Now showing items 21-38 of 38

    • Nod2 Suppresses Borrelia burgdorferi Mediated Murine Lyme Arthritis and Carditis Through the Induction of Tolerance 

      Petnicki-Ocwieja, Tanja; Chung, Erin; Darcy, Courtney T.; Hu, Linden T.; Geijtenbeek, Teunis; DeFrancesco, Alicia S; Bronson, Roderick Terry; Kobayashi, Koichi S (Public Library of Science, 2011)
      The internalization of Borrelia burgdorferi, the causative agent of Lyme disease, by phagocytes is essential for an effective activation of the immune response to this pathogen. The intracellular, cytosolic receptor Nod2 ...
    • A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma 

      Yuan, Jianping; Kashiwagi, Satoshi; Reeves, Patrick; Nezivar, Jean; Yang, Yuan; Arrifin, Nadiah Hashim; Nguyen, Mai; Jean-Mary, Gilberte; Tong, Xiaoyun; Uppal, Paramjit; Korochkina, Svetlana; Forbes, Ben; Chen, Tao; Righi, Elda; Bronson, Roderick; Chen, Huabiao; Orsulic, Sandra; Brauns, Timothy; Leblanc, Pierre; Scholler, Nathalie; Dranoff, Glenn; Gelfand, Jeffrey; Poznansky, Mark C (BioMed Central, 2014)
      Background: Although dendritic cell (DC) vaccines are considered to be promising treatments for advanced cancer, their production and administration is costly and labor-intensive. We developed a novel immunotherapeutic ...
    • p600 Plays Essential Roles in Fetal Development 

      Nakaya, Takeo; Ishiguro, Kei-ichiro; Belzil, Camille; Rietsch, Anna M.; Yu, Qunyan; Mizuno, Shin-ichi; Bronson, Roderick T.; Geng, Yan; Nguyen, Minh Dang; Akashi, Koichi; Sicinski, Piotr; Nakatani, Yoshihiro (Public Library of Science, 2013)
      p600 is a multifunctional protein implicated in cytoskeletal organization, integrin-mediated survival signaling, calcium-calmodulin signaling and the N-end rule pathway of ubiquitin-proteasome-mediated proteolysis. While ...
    • Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer 

      Bowman-Colin, Christian; Xia, B.; Bunting, S.; Klijn, C.; Drost, R.; Bouwman, P.; Fineman, L.; Chen, X.; Culhane, Aedin; Cai, H.; Rodig, Scott J.; Bronson, Roderick Terry; Jonkers, J.; Nussenzweig, A.; Kanellopoulou, C.; Livingston, David Morse (Proceedings of the National Academy of Sciences, 2013)
      Germ-line mutations in PALB2 lead to a familial predisposition to breast and pancreatic cancer or to Fanconi Anemia subtype N. PALB2 performs its tumor suppressor role, at least in part, by supporting homologous ...
    • Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner 

      Calvo, Jennifer A.; Allocca, Mariacarmela; Fake, Kimberly R.; Muthupalani, Sureshkumar; Corrigan, Joshua J.; Bronson, Roderick T.; Samson, Leona D. (Impact Journals LLC, 2016)
      Nephrotoxicity is a common toxic side-effect of chemotherapeutic alkylating agents. Although the base excision repair (BER) pathway is essential in repairing DNA alkylation damage, under certain conditions the initiation ...
    • Perinatal Natural History of the Ts1Cje Mouse Model of Down Syndrome: Growth Restriction, Early Mortality, Heart Defects, and Delayed Development 

      Ferrés, Millie A.; Bianchi, Diana W.; Siegel, Ashley E.; Bronson, Roderick T.; Huggins, Gordon S.; Guedj, Faycal (Public Library of Science, 2016)
      Background: The Ts1Cje model of Down syndrome is of particular interest for perinatal studies because affected males are fertile. This permits affected pups to be carried in wild-type females, which is similar to human ...
    • A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis 

      Yuzugullu, Haluk; Baitsch, Lukas; Von, Thanh; Steiner, Allison; Tong, Haoxuan; Ni, Jing; Clayton, Linda K.; Bronson, Roderick; Roberts, Thomas M.; Gritsman, Kira; Zhao, Jean J. (Nature Pub. Group, 2015)
      The tumour suppressor PTEN, which antagonizes PI3K signalling, is frequently inactivated in haematologic malignancies. In mice, deletion of PTEN in haematopoietic stem cells (HSCs) causes perturbed haematopoiesis, ...
    • Prdx1 Inhibits Tumorigenesis via Regulating PTEN/AKT Activity 

      Cao, Juxiang; Schulte, Jennifer; Knight, Alexander; Leslie, Nicholas R; Zagozdzon, Agnieszka; Bronson, Roderick Terry; Manevich, Yefim; Beeson, Craig; Neumann, Carola A (Nature Publishing Group, 2009)
      It is widely accepted that reactive oxygen species (ROS) promote tumorigenesis. However, the exact mechanisms are still unclear. As mice lacking the peroxidase peroxiredoxin1 (Prdx1) produce more cellular ROS and die ...
    • Prevention of Type 1 Diabetes in Mice by Tolerogenic Vaccination with a Strong Agonist Insulin Mimetope 

      Daniel, Carolin; Weigmann, Benno; Bronson, Roderick Terry; von Boehmer, Harald (The Rockefeller University Press, 2011)
      Type 1 diabetes (T1D) results from the destruction of insulin-secreting pancreatic cells by autoreactive T cells. Insulin is an essential target of the autoimmune attack. Insulin epitopes recognized by diabetogenic T cell ...
    • Protective effect of Cl-amidine against CLP-induced lethal septic shock in mice 

