Browsing by Author "Willett, Walter"

Now showing items 41-60 of 92

    • Genetic risk variants associated with in situ breast cancer 

      Campa, Daniele; Barrdahl, Myrto; Gaudet, Mia M.; Black, Amanda; Chanock, Stephen J.; Diver, W. Ryan; Gapstur, Susan M.; Haiman, Christopher; Hankinson, Susan; Hazra, Aditi; Henderson, Brian; Hoover, Robert N.; Hunter, David J.; Joshi, Amit D.; Kraft, Peter; Le Marchand, Loic; Lindström, Sara; Willett, Walter; Travis, Ruth C.; Amiano, Pilar; Siddiq, Afshan; Trichopoulos, Dimitrios; Sund, Malin; Tjønneland, Anne; Weiderpass, Elisabete; Peeters, Petra H.; Panico, Salvatore; Dossus, Laure; Ziegler, Regina G.; Canzian, Federico; Kaaks, Rudolf (BioMed Central, 2015)
      Introduction: Breast cancer in situ (BCIS) diagnoses, a precursor lesion for invasive breast cancer, comprise about 20 % of all breast cancers (BC) in countries with screening programs. Family history of BC is considered ...

    • A Genome-Wide “Pleiotropy Scan” Does Not Identify New Susceptibility Loci for Estrogen Receptor Negative Breast Cancer 

      Campa, Daniele; Barrdahl, Myrto; Tsilidis, Konstantinos K.; Severi, Gianluca; Diver, W. Ryan; Siddiq, Afshan; Chanock, Stephen; Hoover, Robert N.; Ziegler, Regina G.; Berg, Christine D.; Buys, Saundra S.; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick R.; Le Marchand, Loïc; Flesch-Janys, Dieter; Lindström, Sara; Hunter, David J.; Hankinson, Susan E.; Willett, Walter C.; Kraft, Peter; Cox, David G.; Khaw, Kay-Tee; Tjønneland, Anne; Dossus, Laure; Trichopoulos, Dimitrios; Panico, Salvatore; van Gils, Carla H.; Weiderpass, Elisabete; Barricarte, Aurelio; Sund, Malin; Gaudet, Mia M.; Giles, Graham; Southey, Melissa; Baglietto, Laura; Chang-Claude, Jenny; Kaaks, Rudolf; Canzian, Federico (Public Library of Science, 2014)
      Approximately 15–30% of all breast cancer tumors are estrogen receptor negative (ER−). Compared with ER-positive (ER+) disease they have an earlier age at onset and worse prognosis. Despite the vast number of risk variants ...

    • The Gut Microbiome Modulates the Protective Association Between a Mediterranean Diet and Cardiometabolic Disease Risk 

      Wang, Dong; Nguyen, Long; Li, Yanping; Yan, Yan; Ma, Wenjie; Rinott, Ehud; Ivey, Kerry; Shai, Iris; Willett, Walter; Hu, Frank; Rimm, Eric; Stampfer, Meir; Chan, Andrew; Huttenhower, Curtis (Springer Science and Business Media LLC, 2021-02-11)
      Few studies have formally tested the interaction between diet and the gut microbiome in the context of cardiometabolic health, particularly with the microbiome considered as a potential mediator rather than a target of ...

    • Habitual intake of flavonoid subclasses and risk of colorectal cancer in 2 large prospective cohorts12 

      Nimptsch, Katharina; Zhang, Xuehong; Cassidy, Aedín; Song, Mingyang; O’Reilly, Éilis J; Lin, Jennifer H; Pischon, Tobias; Rimm, Eric B; Willett, Walter C; Fuchs, Charles S; Ogino, Shuji; Chan, Andrew T; Giovannucci, Edward L; Wu, Kana (American Society for Nutrition, 2016)
      Background: Flavonoids inhibit the growth of colon cancer cells in vitro. In a secondary analysis of a randomized controlled trial, the Polyp Prevention Trial, a higher intake of one subclass, flavonols, was statistically ...

