Browsing by Author "Christiani, David"

Now showing items 21-40 of 85

    • Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes 

      Allen, Joseph G.; Flanigan, Skye S.; LeBlanc, Mallory; Vallarino, Jose; MacNaughton, Piers; Stewart, James H.; Christiani, David C. (National Institute of Environmental Health Sciences, 2015)
      Background: There are > 7,000 e-cigarette flavors currently marketed. Flavoring chemicals gained notoriety in the early 2000s when inhalation exposure of the flavoring chemical diacetyl was found to be associated with a ...

    • Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study 

      Liao, Shu-Yi; Lin, Xihong; Christiani, David C (BioMed Central, 2013)
      Background: Previous studies in occupational exposure and lung function have focused only on the main effect of occupational exposure or genetics on lung function. Some disease-susceptible genes may be missed due to their ...

    • Genetic Susceptible Locus in NOTCH2 Interacts with Arsenic in Drinking Water on Risk of Type 2 Diabetes 

      Pan, Wen-Chi; Kile, Molly L.; Seow, Wei Jie; Lin, Xihong; Quamruzzaman, Quazi; Rahman, Mahmuder; Mahiuddin, Golam; Mostofa, Golam; Lu, Quan; Christiani, David C. (Public Library of Science, 2013)
      Background: Chronic exposure to arsenic in drinking water is associated with increased risk of type 2 diabetes mellitus (T2DM) but the underlying molecular mechanism remains unclear. Objectives: This study evaluated the ...

    • Genome Wide Association Identifies PPFIA1 as a Candidate Gene for Acute Lung Injury Risk Following Major Trauma 

      Christie, Jason D.; Wurfel, Mark M.; Feng, Rui; O'Keefe, Grant E.; Bradfield, Jonathan; Ware, Lorraine B.; Calfee, Carolyn S.; Matthay, Michael; Meyer, Nuala J.; Kim, Cecilia; Li, Mingyao; Akey, Joshua; Barnes, Kathleen C.; Sevransky, Jonathan; Lanken, Paul N.; May, Addison K.; Aplenc, Richard; Maloney, James P.; Hakonarson, Hakon; Christiani, David C.; Cohen, Mitchell J. (Public Library of Science, 2012)
      Acute Lung Injury (ALI) is a syndrome with high associated mortality characterized by severe hypoxemia and pulmonary infiltrates in patients with critical illness. We conducted the first investigation to use the genome ...

    • Genome-Wide Analysis of Survival in Early-Stage Non–Small-Cell Lung Cancer 

      Huang, Yen-Tsung; Suk Heist, Rebecca; Chirieac, Lucian; Lin, Xihong; Skaug, Vidar; Zienolddiny, Shanbeh; Haugen, Aage; Wu, Michael C.; Wang, Zhaoxi; Su, Li; Asomaning, Kofi; Christiani, David (American Society of Clinical Oncology (ASCO), 2009-06-01)
      Purpose Lung cancer, of which 85% is non–small-cell (NSCLC), is the leading cause of cancer-related death in the United States. We used genome-wide analysis of tumor tissue to investigate whether single nucleotide ...

    • A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases 

      Zhu, Zhaozhong; Lee, Phil Hyoun; Chaffin, Mark; Chung, Wonil; Loh, Po-Ru; Lu, Quan; Christiani, David Christopher; Liang, Liming (Springer Science and Business Media LLC, 2018-05-21)
      Clinical and epidemiological data suggest that asthma and allergic diseases are associated and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma and allergic diseases in 33,593 cases and ...

    • The Global Contribution of Outdoor Air Pollution to the Incidence, Prevalence, Mortality and Hospital Admission for Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis 

      Song, Qingkun; Christiani, David C.; Wang, Xiaorong; Ren, Jun (MDPI, 2014)
      Objective:: This study aimed to investigate the quantitative effects of outdoor air pollution, represented by 10 µg/m3 increment of PM10, on chronic obstructive pulmonary disease in China, United States and European Union ...

    • Global Gene Expression Profiling in Whole-Blood Samples From Individuals Exposed to Metal Fumes 

      Wang, Zhaoxi; Neuburg, Donna; Li, Cheng; Su, Li; Kim, Jee Young; Chen, Jiu Chiuan; Christiani, David C. (National Institute of Environmental Health Sciences, 2005)
      Accumulating evidence demonstrates that particulate air pollutants can cause both pulmonary and airway inflammation. However, few data show that particulates can induce systemic inflammatory responses. We conducted an ...

    • Global Metabolomic Profiling Reveals an Association of Metal Fume Exposure and Plasma Unsaturated Fatty Acids 

      Wei, Yongyue; Wang, Zhaoxi; Chang, Chiung-yu; Fan, Tianteng; Su, Li; Chen, Feng; Christiani, David C. (Public Library of Science, 2013)
      Background: Welding-associated air pollutants negatively affect the health of exposed workers; however, their molecular mechanisms in causing disease remain largely unclear. Few studies have systematically investigated the ...

