Browsing by FAS Department "Medical Sciences"
Now showing items 21-40 of 256
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CD4 T Cells Regulate Adenovirus Vector-Elicited Cellular and Humoral Immune Responses
(2016-01-08)The processes that regulate viral vector vaccine-elicited cellular and humoral immune responses remain poorly defined. Thus, in this thesis, the role of CD4+ T cells – master regulators of adaptive immunity – in modulating ... -
Cell Shape and Treatment Duration: How They Influence a Cancer Cell's Response to TNF
(2016-05-17)The purpose of my research was to investigate the sources of heterogeneity in cellular decisions that are based on both external and internal cues. I used the signaling network induced by tumor necrosis factor (TNF) as a ... -
Cellular and Molecular Mechanisms of Chronic Inflammation in Aging of Skeletal Muscle
(2015-05-13)Aging of skeletal muscle is typically accompanied by declining regenerative potential, due in part to alternations in the resident muscle stem cell population, known as satellite cells. Previous data suggest that highly ... -
Cellular Metabolism Modulates Ion Channels That Regulate Neuronal Excitability
(2015-05-01)Epilepsy is a common neurological disorder, affecting around 1% of the world’s population. For many, drugs are available that can prevent their seizures. However, for close to one third of those who suffer from epilepsy, ... -
Central Control Circuit for Context-Dependent Micturition
(2016-12-13)Precise control of urine release (micturition) serves an essential physiological function, as well as a critical role in social communication in many animals. Here we show a combined effect of olfaction and social hierarchy ... -
Characterization and Disruption of Cis Regulatory Elements in Cancer
(2016-05-11)Enhancers are cis regulatory elements that play key roles in the control of cell-type specific gene expression programs. In cancer, enhancer deregulation plays a key role in maintaining gene regulatory programs that underlie ... -
Characterization of Dopamine-Responsive Serotonergic Neurons Underlying Aggression Modulation
(2016-04-04)The monoaminergic neuromodulatory systems (including the noraderenergic, serotonergic, and dopaminergic neuronal systems) have long been thought of as the custodians of mental health. Dysfunction amongst these neural ... -
Childhood Resistance to Influenza Mortality: Analysis in a Mouse Model
(2016-08-29)During the 1918 influenza pandemic, children experienced significantly lower mortality compared to adults, with the onset of puberty marking a transition to greater disease susceptibility. To explore the mechanisms that ... -
Clonal analysis of native and malignant hematopoiesis using color barcoding in zebrafish
(2018-01-19)Hematopoietic stem cells (HSCs) emerge from the dorsal aorta during embryogenesis and sustain lifelong blood production. Over time, HSC clones accumulate mutations that may cause clonal expansion at the expense of normal ... -
Coding of Internal Senses: Vagal Gut-to-Brain Circuits
(2016-05-17)Our ability to detect features of environments in and around us is fundamental. Organisms have developed highly specialized systems to allow for transduction of a broad variety of stimuli to convey sensory information to ... -
Combinatorial Pathway Modulation Toward Ex Vivo Maintenance and Propagation of Hematopoietic Stem Cells
(2016-05-18)Hematopoietic stem cells (HSCs) sustain continuous turnover and maintenance of all blood lineages through organismal lifespan. The extensive regenerative potential of HSCs has been harnessed in transplantation medicine ... -
Computational and Statistical Methods for Characterizing Single-Cell Heterogeneity
(2018-01-19)The emergence of single-cell technologies has highlighted the potential to discover novel cellular subpopulations and states within heterogeneous populations. Such technologies are achieving increasingly higher-throughput, ... -
Consequences of Caspase Inhibition in Differentiating Myoblasts
(2017-09-07)The apoptotic caspases are proteases that mediate the process of programmed cell death. Canonically, their activation is a point of no return; however, the disruption of myoblast differentiation resulting from caspase ... -
Contextual Modulation of Early Visual Processing and the Role of Cortico-Cortical Feedback
(2016-05-14)How does the brain form a useful representation of its external environment from the astoundingly complex patterns of sensory signals it receives? This question has motivated the field of systems neuroscience for decades. ... -
The Contribution of Cervicovaginal Microbiota and Hormonal Contraceptives to Genital Inflammation and HIV Acquisition Risk
(2015-05-17)The HIV epidemic persists in many parts of the world, with the majority of new infections occurring through the female genital tract (FGT). The permissiveness of the genital mucosa to HIV is modulated by the integrity of ... -
Control of Drosophila Courtship by Mating Drive
(2018-09-16)Most behaviors are not just actions and reactions, but are the result of self-evaluation and are the means of self-fulfillment. This means that the same external context (e.g. food) can hold different meaning to an animal ... -
Cooperative Binding of Sir Proteins to Nucleosomes and Its Implications for Silent Chromatin Assembly in Saccharomyces Cerevisiae
(2015-05-17)Silent chromatin, or heterochromatin, refers to regions of the genome in which genes are constitutively repressed. These regions are important for regulating developmental genes and for maintaining genome stability, and ... -
Coordinate control of virulence gene expression in Francisella tularensis
(2015-05-19)Francisella tularensis is a Gram-negative, intracellular pathogen and the causative agent of tularemia. Due to its low infectious dose, ability to cause potentially fatal disease, and ability to be easily aerosolized, ... -
Cutaneous Papillomavirus E6 Inhibit NOTCH and TGF-Beta Signaling to Disrupt Keratinocyte Differentiation.
(2017-01-19)Cutaneous beta-papillomaviruses are associated with non-melanoma skin cancers that arise in patients who suffer from a rare genetic disorder, Epidermodysplasia Verruciformis or after immunosuppression following organ ... -
Defining a Role for T Regulatory Cell Expressed MyD88 During the Response to Allografts
(2015-11-16)The myeloid differentiation primary response gene 88 (MyD88) is an adaptor protein proximally downstream of the Toll-like receptor (TLRs) and the IL-1 receptor family (IL-1R, IL- 18R and IL-33R). The TLR-MyD88 signaling ...