Browsing by Author "Raby, Benjamin"

Now showing items 21-35 of 35

    • Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma 

      Raby, Benjamin Alexander; Van Steen, Kristel; Su, Jessica Ann Lasky; Tantisira, Kelan; Kaplan, Feige; Weiss, Scott Tillman (BioMed Central, 2009)
      Background: Glucocorticoid function is dependent on efficient translocation of the glucocorticoid receptor (GR) from the cytoplasm to the nucleus of cells. Importin-13 (IPO13) is a nuclear transport receptor that mediates ...

    • Increased expression of nuclear factor of activated T cells 1 drives IL-9–mediated allergic asthma 

      Koch, Sonja; Graser, Anna; Mirzakhani, Hooman; Zimmermann, Theodor; Melichar, Volker O.; Wölfel, Marco; Croteau-Chonka, Damien C; Raby, Benjamin Alexander; Weiss, Scott Tillman; Finotto, Susetta (Elsevier BV, 2016)
      Nuclear factor of activated T cells (NFAT) is a family of transcription factors activated by dephosphorylation mediated by Ca++-activated calcineurin. NFAT coordinates different aspects of T-cell development and activation ...

    • Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis 

      Bunyavanich, Supinda; Schadt, Eric E; Himes, Blanca E; Lasky-Su, Jessica; Qiu, Weiliang; Lazarus, Ross; Ziniti, John P; Cohain, Ariella; Linderman, Michael; Torgerson, Dara G; Eng, Celeste S; Pino-Yanes, Maria; Padhukasahasram, Badri; Yang, James J; Mathias, Rasika A; Beaty, Terri H; Li, Xingnan; Graves, Penelope; Romieu, Isabelle; Navarro, Blanca del Rio; Salam, M Towhid; Vora, Hita; Nicolae, Dan L; Ober, Carole; Martinez, Fernando D; Bleecker, Eugene R; Meyers, Deborah A; Gauderman, W James; Gilliland, Frank; Burchard, Esteban G; Barnes, Kathleen C; Williams, L Keoki; London, Stephanie J; Zhang, Bin; Raby, Benjamin A; Weiss, Scott T (BioMed Central, 2014)
      Background: Allergic rhinitis is a common disease whose genetic basis is incompletely explained. We report an integrated genomic analysis of allergic rhinitis. Methods: We performed genome wide association studies (GWAS) ...

    • Integration of Mouse and Human Genome-Wide Association Data Identifies KCNIP4 as an Asthma Gene 

      Sheppard, Keith; Berndt, Annerose; Leme, Adriana S.; Myers, Rachel A.; Gignoux, Christopher R.; Gauderman, W. James; Yang, James J.; Mathias, Rasika A.; Romieu, Isabelle; Torgerson, Dara G.; Roth, Lindsey A.; Huntsman, Scott; Eng, Celeste; Klanderman, Barbara; Ziniti, John; Senter-Sylvia, Jody; Szefler, Stanley J.; Lemanske, Robert F.; Zeiger, Robert S.; Strunk, Robert C.; Martinez, Fernando D.; Boushey, Homer; Chinchilli, Vernon M.; Mauger, David; Koppelman, Gerard H.; Postma, Dirkje S.; Nieuwenhuis, Maartje A. E.; Vonk, Judith M.; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Bleecker, Eugene R.; Meyers, Deborah A.; London, Stephanie J.; Gilliland, Frank D.; Burchard, Esteban G.; Nicolae, Dan L.; Ober, Carole; Paigen, Beverly; Churchill, Gary; Himes, Blanca Elena; Levin, Albert M.; Israel, Elliot; Litonjua, Augusto Ampil; Tantisira, Kelan; Raby, Benjamin Alexander; Barnes, Kathleen C.; Williams, L. Keoki; Demeo, Dawn Lisa; Silverman, Edwin Kepner; Shapiro, Steve D.; Weiss, Scott Tillman (Public Library of Science, 2013)
      Asthma is a common chronic respiratory disease characterized by airway hyperresponsiveness (AHR). The genetics of asthma have been widely studied in mouse and human, and homologous genomic regions have been associated with ...