    • Heart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders: a repeated-measures panel study 

      Fan, Tianteng; Fang, Shona C; Cavallari, Jennifer M; Barnett, Ian J; Wang, Zhaoxi; Su, Li; Byun, Hyang-Min; Lin, Xihong; Baccarelli, Andrea A; Christiani, David C (BioMed Central, 2014)
      Background: In occupational settings, boilermakers are exposed to high levels of metallic fine particulate matter (PM2.5) generated during the welding process. The effect of welding PM2.5 on heart rate variability (HRV) ...

    • Hemopexin in severe inflammation and infection: mouse models and human diseases 

      Lin, Tian; Maita, Dayana; Thundivalappil, Sujatha R; Riley, Frank E; Hambsch, Jasmin; Van Marter, Linda J; Christou, Helen A; Berra, Lorenzo; Fagan, Shawn; Christiani, David C; Warren, H Shaw (BioMed Central, 2015)
      Introduction: Cell-free plasma hemoglobin is associated with poor outcome in patients with sepsis. Extracellular hemoglobin and secondarily released heme amplify inflammation in the presence of microbial TLR ligands and/or ...

    • IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans 

      Pearce, Neil; Blair, Aaron; Vineis, Paolo; Ahrens, Wolfgang; Andersen, Aage; Anto, Josep M.; Armstrong, Bruce K.; Baccarelli, Andrea A.; Beland, Frederick A.; Berrington, Amy; Bertazzi, Pier Alberto; Birnbaum, Linda S.; Brownson, Ross C.; Bucher, John R.; Cantor, Kenneth P.; Cardis, Elisabeth; Cherrie, John W.; Christiani, David C.; Cocco, Pierluigi; Coggon, David; Comba, Pietro; Demers, Paul A.; Dement, John M.; Douwes, Jeroen; Eisen, Ellen A.; Engel, Lawrence S.; Fenske, Richard A.; Fleming, Lora E.; Fletcher, Tony; Fontham, Elizabeth; Forastiere, Francesco; Frentzel-Beyme, Rainer; Fritschi, Lin; Gerin, Michel; Goldberg, Marcel; Grandjean, Philippe; Grimsrud, Tom K.; Gustavsson, Per; Haines, Andy; Hartge, Patricia; Hansen, Johnni; Hauptmann, Michael; Heederik, Dick; Hemminki, Kari; Hemon, Denis; Hertz-Picciotto, Irva; Hoppin, Jane A.; Huff, James; Jarvholm, Bengt; Kang, Daehee; Karagas, Margaret R.; Kjaerheim, Kristina; Kjuus, Helge; Kogevinas, Manolis; Kriebel, David; Kristensen, Petter; Kromhout, Hans; Laden, Francine; Lebailly, Pierre; LeMasters, Grace; Lubin, Jay H.; Lynch, Charles F.; Lynge, Elsebeth; ‘t Mannetje, Andrea; McMichael, Anthony J.; McLaughlin, John R.; Marrett, Loraine; Martuzzi, Marco; Merchant, James A.; Merler, Enzo; Merletti, Franco; Miller, Anthony; Mirer, Franklin E.; Monson, Richard; Nordby, Karl-Cristian; Olshan, Andrew F.; Parent, Marie-Elise; Perera, Frederica P.; Perry, Melissa J.; Pesatori, Angela Cecilia; Pirastu, Roberta; Porta, Miquel; Pukkala, Eero; Rice, Carol; Richardson, David B.; Ritter, Leonard; Ritz, Beate; Ronckers, Cecile M.; Rushton, Lesley; Rusiecki, Jennifer A.; Rusyn, Ivan; Samet, Jonathan M.; Sandler, Dale P.; de Sanjose, Silvia; Schernhammer, Eva; Costantini, Adele Seniori; Seixas, Noah; Shy, Carl; Siemiatycki, Jack; Silverman, Debra T.; Simonato, Lorenzo; Smith, Allan H.; Smith, Martyn T.; Spinelli, John J.; Spitz, Margaret R.; Stallones, Lorann; Stayner, Leslie T.; Steenland, Kyle; Stenzel, Mark; Stewart, Bernard W.; Stewart, Patricia A.; Symanski, Elaine; Terracini, Benedetto; Tolbert, Paige E.; Vainio, Harri; Vena, John; Vermeulen, Roel; Victora, Cesar G.; Ward, Elizabeth M.; Weinberg, Clarice R.; Weisenburger, Dennis; Wesseling, Catharina; Weiderpass, Elisabete; Zahm, Shelia Hoar (NLM-Export, 2015)
      Background: Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used ...

    • Imaging Phenotype of Occupational Endotoxin-Related Lung Function Decline 

      Lai, Peggy S.; Hang, Jing-qing; Zhang, Feng-ying; Sun, J.; Zheng, Bu-Yong; Su, Li; Washko, George R.; Christiani, David C. (National Institute of Environmental Health Sciences, 2016)
      Background: Although occupational exposures contribute to a significant proportion of obstructive lung disease, the phenotype of obstructive lung disease associated with work-related organic dust exposure independent of ...