    • Healthy Dietary Patterns and Oxidative Stress as Measured by Fluorescent Oxidation Products in Nurses’ Health Study 

      Jung, Seungyoun; Smith-Warner, Stephanie A.; Willett, Walter C.; Wang, Molin; Wu, Tianying; Jensen, Majken; Hankinson, Susan E.; Eliassen, A. Heather (MDPI, 2016)
      Healthy diets may lower oxidative stress and risk of chronic diseases. However, no previous studies examined associations between diet and fluorescent oxidation products (FlOP), a global marker of oxidative stress. We ...

    • Identification of Novel Genetic Markers of Breast Cancer Survival 

      Guo, Qi; Schmidt, Marjanka K.; Kraft, Peter; Canisius, Sander; Chen, Constance; Khan, Sofia; Tyrer, Jonathan; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Michailidou, Kyriaki; Lush, Michael; Kar, Siddhartha; Beesley, Jonathan; Dunning, Alison M.; Shah, Mitul; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Lambrechts, Diether; Weltens, Caroline; Leunen, Karin; Bojesen, Stig E.; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Chang-Claude, Jenny; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Blomqvist, Carl; Aittomäki, Kristiina; Fagerholm, Rainer; Muranen, Taru A.; Couch, Fergus J.; Olson, Janet E.; Vachon, Celine; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Mulligan, Anna Marie; Broeks, Annegien; Hogervorst, Frans B.; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Hopper, John L.; Tsimiklis, Helen; Apicella, Carmel; Southey, Melissa C.; Cox, Angela; Cross, Simon S.; Reed, Malcolm W. R.; Giles, Graham G.; Milne, Roger L.; McLean, Catriona; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Hooning, Maartje J.; Hollestelle, Antoinette; Martens, John W. M.; van den Ouweland, Ans M. W.; Marme, Federik; Schneeweiss, Andreas; Yang, Rongxi; Burwinkel, Barbara; Figueroa, Jonine; Chanock, Stephen J.; Lissowska, Jolanta; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Brenner, Hermann; Dieffenbach, Aida Karina; Arndt, Volker; Holleczek, Bernd; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Li, Jingmei; Brand, Judith S.; Humphreys, Keith; Devilee, Peter; Tollenaar, Rob A. E. M.; Seynaeve, Caroline; Radice, Paolo; Peterlongo, Paolo; Bonanni, Bernardo; Mariani, Paolo; Fasching, Peter A.; Beckmann, Matthias W.; Hein, Alexander; Ekici, Arif B.; Chenevix-Trench, Georgia; Balleine, Rosemary; Phillips, Kelly-Anne; Benitez, Javier; Zamora, M. Pilar; Arias Perez, Jose Ignacio; Menéndez, Primitiva; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Hamann, Ute; Kabisch, Maria; Ulmer, Hans Ulrich; Rüdiger, Thomas; Margolin, Sara; Kristensen, Vessela; Nord, Silje; Evans, D. Gareth; Abraham, Jean E.; Earl, Helena M.; Hiller, Louise; Dunn, Janet A.; Bowden, Sarah; Berg, Christine; Campa, Daniele; Diver, W. Ryan; Gapstur, Susan M.; Gaudet, Mia M.; Hankinson, Susan E.; Hoover, Robert N.; Hüsing, Anika; Kaaks, Rudolf; Machiela, Mitchell J.; Willett, Walter; Barrdahl, Myrto; Canzian, Federico; Chin, Suet-Feung; Caldas, Carlos; Hunter, David J.; Lindstrom, Sara; García-Closas, Montserrat; Hall, Per; Easton, Douglas F.; Eccles, Diana M.; Rahman, Nazneen; Nevanlinna, Heli; Pharoah, Paul D. P. (Oxford University Press, 2015)
      Background: Survival after a diagnosis of breast cancer varies considerably between patients, and some of this variation may be because of germline genetic variation. We aimed to identify genetic markers associated with ...

