Now showing items 21-40 of 1236

    • Adiabatic quantum optimization in the presence of discrete noise: Reducing the problem dimensionality 

      Mandra, Salvatore; Guerreschi, Gian Giacomo; Aspuru-Guzik, Alan (American Physical Society (APS), 2015)
      Adiabatic quantum optimization is a procedure to solve a vast class of optimization problems by slowly changing the Hamiltonian of a quantum system. The evolution time necessary for the algorithm to be successful scales ...
    • Adiabatic Quantum Simulation of Quantum Chemistry 

      Babbush, Ryan Joseph; Love, Peter; Aspuru-Guzik, Alan (Nature Publishing Group, 2014)
      We show how to apply the quantum adiabatic algorithm directly to the quantum computation of molecular properties. We describe a procedure to map electronic structure Hamiltonians to 2-body qubit Hamiltonians with a small ...
    • Adiabatic Quantum Simulators 

      Biamonte, J. D; Bergholm, V.; Whitfield, James D.; Fitzsimons, J.; Aspuru-Guzik, Alan (2011)
      In his famous 1981 talk, Feynman proposed that unlike classical computers, which would presumably experience an exponential slowdown when simulating quantum phenomena, a universal quantum simulator would not. An ideal ...
    • Advanced atomic layer deposition and epitaxy processes 

      Gordon, Roy Gerald; Lou, Xiabing; Kim, Sang Bok (2015)
      Atomic Layer Deposition (ALD) was used to grow single-crystalline epitaxial layers of high-k dielectric oxides on semiconductors with remarkably few defects or traps at the interfaces. La2O3 on GaAs(111) produced record-breaking ...
    • Advanced Metallization Processes for Complex Structures in Microelectronics by Direct-Liquid-Evaporation Chemical Vapor Deposition 

      Feng, Jun (2017-07-27)
      With the rapid advancement of semiconductor industry, fabrications of complex microelectronic devices are going beyond the conventional planar geometries into three-dimensionality (3D). Besides, since the emerging of ...
    • Advanced Physical Techniques in Inorganic Chemistry: Probing Small Molecule Activation 

      Anderson, Bryce L. (2016-05-16)
      Robust and efficient catalysts are necessary for realizing chemical energy storage as a solution for the intermittency associated with renewable energy sources. To aid in the development of such catalysts, physical methods ...
    • Advances in Crystal Growth and Assembly for Imparting Novel Photonic Properties to Semiconductor Nanowires 

      Mankin, Max Nathan (2015-08-17)
      Semiconductor nanowires comprise a versatile materials platform with which to characterize the properties of nanomaterials. The vast range of structural and compositional diversity of nanowires has also enabled their use ...
    • Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes 

      Schreiber, Stuart L.; Kotz, Joanne D.; Li, Min; Aubé, Jeffrey; Austin, Christopher P.; Reed, John C.; Rosen, Hugh; White, E. Lucile; Sklar, Larry A.; Lindsley, Craig W.; Alexander, Benjamin R.; Bittker, Joshua A.; Clemons, Paul A.; de Souza, Andrea; Foley, M; Palmer, Michelle; Shamji, Alykhan Farid; Wawer, Mathias J.; McManus, Owen; Wu, Meng; Zou, Beiyan; Yu, Haibo; Golden, Jennifer E.; Schoenen, Frank J.; Simeonov, Anton; Jadhav, Ajit; Jackson, Michael R.; Pinkerton, Anthony B.; Chung, Thomas D.Y.; Griffin, Patrick R.; Cravatt, Benjamin F.; Hodder, Peter S.; Roush, William R.; Roberts, Edward; Chung, Dong-Hoon; Jonsson, Colleen B.; Noah, James W.; Severson, William E.; Ananthan, Subramaniam; Edwards, Bruce; Oprea, Tudor I.; Conn, P. Jeffrey; Hopkins, Corey R.; Wood, Michael R.; Stauffer, Shaun R.; Emmitte, Kyle A.; Brady, Linda S.; Driscoll, Jamie; Li, Ingrid Y.; Loomis, Carson R.; Margolis, Ronald N.; Michelotti, Enrique; Perry, Mary E.; Pillai, Ajay; Yao, Yong (Elsevier BV, 2015)
      Small-molecule probes can illuminate biological processes and aid in the assessment of emerging therapeutic targets by perturbing biological systems in a manner distinct from other experimental approaches. Despite the ...
    • ALD of Manganese Silicate 

      Gordon, Roy Gerald; Sun, Lu; Chen, Qiang; Park, Jin-Seong; Kim, Sang Bok (2015)
    • All-Atom Model for Stabilization of α-Helical Structure in Peptides by Hydrocarbon Staples 

