Now showing items 21-24 of 24

    • Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice 

      Sun, Jiusong; Sukhova, Galina K.; Yang, Min; Wolters, Paul J.; MacFarlane, Lindsey Adair; Libby, Peter; Sun, Chongxiu; Zhang, Yadong; Liu, Jianming; Ennis, Terri L.; Knispel, Rebecca; Xiong, Wanfen; Thompson, Robert W.; Baxter, B. Timothy; Shi, Guo-Ping (American Society for Clinical Investigation, 2007)
      Abdominal aortic aneurysm (AAA), an inflammatory disease, involves leukocyte recruitment, immune responses, inflammatory cytokine production, vascular remodeling, neovascularization, and vascular cell apoptosis, all of ...
    • Plasma Cathepsin S and Cystatin C Levels and Risk of Abdominal Aortic Aneurysm: A Randomized Population–Based Study 

      Lv, Bing-Jie; Lindholt, Jes S.; Cheng, Xiang; Wang, Jing; Shi, Guo-Ping (Public Library of Science, 2012)
      Background: Human abdominal aortic aneurysm (AAA) lesions contain high levels of cathepsin S (CatS), but are deficient in its inhibitor, cystatin C. Whether plasma CatS and cystatin C levels are also altered in AAA patients ...
    • Thin-Capped Atheromata With Reduced Collagen Content in Pigs Develop in Coronary Arterial Regions Exposed to Persistently Low Endothelial Shear Stress 

      Koskinas, K. C.; Sukhova, Galina K.; Baker, A. B.; Papafaklis, M. I.; Chatzizisis, Y. S.; Coskun, A. U.; Quillard, T.; Jonas, M.; Maynard, C.; Antoniadis, Antonios; Shi, Guo-Ping; Libby, Peter; Edelman, Elazer Reuven; Feldman, Charles Lawrence; Stone, Peter Howard (Ovid Technologies (Wolters Kluwer Health), 2013)
      Objective—The mechanisms promoting the focal formation of rupture-prone coronary plaques in vivo remain incompletely understood. This study tested the hypothesis that coronary regions exposed to low endothelial shear stress ...
    • Vasa Vasorum in Atherosclerosis and Clinical Significance 

      Xu, Junyan; Lu, Xiaotong; Shi, Guo-Ping (MDPI, 2015)
      Atherosclerosis is a chronic inflammatory disease that leads to several acute cardiovascular complications with poor prognosis. For decades, the role of the adventitial vasa vasorum (VV) in the initiation and progression ...