Now showing items 21-40 of 63

    • IRF3 and type I interferons fuel a fatal response to myocardial infarction 

      King, Kevin R; Aguirre, Aaron Dominic; Ye, Yu-Xiang; Sun, Yuan; Roh, Jason David; Ng, Richard Patrick; Kohler, Rainer H.; Arlauckas, Sean Philip; Iwamoto, Yoshiko; Savol, Andrej J; Sadreyev, Ruslan; Kelly, Mark; Fitzgibbons, Timothy P; Fitzgerald, Katherine A; Mitchison, Timothy J.; Libby, Peter; Nahrendorf, Matthias; Weissleder, Ralph (Springer Nature, 2017)
      Interferon regulatory factor 3 (IRF3) and type I interferons (IFNs) protect against infections and cancer, but excessive IRF3 activation and type I IFN production cause autoinflammatory conditions such as Aicardi–Goutières ...
    • Live Imaging of Cysteine-Cathepsin Activity Reveals Dynamics of Focal Inflammation, Angiogenesis, and Polyp Growth 

      Gounaris, Elias; Tung, Ching H.; Restaino, Clifford; Maehr, Rene; Kohler, Rainer H.; Joyce, Johanna A.; Plough, Hidde L.; Barrett, Terrence A.; Weissleder, Ralph; Khazaie, Khashayarsha (Public Library of Science, 2008)
      It has been estimated that up to 30% of detectable polyps in patients regress spontaneously. One major challenge in the evaluation of effective therapy of cancer is the readout for tumor regression and favorable biological ...
    • Local proliferation dominates lesional macrophage accumulation in atherosclerosis 

      Robbins, Clinton S.; Hilgendorf, Ingo; Weber, Georg F.; Theurl, Igor; Iwamoto, Yoshiko; Figueiredo, Jose-Luiz; Gorbatov, Rostic; Sukhova, Galina K.; Gerhardt, Louisa M.S.; Smyth, David; Zavitz, Caleb C. J.; Shikatani, Eric A.; Parsons, Michael; van Rooijen, Nico; Lin, Herbert Y.; Husain, Mansoor; Libby, Peter; Nahrendorf, Matthias; Weissleder, Ralph; Swirski, Filip K. (2013)
      During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall1,2. The observation that circulating monocytes give rise to lesional macrophages3–9 has ...
    • Lp-PLA 2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative MacrophagesCLINICAL PERSPECTIVE 

      He, Shun; Chousterman, Benjamin; Fenn, Ashley Margaret; Anzai, Atsushi; Nairz, Manfred; Brandt, Martin; Hilgendorf, Ingo; Sun, Yuan; Ye, Yu-Xiang; Iwamoto, Yoshiko; Tricot, Benoit; Weissleder, Ralph; Macphee, Colin; Libby, Peter; Nahrendorf, Matthias; Swirski, Filip K. (Ovid Technologies (Wolters Kluwer Health), 2015)
      Background—Healing after myocardial infarction (MI) involves the biphasic accumulation of inflammatory Ly-6Chigh and reparative Ly-6Clow monocytes/macrophages. Excessive inflammation disrupts the balance between the 2 ...
    • Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages 

      He, Shun; Chousterman, Benjamin G.; Fenn, Ashley; Anzai, Atsushi; Nairz, Manfred; Brandt, Martin; Hilgendorf, Ingo; Sun, Yuan; Ye, Yu-Xiang; Iwamoto, Yoshiko; Tricot, Benoit; Weissleder, Ralph; Macphee, Colin; Libby, Peter; Nahrendorf, Matthias; Swirski, Filip K. (Lippincott Williams & Wilkins, 2015)
      Background— Healing after myocardial infarction (MI) involves the biphasic accumulation of inflammatory Ly-6Chigh and reparative Ly-6Clow monocytes/macrophages. Excessive inflammation disrupts the balance between the 2 ...
    • Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata 

      Swirski, Filip K.; Libby, Peter; Aikawa, Elena; Alcaide, Pilar; Luscinskas, Francis William; Weissleder, Ralph; Pittet, Mikael J. (American Society for Clinical Investigation, 2007)
      Macrophage accumulation participates decisively in the development and exacerbation of atherosclerosis. Circulating monocytes, the precursors of macrophages, display heterogeneity in mice and humans, but their relative ...
    • Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 

