Now showing items 41-60 of 165

    • Cardiac Autonomic Dysfunction: Particulate Air Pollution Effects Are Modulated by Epigenetic Immunoregulation of Toll‐like Receptor 2 and Dietary Flavonoid Intake 

      Zhong, Jia; Colicino, Elena; Lin, Xinyi; Mehta, Amar; Kloog, Itai; Zanobetti, Antonella; Byun, Hyang‐Min; Bind, Marie‐Abèle; Cantone, Laura; Prada, Diddier; Tarantini, Letizia; Trevisi, Letizia; Sparrow, David; Vokonas, Pantel; Schwartz, Joel; Baccarelli, Andrea A. (Blackwell Publishing Ltd, 2015)
      Background: Short‐term fine particles (PM2.5) exposure is associated with reduced heart rate variability, a strong predictor of cardiac mortality among older people. Identifying modifiable factors that confer susceptibility ...
    • A Case–Control Analysis of Exposure to Traffic and Acute Myocardial Infarction 

      Tonne, Cathryn; Melly, Steven John; Mittleman, Murray A.; Coull, Brent Andrew; Goldberg, Robert; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2006)
      Background: Long-term exposure to particulate air pollution has been associated with an increased risk of dying from cardiopulmonary and ischemic heart disease, yet few studies have evaluated cardiovascular end points other ...
    • Chimney Stove Intervention to Reduce Long-term Wood Smoke Exposure Lowers Blood Pressure among Guatemalan Women 

      McCracken, John Patrick; Smith, Kirk R.; Díaz, Anaité; Mittleman, Murray A.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2007)
      Background and Objective: RESPIRE, a randomized trial of an improved cookstove, was conducted in Guatemala to assess health effects of long-term reductions in wood smoke exposure. Given the evidence that ambient particles ...
    • Chronic effects of temperature on mortality in the Southeastern USA using satellite-based exposure metrics 

      Shi, Liuhua; Liu, Pengfei; Wang, Yan; Zanobetti, Antonella; Kosheleva, Anna; Koutrakis, Petros; Schwartz, Joel (Nature Publishing Group, 2016)
      Climate change may affect human health, particularly for elderly individuals who are vulnerable to temperature changes. While many studies have investigated the acute effects of heat, only a few have dealt with the chronic ...
    • Chronic Exposure to Fine Particles and Mortality: An Extended Follow-up of the Harvard Six Cities Study from 1974 to 2009 

      Lepeule, Johanna; Laden, Francine; Dockery, Douglas W.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2012)
      Background: Epidemiologic studies have reported associations between fine particles (aerodynamic diameter ≤ 2.5 µm; PM:2.5) and mortality. However, concerns have been raised regarding the sensitivity of the results to model ...
    • Chronic Fine and Coarse Particulate Exposure, Mortality, and Coronary Heart Disease in the Nurses’ Health Study 

      Puett, Robin C.; Yanosky, Jeff D; Hart, Jaime Elizabeth; Paciorek, Christopher Joseph; Schwartz, Joel David; Suh MacIntosh, Helen H.; Speizer, Frank Erwin; Laden, Francine (National Institute of Environmental Health Sciences, 2009)
      Background: The relationship of fine particulate matter < 2.5 μm in diameter (PM2.5) air pollution with mortality and cardiovascular disease is well established, with more recent long-term studies reporting larger effect ...
    • Comparison of multiplexed reduced representation bisulfite sequencing (mRRBS) with the 450K Illumina Human BeadChip: from concordance to practical applications for methylomic profiling in epigenetic epidemiologic studies 

      Carmona, Juan Jose; Izzi, Benedetta; Just, Allan Carpenter; Barupal, Jitendra; Binder, Alexandra Margaret Lynn; Hutchinson, John N; Hofmann, Oliver Marc; Schwartz, Joel David; Baccarelli, Andrea; Michels, Karin B. (BioMed Central, 2013)
    • The Concentration-Response Relation Between PM\(_{2.5}\) and Daily Deaths. 

      Schwartz, Joel David; Laden, Francine; Zanobetti, Antonella (National Institute of Environmental Health Sciences, 2002)
      Particulate air pollution at commonly occurring concentrations is associated with daily deaths. Recent attention has focused on the shape of the concentration-response curve, particularly at low doses. Several recent ...
    • Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study 

      Perlstein, Todd Steven; Weuve, Jennifer Lynn; Schwartz, Joel David; Sparrow, David; Wright, Robert O.; Litonjua, Augusto Ampil; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007)
      Background: Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote ...
    • Cumulative Exposure to Lead in Relation to Cognitive Function in Older Women 