    • The Impact of Diet and Betel Nut Use on Skin Lesions Associated with Drinking-Water Arsenic in Pabna, Bangladesh 

      McCarty, Kathleen M.; Houseman, Eugene Andres; Quamruzzaman, Quazi; Rahman, Mahmuder; Mahiuddin, Golam; Smith, Thomas J.; Ryan, Louise Marie; Christiani, David C. (National Institute of Environmental Health Sciences, 2005)
      An established exposure–response relationship exists between water arsenic levels and skin lesions. Results of previous studies with limited historical exposure data, and laboratory animal studies suggest that diet may ...

    • Impact of environmental microbiota on human microbiota of workers in academic mouse research facilities: An observational study 

      Lai, Peggy Sue; Allen, Joseph Gardner; Hutchinson, Diane S.; Ajami, Nadim J.; Petrosino, Joseph F.; Winters, Thomas H.; Hug, Christopher; Wartenberg, Gary R.; Vallarino, Jose A.; Christiani, David Christopher (Public Library of Science (PLoS), 2017)

    • In-Home Solid Fuel Use and Cardiovascular Disease: A Cross-Sectional Analysis of the Shanghai Putuo Study 

      Lee, Mi-Sun; Hang, Jing-qing; Zhang, Feng-ying; Dai, He-lian; Su, Li; Christiani, David C. (BioMed Central, 2012)
      Background: Although recent research evidence suggests an association between household air pollution from solid fuel use, such as coal or biomass, and cardiovascular events such as hypertension, little epidemiologic data ...

    • Increased Risk of Respiratory Mortality Associated with the High-Tech Manufacturing Industry: A 26-Year Study 

      Lin, Ro-Ting; Christiani, David Christopher; Kawachi, Ichiro; Chan, Ta-Chien; Chiang, Po-Huang; Chan, Chang-Chuan (MDPI AG, 2016)
      Global high-tech manufacturers are mainly located in newly industrialized countries, raising concerns about adverse health consequences from industrial pollution for people living nearby. We investigated the ecological ...

    • Inflammation and Immune-Related Candidate Gene Associations with Acute Lung Injury Susceptibility and Severity: A Validation Study 

      O'Mahony, D. Shane; Glavan, Bradford J.; Holden, Tarah D.; Fong, Christie; Black, R. Anthony; Rona, Gail; Tejera, Paul; Christiani, David C.; Wurfel, Mark M. (Public Library of Science, 2012)
      Introduction: Common variants in genes related to inflammation, innate immunity, epithelial cell function, and angiogenesis have been reported to be associated with risks for Acute Lung Injury (ALI) and related outcomes. ...

    • Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies 

      Zaitlen, Noah; Lindström, Sara; Pasaniuc, Bogdan; Cornelis, Marilyn; Genovese, Giulio; Pollack, Samuela; Barton, Anne; Bickeböller, Heike; Bowden, Donald W.; Eyre, Steve; Freedman, Barry I.; Friedman, David J.; Field, John K.; Groop, Leif; Haugen, Aage; Heinrich, Joachim; Henderson, Brian E.; Hicks, Pamela J.; Hocking, Lynne J.; Kolonel, Laurence N.; Landi, Maria Teresa; Langefeld, Carl D.; Le Marchand, Loic; Meister, Michael; Morgan, Ann W.; Raji, Olaide Y.; Risch, Angela; Rosenberger, Albert; Scherf, David; Steer, Sophia; Walshaw, Martin; Waters, Kevin M.; Wilson, Anthony G.; Wordsworth, Paul; Zienolddiny, Shanbeh; Tchetgen, Eric Tchetgen; Haiman, Christopher; Hunter, David J.; Plenge, Robert M.; Worthington, Jane; Christiani, David C.; Schaumberg, Debra Ann; Chasman, Daniel Ian; Altshuler, David Matthew; Voight, Benjamin; Kraft, Peter Elias; Patterson, Nick; Price, Alkes (Public Library of Science, 2012)
      Genetic case-control association studies often include data on clinical covariates, such as body mass index (BMI), smoking status, or age, that may modify the underlying genetic risk of case or control samples. For example, ...

    • Integrating Murine Gene Expression Studies to Understand Obstructive Lung Disease due to Chronic Inhaled Endotoxin 

      Lai, Peggy Sue; Hofmann, Oliver Marc; Baron, Rebecca Marlene; Cernadas, Manuela; Meng, Quanxin Ryan; Bresler, Herbert S.; Brass, David M.; Yang, Ivana V.; Schwartz, David A.; Christiani, David C.; Hide, Winston (Public Library of Science, 2013)
      Rationale: Endotoxin is a near ubiquitous environmental exposure that that has been associated with both asthma and chronic obstructive pulmonary disease (COPD). These obstructive lung diseases have a complex pathophysiology, ...