Browsing by Author "Wright, Robert"

Now showing items 21-38 of 38

    • Iron Metabolism Genes, Low-Level Lead Exposure, and QT Interval 

      Park, Sung Kyun; Hu, Howard; Wright, Robert O.; Schwartz, Joel David; Cheng, Yawen; Sparrow, David; Vokonas, Pantel S; Weisskopf, Marc G. (National Institute of Environmental Health Sciences, 2008)
      Background: Cumulative exposure to lead has been shown to be associated with depression of electrocardiographic conduction, such as QT interval (time from start of the Q wave to end of the T wave). Because iron can enhance ...

    • Lead Concentrations in Relation to Multiple Biomarkers of Cardiovascular Disease: The Normative Aging Study 

      Peters, Junenette L.; Kubzansky, Laura Diane; Ikeda, Ai; Fang, Shona C.; Sparrow, David; Weisskopf, Marc G.; Wright, Robert O.; Vokonas, Pantel S; Hu, Howard; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2012)
      Background: Lead exposure has been associated with cardiovascular disease (CVD) in animal and human studies. However, the mechanisms of action have not been fully elucidated. We therefore examined the relationship between ...

    • Lead Exposure and Behavior Among Young Children in Chennai, India 

      Roy, Ananya; Bellinger, David C.; Hu, Howard; Schwartz, Joel David; Ettinger, Adrienne S; Wright, Robert O.; Bouchard, Maryse; Palaniappan, Kavitha; Balakrishnan, Kalpana (National Institute of Environmental Health Sciences, 2009)
      Background: Lead exposure has long been associated with deficits in IQ among children. However, few studies have assessed the impact of lead on specific domains of behavior and cognition. Objective: We evaluated the ...

    • Lead Levels and Ischemic Heart Disease in a Prospective Study of Middle-Aged and Elderly Men: The VA Normative Aging Study 

      Jain, Nitin; Potula, Vijayalakshmi; Schwartz, Joel David; Vokonas, Pantel S; Sparrow, David; Wright, Robert O.; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007)
      Background: Lead exposure has been associated with higher blood pressure, hypertension, electrocardiogram abnormalities, and increased mortality from circulatory causes.Objective We assessed the association between bone ...

    • Low-Level Lead Exposure, Metabolic Syndrome, and Heart Rate Variability: The VA Normative Aging Study 

      Park, Sung Kyun; Schwartz, Joel David; Weisskopf, Marc G.; Sparrow, David; Vokonas, Pantel S; Wright, Robert O.; Coull, Brent Andrew; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2006)
      Background: Altered heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with sudden cardiac death and heart failure. Objective: We examined the association of low-level lead ...

    • Maternal arsenic exposure and impaired glucose tolerance during pregnancy 

      Ettinger, Adrienne S; Zota, Ami R.; Amarasiriwardena, Chitra J.; Hopkins, Marianne; Schwartz, Joel David; Hu, Howard; Wright, Robert O. (National Institute of Environmental Health Sciences, 2009)
      Background: Accumulating evidence has shown an increased risk of type 2 diabetes in general populations exposed to arsenic, but little is known about exposures during pregnancy and the association with gestational diabetes ...

    • Maternal Fish Consumption, Hair Mercury, and Infant Cognition in a U.S. Cohort 

      Oken, Emily; Wright, Robert O.; Kleinman, Ken Paul; Bellinger, David C.; Amarasiriwardena, Chitra J.; Hu, Howard; Rich-Edwards, Janet Wilson; Gillman, Matthew William (National Institute of Environmental Health Sciences, 2005)
      Fish and other seafood may contain organic mercury but also beneficial nutrients such as n-3 polyunsaturated fatty acids. We endeavored to study whether maternal fish consumption during pregnancy harms or benefits fetal ...

    • Modification by hemochromatosis gene polymorphisms of the association between traffic-related air pollution and cognition in older men: a cohort study 

      Power, Melinda C.; Weisskopf, Marc G.; Alexeeff, Stacey E; Wright, Robert O.; Coull, Brent Andrew; Spiro, Avron; Schwartz, Joel David (BioMed Central, 2013)
      Background: Previous studies found effect modification of associations between traffic-related air pollution and cardiovascular outcomes by polymorphisms in the hemochromatosis gene (HFE). As traffic-related air pollution ...

    • Modifying Effects of the HFE Polymorphisms on the Association Between Lead Burden and Cognitive Decline 

      Wang, Florence T.; Hu, Howard; Schwartz, Joel David; Weuve, Jennifer Lynn; Spiro, Avron S.; Sparrow, David; Nie, Huiling; Silverman, Edwin Kepner; Weiss, Scott Tillman; Wright, Robert O. (National Institute of Environmental Health Sciences, 2007)
      Background: As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship. Objective: ...