      Weuve, Jennifer Lynn; Korrick, Susan Abigail; Weisskopf, Marc G.; Ryan, Louise Marie; Schwartz, Joel David; Nie, Huiling; Grodstein, Francine; Hu, Howard (National Institute of Environmental Health Sciences, 2008)
      Background: Recent data indicate that chronic low-level exposure to lead is associated with accelerated declines in cognition in older age, but this has not been examined in women. Objective: We examined biomarkers of lead ...
    • Decreased PM10 Exposure Attenuates Age-Related Lung Function Decline: Genetic Variants in p53, p21, and CCND1 Modify This Effect 

      Imboden, Medea; Schwartz, Joel David; Schindler, Christian; Curjuric, Ivan; Berger, Wolfgang; Liu, Sally L.J.; Russi, Erich W.; Ackermann-Liebrich, Ursula; Rochat, Thierry; Probst-Hensch, Nicole M. (National Institute of Environmental Health Sciences, 2009)
      Background: Decreasing exposure to airborne particulates was previously associated with reduced age-related decline in lung function. However, whether the benefit from improved air quality depends on genetic background is ...
    • A delta-aminolevulinic acid dehydratase (ALAD) polymorphism may modify the relationship of low-level lead exposure to uricemia and renal function: the normative aging study. 

      Wu, Ming-Tsang; Kelsey, Karl; Schwartz, Joel David; Sparrow, David; Weiss, Scott Tillman; Hu, Howard (2003)
      In this study we investigated whether a known delta-aminolevulinic acid dehydratase (ALAD) exon 4 polymorphism has a modifying effect on the association of blood or bone lead level with uricemia and indices of renal function ...
    • Diabetes, Obesity, and Hypertension May Enhance Associations between Air Pollution and Markers of Systemic Inflammation 

      Dubowsky, Sara D.; Suh, Helen; Schwartz, Joel David; Coull, Brent Andrew; Gold, Diane R. (National Institute of Environmental Health Sciences, 2006)
      Airborne particulate matter (PM) may lead to increased cardiac risk through an inflammatory pathway. Therefore, we investigated associations between ambient PM and markers of systemic inflammation among repeated measures ...
    • Dietary anthocyanin intake and age-related decline in lung function: longitudinal findings from the VA Normative Aging Study123 

      Mehta, Amar J; Cassidy, Aedín; Litonjua, Augusto A; Sparrow, David; Vokonas, Pantel; Schwartz, Joel (American Society for Nutrition, 2016)
      Background: It is unknown whether habitual intake of dietary flavonoids, known for their antioxidative and anti-inflammatory properties, affects longitudinal change in lung function. Objective: We investigated whether ...
    • Differences in Heart Rate Variability Associated with Long-Term Exposure to NO2 

      Dietrich, Denise Felber; Gemperli, Armin; Gaspoz, Jean-Michel; Schindler, Christian; Rochat, Thierry; Barthélémy, Jean-Claude; Pons, Marco; Roche, Frédéric; Probst Hensch, Nicole M.; Bridevaux, Pierre-Olivier; Gerbase, Margaret W.; Neu, Urs; Ackermann-Liebrich, Ursula; Liu, L.-J. Sally; Gold, Diane R.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2008)
      Background: Heart rate variability (HRV), a measure of cardiac autonomic tone, has been associated with cardiovascular morbidity and mortality. Short-term studies have shown that subjects exposed to higher traffic-associated ...
    • DNA methylation age of blood predicts all-cause mortality in later life 

      Marioni, Riccardo E; Shah, Sonia; McRae, Allan F; Chen, Brian H; Colicino, Elena; Harris, Sarah E; Gibson, Jude; Henders, Anjali K; Redmond, Paul; Cox, Simon R; Pattie, Alison; Corley, Janie; Murphy, Lee; Martin, Nicholas G; Montgomery, Grant W; Feinberg, Andrew P; Fallin, M Daniele; Multhaup, Michael L; Jaffe, Andrew E; Joehanes, Roby; Schwartz, Joel; Just, Allan C; Lunetta, Kathryn L; Murabito, Joanne M; Starr, John M; Horvath, Steve; Baccarelli, Andrea A; Levy, Daniel; Visscher, Peter M; Wray, Naomi R; Deary, Ian J (BioMed Central, 2015)
      Background: DNA methylation levels change with age. Recent studies have identified biomarkers of chronological age based on DNA methylation levels. It is not yet known whether DNA methylation age captures aspects of ...
    • DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases 

