Now showing items 21-40 of 77

    • Factors Predicting Discordant Virological and Immunological Responses to Antiretroviral Therapy in HIV-1 Clade C Infected Zulu/Xhosa in South Africa 

      Julg, Boris; Poole, Danielle; Ghebremichael, Musie Syum; Castilla, Carmen; Altfeld, Marcus; Sunpath, Henry; Murphy, Richard A.; Walker, Bruce David (Public Library of Science, 2012)
      Factors predicting suboptimal CD4 cell recovery have been studied in HIV clade-B infected US and European populations. It is, however, uncertain to what extent these results are applicable to HIV clade-C infected African ...
    • The Fitness Landscape of HIV-1 Gag: Advanced Modeling Approaches and Validation of Model Predictions by In Vitro Testing 

      Mann, Jaclyn K.; Barton, John P.; Ferguson, Andrew L.; Omarjee, Saleha; Walker, Bruce D.; Chakraborty, Arup; Ndung'u, Thumbi (Public Library of Science, 2014)
      Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design. To address this challenge, our group has developed a computational model, rooted in physics, that aims to predict the fitness landscape ...
    • Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes 

      Heesters, Balthasar A.; Lindqvist, Madelene; Vagefi, Parsia A.; Scully, Eileen P.; Schildberg, Frank A.; Altfeld, Marcus; Walker, Bruce D.; Kaufmann, Daniel E.; Carroll, Michael C. (Public Library of Science, 2015)
      Despite the success of antiretroviral therapy (ART), it does not cure Human Immunodeficiency Virus (HIV) and discontinuation results in viral rebound. Follicular dendritic cells (FDC) are in direct contact with CD4+ T cells ...
    • Fully Differentiated HIV-1 Specific CD8+ T Effector Cells are More Frequently Detectable in Controlled than in Progressive HIV-1 Infection 

      Draenert, Rika; Rathod, Almas; Verrill, Cori L.; Stone, David R.; Johnston, Mary N.; Flynn, Theresa; Addo, Marylyn Martina; Davis, Benjamin Thomas; Gandhi, Rajesh Tim; Robbins, Gregory Kimball; Basgov, Nesli; Cohen, Daniel E.; Wurcel, Alysse Gail; Rosenberg, Eric Scott; Altfeld, Marcus; Walker, Bruce David (Public Library of Science, 2007)
      Background: CD8+ T cells impact control of viral infections by direct elimination of infected cells and secretion of a number of soluble factors. In HIV-1 infection, persistent HIV-1 specific IFN-γ+ CD8+ T cell responses ...
    • Genotypic and Functional Impact of HIV-1 Adaptation to Its Host Population during the North American Epidemic 

      Cotton, Laura A.; Kuang, Xiaomei T.; Le, Anh Q.; Carlson, Jonathan M.; Chan, Benjamin; Chopera, Denis R.; Brumme, Chanson J.; Markle, Tristan J.; Martin, Eric; Shahid, Aniqa; Anmole, Gursev; Mwimanzi, Philip; Nassab, Pauline; Penney, Kali A.; Rahman, Manal A.; Milloy, M.-J.; Schechter, Martin T.; Markowitz, Martin; Carrington, Mary; Walker, Bruce D.; Wagner, Theresa; Buchbinder, Susan; Fuchs, Jonathan; Koblin, Beryl; Mayer, Kenneth H.; Harrigan, P. Richard; Brockman, Mark A.; Poon, Art F. Y.; Brumme, Zabrina L. (Public Library of Science, 2014)
      HLA-restricted immune escape mutations that persist following HIV transmission could gradually spread through the viral population, thereby compromising host antiviral immunity as the epidemic progresses. To assess the ...
    • High Avidity CD8+ T Cells Efficiently Eliminate Motile HIV-Infected Targets and Execute a Locally Focused Program of Anti-Viral Function 

      Foley, Maria Hottelet; Forcier, Talitha; McAndrew, Elizabeth; Gonzalez, Michael; Chen, Huabiao; Juelg, Boris; Walker, Bruce D.; Irvine, Darrell J. (Public Library of Science, 2014)
      The dissemination of HIV from an initial site of infection is facilitated by motile HIV-infected CD4+ T-cells. However, the impact of infected target cell migration on antigen recognition by HIV-specific CD8+ T-cells is ...
    • High Frequency of Transmitted HIV-1 Gag HLA Class I-Driven Immune Escape Variants but Minimal Immune Selection over the First Year of Clade C Infection 