      Zhao, Ting; Pan, Baihong; Alam, Hasan B.; Liu, Baoling; Bronson, Roderick T.; Deng, Qiufang; Wu, Erxi; Li, Yongqing (Nature Publishing Group, 2016)
      Production of innate and adaptive immune cells from hematopoietic stem cells, and maturation of T lymphocytes are effective immune responses to fight severe microbial infection. In sepsis, this emergency myelopoiesis is ...
    • Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome–associated PTPN11 mutation 

      Marin, Talita M.; Keith, Kimberly; Davies, Benjamin Ivor; Conner, David Atwater; Guha, Prajna; Kalaitzidis, Demetrios; Wu, Xue; Lauriol, Jessica; Wang, Bo; Bauer, Michael; Bronson, Roderick Terry; Franchini, Kleber G.; Neel, Benjamin G.; Kontaridis, Maria Irene (American Society for Clinical Investigation, 2011)
      LEOPARD syndrome (LS) is an autosomal dominant “RASopathy” that manifests with congenital heart disease. Nearly all cases of LS are caused by catalytically inactivating mutations in the protein tyrosine phosphatase (PTP), ...
    • Rapid modeling of cooperating genetic events in cancer through somatic genome editing 

      Sánchez-Rivera, Francisco J.; Papagiannakopoulos, Thales; Romero, Rodrigo; Tammela, Tuomas; Bauer, Matthew R.; Bhutkar, Arjun; Joshi, Nikhil S.; Subbaraj, Lakshmipriya; Bronson, Roderick T.; Xue, Wen; Jacks, Tyler (2014)
      Cancer is a multistep process that involves mutations and other alterations in oncogenes and tumor suppressor genes1. Genome sequencing studies have identified a large collection of genetic alterations that occur in human ...
    • Receptor-Binding and Oncogenic Properties of Polyoma Viruses Isolated from Feral Mice 

      Carroll, John; Dey, Dilip; Kreisman, Lori; Velupillai, Palanivel; Dahl, Jean Stokes; Telford, Samuel; Bronson, Roderick Terry; Benjamin, Thomas L. (Public Library of Science, 2007)
      Laboratory strains of the mouse polyoma virus differ markedly in their abilities to replicate and induce tumors in newborn mice. Major determinants of pathogenicity lie in the sialic binding pocket of the major capsid ...
    • Role of aberrant PI3K pathway activation in gallbladder tumorigenesis 

      Lunardi, Andrea; Webster, Kaitlyn A.; Papa, Antonella; Padmani, Bhavik; Clohessy, John G.; Bronson, Roderick T.; Pandolfi, Pier Paolo (Impact Journals LLC, 2014)
      The PI3K/AKT pathway governs a plethora of cellular processes, including cell growth, proliferation, and metabolism, in response to growth factors and cytokines. By acting as a unique lipid phosphatase converting ...
    • A Spontaneous Mutation in Contactin 1 in the Mouse 

      Davisson, Muriel T.; Bronson, Roderick Terry; Tadenev, Abigail L. D.; Motley, William W.; Krishnaswamy, Arjun Sriram; Seburn, Kevin L.; Burgess, Robert W. (Public Library of Science, 2011)
      Mutations in the gene encoding the immunoglobulin-superfamily member cell adhesion molecule contactin1 (CNTN1) cause lethal congenital myopathy in human patients and neurodevelopmental phenotypes in knockout mice. Whether ...
    • Stochastic Model of Tsc1 Lesions in Mouse Brain 

      Prabhakar, Shilpa; Goto, June; Zuang, Xuan; Sena-Esteves, Miguel; Bronson, Roderick Terry; Brockmann, Jillian; Gianni, Davide; Wojtkiewicz, Gregory R.; Chen, John Wen-Yueh; Stemmer-Rachamimov, Anat; Kwiatkowski, David Joseph; Breakefield, Xandra Owens (Public Library of Science, 2013)
      Tuberous sclerosis complex (TSC) is an autosomal dominant disorder due to mutations in either TSC1 or TSC2 that affects many organs with hamartomas and tumors. TSC-associated brain lesions include subependymal nodules, ...
    • A suppressive role of ionizing radiation-responsive miR-29c in the development of liver carcinoma via targeting WIP1 

      Wang, Bo; Li, Dongping; Sidler, Corinne; Rodriguez-Juarez, Rocio; Singh, Natasha; Heyns, Mieke; Ilnytskyy, Yaroslav; Bronson, Roderick T.; Kovalchuk, Olga (Impact Journals LLC, 2015)
      Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide, and it has been linked to radiation exposure. As a well-defined oncogene, wild-type p53-induced phosphatase 1 (WIP1) plays ...
    • VAC14 Nucleates a Protein Complex Essential for the Acute Interconversion of PI3P and PI(3,5)P2 in Yeast and Mouse 

      Jin, Natsuko; Chow, Clement Y; Zolov, Sergey N; Davisson, Muriel; Petersen, Jason L; Zhang, Yanling; Park, Sujin; Duex, Jason E; Goldowitz, Daniel; Meisler, Miriam H; Weisman, Lois S; Liu, Li; Bronson, Roderick Terry (Nature Publishing Group, 2008)
      The signalling lipid PI(3,5)P2 is generated on endosomes and regulates retrograde traffic to the trans-Golgi network. Physiological signals regulate rapid, transient changes in PI(3,5)P2 levels. Mutations that lower PI(3,5)P2 ...