Browsing by Author "Shi, Guo-Ping"
Now showing items 21-25 of 25
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Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages
Zhou, Yi; Yu, Xueqing; Chen, Huimei; Sjöberg, Sara; Roux, Joséphine; Zhang, Lijun; Ivoulsou, Al-Habib; Bensaid, Farid; Liu, Jian; Tordjman, Joan; Clement, Karine; Lee, Chih-Hao; Libby, Peter; Shi, Guo-Ping; Hotamisligil, Gokhan; Liu, Conglin (Elsevier BV, 2015-12)Mast cells (MCs) contribute to the pathogenesis of obesity and diabetes. This study demonstrates that leptin deficiency slants MCs toward anti-inflammatory functions. MCs in the white adipose tissue (WAT) of lean humans ... -
Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice
Sun, Jiusong; Sukhova, Galina K.; Yang, Min; Wolters, Paul J.; MacFarlane, Lindsey Adair; Libby, Peter; Sun, Chongxiu; Zhang, Yadong; Liu, Jianming; Ennis, Terri L.; Knispel, Rebecca; Xiong, Wanfen; Thompson, Robert W.; Baxter, B. Timothy; Shi, Guo-Ping (American Society for Clinical Investigation, 2007)Abdominal aortic aneurysm (AAA), an inflammatory disease, involves leukocyte recruitment, immune responses, inflammatory cytokine production, vascular remodeling, neovascularization, and vascular cell apoptosis, all of ... -
Plasma Cathepsin S and Cystatin C Levels and Risk of Abdominal Aortic Aneurysm: A Randomized Population–Based Study
Lv, Bing-Jie; Lindholt, Jes S.; Cheng, Xiang; Wang, Jing; Shi, Guo-Ping (Public Library of Science, 2012)Background: Human abdominal aortic aneurysm (AAA) lesions contain high levels of cathepsin S (CatS), but are deficient in its inhibitor, cystatin C. Whether plasma CatS and cystatin C levels are also altered in AAA patients ... -
Thin-Capped Atheromata With Reduced Collagen Content in Pigs Develop in Coronary Arterial Regions Exposed to Persistently Low Endothelial Shear Stress
Koskinas, K. C.; Sukhova, Galina K.; Baker, A. B.; Papafaklis, M. I.; Chatzizisis, Y. S.; Coskun, A. U.; Quillard, T.; Jonas, M.; Maynard, C.; Antoniadis, Antonios; Shi, Guo-Ping; Libby, Peter; Edelman, Elazer Reuven; Feldman, Charles Lawrence; Stone, Peter Howard (Ovid Technologies (Wolters Kluwer Health), 2013)Objective—The mechanisms promoting the focal formation of rupture-prone coronary plaques in vivo remain incompletely understood. This study tested the hypothesis that coronary regions exposed to low endothelial shear stress ... -
Vasa Vasorum in Atherosclerosis and Clinical Significance
Xu, Junyan; Lu, Xiaotong; Shi, Guo-Ping (MDPI, 2015)Atherosclerosis is a chronic inflammatory disease that leads to several acute cardiovascular complications with poor prognosis. For decades, the role of the adventitial vasa vasorum (VV) in the initiation and progression ...