Browsing by Author "Mitchison, Timothy"
Now showing items 21-24 of 24
-
Spatio-temporal control of the cytosolic redox environment in C. elegans
Romero, Catalina (2013-10-18)Compartmentalization of redox reactions is essential to all life forms. Protein activity can respond to changes in the local redox environment through the reversible oxidation of cysteine thiols. For the majority of cysteines ... -
Super Resolution Imaging by Programmable Autonomous Blinking
Avendaño Amado, Maier S. (2015-05-18)Current far-field super-resolution techniques offer unprecedented spatial resolution, however, the identification and quantification of multiple molecules that cannot be spatially resolved remains challenging, mainly ... -
Vascular Disrupting Agent Drug Classes Differ in Effects on the Cytoskeleton
Kim, Sujeong; Peshkin, Lenoid; Mitchison, Timothy J. (Public Library of Science, 2012)Vascular disrupting agents (VDAs), anti-cancer drugs that target established tumor blood vessels, fall into two main classes: microtubule targeting drugs, exemplified by combretastatin A4 (CA4), and flavonoids, exemplified ... -
Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities
Barkauskaite, Eva; Brassington, Amy; Tan, Edwin S.; Warwicker, Jim; Dunstan, Mark S.; Banos, Benito; Lafite, Pierre; Ahel, Marijan; Mitchison, Timothy J.; Ahel, Ivan; Leys, David (Nature Pub. Group, 2013)Poly-ADP-ribosylation is a post-translational modification that regulates processes involved in genome stability. Breakdown of the poly(ADP-ribose) (PAR) polymer is catalysed by poly(ADP-ribose) glycohydrolase (PARG), whose ...