Now showing items 21-40 of 44

    • Head Circumference as a Useful Surrogate for Intracranial Volume in Older Adults 

      Hshieh, Tammy; Fox, Meaghan L.; Kosar, Cyrus M.; Cavallari, Michele; Guttmann, Charles; Alsop, David; Marcantonio, Edward; Schmitt, Eva M.; Jones, Richard N.; Inouye, Sharon (Cambridge University Press (CUP), 2016-01)
      Background Intracranial volume (ICV) has been proposed as a measure of maximum lifetime brain size. Accurate ICV measures require neuroimaging which is not always feasible for epidemiologic investigations. We examined ...
    • Identifying Indicators of Important Diagnostic Features of Delirium 

      Huang, Li-Wen; Inouye, Sharon; Jones, Richard Norman; Fong, Tamara G; Rudolph, James; O, Margaret G.; Metzger, Eran Daniel; Crane, Paul K.; Marcantonio, Edward Ralph (Wiley-Blackwell, 2012)
      OBJECTIVES: To use an expert consensus process to identify indicators of delirium features to help enhance bedside recognition of delirium. DESIGN: Modified Delphi consensus process to assign existing cognitive and ...
    • Independent Vascular and Cognitive Risk Factors for Postoperative Delirium 

      Rudolph, James; Jones, Richard Norman; Rasmussen, Lars S.; Silverstein, Jeffrey H.; Inouye, Sharon; Marcantonio, Edward Ralph (Elsevier BV, 2007)
    • The Language of Delirium: Keywords for Identifying Delirium from Medical Records 

      Puelle, Margaret R.; Kosar, Cyrus M.; Xu, Guoquan; Schmitt, Eva; Jones, Richard N.; Marcantonio, Edward Ralph; Cooper, Zara R; Inouye, Sharon K.; Saczynski, Jane S. (SLACK, Inc., 2015)
      Electronic medical records (EMRs) offer the opportunity to streamline the search for patients with possible delirium. The purpose of the current study was to identify words and phrases commonly noted in charts of patients ...
    • Maximizing Clinical Research Participation in Vulnerable Older Persons: Identification of Barriers and Motivators 

      Marcantonio, Edward Ralph; Aneja, Jasneet; Jones, Richard Norman; Alsop, David C.; Fong, Tamara G; Crosby, Gregory; Culley, Deborah Jean; Cupples, L. Adrienne; Inouye, Sharon (Wiley-Blackwell, 2008)
      OBJECTIVES: To identify barriers and motivators to participation in long-term clinical research by high-risk elderly people and to develop procedures to maximize recruitment and retention. DESIGN: Quantitative and ...
    • Novel Risk Markers and Long-Term Outcomes of Delirium: The Successful Aging after Elective Surgery (SAGES) Study Design and Methods 

      Schmitt, Eva M.; Marcantonio, Edward Ralph; Alsop, David C.; Jones, Richard Norman; Rogers, Selwyn O.; Fong, Tamara G; Metzger, Eran Daniel; Inouye, Sharon (Elsevier BV, 2012)
      Objectives: Delirium, a costly, life-threatening, and potentially preventable condition, is a common complication for older adults following major surgery. Although the basic epidemiology of delirium after surgery has been ...
    • One-Year Health Care Costs Associated With Delirium in the Elderly Population 

      Leslie, Douglas L.; Marcantonio, Edward Ralph; Zhang, Ying; Leo-Summers, Linda; Inouye, Sharon (American Medical Association (AMA), 2008)
    • Participation in Activity and Risk for Incident Delirium 

      Yang, Frances M.; Inouye, Sharon; Fearing, Michael A.; Kiely, Dan K.; Marcantonio, Edward Ralph; Jones, Richard Norman (Wiley-Blackwell, 2008)
    • Peripheral Surgical Wounding and Age-Dependent Neuroinflammation in Mice 

      Xu, Zhipeng; Dong, Yuanlin; Wang, Hui; Culley, Deborah J.; Marcantonio, Edward R.; Crosby, Gregory; Tanzi, Rudolph E.; Zhang, Yiying; Xie, Zhongcong (Public Library of Science, 2014)
      Post-operative cognitive dysfunction is associated with morbidity and mortality. However, its neuropathogenesis remains largely to be determined. Neuroinflammation and accumulation of β-amyloid (Aβ) have been reported to ...
    • Persistent Delirium Predicts Greater Mortality 

      Kiely, Dan K.; Marcantonio, Edward Ralph; Inouye, Sharon; Shaffer, Michele L.; Bergmann, Margaret A.; Yang, Frances Margaret; Fearing, Michael A.; Jones, Richard Norman (Wiley-Blackwell, 2009)
      OBJECTIVES: To examine the association between persistent delirium and 1-year mortality in newly admitted post-acute care (PAC) facility patients with delirium who were followed regardless of residence. DESIGN: Observational ...
    • Phenomenological Subtypes of Delirium in Older Persons: Patterns, Prevalence, and Prognosis 

