Browsing by Author "Ritter, Tobias"
Now showing items 21-37 of 37
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Nickel-Mediated Oxidative Fluorination for PET with Aqueous [\(^{18}F\)] Fluoride
Lee, Eunsung; Hooker, Jacob M; Ritter, Tobias (American Chemical Society, 2012)A one-step oxidative fluorination for carbon–fluorine bond formation from well-defined nickel complexes with oxidant and aqueous fluoride is presented, which enables a straightforward and practical \(^{18}F\) late-stage ... -
Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma1
Kumar, Vidhya; Boucher, Yves; Liu, Hao; Ferreira, Diego; Hooker, Jacob; Catana, Ciprian; Hoover, Andrew J.; Ritter, Tobias; Jain, Rakesh K.; Guimaraes, Alexander R. (Neoplasia Press, 2016)PURPOSE: Losartan, an angiotensin II receptor blocker, can reduce desmoplasia and enhance drug delivery and efficacy through improving interstitial transport and vascular perfusion in pancreatic ductal adenocarcinoma (PDAC) ... -
One-Dimensional Palladium Wires: Influence of Molecular Changes on Supramolecular Structure
Campbell, Michael Glenn; Zheng, Shao-Liang; Ritter, Tobias (American Chemical Society (ACS), 2013)Nanostructured materials based on one-dimensional (1D) metal wires are of potential utility; however, to date, there is a lack of synthetic methods that allow for variation of structure and therefore properties. Here we ... -
Palladium(III)-Catalyzed Fluorination of Arylboronic Acid Derivatives
Mazzotti, Anthony Renato; Campbell, Michael Glenn; Tang, Pingping; Murphy, Jennifer Ann; Ritter, Tobias (American Chemical Society (ACS), 2013)A practical, palladium-catalyzed synthesis of aryl fluorides from arylboronic acid derivatives is presented. The reaction is operationally simple and amenable to multigram-scale synthesis. Evaluation of the reaction mechanism ... -
Palladium-Catalyzed Arene Functionalization via Single-Electron Reduction of Selectfluor
Mazzotti, Anthony Renato (2016-08-26)Palladium-catalysis is commonly used in the functionalization of aromatic rings, ranging from prefunctionalized substrates such as aryl metals or aryl (pseudo)halides to the direct functionalization of aromatic C–H bonds. ... -
Palladium-Mediated Fluorination of Arylboronic Acids
Furuya, Takeru; Kaiser, Hanns Martin; Ritter, Tobias (Wiley, 2008)Saving the best for last: Novel palladium complexes allow mild, two-step fluorination of aryl boronic acids (see scheme). The reaction is regiospecific, functional-group tolerant, has a broad substrate scope, and is ideally ... -
Pd-Catalyzed Aryl C–H Imidation with Arene as the Limiting Reagent
Boursalian, Gregory Bagrad; Ngai, Ming-Yu; Hojczyk, Katarzyna Natalia; Ritter, Tobias (American Chemical Society (ACS), 2013)An amine-N-oxide-ligated palladium complex, in conjunction with a silver cocatalyst, catalyzes imidation of arenes by the reagent N-fluorobenzenesulfonimide. The reaction enables imidation of a variety of arenes at or below ... -
PhenoFluor: Practical Synthesis, New Formulation, and Deoxyfluorination of Heteroaromatics
Fujimoto, Teppei; Becker, Fabian; Ritter, Tobias (American Chemical Society, 2014)We report a practical synthesis method of the reagent PhenoFluor on decagram scale, provide a new formulation of PhenoFluor as a toluene solution, which should decrease challenges associated with the moisture sensitivity ... -
Reactivity and Selectivity in Aryl C–H Functionalization by Electrophilic Radicals
Boursalian, Gregory Bagrad (2016-05-04)Two main challenges hinder the development of new, broadly useful C–H functionalization reactions: (1) most C–H bonds constitute part of the relatively inert backbone of an organic molecule, so it is difficult to elicit ... -
Silver-Mediated Fluorination of Functionalized Aryl Stannanes
Furuya, Takeru; Strom, Alexandra E.; Ritter, Tobias (American Chemical Society, 2009)We report a regiospecific silver-mediated fluorination of aryl stannanes. The presented reaction can afford complex fluoroarenes from readily available phenols in three steps. The operational simplicity and the broad ... -
Silver-Mediated Trifluoromethoxylation of Aryl Nucleophiles and Synthesis of 3-Deoxy-3-Fluoromorphine
Liang, Theresa (2012-11-14)Fluorine incorporation has become increasingly important in pharmaceutical applications. Upon fluorination and incorporation of fluorinated moieties such as trifluoromethoxy groups, many small molecules become more ... -
Silver-Mediated Trifluoromethoxylation of Aryl Stannanes and Arylboronic Acids
Huang, Chenghong; Liang, Theresa; Harada, Shinji; Lee, Eunsung; Ritter, Tobias (American Chemical Society, 2011)A silver-mediated cross-coupling of trifluoromethoxide with aryl stannanes and arylboronic acids to give aryl trifluoromethyl ethers is reported. This is the first report of a transition-metal-mediated \(C_{aryl}–OCF_3\) ... -
Synthesis and Structure of Solution-Stable One-Dimensional Palladium Wires
Campbell, Michael Glenn; Powers, David C.; Raynaud, Jean; Graham, Michael J.; Xie, Ping; Lee, Eunsung; Ritter, Tobias (Nature Publishing Group, 2011)One-dimensional metal wires are valuable materials because of their optical and electronic anisotropy, and they have potential utility in devices such as photovoltaic cells and molecular sensors. However, despite more than ... -
Synthesis, Structure, and Reactivity of New Palladium(III) Complexes
Campbell, Michael Glenn (2014-06-06)Palladium is one of the most common and versatile transition metals used in modern organometallic chemistry. The chemistry of palladium in its 0, +II, and +IV oxidation states is well-known; by comparison, the chemistry ... -
A Transition State Analogue for the Oxidation of Binuclear Palladium(II) to Binuclear Palladium(III) Complexes
Powers, David Charles; Ritter, Tobias (American Chemical Society (ACS), 2013)Cooperative metal–metal (M–M) redox chemistry has the potential to lower activation barriers for redox transformations relevant to catalysis. Pd2(III,III) complexes, generated by oxidation of Pd2(II,II) complexes, have ... -
A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil From [18F]Fluoride for Human PET Imaging
Hoover, Andrew (2015-07-20)5-Fluorouracil is a broad-spectrum chemotherapeutic for cancer treatment. [18F]5-Fluorouracil, which contains the radioactive isotope fluorine-18, is a tracer for positron emission tomography (PET) imaging and has been ... -
A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging
Hoover, Andrew J.; Lazari, Mark; Ren, Hong; Narayanam, Maruthi Kumar; Murphy, Jennifer M.; van Dam, R. Michael; Hooker, Jacob M.; Ritter, Tobias (American Chemical Society, 2016)Translation of new 18F-fluorination reactions to produce radiotracers for human positron emission tomography (PET) imaging is rare because the chemistry must have useful scope and the process for 18F-labeled tracer production ...