Browsing by Author "Nahrendorf, Matthias"

Now showing items 21-37 of 37

    • Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction 

      Zangi, Lior; Lui, Kathy O; von Gise, Alexander; Ma, Qing; Ebina, Wataru; Ptaszek, Leon M.; Später, Daniela; Xu, Huansheng; Tabebordbar, Mohammadsharif; Gorbatov, Rostic; Sena, Brena; Nahrendorf, Matthias; Briscoe, David Michael; Li, Ronald A; Wagers, Amy Jo; Rossi, Derrick J; Pu, William T.; Chien, Kenneth R (Nature Publishing Group, 2013)
      In a cell-free approach to regenerative therapeutics, transient application of paracrine factors in vivo could be used to alter the behavior and fate of progenitor cells to achieve sustained clinical benefits. Here we show ...

    • Molecularly Self-Assembled Nucleic Acid Nanoparticles for Targeted In Vivo siRNA Delivery 

      Lee, Hyukjin; Lytton-Jean, Abigail K. R.; Chen, Yi; Love, Kevin T.; Park, Angela I.; Karagiannis, Emmanouil D.; Sehgal, Alfica; Querbes, William; Zurenko, Christopher S.; Jayaraman, Muthusamy; Peng, Chang G.; Charisse, Klaus; Borodovsky, Anna; Manoharan, Muthiah; Donahoe, Jessica S.; Truelove, Jessica; Nahrendorf, Matthias; Langer, Robert; Anderson, Daniel G. (2013)
      Nanoparticles are employed for delivering therapeutics into cells1,2. However, size, shape, surface chemistry and the presentation of targeting ligands on the surface of nanoparticles can affect circulation half-life and ...

    • Monocyte Subset Dynamics in Human Atherosclerosis Can Be Profiled with Magnetic Nano-Sensors 

      Wildgruber, Moritz; Chudnovskiy, Aleksey; Yoon, Tae-Jong; Etzrodt, Martin; Lee, Hakho; Pittet, Mikael J.; Nahrendorf, Matthias; Croce, Kevin James; Libby, Peter; Weissleder, Ralph; Swirski, Filip K. (Public Library of Science, 2009)
      Monocytes are circulating macrophage and dendritic cell precursors that populate healthy and diseased tissue. In humans, monocytes consist of at least two subsets whose proportions in the blood fluctuate in response to ...

    • Multimodal imaging of bacterial-host interface in mice and piglets with Staphylococcus aureus endocarditis 

      Panizzi, Peter; Krohn-Grimberghe, Marvin; Keliher, Edmund J.; Ye, Yu-Xiang; Grune, Jana; Frodermann, Vanessa; Sun, Yuan; Muse, Charlotte G.; Bushey, Kaitlyn; Iwamoto, Yoshiko; van Leent, Mandy M. T.; Meerwaldt, Anu; Toner, Yohana C.; Munitz, Jazz; Maier, Alexander; Soultanidis, Georgios; Calcagno, Claudia; Pérez-Medina, Carlos; Carlucci, Giuseppe; Riddell, Kay P.; Barney, Sharron; Horne, Glenn; Anderson, Brian; Maddur-Appajaiah, Ashoka; Verhamme, Ingrid M.; Bock, Paul E.; Wojtkiewicz, Gregory R.; Courties, Gabriel; Swirski, Filip; Church, William R.; Walz, Paul H.; Tillson, D. Michael; Mulder, Willem J. M.; Nahrendorf, Matthias (American Association for the Advancement of Science (AAAS), 2020-11-04)
      Acute bacterial endocarditis is a rapid, difficult to manage and frequently lethal disease. Even potent antibiotics often cannot efficiently kill Staphylococcus aureus (S. aureus) that colonizes the heart’s valves. S. ...

