Now showing items 21-25 of 25

    • RIP Kinase-Mediated Necrosis as an Alternative Mechanism of Photoreceptor Death 

      Murakami, Yusuke; Miller, Joan Whitten; Vavvas, Demetrios (Impact Journals LLC, 2011)
      Photoreceptor cell death is the terminal event in a variety of retinal disorders including age-related macular degeneration, retinitis pigmentosa, and retinal detachment. Apoptosis has been thought to be the major form of ...
    • Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration 

      Morrison, Margaux A; Silveira, Alexandra C; Huynh, Nancy; Jun, Gyungah; Smith, Silvia E; Zacharaki, Fani; Sato, Hajime; Loomis, Stephanie; Andreoli, Michael T; Adams, Scott M; Radeke, Monte J; Jelcick, Austin S; Yuan, Yang; Tsiloulis, Aristoteles N; Chatzoulis, Dimitrios Z; Silvestri, Giuliana; Kotoula, Maria G; Tsironi, Evangelia E; Hollis, Bruce W; Chen, Rui; Haider, Neena B; Miller, Joan W; Farrer, Lindsay A; Hageman, Gregory S; Kim, Ivana K; Schaumberg, Debra A; DeAngelis, Margaret M (BioMed Central, 2011)
      Vitamin D has been shown to have anti-angiogenic properties and to play a protective role in several types of cancer, including breast, prostate and cutaneous melanoma. Similarly, vitamin D levels have been shown to be ...
    • Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization 

      Salehi-Had, Hani; Roh, Mi In; Giani, Andrea; Hisatomi, Toshio; Nakao, Shintaro; Kim, Ivana Kyung; Gragoudas, Evangelos Stelios; Vavvas, Demetrios; Guccione, Samira; Miller, Joan Whitten (Public Library of Science, 2011)
      Purpose: The integrin αvβ3 is differentially expressed on neovascular endothelial cells. We investigated whether a novel intravenously injectable αvβ3 integrin-ligand coupled nanoparticle (NP) can target choroidal neovascular ...
    • VEGF164-mediated Inflammation Is Required for Pathological, but Not Physiological, Ischemia-induced Retinal Neovascularization 

      Ishida, Susumu; Usui, Tomohiko; Yamashiro, Kenji; Kaji, Yuichi; Amano, Shiro; Ogura, Yuichiro; Hida, Tetsuo; Oguchi, Yoshihisa; Ambati, Jayakrishna; Miller, Joan Whitten; Gragoudas, Evangelos Stelios; Ng, Yin-Shan; D'Amore, Patricia Ann; Shima, David T.; Adamis, Anthony Peter (Rockefeller University Press, 2003)
      Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared ...
    • VEGF: From Discovery to Therapy: The Champalimaud Award Lecture 

      Miller, Joan W. (The Association for Research in Vision and Ophthalmology, 2016)
      Purpose Intraocular vascular diseases are leading causes of adult vision loss, and in the mid-1900s, I. C. Michaelson postulated that the retina releases a soluble, diffusible factor that causes abnormal vascular growth ...