    • Interactions between Plasma Levels of 25-Hydroxyvitamin D, Insulin-Like Growth Factor (IGF)-1 and C-Peptide with Risk of Colorectal Cancer 

      Wu, Kana; Feskanich, Diane; Fuchs, Charles Stewart; Chan, Andrew Tan; Willett, Walter C.; Hollis, Bruce W.; Pollak, Michael N.; Giovannucci, Edward L. (Public Library of Science, 2011)
      Background: Vitamin D status and levels of insulin-like growth factor (IGF)-1 and C-peptide have been implicated in colorectal carcinogenesis. However, in contrast to vitamin D IGF-1 is not an easily modifiable risk factor. ...

    • Iron Status Predicts Treatment Failure and Mortality in Tuberculosis Patients: A Prospective Cohort Study from Dar es Salaam, Tanzania 

      Isanaka, Sheila; Aboud, Said; Mugusi, Ferdinand; Bosch, Ronald J.; Willett, Walter C.; Spiegelman, Donna Lynn; Duggan, Christopher Paul; Fawzi, Wafaie W. (Public Library of Science, 2012)
      Background: Experimental data suggest a role for iron in the course of tuberculosis (TB) infection, but there is limited evidence on the potential effects of iron deficiency or iron overload on the progression of TB disease ...

    • Is grand-parental smoking associated with adolescent obesity? A three-generational study 

      Dougan, M M; Field, A E; Rich-Edwards, Janet Wilson; Hankinson, Susan Elizabeth; Glynn, Robert James; Willett, Walter C.; Michels, Karin B. (Nature Publishing Group, 2015)
      Background/Objectives: Data from previous studies consistently suggest that maternal smoking is positively associated with obesity later in life. Whether this association persists across generations is unknown. We examined ...

    • Lifestyle‐Based Prediction Model for the Prevention of CVD: The Healthy Heart Score 

      Chiuve, Stephanie E.; Cook, Nancy R.; Shay, Christina M.; Rexrode, Kathryn M.; Albert, Christine M.; Manson, JoAnn E.; Willett, Walter C.; Rimm, Eric B. (Blackwell Publishing Ltd, 2014)
      Background: Clinical practice focuses on the primary prevention of cardiovascular (CV) disease (CVD) through the modification and pharmacological treatment of elevated risk factors. Prediction models based on established ...

    • Light to moderate intake of alcohol, drinking patterns, and risk of cancer: results from two prospective US cohort studies 

      Cao, Yin; Willett, Walter C; Rimm, Eric B; Stampfer, Meir J; Giovannucci, Edward L (BMJ Publishing Group Ltd., 2015)
      Objectives: To quantify risk of overall cancer across all levels of alcohol consumption among women and men separately, with a focus on light to moderate drinking and never smokers; and assess the influence of drinking ...

    • Low Carbohydrate Diet From Plant or Animal Sources and Mortality Among Myocardial Infarction Survivors 

      Li, Shanshan; Flint, Alan; Pai, Jennifer K.; Forman, John P.; Hu, Frank B.; Willett, Walter C.; Rexrode, Kathryn M.; Mukamal, Kenneth J.; Rimm, Eric B. (Blackwell Publishing Ltd, 2014)
      Background: The healthiest dietary pattern for myocardial infarction (MI) survivors is not known. Specific long‐term benefits of a low‐carbohydrate diet (LCD) are unknown, whether from animal or vegetable sources. There ...

    • Magnesium intake, plasma C-peptide, and colorectal cancer incidence in US women: a 28-year follow-up study 

      Zhang, Xiaoxiao; Giovannucci, Edward L.; Wu, Kunling; Smith-Warner, Stephanie A.; Fuchs, Charles Stewart; Pollak, Martin Russell; Willett, Walter C.; Ma, Jing (Nature Publishing Group, 2012)
      Background: Laboratory studies suggest a possible role of magnesium intake in colorectal carcinogenesis but epidemiological evidence is inconclusive. Method: We tested magnesium–colorectal cancer hypothesis in the Nurses' ...