      Dutta, Partha; Hoyer, Friedrich Felix; Grigoryeva, Lubov S.; Sager, Hendrik B.; Leuschner, Florian; Courties, Gabriel; Borodovsky, Anna; Novobrantseva, Tatiana; Ruda, Vera M.; Fitzgerald, Kevin; Iwamoto, Yoshiko; Wojtkiewicz, Gregory; Sun, Yuan; Da Silva, Nicolas; Libby, Peter; Anderson, Daniel G.; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (The Rockefeller University Press, 2015)
      Splenic myelopoiesis provides a steady flow of leukocytes to inflamed tissues, and leukocytosis correlates with cardiovascular mortality. Yet regulation of hematopoietic stem cell (HSC) activity in the spleen is incompletely ...
    • Magnetic Nanoparticles and MicroNMR for Diagnostic Applications 

      Shao, Huilin; Min, Changwook; Issadore, David Aaron; Liong, Monty; Yoon, Tae-Jong; Weissleder, Ralph; Lee, Hakho (Ivyspring International Publisher, 2012)
      Sensitive and quantitative measurements of clinically relevant protein biomarkers, pathogens and cells in biological samples would be invaluable for disease diagnosis, monitoring of malignancy, and for evaluating therapy ...
    • A magneto-DNA nanoparticle system for the rapid and sensitive diagnosis of enteric fever 

      Park, Ki Soo; Chung, Hyun Jung; Khanam, Farhana; Lee, Hakho; Rashu, Rasheduzzaman; Bhuiyan, Md. Taufiqur; Berger, Amanda; Harris, Jason B.; Calderwood, Stephen B.; Ryan, Edward T.; Qadri, Firdausi; Weissleder, Ralph; Charles, Richelle C. (Nature Publishing Group, 2016)
      There is currently no widely available optimal assay for diagnosing patients with enteric fever. Here we present a novel assay designed to detect amplified Salmonella nucleic acid (mRNA) using magneto-DNA probes and a ...
    • Mapping Molecular Agents Distributions in Whole Mice Hearts Using Born-Normalized Optical Projection Tomography 

      Vinegoni, Claudio; Feruglio, Paolo Fumene; Razansky, Daniel; Gorbatov, Rostic; Ntziachristos, Vasilis; Sbarbati, Andrea; Nahrendorf, Matthias; Weissleder, Ralph (Public Library of Science, 2012)
      To date there is a lack of tools to map the spatio-temporal dynamics of diverse cells in experimental heart models. Conventional histology is labor intensive with limited coverage, whereas many imaging techniques do not ...
    • Monocyte Subset Dynamics in Human Atherosclerosis Can Be Profiled with Magnetic Nano-Sensors 

      Wildgruber, Moritz; Chudnovskiy, Aleksey; Yoon, Tae-Jong; Etzrodt, Martin; Lee, Hakho; Pittet, Mikael J.; Nahrendorf, Matthias; Croce, Kevin James; Libby, Peter; Weissleder, Ralph; Swirski, Filip K. (Public Library of Science, 2009)
      Monocytes are circulating macrophage and dendritic cell precursors that populate healthy and diseased tissue. In humans, monocytes consist of at least two subsets whose proportions in the blood fluctuate in response to ...
    • Multimodal targeted high relaxivity thermosensitive liposome for in vivo imaging 

      Kuijten, Maayke M. P.; Hannah Degeling, M.; Chen, John W.; Wojtkiewicz, Gregory; Waterman, Peter; Weissleder, Ralph; Azzi, Jamil; Nicolay, Klaas; Tannous, Bakhos A. (Nature Publishing Group, 2015)
      Liposomes are spherical, self-closed structures formed by lipid bilayers that can encapsulate drugs and/or imaging agents in their hydrophilic core or within their membrane moiety, making them suitable delivery vehicles. ...
    • Myocardial Infarction Accelerates Atherosclerosis 

      Leuschner, Florian; Robbins, Clinton; Iwamoto, Yoshiko; Thompson, Brian; Carlson, Alicia L.; Heidt, Timo; Lasitschka, Felix; Etzrodt, Martin; Waterman, Peter; Waring, Michael T.; Chicoine, Adam T.; van der Laan, Anja M.; Niessen, Hans W.M.; Piek, Jan J.; Rubin, Barry B.; Butany, Jagdish; Katus, Hugo A.; Murphy, Sabina A.; Pittet, Mikael J.; Lin, Charles P.; Dutta, Partha; Courties, Gabriel P; Wei, Ying; Gorbatov, Rostic; Majmudar, Maulik D; Stone, James Robert; Morrow, David Andrew; Sabatine, Marc Steven; Vinegoni, Claudio; Moskowitz, Michael Arthur; Libby, Peter; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (Nature Publishing Group, 2012)
      During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaque in the arterial wall and cause its rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a ...
    • Myocardial Infarction Activates CCR2+ Hematopoietic Stem and Progenitor Cells 