      Gounder, Kamini; Padayachi, Nagavelli; Mann, Jaclyn K.; Radebe, Mopo; Mokgoro, Mammekwa; van der Stok, Mary; Mkhize, Lungile; Mncube, Zenele; Jaggernath, Manjeetha; Reddy, Tarylee; Walker, Bruce D.; Ndung’u, Thumbi (Public Library of Science, 2015)
      In chronic HIV infection, CD8+ T cell responses to Gag are associated with lower viral loads, but longitudinal studies of HLA-restricted CD8+ T cell-driven selection pressure in Gag from the time of acute infection are ...
    • A High-Dimensional Immune Monitoring Model of HIV-1-Specific CD8 T Cell Responses Accurately Identifies Subjects Achieving Spontaneous Viral Control 

      Proudfoot, J; Vine, S; Cesa, K; Piechocka-Trocha, A; Ndhlovu, Zaza Mtine; Chibnik, Lori; McMullen, A; Porichis, Filippos; Alvino, Donna Marie Lucia; De Jager, Philip Lawrence; Walker, Bruce David; Kaufmann, Daniel (BioMed Central, 2012)
    • Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes 

      Jones, Richard Brad; O'Connor, Rachel; Mueller, Stefanie; Foley, Maria; Szeto, Gregory L.; Karel, Dan; Lichterfeld, Mathias; Kovacs, Colin; Ostrowski, Mario A.; Trocha, Alicja; Irvine, Darrell J.; Walker, Bruce D. (Public Library of Science, 2014)
      Resting memory CD4+ T-cells harboring latent HIV proviruses represent a critical barrier to viral eradication. Histone deacetylase inhibitors (HDACis), such as suberanilohydroxamic acid (SAHA), romidepsin, and panobinostat ...
    • HIV-1 persistence in CD4+ T cells with stem cell-like properties 

      Buzon, Maria J.; Sun, Hong; Li, Chun; Shaw, Amy; Seiss, Katherine; Ouyang, Zhengyu; Martin-Gayo, Enrique; Leng, Jin; Henrich, Timothy J.; Li, Jonathan Z.; Pereyra, Florencia; Zurakowski, Ryan; Walker, Bruce D.; Rosenberg, Eric S.; Yu, Xu G.; Lichterfeld, Mathias (2014)
      Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM) harbor high per-cell levels of HIV-1 ...
    • HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1 

      Kalife, Elizabeth T; Qi, Ying; Johnston, Mary N; Burgett, Nicole; Swartz, Martha E; Yang, Amy; Rockstroh, Juergen K; Jessen, Heiko; Carrington, Mary; Altfeld, Marcus; Streeck, Hendrik; Lichterfeld, Mathias; Alter, Galit; Yu, Xu; Meier, Angela; Allen, Todd; Rosenberg, Eric Scott; Walker, Bruce David (Public Library of Science, 2006)
      Background: Very little is known about the immunodominance patterns of HIV-1-specific T cell responses during primary HIV-1 infection and the reasons for human lymphocyte antigen (HLA) modulation of disease progression. ...
    • Human Immunodeficiency Virus Type 1 Specific Cytotoxic T Lymphocyte Responses in Chinese Infected with HIV-1 B'/C Recombinant (CRF07_BC) 

      Chen, Jianping; Hong, Kunxue; Jia, Mingming; Liu, Hongwei; Zhang, Yuanzhi; Zhang, Xiaoqing; Zhao, Hongjing; Peng, Hong; Ma, Pengfei; Xing, Hui; Ruan, Yuhua; Shao, Yiming; Liu, Sha; Altfeld, Marcus; Walker, Bruce David; Williams, Katie L.; Yu, Xu G. (BioMed Central, 2007)
      Background: The characterization of HIV-1-specific T cell responses in people infected with locally circulating HIV-1 strain will facilitate the development of HIV-1 vaccine. Sixty intravenous drug users infected with HIV-1 ...
    • IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection 

      Adoro, Stanley; Cubillos-Ruiz, Juan R.; Chen, Xi; Deruaz, Maud; Vrbanac, Vladimir D.; Song, Minkyung; Park, Suna; Murooka, Thomas T.; Dudek, Timothy E.; Luster, Andrew D.; Tager, Andrew M.; Streeck, Hendrik; Bowman, Brittany; Walker, Bruce D.; Kwon, Douglas S.; Lazarevic, Vanja; Glimcher, Laurie H. (Nature Pub. Group, 2015)
      Initial events after exposure determine HIV-1 disease progression, underscoring a critical need to understand host mechanisms that interfere with initial viral replication. Although associated with chronic HIV-1 control, ...
    • Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial 