      Ligthart, Symen; Marzi, Carola; Aslibekyan, Stella; Mendelson, Michael M.; Conneely, Karen N.; Tanaka, Toshiko; Colicino, Elena; Waite, Lindsay L.; Joehanes, Roby; Guan, Weihua; Brody, Jennifer A.; Elks, Cathy; Marioni, Riccardo; Jhun, Min A.; Agha, Golareh; Bressler, Jan; Ward-Caviness, Cavin K.; Chen, Brian H.; Huan, Tianxiao; Bakulski, Kelly; Salfati, Elias L.; Fiorito, Giovanni; Wahl, Simone; Schramm, Katharina; Sha, Jin; Hernandez, Dena G.; Just, Allan C.; Smith, Jennifer A.; Sotoodehnia, Nona; Pilling, Luke C.; Pankow, James S.; Tsao, Phil S.; Liu, Chunyu; Zhao, Wei; Guarrera, Simonetta; Michopoulos, Vasiliki J.; Smith, Alicia K.; Peters, Marjolein J.; Melzer, David; Vokonas, Pantel; Fornage, Myriam; Prokisch, Holger; Bis, Joshua C.; Chu, Audrey Y.; Herder, Christian; Grallert, Harald; Yao, Chen; Shah, Sonia; McRae, Allan F.; Lin, Honghuang; Horvath, Steve; Fallin, Daniele; Hofman, Albert; Wareham, Nicholas J.; Wiggins, Kerri L.; Feinberg, Andrew P.; Starr, John M.; Visscher, Peter M.; Murabito, Joanne M.; Kardia, Sharon L. R.; Absher, Devin M.; Binder, Elisabeth B.; Singleton, Andrew B.; Bandinelli, Stefania; Peters, Annette; Waldenberger, Melanie; Matullo, Giuseppe; Schwartz, Joel D.; Demerath, Ellen W.; Uitterlinden, André G.; van Meurs, Joyce B. J.; Franco, Oscar H.; Chen, Yii-Der Ida; Levy, Daniel; Turner, Stephen T.; Deary, Ian J.; Ressler, Kerry J.; Dupuis, Josée; Ferrucci, Luigi; Ong, Ken K.; Assimes, Themistocles L.; Boerwinkle, Eric; Koenig, Wolfgang; Arnett, Donna K.; Baccarelli, Andrea A.; Benjamin, Emelia J.; Dehghan, Abbas (BioMed Central, 2016)
      Background: Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade ...
    • DNA methylation-based measures of biological age: meta-analysis predicting time to death 

      Chen, Brian H.; Marioni, Riccardo E.; Colicino, Elena; Peters, Marjolein J.; Ward-Caviness, Cavin K.; Tsai, Pei-Chien; Roetker, Nicholas S.; Just, Allan C.; Demerath, Ellen W.; Guan, Weihua; Bressler, Jan; Fornage, Myriam; Studenski, Stephanie; Vandiver, Amy R.; Moore, Ann Zenobia; Tanaka, Toshiko; Kiel, Douglas P.; Liang, Liming; Vokonas, Pantel; Schwartz, Joel; Lunetta, Kathryn L.; Murabito, Joanne M.; Bandinelli, Stefania; Hernandez, Dena G.; Melzer, David; Nalls, Michael; Pilling, Luke C.; Price, Timothy R.; Singleton, Andrew B.; Gieger, Christian; Holle, Rolf; Kretschmer, Anja; Kronenberg, Florian; Kunze, Sonja; Linseisen, Jakob; Meisinger, Christine; Rathmann, Wolfgang; Waldenberger, Melanie; Visscher, Peter M.; Shah, Sonia; Wray, Naomi R.; McRae, Allan F.; Franco, Oscar H.; Hofman, Albert; Uitterlinden, André G.; Absher, Devin; Assimes, Themistocles; Levine, Morgan E.; Lu, Ake T.; Tsao, Philip S.; Hou, Lifang; Manson, JoAnn E.; Carty, Cara L.; LaCroix, Andrea Z.; Reiner, Alexander P.; Spector, Tim D.; Feinberg, Andrew P.; Levy, Daniel; Baccarelli, Andrea; van Meurs, Joyce; Bell, Jordana T.; Peters, Annette; Deary, Ian J.; Pankow, James S.; Ferrucci, Luigi; Horvath, Steve (Impact Journals LLC, 2016)
      Estimates of biological age based on DNA methylation patterns, often referred to as “epigenetic age”, “DNAm age”, have been shown to be robust biomarkers of age in humans. We previously demonstrated that independent of ...
    • Effect modification by vitamin D receptor genetic polymorphisms in the association between cumulative lead exposure and pulse pressure: a longitudinal study 

      Jhun, Min A; Hu, Howard; Schwartz, Joel; Weisskopf, Marc G; Nie, Linda H; Sparrow, David; Vokonas, Pantel S; Park, Sung Kyun (BioMed Central, 2015)
      Background: Although the association between lead and cardiovascular disease is well established, potential mechanisms are still poorly understood. Calcium metabolism plays a role in lead toxicity and thus, vitamin D ...
    • Effect Modification of Air Pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by Genotypes: An Application of the Multiple Testing Procedure to Identify Significant SNP Interactions 

      Ren, Cizao; Vokonas, Pantel S; Suh MacIntosh, Helen H.; Fang, Shona C.; Christiani, David C.; Schwartz, Joel David (BioMed Central, 2010)
      Background: Air pollution is associated with adverse human health, but mechanisms through which pollution exerts effects remain to be clarified. One suggested pathway is that pollution causes oxidative stress. If so, ...