      Yang, Frances Margaret; Marcantonio, Edward Ralph; Inouye, Sharon; Kiely, Dan K.; Rudolph, James; Fearing, Michael A.; Jones, Richard Norman (Elsevier BV, 2009)
    • Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium 

      Xie, Zhongcong; Swain, Celeste A; Ward, Sarah A P; Zheng, Hui; Dong, Yuanlin; Sunder, Neelakantan; Burke, Dennis W; Escobar, Diana; Zhang, Yiying; Marcantonio, Edward R (BlackWell Publishing Ltd, 2014)
      Objective: The neuropathogenesis of postoperative delirium remains unknown. Low cerebrospinal fluid (CSF) β-amyloid protein (Aβ) and high CSF Tau levels are associated with Alzheimer's disease. We, therefore, assessed ...
    • Preoperative Cognitive Performance Dominates Risk for Delirium Among Older Adults 

      Jones, Richard N.; Marcantonio, Edward; Saczynski, Jane S.; Tommet, Douglas; Gross, Alden L.; Travison, Thomas; Alsop, David; Schmitt, Eva M.; Fong, Tamara; Cizginer, Sevdenur; Shafi, Mouhsin; Pascual-Leone, Alvaro; Inouye, Sharon (SAGE Publications, 2016-11)
      Background Cognitive impairment is a well-recognized risk factor for delirium. Our goal was to determine if the level of cognitive performance across the non-demented cognitive ability spectrum is correlated with delirium ...
    • Review Article: Serum Biomarkers for Delirium 

      Marcantonio, Edward; Rudolph, James; Culley, Deborah; Crosby, Gregory; Alsop, David; Inouye, Sharon (Oxford University Press (OUP), 2006-12-01)
      This narrative review examines serum biomarkers for the diagnosis and monitoring of delirium. Serum biomarkers for delirium fall into three major groups: 1) those that are present or elevated prior to disease onset—risk ...
    • Risk Factors for Delirium at Discharge 

      Inouye, Sharon; Zhang, Ying; Jones, Richard Norman; Kiely, Dan K.; Yang, Frances Margaret; Marcantonio, Edward Ralph (American Medical Association (AMA), 2007)
    • Risk Factors for Hospitalization Among Community-Dwelling Primary Care Older Patients 

      Inouye, Sharon; Zhang, Ying; Jones, Richard Norman; Shi, Peilin; Cupples, L Adrienne; Calderon, Harold N.; Marcantonio, Edward Ralph (Ovid Technologies (Wolters Kluwer Health), 2008)
      Background: Unplanned hospitalization often represents a costly and hazardous event for the older population. Objectives: To develop and validate a predictive model for unplanned medical hospitalization from administrative ...
    • Selecting Optimal Screening Items for Delirium: An Application of Item Response Theory 

      Yang, Frances Margaret; Jones, Richard Norman; Inouye, Sharon; Tommet, Douglas; Crane, Paul K; Rudolph, James; Ngo, Long H.; Marcantonio, Edward Ralph (BioMed Central, 2013)
      Background: Delirium (acute confusion), is a common, morbid, and costly complication of acute illness in older adults. Yet, researchers and clinicians lack short, efficient, and sensitive case identification tools for ...
    • The Short-Term and Long-Term Relationship Between Delirium and Cognitive Trajectory in Older Surgical Patients 

      Inouye, Sharon; Marcantonio, Edward; Kosar, Cyrus M.; Tommet, Douglas; Schmitt, Eva M.; Travison, Thomas; Saczynski, Jane S.; Ngo, Long; Alsop, David; Jones, Richard N. (Wiley, 2016-07)
      INTRODUCTION Since the relationship between delirium and long-term cognitive decline has not been well-explored, we evaluated this association in a prospective study. METHODS SAGES is an on-going study involving 560 ...
    • The Successful Aging After Elective Surgery Study: Cohort Description and Data Quality Procedures 

      Schmitt, Eva M.; Saczynski, Jane S.; Kosar, Cyrus M.; Jones, Richard N.; Alsop, David C.; Fong, Tamara G.; Metzger, Eran; Cooper, Zara R; Marcantonio, Edward Ralph; Travison, Thomas G; Inouye, Sharon K. (Wiley-Blackwell, 2015)
      Background/Objectives Delirium is the most common complication of major elective surgery in older patients. The Successful Aging after Elective Surgery (SAGES) study was designed to examine novel risk factors and long-term ...
    • Surgery plus anesthesia induces loss of attention in mice 

      Ren, Quan; Peng, Mian; Dong, Yuanlin; Zhang, Yiying; Chen, Ming; Yin, Ning; Marcantonio, Edward R.; Xie, Zhongcong (Frontiers Media S.A., 2015)
      There is a need to develop animal models to study postoperative delirium. Inattention is one of the symptoms of delirium. Increases in the levels of α-synuclein and S100β have been reported to be associated with delirium. ...