Browsing by Author "Kuritzkes, Daniel"
Now showing items 21-29 of 29
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Paper and Flexible Substrates as Materials for Biosensing Platforms to Detect Multiple Biotargets
Shafiee, Hadi; Asghar, Waseem; Inci, Fatih; Yuksekkaya, Mehmet; Jahangir, Muntasir; Zhang, Michael H.; Durmus, Naside Gozde; Gurkan, Umut Atakan; Kuritzkes, Daniel R.; Demirci, Utkan (Nature Publishing Group, 2015)The need for sensitive, robust, portable, and inexpensive biosensing platforms is of significant interest in clinical applications for disease diagnosis and treatment monitoring at the point-of-care (POC) settings. Rapid, ... -
Patients Infected with CRF07_BC Have Significantly Lower Viral Loads than Patients with HIV-1 Subtype B: Mechanism and Impact on Disease Progression
Huang, Szu-Wei; Wang, Sheng-Fan; Lin, Yu-Ting; Yen, Chia-Hung; Lee, Chih-Hao; Wong, Wing-Wai; Tsai, Hung-Chin; Yang, Chia-Jui; Hu, Bor-Shen; Lin, Yu-Huei; Wang, Chin-Tien; Wang, Jaang-Jiun; Hu, Zixin; Kuritzkes, Daniel R.; Chen, Yen-Hsu; Chen, Yi-Ming Arthur (Public Library of Science, 2014)The circulating recombinant form (CRF) 07_BC is the most prevalent HIV-1 strain among injection drug users (IDUs) in Taiwan. It contains a 7 amino-acid deletion in its p6gag. We conducted a cohort study to compare viral ... -
Printed Flexible Plastic Microchip for Viral Load Measurement through Quantitative Detection of Viruses in Plasma and Saliva
Shafiee, Hadi; Kanakasabapathy, Manoj Kumar; Juillard, Franceline; Keser, Mert; Sadasivam, Magesh; Yuksekkaya, Mehmet; Hanhauser, Emily; Henrich, Timothy J.; Kuritzkes, Daniel R.; Kaye, Kenneth M.; Demirci, Utkan (Nature Publishing Group, 2014)We report a biosensing platform for viral load measurement through electrical sensing of viruses on a flexible plastic microchip with printed electrodes. Point-of-care (POC) viral load measurement is of paramount importance ... -
Quantitative deep sequencing reveals dynamic HIV-1 escape and large population shifts during CCR5 antagonist therapy in vivo
Korber, Bette; Russ, Carsten; Lo, Chien-Chi; Leitner, Thomas; Gaschen, Brian; Theiler, James; Paredes, Roger; Su, Zhaohui; Gulick, Roy M.; Greaves, Wayne; Coakley, Eoin; Flexner, Charles; Nusbaum, Chad; Tsibris, Athe Michael Noel; Arnaout, Ramy; Hughes, Michael David; Kuritzkes, Daniel Robert (Public Library of Science, 2009)High-throughput sequencing platforms provide an approach for detecting rare HIV-1 variants and documenting more fully quasispecies diversity. We applied this technology to the V3 loop-coding region of env in samples collected ... -
Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV
Hill, Alison L.; Rosenbloom, Daniel I. S.; Goldstein, Edward; Hanhauser, Emily; Kuritzkes, Daniel R.; Siliciano, Robert F.; Henrich, Timothy J. (Public Library of Science, 2016)Monitoring the efficacy of novel reservoir-reducing treatments for HIV is challenging. The limited ability to sample and quantify latent infection means that supervised antiretroviral therapy (ART) interruption studies are ... -
Safety and immunogenicity of therapeutic DNA vaccination in individuals treated with antiretroviral therapy during acute/early HIV-1 infection
Graham, Barney S.; Stocker, Vicki; Maenza, Janine; Markowitz, Martin; Little, Susan; Collier, Ann C.; Nabel, Gary; Saindon, Suzanne; Flynn, Theresa; Ostrowski, Mario A.; Rosenberg, Eric Scott; Chan, Ellen S.L.; Bosch, Ronald J.; Sax, Paul Edward; Kuritzkes, Daniel Robert; Barouch, Dan Hung (Public Library of Science, 2010)Background: An effective therapeutic vaccine that could augment immune control of HIV-1 replication may abrogate or delay the need for antiretroviral therapy. AIDS Clinical Trials Group (ACTG) A5187 was a phase I/II, ... -
Simple filter microchip for rapid separation of plasma and viruses from whole blood
Wang, Shuqi; Sarenac, Dusan; Chen, Michael; Huang, Shih-Han; Giguel, Francoise F; Kuritzkes, Daniel Robert; Demirci, Utkan (Dove Medical Press, 2012)Sample preparation is a significant challenge for detection and sensing technologies, since the presence of blood cells can interfere with the accuracy and reliability of virus detection at the nanoscale for point-of-care ... -
Treatment-Mediated Alterations in HIV Fitness Preserve CD4+ T Cell Counts but Have Minimal Effects on Viral Load
Vaidya, Naveen K.; Rong, Libin; Marconi, Vincent C.; Kuritzkes, Daniel Robert; Deeks, Steven G.; Perelson, Alan S. (Public Library of Science, 2010)For most HIV-infected patients, antiretroviral therapy controls viral replication. However, in some patients drug resistance can cause therapy to fail. Nonetheless, continued therapy with a failing regimen can preserve or ... -
Virologic Failure of Protease Inhibitor-Based Second-Line Antiretroviral Therapy without Resistance in a Large HIV Treatment Program in South Africa
Levison, Julie H.; Orrell, Catherine; Gallien, Sébastien; Kuritzkes, Daniel Robert; Fu, Naishin; Losina, Elena; Freedberg, Kenneth Alan; Wood, Robin (Public Library of Science, 2012)Background: We investigated the prevalence of wild-type virus (no major drug resistance) and drug resistance mutations at second-line antiretroviral treatment (ART) failure in a large HIV treatment program in South Africa. ...