      Dutta, Partha; Sager, Hendrik B; Stengel, Kristy R.; Naxerova, Kamila; Courties, Gabriel P; Saez, Borja; Silberstein, Lev; Heidt, Timo; Sebas, Matthew; Sun, Yuan; Wojtkiewicz, Gregory; Feruglio, Paolo Fumene; King, Kevin Robert; Baker, Joshua N.; van der Laan, Anja M.; Borodovsky, Anna; Fitzgerald, Kevin; Hulsmans, Maarten; Hoyer, Friedrich Felix; Iwamoto, Yoshiko; Vinegoni, Claudio; Brown, Dennis; Di Carli, Marcelo; Libby, Peter; Hiebert, Scott W.; Scadden, David Thomas; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (Elsevier BV, 2015)
      Following myocardial infarction (MI), myeloid cells derived from the hematopoietic system drive a sharp increase in systemic leukocyte levels that correlates closely with mortality. The origin of these myeloid cells, and ...
    • Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury 

      Chung, Hyun Jung; Pellegrini, Kathryn L.; Chung, Jaehoon; Wanigasuriya, Kamani; Jayawardene, Innocent; Lee, Kyungheon; Lee, Hakho; Vaidya, Vishal S.; Weissleder, Ralph (Public Library of Science, 2015)
      The high incidence of acute and chronic kidney injury due to various environmental factors such as heavy metals or chemicals has been a major problem in developing countries. However, the diagnosis of kidney injury in these ...
    • A Near-Infrared Cell Tracker Reagent for Multiscopic In Vivo Imaging and Quantification of Leukocyte Immune Responses 

      Berger, Cedric R.; Figueiredo, Jose-Luiz; Swirski, Filip K.; Mempel, Thorsten Roman; Von Andrian, Ulrich H.; Pittet, Mikael J.; Weissleder, Ralph (Public Library of Science, 2007)
      The complexity of the tumor microenvironment necessitates that cell behavior is studied in a broad, multi-scale context. Although tomographic and microscopy-based far and near infrared fluorescence (NIRF, >650 nm) imaging ...
    • The neuropeptide neuromedin U promotes autoantibody-mediated arthritis 

      Rao, Sindhuja M; Auger, Jennifer L; Gaillard, Philippe; Weissleder, Ralph; Wada, Etsuko; Torres, Richard; Kojima, Masayasu; Benoist, Christophe O.; Mathis, Diane J.; Binstadt, Bryce A (BioMed Central, 2012)
      Introduction: Neuromedin U (NMU) is a neuropeptide with pro-inflammatory activity. The primary goal of this study was to determine if NMU promotes autoantibody-induced arthritis. Additional studies addressed the cellular ...
    • New techniques for motion-artifact-free in vivo cardiac microscopy 

      Vinegoni, Claudio; Lee, Sungon; Aguirre, Aaron D.; Weissleder, Ralph (Frontiers Media S.A., 2015)
      Intravital imaging microscopy (i.e., imaging in live animals at microscopic resolution) has become an indispensable tool for studying the cellular micro-dynamics in cancer, immunology and neurobiology. High spatial and ...
    • On Chip Analysis of CNS Lymphoma in Cerebrospinal Fluid 

      Turetsky, Anna; Lee, Kyungheon; Song, Jun; Giedt, Randy J.; Kim, Eunha; Kovach, Alexandra E.; Hochberg, Ephraim P.; Castro, Cesar M.; Lee, Hakho; Weissleder, Ralph (Ivyspring International Publisher, 2015)
      Molecular profiling of central nervous system lymphomas in cerebrospinal fluid (CSF) samples can be challenging due to the paucicellular and limited nature of the samples. Presented herein is a microfluidic platform for ...
    • On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver 

      Theurl, Igor; Hilgendorf, Ingo; Nairz, Manfred; Tymoszuk, Piotr; Haschka, David; Asshoff, Malte; He, Shun; Gerhardt, Louisa M. S.; Holderried, Tobias A. W.; Seifert, Markus; Sopper, Sieghart; Fenn, Ashley M.; Anzai, Atsushi; Rattik, Sara; McAlpine, Cameron; Theurl, Milan; Wieghofer, Peter; Iwamoto, Yoshiko; Weber, Georg F.; Harder, Nina K.; Chousterman, Benjamin G.; Arvedson, Tara L.; McKee, Mary; Wang, Fudi; Lutz, Oliver M. D.; Rezoagli, Emanuele; Babitt, Jodie L.; Berra, Lorenzo; Prinz, Marco; Nahrendorf, Matthias; Weiss, Guenter; Weissleder, Ralph; Lin, Herbert Y.; Swirski, Filip K. (2016)
      Iron is an essential component of the erythrocyte protein hemoglobin and is crucial to oxygen transport in vertebrates. In the steady state, erythrocyte production is in equilibrium with erythrocyte removal1. In various ...