      Gandhi, Rajesh T.; Kwon, Douglas S.; Macklin, Eric A.; Shopis, Janet R.; McLean, Anna P.; McBrine, Nicole; Flynn, Theresa; Peter, Lauren; Sbrolla, Amy; Kaufmann, Daniel E.; Porichis, Filippos; Walker, Bruce D.; Bhardwaj, Nina; Barouch, Dan H.; Kavanagh, Daniel G. (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2015)
      Background: HIV-1 eradication may require reactivation of latent virus along with stimulation of HIV-1-specific immune responses to clear infected cells. Immunization with autologous dendritic cells (DCs) transfected with ...
    • Immunodominance and Viral Ditness in Gag May Contribute to Differential Viral Control in HLA-B*7 Supertype Individuals Acutely Infected with HIV-1C 

      Gounder, K; Leshwedi, M; van der Stok, M; Chonco, F; Padayachee, N; Ndimande, B; Mokgoro, M; Jaggernath, M; Wright, J; Walker, Bruce David; Goulder, Philip J. (BioMed Central, 2012)
    • Immunodominant HIV-1 Cd4+ T Cell Epitopes in Chronic Untreated Clade C HIV-1 Infection 

      Ramduth, Danni; Day, Cheryl L.; Thobakgale, Christina F.; Mkhwanazi, Nompumelelo P.; de Pierres, Chantal; Reddy, Sharon; van der Stok, Mary; Mncube, Zenele; Nair, Kriebashne; Moodley, Eshia S.; Coovadia, Hoosen M.; Kiepiela, Photini; Kaufmann, Daniel; Streeck, Hendrik; Goulder, Philip J.; Walker, Bruce David (Public Library of Science, 2009)
      Background: A dominance of Gag-specific CD8+ T cell responses is significantly associated with a lower viral load in individuals with chronic, untreated clade C human immunodeficiency virus type 1 (HIV-1) infection. This ...
    • Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality 

      Mkhwanazi, Nompumelelo; Thobakgale, Christina F.; van der Stok, Mary; Reddy, Shabashini; Mncube, Zenele; Chonco, Fundisiwe; Walker, Bruce David; Altfeld, Marcus; Goulder, Philip J.; Ndung'u, Thumbi (Academic Press, 2010)
      HIV-1 specific HLA-B-restricted CD8+ T cell responses differ from HLA-C-restricted responses in antiviral effectiveness. To investigate possible reasons for these differences, we characterized the frequency and polyfunctionality ...
    • Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence 

      Payne, Rebecca; Muenchhoff, Maximilian; Mann, Jaclyn; Roberts, Hannah E.; Matthews, Philippa; Adland, Emily; Hempenstall, Allison; Huang, Kuan-Hsiang; Brockman, Mark; Brumme, Zabrina; Sinclair, Marc; Miura, Toshiyuki; Frater, John; Essex, Myron Elmer; Shapiro, Roger L.; Walker, Bruce David; Ndung’u, Thumbi; McLean, Angela R.; Carlson, Jonathan M.; Goulder, Philip J. R. (Proceedings of the National Academy of Sciences, 2014)
      It is widely believed that epidemics in new hosts diminish in virulence over time, with natural selection favoring pathogens that cause minimal disease. However, a tradeoff frequently exists between high virulence shortening ...
    • Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection 

      Kim, Arthur Yu-Shin; Schulze zur Wiesch, Julian; Kuntzen, Thomas; Timm, Joerg; Kaufmann, Daniel; Duncan, Jared E.; Jones, Andrea M.; Wurcel, Alysse G.; Davis, Benjamin Thomas; Gandhi, Rajesh Tim; Robbins, Gregory Kimball; Allen, Todd; Chung, Raymond Taeyong; Lauer, Georg; Walker, Bruce David (Public Library of Science, 2006)
      Background: Hepatitis C virus (HCV)-specific T cell responses are critical for spontaneous resolution of HCV viremia. Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to ...
    • In Vitro Priming Recapitulates In Vivo HIV-1 Specific T Cell Responses, Revealing Rapid Loss of Virus Reactive CD4+ T Cells in Acute HIV-1 Infection 

      Lubong Sabado, Rachel; Kavanagh, Daniel Garrett; Kaufmann, Daniel; Fru, Karlhans; Babcock, Ethan; Rosenberg, Eric Scott; Walker, Bruce David; Lifson, Jeffrey; Bhardwaj, Nina; Larsson, Marie (Public Library of Science, 2009)
      Background: The requirements for priming of HIV-specific T cell responses initially seen in infected individuals remain to be defined. Activation of T cell responses in lymph nodes requires cell-cell contact between T cells ...