      Kutchukian, Peter S.; Yang, Jae Shick; Verdine, Gregory L.; Shakhnovich, Eugene Isaacovitch (American Chemical Society (ACS), 2009)
      Recent work has shown that the incorporation of an all-hydrocarbon “staple” into peptides can greatly increase their α-helix propensity, leading to an improvement in pharmaceutical properties such as proteolytic stability, ...
    • All-Optical Interrogation of Neural Circuits 

      Emiliani, V.; Cohen, Adam Ezra; Deisseroth, K.; Hausser, M. (Society for Neuroscience, 2015)
      There have been two recent revolutionary advances in neuroscience: First, genetically encoded activity sensors have brought the goal of optical detection of single action potentials in vivo within reach. Second, optogenetic ...
    • Allene Synthesis from 2-Alkyn-1-Ols 

      Myers, Andrew; Finney, Nathaniel S.; Kuo, Elaine Y. (Elsevier, 1989)
      Activation of 2-alkyn-1-01s as their methanesulfonate esters and displacement with hydrazine urnishes the corresponding alkynyl hydrazine derivatives which undergo smooth oxidative rearrangement with diethyl azodicarboxylate ...
    • Allosteric Communication in Myosin V: From Small Conformational Changes to Large Directed Movements 

      Cecchini, M.; Houdusse, A.; Karplus, Martin (Public Library of Science, 2008)
      The rigor to post-rigor transition in myosin, a consequence of ATP binding, plays an essential role in the Lymn–Taylor functional cycle because it results in the dissociation of the actomyosin complex after the powerstroke. ...
    • Alternating layer addition approach to CdSe/CdS core/shell quantum dots with near-unity quantum yield and high on-time fractions 

      Greytak, Andrew B.; Allen, Peter M.; Liu, Wenhao; Zhao, Jing; Young, Elizabeth R.; Popovic, Zoran; Walker, Brian J.; Nocera, Daniel; Bawendi, Moungi G. (Royal Society of Chemistry (RSC), 2012)
      We report single-particle photoluminescence (PL) intermittency (blinking) with high on-time fractions in colloidal CdSe quantum dots (QD) with conformal CdS shells of 1.4 nm thickness, equivalent to approximately 4 CdS ...
    • Amino Acid Metabolic Origin as an Evolutionary Influence on Protein Sequence in Yeast 

      de Bivort, Benjamin Lovegren; Perlstein, Ethan O.; Kunes, Samuel M.; Schreiber, Stuart L. (Springer-Verlag, 2009)
      The metabolic cycle of Saccharomyces cerevisiae consists of alternating oxidative (respiration) and reductive (glycolysis) energy-yielding reactions. The intracellular concentrations of amino acid precursors generated by ...
    • Analog Modeling of Worm-Like Chain Molecules Using Macroscopic Beads-on-a-String 

      Tricard, Simon; Feinstein, Efraim; Shepherd, Robert F.; Reches, Meital; Snyder, Phillip W.; Bandarage, Dileni C.; Prentiss, Mara; Whitesides, George M. (Royal Society of Chemistry (RSC), 2012)
      This paper describes an empirical model of polymer dynamics, based on the agitation of millimeter-sized polymeric beads. Although the interactions between the particles in the macroscopic model, and those between the ...
    • Analysis of Inorganic Polyphosphates by Capillary Gel Electrophoresis 

      Lee, Andrew; Whitesides, George M. (American Chemical Society, 2010)
      This paper describes the development of a method that uses capillary gel electrophoresis (CGE) to analyze mixtures of inorganic polyphosphate ((P\(_i\))\(_n\)). Resolution of (P\(_i\))\(_n\) on the basis of n, the number ...
    • Analytical Devices Based on Direct Synthesis of DNA on Paper 

      Glavan, Ana C; Niu, Jia; Chen, Zhen; Güder, Firat; Cheng, Chao-Min; Liu, David Ruchien; Whitesides, George McClelland (American Chemical Society (ACS), 2016)
      This paper addresses a growing need in clinical diagnostics for parallel, multiplex analysis of biomarkers from small biological samples. It describes a new procedure for assembling microarrays of ssDNA and proteins on ...
    • Analytical nuclear gradients for the range-separated many-body dispersion model of noncovalent interactions 

      Blood-Forsythe, Martin; Markovich, Thomas Lee; DiStasio, Robert A.; Car, Roberto; Aspuru-Guzik, Alan (Royal Society of Chemistry (RSC), 2016)
      An accurate treatment of the long-range electron correlation energy, including van der Waals (vdW) or dispersion interactions, is essential for describing the structure, dynamics, and function of a wide variety of systems. ...