    • Major Dietary Patterns and Cardiovascular Risk Factors among Young Brazilian Adults 

      Olinto, Maria Teresa A.; Gigante, Denise P.; Horta, Bernardo; Silveira, Vera; Oliveira, Isabel; Willett, Walter C. (Springer-Verlag, 2011)
      Purpose: Diet is one of the most important modifiable risk factors for cardiovascular diseases. The scientific literature has consistently shown the effects of certain diets on health; however, given the variety of cultures ...

    • Mercury Exposure and Risk of Cardiovascular Disease in Two U.S. Cohorts 

      Mozaffarian, Dariush; Shi, Peilin; Morris, J. Steven; Spiegelman, Donna Lynn; Grandjean, Philippe; Siscovick, David S.; Willett, Walter C.; Rimm, Eric Bruce (New England Journal of Medicine (NEJM/MMS), 2011)
      BACKGROUND: Exposure to methylmercury from fish consumption has been linked to a potentially increased risk of cardiovascular disease, but evidence from prior studies is equivocal. Beneficial effects of the ingestion of ...

    • Mercury Exposure and Risk of Hypertension in US Men and Women in 2 Prospective Cohorts 

      Mozaffarian, D.; Shi, Peilin; Morris, J. Steven; Grandjean, Philippe; Siscovick, D. S.; Spiegelman, Donna Lynn; Willett, Walter C.; Rimm, Eric Bruce; Curhan, Gary Craig; Forman, John Phillip (Ovid Technologies (Wolters Kluwer Health), 2012)
      Cross-sectional studies and animal-experiments suggest that methylmercury exposure could increase risk of hypertension. This relationship has not been evaluated in large prospective studies. Using data from prior nested ...

    • Milk Consumption and the Prepubertal Somatotropic Axis 

      Rich-Edwards, Janet Wilson; Ganmaa, Davaasambuu; Pollak, Michael N; Nakamoto, Erika K; Kleinman, Ken Paul; Tserendolgor, Uush; Willett, Walter C.; Frazier, A. Lindsay (BioMed Central, 2007)
      Background: Nutrients, hormones and growth factors in dairy foods may stimulate growth hormone (GH), insulin-like growth factor I (IGF-I), and raise the ratio of IGF-I to its binding protein, IGFBP-3. We conducted pilot ...

    • Muscle-Strengthening and Conditioning Activities and Risk of Type 2 Diabetes: A Prospective Study in Two Cohorts of US Women 

      Grøntved, Anders; Pan, An; Mekary, Rania A.; Stampfer, Meir; Willett, Walter C.; Manson, JoAnn E.; Hu, Frank B. (Public Library of Science, 2014)
      Background: It is well established that aerobic physical activity can lower the risk of type 2 diabetes (T2D), but whether muscle-strengthening activities are beneficial for the prevention of T2D is unclear. This study ...

    • Non-communicable diseases in sub-Saharan Africa: the case for cohort studies 

      Holmes, Michelle D.; Dalal, Shona; Volmink, Jimmy; Adebamowo, Clement Adebayo; Njelekela, Marina; Fawzi, Wafaie W.; Willett, Walter C.; Adami, Hans-Olov (Public Library of Science, 2010)
      Michelle Holmes and colleagues argue that there is an urgent need for longitudinal cohorts based in sub-Saharan Africa to address the growing burden of noncommunicable diseases in the region.

    • Nondense Mammographic Area and Risk of Breast Cancer 

      Pettersson, Andreas; Hankinson, Susan Elizabeth; Willett, Walter C.; Lagiou, Pagona; Trichopoulos, Dimitrios; Tamimi, Rulla May (BioMed Central, 2011)
      Introduction: The mechanisms underlying the strong association between percentage dense area on a mammogram and the risk of breast cancer are unknown. We investigated separately the absolute dense area and the absolute ...