    • Myocardial Infarction Accelerates Atherosclerosis 

      Leuschner, Florian; Robbins, Clinton; Iwamoto, Yoshiko; Thompson, Brian; Carlson, Alicia L.; Heidt, Timo; Lasitschka, Felix; Etzrodt, Martin; Waterman, Peter; Waring, Michael T.; Chicoine, Adam T.; van der Laan, Anja M.; Niessen, Hans W.M.; Piek, Jan J.; Rubin, Barry B.; Butany, Jagdish; Katus, Hugo A.; Murphy, Sabina A.; Pittet, Mikael J.; Lin, Charles P.; Dutta, Partha; Courties, Gabriel P; Wei, Ying; Gorbatov, Rostic; Majmudar, Maulik D; Stone, James Robert; Morrow, David Andrew; Sabatine, Marc Steven; Vinegoni, Claudio; Moskowitz, Michael Arthur; Libby, Peter; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (Nature Publishing Group, 2012)
      During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaque in the arterial wall and cause its rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a ...

    • Myocardial Infarction Activates CCR2+ Hematopoietic Stem and Progenitor Cells 

      Dutta, Partha; Sager, Hendrik B; Stengel, Kristy R.; Naxerova, Kamila; Courties, Gabriel P; Saez, Borja; Silberstein, Lev; Heidt, Timo; Sebas, Matthew; Sun, Yuan; Wojtkiewicz, Gregory; Feruglio, Paolo Fumene; King, Kevin Robert; Baker, Joshua N.; van der Laan, Anja M.; Borodovsky, Anna; Fitzgerald, Kevin; Hulsmans, Maarten; Hoyer, Friedrich Felix; Iwamoto, Yoshiko; Vinegoni, Claudio; Brown, Dennis; Di Carli, Marcelo; Libby, Peter; Hiebert, Scott W.; Scadden, David Thomas; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (Elsevier BV, 2015)
      Following myocardial infarction (MI), myeloid cells derived from the hematopoietic system drive a sharp increase in systemic leukocyte levels that correlates closely with mortality. The origin of these myeloid cells, and ...

    • Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche 

      Krohn-Grimberghe, Marvin; Mitchell, Michael J.; Schloss, Maximilian J.; Khan, Omar F.; Courties, Gabriel; Guimaraes, Pedro P. G.; Rohde, David; Cremer, Sebastian; Kowalski, Piotr S.; Sun, Yuan; Tan, Mingchee; Webster, Jamie; Wang, Karin; Iwamoto, Yoshiko; Schmidt, Stephen P.; Wojtkiewicz, Gregory R.; Nayar, Ribhu; Frodermann, Vanessa; Hulsmans, Maarten; Chung, Amanda; Hoyer, Friedrich Felix; Swirski, Filip K.; Langer, Robert; Anderson, Daniel G.; Nahrendorf, Matthias (Springer Science and Business Media LLC, 2020-10-05)
      Bone marrow hematopoietic stem and progenitor cells (HSPC) give rise to billions of blood cells every day. Bone marrow endothelial cells (BMECs) form a network of blood vessels that regulates HSC maintenance and blood ...

    • On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver 

      Theurl, Igor; Hilgendorf, Ingo; Nairz, Manfred; Tymoszuk, Piotr; Haschka, David; Asshoff, Malte; He, Shun; Gerhardt, Louisa M. S.; Holderried, Tobias A. W.; Seifert, Markus; Sopper, Sieghart; Fenn, Ashley M.; Anzai, Atsushi; Rattik, Sara; McAlpine, Cameron; Theurl, Milan; Wieghofer, Peter; Iwamoto, Yoshiko; Weber, Georg F.; Harder, Nina K.; Chousterman, Benjamin G.; Arvedson, Tara L.; McKee, Mary; Wang, Fudi; Lutz, Oliver M. D.; Rezoagli, Emanuele; Babitt, Jodie L.; Berra, Lorenzo; Prinz, Marco; Nahrendorf, Matthias; Weiss, Guenter; Weissleder, Ralph; Lin, Herbert Y.; Swirski, Filip K. (2016)
      Iron is an essential component of the erythrocyte protein hemoglobin and is crucial to oxygen transport in vertebrates. In the steady state, erythrocyte production is in equilibrium with erythrocyte removal1. In various ...

    • Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis 

      Weber, Georg F.; Chousterman, Benjamin G.; Hilgendorf, Ingo; Robbins, Clinton S.; Theurl, Igor; Gerhardt, Louisa M.S.; Iwamoto, Yoshiko; Quach, Tam D.; Ali, Muhammad; Chen, John W.; Rothstein, Thomas L.; Nahrendorf, Matthias; Weissleder, Ralph; Swirski, Filip K. (The Rockefeller University Press, 2014)
      Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine, but the immunophysiological processes that confer either protection or morbidity are not completely understood. We show ...

    • Probing Myeloid Cell Dynamics in Ischaemic Heart Disease by Nanotracer Hot-Spot Imaging 

      Senders, Max L.; Meerwaldt, Anu E.; van Leent, Mandy M. T.; Sanchez-Gaytan, Brenda L.; van de Voort, Jan C.; Toner, Yohana C.; Maier, Alexander; Klein, Emma D.; Sullivan, Nathaniel A. T.; Sofias, Alexandros Marios; Groenen, Hannah; Faries, Christopher; Oosterwijk, Roderick S.; van Leeuwen, Esther M.; Fay, Francois; Chepurko, Elena; Reiner, Thomas; Duivenvoorden, Raphael; Zangi, Lior; Dijkhuizen, Rick M.; Hak, Sjoerd; Swirski, Filip; Nahrendorf, Matthias; Pérez-Medina, Carlos; Teunissen, Abraham J. P.; Fayad, Zahi A.; Calcagno, Claudia; Strijkers, Gustav J.; Mulder, Willem J. M.; Mulder (Springer Science and Business Media LLC, 2020-04-20)
      Ischemic heart disease evokes a complex immune response. However, tools to noninvasively track leukocytes’ systemic behaviour and dynamics in vivo are lacking. Here, we present a multimodal hot spot imaging approach using ...

    • Probing Myeloid Cell Dynamics in Ischaemic Heart Disease by Nanotracer Hot-Spot Imaging 

      Senders, Max L.; Meerwaldt, Anu E.; van Leent, Mandy M. T.; Sanchez-Gaytan, Brenda L.; van de Voort, Jan C.; Toner, Yohana C.; Maier, Alexander; Klein, Emma D.; Sullivan, Nathaniel A. T.; Sofias, Alexandros Marios; Groenen, Hannah; Faries, Christopher; Oosterwijk, Roderick S.; van Leeuwen, Esther M.; Fay, Francois; Chepurko, Elena; Reiner, Thomas; Duivenvoorden, Raphael; Zangi, Lior; Dijkhuizen, Rick M.; Hak, Sjoerd; Swirski, Filip K.; Nahrendorf, Matthias; Pérez-Medina, Carlos; Teunissen, Abraham J. P.; Fayad, Zahi A.; Calcagno, Claudia; Strijkers, Gustav J.; Mulder, Willem J. M. (Springer Science and Business Media LLC, 2020-04-20)
      Ischemic heart disease evokes a complex immune response. However, tools to noninvasively track leukocytes’ systemic behaviour and dynamics in vivo are lacking. Here, we present a multimodal hot spot imaging approach ...

    • Programming human pluripotent stem cells into white and brown adipocytes 

      Ahfeldt, Tim; Schinzel, Robert T.; Lee, Youn-Kyoung; Hendrickson, David Gillis; Kaplan, Adam; Lum, David H.; Camahort, Raymond; Xia, Fang; Shay, Jennifer B.; Rhee, Eugene Park; Clish, Clary B.; Deo, Rahul C.; Shen, Tony; Lau, Frank; Cowley, Alicia; Mowrer, Greg; Al-Siddiqi, Heba; Nahrendorf, Matthias; Musunuru, Kiran; Gerszten, Robert Edgardo; Rinn, John L; Cowan, Chad A. (Nature Publishing Group, 2012)
      The utility of human pluripotent stem cells is dependent on efficient differentiation protocols that convert these cells into relevant adult cell types. Here we report the robust and efficient differentiation of human ...

    • Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure 

      Sager, Hendrik B.; Hulsmans, Maarten; Lavine, Kory J.; Moreira, Marina B.; Heidt, Timo; Courties, Gabriel P; Sun, Yuan; Iwamoto, Yoshiko; Tricot, Benoit; Khan, Omar F.; Dahlman, James E.; Borodovsky, Anna; Fitzgerald, Kevin; Anderson, Daniel Griffith; Weissleder, Ralph; Libby, Peter; Swirski, Filip K.; Nahrendorf, Matthias (Ovid Technologies (Wolters Kluwer Health), 2016)
      Rationale: Macrophages reside in the healthy myocardium, participate in ischemic heart disease, and modulate myocardial infarction (MI) healing. Their origin and roles in post-MI remodeling of nonischemic remote myocardium, ...

    • Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis 

      Leuschner, Florian; Rauch, Philipp J.; Ueno, Takuya; Gorbatov, Rostic; Marinelli, Brett; Lee, Won Woo; Dutta, Partha; Wei, Ying; Robbins, Clinton; Iwamoto, Yoshiko; Sena, Brena; Chudnovskiy, Aleksey; Panizzi, Peter; Higgins, John Matthew; Libby, Peter; Moskowitz, Michael Arthur; Pittet, Mikael J.; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (The Rockefeller University Press, 2012)
      IL-1b signaling augments continued splenic monocyte supply during acute inflammation.

    • A Statin-Loaded Reconstituted High-Density Lipoprotein Nanoparticle Inhibits Atherosclerotic Plaque Inflammation 

      Duivenvoorden, Raphaël; Tang, Jun; Cormode, David P.; Mieszawska, Aneta J.; Izquierdo-Garcia, David; Ozcan, Canturk; Otten, Maarten J.; Zaidi, Neeha; Lobatto, Mark E.; van Rijs, Sarian M.; Priem, Bram; Kuan, Emma L.; Martel, Catherine; Hewing, Bernd; Sager, Hendrik; Nahrendorf, Matthias; Randolph, Gwendalyn J.; Stroes, Erik S.G.; Fuster, Valentin; Fisher, Edward A.; Fayad, Zahi A.; Mulder, Willem J.M. (2014)
      Inflammation is a key feature of atherosclerosis and a target for therapy. Statins have potent anti-inflammatory properties but these cannot be fully exploited with oral statin therapy due to low systemic bioavailability. ...

    • Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells 

      Novobrantseva, Tatiana I; Borodovsky, Anna; Wong, Jamie; Klebanov, Boris; Zafari, Mohammad; Yucius, Kristina; Querbes, William; Ge, Pei; Ruda, Vera M.; Milstein, Stuart; Speciner, Lauren; Duncan, Rick; Barros, Scott; Basha, Genc; Cullis, Pieter; Akinc, Akin; Donahoe, Jessica S; Narayanannair Jayaprakash, K; Jayaraman, Muthusamy; Bogorad, Roman L; Love, Kevin; Whitehead, Katie; Levins, Chris; Manoharan, Muthiah; Swirski, Filip K.; Weissleder, Ralph; Langer, Robert S.; Anderson, Daniel Griffith; de Fougerolles, Antonin; Nahrendorf, Matthias; Koteliansky, Victor (Nature Publishing Group, 2012)
      Leukocytes are central regulators of inflammation and the target cells of therapies for key diseases, including autoimmune, cardiovascular, and malignant disorders. Efficient in vivo delivery of small interfering RNA (siRNA) ...

    • Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction 

      Sager, Hendrik B.; Heidt, Timo; Hulsmans, Maarten; Dutta, Partha; Courties, Gabriel P; Sebas, Matthew; Wojtkiewicz, Gregory R.; Tricot, Benoit; Iwamoto, Yoshiko; Sun, Yuan; Weissleder, Ralph; Libby, Peter; Swirski, Filip K.; Nahrendorf, Matthias (Ovid Technologies (Wolters Kluwer Health), 2015)
      Background—Myocardial infarction (MI) is an ischemic wound that recruits millions of leukocytes. MI-associated blood leukocytosis correlates inversely with patient survival, yet the signals driving heightened leukocyte ...