    • Neurotoxic Metal Coexposures: Claus Henn et al. Respond 

      Henn, Birgit Claus; Bellinger, David C.; Wright, Robert O. (National Institute of Environmental Health Sciences, 2012)

    • A Novel Genetic Score Approach Using Instruments to Investigate Interactions between Pathways and Environment: Application to Air Pollution 

      Bind, Marie-Abele; Coull, Brent; Suh, Helen; Wright, Robert; Baccarelli, Andrea; Vokonas, Pantel; Schwartz, Joel (Public Library of Science, 2014)
      Air pollution has been associated with increased systemic inflammation markers. We developed a new pathway analysis approach to investigate whether gene variants within relevant pathways (oxidative stress, endothelial ...

    • Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort 

      Chahine, Teresa; Baccarelli, Andrea; Litonjua, Augusto Ampil; Wright, Robert O.; Suh MacIntosh, Helen H.; Gold, Diane R.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2007)
      Background and Objectives: We have previously shown that reduced defenses against oxidative stress due to glutathione S-transferase M1 (GSTM1) deletion modify the effects of PM[2.5] (fine-particulate air pollution of < 2.5 ...

    • A pilot randomized controlled trial to promote healthful fish consumption during pregnancy: The Food for Thought Study 

      Oken, Emily; Guthrie, Lauren B; Bloomingdale, Arienne; Platek, Deborah Nehama; Price, Sarah; Haines, Jess; Gillman, Matthew William; Olsen, Sjurdur F.; Bellinger, David C.; Wright, Robert O. (BioMed Central, 2013)
      Background: Nutritionists advise pregnant women to eat fish to obtain adequate docosahexaenoic acid (DHA), an essential nutrient important for optimal brain development. However, concern exists that this advice will lead ...

    • Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter 

      Wilker, Elissa Hope; Mittleman, Murray A.; Litonjua, Augusto Ampil; Poon, Audrey; Baccarelli, Andrea; Suh, Helen; Wright, Robert O.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2009)
      Background: Fine particulate matter [aerodynamic diameter ≤ 2.5 μm (PM2.5)] has been associated with autonomic dysregulation.Objective We hypothesized that PM2.5 influences postural changes in systolic blood pressure (ΔSBP) ...

    • Prenatal Arsenic Exposure and DNA Methylation in Maternal and Umbilical Cord Blood Leukocytes 

      Kile, Molly Louise; Baccarelli, Andrea; Hoffman, Elaine Borland; Tarantini, Letizia; Quamruzzaman, Quazi; Rahman, Mahmuder; Mahiuddin, Golam; Mostofa, Golam; Hsueh, Yu-Mei; Wright, Robert O.; Christiani, David C. (National Institute of Environmental Health Sciences, 2012)
      Background: Arsenic is an epigenetic toxicant and could influence fetal developmental programming. Objectives: We evaluated the association between arsenic exposure and DNA methylation in maternal and umbilical cord ...

    • Proton Magnetic Resonance Spectroscopic Evidence of Glial Effects of Cumulative Lead Exposure in the Adult Human Hippocampus 

      Weisskopf, Marc G.; Hu, Howard; Sparrow, David; Lenkinski, Robert E.; Wright, Robert O. (National Institute of Environmental Health Sciences, 2007)
      Background: Exposure to lead is known to have adverse effects on cognition in several different populations. Little is known about the underlying structural and functional correlates of such exposure in humans. Objectives: ...

    • Stress as a Potential Modifier of the Impact of Lead Levels on Blood Pressure: The Normative Aging Study 

      Peters, Junenette L.; Kubzansky, Laura Diane; McNeely, Eileen; Schwartz, Joel David; Spiro, Avron; Sparrow, David; Wright, Robert O.; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007)
      Background: Lead exposure and psychological stress have been independently associated with hypertension in various populations, and animal studies suggest that when they co-occur, their effects may be exacerbated. Objectives: ...

    • Variants in iron metabolism genes predict higher blood lead levels in young children 

      Hopkins, Marianne; Ettinger, Adrienne S; Hernández-Avila, Mauricio; Schwartz, Joel David; Téllez-Rojo, Martha María; Lamadrid-Figueroa, Héctor; Bellinger, David C.; Hu, Howard; Wright, Robert O. (National Institute of Environmental Health Sciences, 2008)
      Background: Given the association between iron deficiency and lead absorption, we hypothesized that variants in iron metabolism genes would predict higher blood lead levels in young children. Objective: We examined the ...