Browsing by Author "Mandl, Kenneth"
Now showing items 21-40 of 47
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Exclusion of Elderly People from Randomized Clinical Trials of Drugs for Ischemic Heart Disease
Bourgeois, Florence Tanya; Orenstein, Liat; Ballakur, Sarita; Mandl, Kenneth David; Ioannidis, John (Wiley-Blackwell, 2017)Objectives To measure exclusion of elderly adults from randomized trials studying drug interventions for ischemic heart disease (IHD) and describe the characteristics of these trials. Design Cross-sectional ... -
An i2b2-based, generalizable, open source, self-scaling chronic disease registry
Natter, Marc D; Quan, Justin; Ortiz, David M; Bousvaros, Athos; Ilowite, Norman T; Inman, Christi J; Marsolo, Keith; McMurry, Andrew J; Sandborg, Christy I; Schanberg, Laura E; Wallace, Carol A; Warren, Robert W; Weber, Griffin M; Mandl, Kenneth D (BMJ Group, 2012)Objective: Registries are a well-established mechanism for obtaining high quality, disease-specific data, but are often highly project-specific in their design, implementation, and policies for data use. In contrast to the ... -
Indivo: A Personally Controlled Health Record for Health Information Exchange and Communication
Mandl, Kenneth David; Simons, William; Crawford, William CR; Abbett, Jonathan M (BioMed Central, 2007)Background: Personally controlled health records (PCHRs), a subset of personal health records (PHRs), enable a patient to assemble, maintain and manage a secure copy of his or her medical data. Indivo (formerly PING) is ... -
Industry-sponsored clinical research outside high-income countries: an empirical analysis of registered clinical trials from 2006 to 2013
Murthy, Srinivas; Mandl, Kenneth D.; Bourgeois, Florence T. (BioMed Central, 2015)Background: Industry-sponsored clinical trials, in the past performed almost exclusively in more developed countries, now often recruit participants globally. However, recruitment from outside high-income countries may not ... -
Integration of a standardized pharmacogenomic platform for clinical decision support at Boston Children's Hospital
Brownstein, Catherine A.; Fusaro, Vincent Alfred; Savage, Sarah; Clinton, Catherine; Mandl, Kenneth David; Margulies, David Michael; Wolf, Wendy; Manzi, Shannon (BioMed Central, 2012) -
An iOS Framework for the Indivo X Personally Controlled Health Record
Pfiffner, Pascal B; Mandl, Kenneth D (American Medical Informatics Association, 2013)The Indivo X personally controlled health record creates a channel between researchers and the patient/subject in several large scale projects. Indivo enables patients to access their health data through a web interface ... -
Longitudinal Histories as Predictors of Future Diagnoses of Domestic Abuse: Modelling Study
Reis, Ben Y.; Kohane, Isaac Samuel; Mandl, Kenneth David (BMJ Publishing Group Ltd., 2009)Objective: To determine whether longitudinal data in patients’ historical records, commonly available in electronic health record systems, can be used to predict a patient’s future risk of receiving a diagnosis of domestic ... -
My Sister's Keeper?: Genomic Research and the Identifiability of Siblings
Cassa, Christopher Anthony; Schmidt, Brian; Kohane, Isaac Samuel; Mandl, Kenneth David (BioMed Central, 2008)Background: Genomic sequencing of SNPs is increasingly prevalent, though the amount of familial information these data contain has not been quantified. Methods: We provide a framework for measuring the risk to siblings of ... -
A numerical similarity approach for using retired Current Procedural Terminology (CPT) codes for electronic phenotyping in the Scalable Collaborative Infrastructure for a Learning Health System (SCILHS)
Klann, Jeffrey G.; Phillips, Lori C.; Turchin, Alexander; Weiler, Sarah; Mandl, Kenneth D.; Murphy, Shawn N. (BioMed Central, 2015)Background: Interoperable phenotyping algorithms, needed to identify patient cohorts meeting eligibility criteria for observational studies or clinical trials, require medical data in a consistent structured, coded format. ... -
Premarket Safety and Efficacy Studies for ADHD Medications in Children
Bourgeois, Florence T.; Kim, Jeong Min; Mandl, Kenneth D. (Public Library of Science, 2014)Background: Attention-deficit hyperactivity disorder (ADHD) is a chronic condition and pharmacotherapy is the mainstay of treatment, with a variety of ADHD medications available to patients. However, it is unclear to what ... -
Prevalence and Characteristics of Interventional Trials Conducted Exclusively in Elderly Persons: A Cross-Sectional Analysis of Registered Clinical Trials
