes in relation to adiposity. We tested the effect of FTO variant on weight loss in response to 2-year ... -
FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials
Livingstone, Katherine M; Celis-Morales, Carlos; Papandonatos, George D; Erar, Bahar; Florez, Jose Carlos; Jablonski, Kathleen A; Razquin, Cristina; Marti, Amelia; Heianza, Yoriko; Huang, Tao; Sacks, Frank Martin; Svendstrup, Mathilde; Sui, Xuemei; Church, Timothy S; Jääskeläinen, Tiina; Lindström, Jaana; Tuomilehto, Jaakko; Uusitupa, Matti; Rankinen, Tuomo; Saris, Wim H M; Hansen, Torben; Pedersen, Oluf; Astrup, Arne; Sørensen, Thorkild I A; Qi, Lu; Bray, George A; Martinez-Gonzalez, Miguel A; Martinez, Jose; Franks, Paul; McCaffery, Jeanne M; Lara, Jose; Mathers, John B (BMJ, 2016)Objective: To assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomised controlled trials. Design: Systematic review and random effects meta-analysis ...