    • Joint GWAS Analysis: Comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases 

      McGeachie, Michael John; Clemmer, George L.; Lasky-Su, Jessica A. Lasky; Dahlin, Amber Aziza; Raby, Benjamin Alexander; Weiss, Scott Tillman (Elsevier BV, 2014)
      We show here that combining two existing genome wide association studies (GWAS) yields additional biologically relevant information, beyond that obtained by either GWAS separately. We propose Joint GWAS Analysis, a method ...

    • A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations 

      Levin, Albert M.; Mathias, Rasika A.; Huang, Liling; Roth, Lindsey A.; Daley, Denise; Myers, Rachel A.; Himes, Blanca; Romieu, Isabelle; Yang, Mao; Eng, Celeste; Park, Julie E.; Zoratti, Karla; Gignoux, Christopher R.; Torgerson, Dara G.; Galanter, Joshua M.; Huntsman, Scott; Nguyen, Elizabeth A.; Becker, Allan B.; Chan-Yeung, Moira; Kozyrskyj, Anita L.; Kwok, Pui-Yan; Gilliland, Frank D.; Gauderman, W. James; Bleecker, Eugene R.; Raby, Benjamin Alexander; Meyers, Deborah A.; London, Stephanie J.; Martinez, Fernando D.; Weiss, Scott Tillman; Burchard, Esteban G.; Nicolae, Dan L.; Ober, Carole; Barnes, Kathleen C.; Williams, L. Keoki (Elsevier BV, 2013)
      Background: Immunoglobulin E (IgE) is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino individuals have not been ...

    • The metabolomics of asthma control: a promising link between genetics and disease 

      McGeachie, Michael J; Dahlin, Amber; Qiu, Weiliang; Croteau-Chonka, Damien C; Savage, Jessica; Wu, Ann Chen; Wan, Emily S; Sordillo, Joanne E; Al-Garawi, Amal; Martinez, Fernando D; Strunk, Robert C; Lemanske, Robert F; Liu, Andrew H; Raby, Benjamin A; Weiss, Scott; Clish, Clary B; Lasky-Su, Jessica A (John Wiley & Sons, Ltd, 2015)
      Short-acting β agonists (e.g., albuterol) are the most commonly used medications for asthma, a disease that affects over 300 million people in the world. Metabolomic profiling of asthmatics taking β agonists presents a new ...

    • MUC1 Inhibition Leads to Decrease in PD-L1 Levels via Up-Regulation of miRNAs 

      Pyzer, Athalia Rachel; Stroopinsky, Dina; Rosenblatt, Jacalyn Mara; Anastasiadou, Eleni; Rajabi, Hasan Nabeel; Washington, Abigail; Tagde, Ashujit; Chu, Jen-Hwa; Coll, Maxwell; Jiao, AL; Tsai, LT; Tenen, DE; Cole, Leandra Samantha; Palmer, Kristen; Ephraim, A; Leaf, Rebecca Karp; Nahas, Myrna Rita; Apel, Arie; Bar-Natan, M; Jain, Salvia; McMasters, Malgorzata; Mendez, Lourdes Maria; Arnason, Jon E; Raby, Benjamin Alexander; Slack, Frank; Kufe, Donald William; Avigan, David E. (Springer Nature, 2017)
      The PD-L1/PD-1 pathway is a critical component of the immunosuppressive tumor microenvironment in acute myeloid leukemia (AML), but little is known about its regulation. We investigated the role of the MUC1 oncoprotein in ...

    • Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis 

      Paternoster, Lavinia; Standl, Marie; Waage, Johannes; Baurecht, Hansjörg; Hotze, Melanie; Strachan, David P; Curtin, John A; Bønnelykke, Klaus; Tian, Chao; Takahashi, Atsushi; Esparza-Gordillo, Jorge; Alves, Alexessander Couto; Thyssen, Jacob P; den Dekker, Herman T; Ferreira, Manuel A; Altmaier, Elisabeth; Sleiman, Patrick MA; Xiao, Feng Li; Gonzalez, Juan R; Marenholz, Ingo; Kalb, Birgit; Yanes, Maria Pino; Xu, Cheng-Jian; Carstensen, Lisbeth; Groen-Blokhuis, Maria M; Venturini, Cristina; Pennell, Craig E; Barton, Sheila J; Levin, Albert M; Curjuric, Ivan; Bustamante, Mariona; Kreiner-Møller, Eskil; Lockett, Gabrielle A; Bacelis, Jonas; Bunyavanich, Supinda; Myers, Rachel A; Matanovic, Anja; Kumar, Ashish; Tung, Joyce Y; Hirota, Tomomitsu; Kubo, Michiaki; McArdle, Wendy L; Henderson, A J; Kemp, John P; Zheng, Jie; Smith, George Davey; Rüschendorf, Franz; Bauerfeind, Anja; Lee-Kirsch, Min Ae; Arnold, Andreas; Homuth, Georg; Schmidt, Carsten O; Mangold, Elisabeth; Cichon, Sven; Keil, Thomas; Rodríguez, Elke; Peters, Annette; Franke, Andre; Lieb, Wolfgang; Novak, Natalija; Fölster-Holst, Regina; Horikoshi, Momoko; Pekkanen, Juha; Sebert, Sylvain; Husemoen, Lise L; Grarup, Niels; de Jongste, Johan C; Rivadeneira, Fernando; Hofman, Albert; Jaddoe, Vincent WV; Pasmans, Suzanne GMA; Elbert, Niels J; Uitterlinden, André G; Marks, Guy B; Thompson, Philip J; Matheson, Melanie C; Robertson, Colin F; Ried, Janina S; Li, Jin; Zuo, Xian Bo; Zheng, Xiao Dong; Yin, Xian Yong; Sun, Liang Dan; McAleer, Maeve A; O'Regan, Grainne M; Fahy, Caoimhe MR; Campbell, Linda E; Macek, Milan; Kurek, Michael; Hu, Donglei; Eng, Celeste; Postma, Dirkje S; Feenstra, Bjarke; Geller, Frank; Hottenga, Jouke Jan; Middeldorp, Christel M; Hysi, Pirro; Bataille, Veronique; Spector, Tim; Tiesler, Carla MT; Thiering, Elisabeth; Pahukasahasram, Badri; Yang, James J; Imboden, Medea; Huntsman, Scott; Vilor-Tejedor, Natàlia; Relton, Caroline L; Myhre, Ronny; Nystad, Wenche; Custovic, Adnan; Weiss, Scott T; Meyers, Deborah A; Söderhäll, Cilla; Melén, Erik; Ober, Carole; Raby, Benjamin A; Simpson, Angela; Jacobsson, Bo; Holloway, John W; Bisgaard, Hans; Sunyer, Jordi; Hensch, Nicole M Probst; Williams, L Keoki; Godfrey, Keith M; Wang, Carol A; Boomsma, Dorret I; Melbye, Mads; Koppelman, Gerard H; Jarvis, Deborah; McLean, WH Irwin; Irvine, Alan D; Zhang, Xue Jun; Hakonarson, Hakon; Gieger, Christian; Burchard, Esteban G; Martin, Nicholas G; Duijts, Liesbeth; Linneberg, Allan; Jarvelin, Marjo-Riitta; Noethen, Markus M; Lau, Susanne; Hübner, Norbert; Lee, Young-Ae; Tamari, Mayumi; Hinds, David A; Glass, Daniel; Brown, Sara J; Heinrich, Joachim; Evans, David M; Weidinger, Stephan (2015)
      Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common complex skin disease, ...

    • Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma 

      McGeachie, Michael John; Yates, Katherine; Zhou, Xiaobo; Guo, Feng; Sternberg, Alice L.; Van Natta, Mark L.; Wise, Robert A.; Szefler, Stanley J.; Sharma, Sunita; Kho, Alvin Thong-Juak; Cho, Michael Hyosang; Croteau-Chonka, Damien C; Castaldi, Peter Jose; Jain, Gaurav; Sanyal, Amartya; Zhan, Ye; Lajoie, Bryan R.; Dekker, Job; Stamatoyannopoulos, John; Covar, Ronina A.; Zeiger, Robert S.; Adkinson, N. Franklin; Williams, Paul; Kelly, H. William; Grasemann, Hartmut; Vonk, Judith M.; Koppelman, Gerard H.; Postma, Dirkje S.; Raby, Benjamin Alexander; Houston, Isaac Benjamin; Lu, Quan; Fuhlbrigge, Anne Louise; Tantisira, Kelan; Silverman, Edwin Kepner; Tonascia, James; Weiss, Scott Tillman; Strunk, Robert C. (New England Journal of Medicine (NEJM/MMS), 2016)
      BACKGROUND: Tracking longitudinal measurements of growth and decline in lung function in patients with persistent childhood asthma may reveal links between asthma and subsequent chronic airflow obstruction. METHODS: We ...

    • Polymorphisms in IL12A and Cockroach Allergy in Children with Asthma 

      Pistiner, Michael; Hunninghake, Gary Matthew; Soto-Quiros, Manuel E; Avila, Lydiana; Murphy, Amy; Su, Jessica Ann Lasky; Schuemann, Brooke; Klanderman, Barbara Jordan; Raby, Benjamin Alexander; Celedón, Juan C (BioMed Central, 2008)
      Background: IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases. Methods: We tested for association between four linkage disequilibrium (LD)-tagging SNPs ...

    • TSLP Polymorphisms are Associated with Asthma in a Sex-Specific Fashion 

      Hunninghake, Gary; Soto-Quirós, Manuel E.; Avila, Lydiana; Kim, Hong P.; Lasky‐Su, Jessica A.; Rafaels, Nicholas; Ruczinski, Ingo; Beaty, Terry H.; Mathias, Rasika A.; Barnes, Kathleen C.; Wilk, Jemma B.; O’Connor, George T.; Gauderman, W. James; Vora, Hita; Baurley, James W.; Gilliland, Frank; Liang, Catherine; Sylvia, Jody; Klanderman, Barbara; Sharma, Sunita; Himes, Blanca E.; Bossley, Cara J.; Israel, Elliot; Raby, Benjamin; Bush, Andrew; Choi, Augustine M.K.; Weiss, Scott; Celedón, Juan C. (Wiley, 2010-12)
      Background Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma ...

    • Using Canonical Correlation Analysis to Discover Genetic Regulatory Variants 

      Naylor, Melissa G.; Lin, Xihong; Weiss, Scott Tillman; Raby, Benjamin Alexander; Lange, Christoph (Public Library of Science, 2010)
      Background: Discovering genetic associations between genetic markers and gene expression levels can provide insight into gene regulation and, potentially, mechanisms of disease. Such analyses typically involve a linkage ...

    • Very important pharmacogene summary for VDR 

      Poon, Audrey H.; Gong, Li; Brasch-Andersen, Charlotte; Litonjua, Augusto Ampil; Raby, Benjamin Alexander; Hamid, Qutayba; Laprise, Catherine; Weiss, Scott Tillman; Altman, Russ B.; Klein, Teri E. (Ovid Technologies (Wolters Kluwer Health), 2012)

    • Whole genome prediction and heritability of childhood asthma phenotypes 

      McGeachie, Michael J.; Clemmer, George L.; Croteau‐Chonka, Damien C.; Castaldi, Peter J.; Cho, Michael H.; Sordillo, Joanne E.; Lasky‐Su, Jessica A.; Raby, Benjamin A.; Tantisira, Kelan G.; Weiss, Scott T. (John Wiley and Sons Inc., 2016)
      Abstract Introduction: While whole genome prediction (WGP) methods have recently demonstrated successes in the prediction of complex genetic diseases, they have not yet been applied to asthma and related phenotypes. ...