Bourgeois, Florence T.; Olson, Karen L.; Tse, Tony; Ioannidis, John P. A.; Mandl, Kenneth D. (Public Library of Science, 2016)Background: Elderly patients represent the greatest consumers of healthcare per capita but have historically been underrepresented in clinical trials. It is unknown how many trials are designed to focus exclusively on ... -
Re-Identification of Home Addresses from Spatial Locations Anonymized by Gaussian Skew
Cassa, Christopher Anthony; Wieland, Shannon C.; Mandl, Kenneth David (BioMed Central, 2008)Background: Knowledge of the geographical locations of individuals is fundamental to the practice of spatial epidemiology. One approach to preserving the privacy of individual-level addresses in a data set is to de-identify ... -
Real Time Spatial Cluster Detection Using Interpoint Distances Among Precise Patient Locations
Olson, Karen Lea; Bonetti, Marco; Pagano, Marcello; Mandl, Kenneth David (BioMed Central, 2005)Background: Public health departments in the United States are beginning to gain timely access to health data, often as soon as one day after a visit to a health care facility. Consequently, new approaches to outbreak ... -
Reimagining Health Data Exchange: An Application Programming Interface–Enabled Roadmap for India
Balsari, Satchit Siddharth; Fortenko, Alexander; Blaya, Joaquin Andres; Gropper, Adrian; Jayaram, Malavika; Matthan, Rahul; Sahasranam, Ram; Shankar, Mark Thomas; Sarbadhikari, Suptendra N; Bierer, Barbara Emily; Mandl, Kenneth David; Mehendale, Sanjay; Khanna, Tarun (JMIR Publications Inc., 2018)In February 2018, the Government of India announced a massive public health insurance scheme extending coverage to 500 million citizens, in effect making it the world’s largest insurance program. To meet this target, the ... -
Relative Impact of Influenza and Respiratory Syncytial Virus in Young Children
Bourgeois, Florence; Valim, Clarissa; McAdam, Alexander; Mandl, Kenneth (American Academy of Pediatrics (AAP), 2009-12)OBJECTIVE We measured the relative impact of influenza and respiratory syncytial virus (RSV) infections in young children in terms of emergency department (ED) visits, clinical care requirements, and overall resource ... -
The role of absolute humidity on transmission rates of the COVID-19 outbreak
Luo, Wei; Majumder, Maimuna; Liu, Dianbo; Poirier, Canelle; Mandl, Kenneth; Lipsitch, Marc; Santillana, Mauricio (2020-02-17)A novel coronavirus (COVID-19) was identified in Wuhan, Hubei Province, China, in December 2019 and has caused over 40,000 cases worldwide to date. Previous studies have supported an epidemiological hypothesis that cold ... -
Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): Architecture
Mandl, Kenneth D; Kohane, Isaac S; McFadden, Douglas; Weber, Griffin M; Natter, Marc; Mandel, Joshua; Schneeweiss, Sebastian; Weiler, Sarah; Klann, Jeffrey G; Bickel, Jonathan; Adams, William G; Ge, Yaorong; Zhou, Xiaobo; Perkins, James; Marsolo, Keith; Bernstam, Elmer; Showalter, John; Quarshie, Alexander; Ofili, Elizabeth; Hripcsak, George; Murphy, Shawn N (BMJ Publishing Group, 2014)We describe the architecture of the Patient Centered Outcomes Research Institute (PCORI) funded Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS, http://www.SCILHS.org) clinical data research ... -
Sharing Data for Public Health Research by Members of an International Online Diabetes Social Network
Weitzman, Elissa R.; Adida, Ben; Kelemen, Skyler; Mandl, Kenneth David (Public Library of Science, 2011)Background: Surveillance and response to diabetes may be accelerated through engaging online diabetes social networks (SNs) in consented research. We tested the willingness of an online diabetes community to share data for ... -
The SMART Platform: early experience enabling substitutable applications for electronic health records
Mandl, Kenneth David; Mandel, Joshua; Murphy, Shawn Norman; Bernstam, Elmer Victor; Ramoni, Rachel L; Kreda, David A; McCoy, J. Michael; Adida, Ben; Kohane, Isaac Samuel (BMJ Group, 2012)Objective: The Substitutable Medical Applications, Reusable Technologies (SMART) Platforms project seeks to develop a health information technology platform with substitutable applications (apps) constructed around core ... -
A software tool for creating simulated outbreaks to benchmark surveillance systems
Cassa, Christopher Anthony; Iancu, Karin; Olson, Karen Lea; Mandl, Kenneth David (BioMed Central, 2005)Background: Evaluating surveillance systems for the early detection of bioterrorism is particularly challenging when systems are designed to detect events for which there are few or no historical examples. One approach to ...