Now showing items 580-599 of 40162

    • Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication 

      Annes, J. P.; Ryu, J. H.; Lam, K.; Carolan, Peter Joseph; Utz, K.; Hollister-Lock, J.; Anthony, Anthony; Rubin, Lee; Weir, Gordon Campbell; Melton, Douglas A. (Proceedings of the National Academy of Sciences, 2012)
      Diabetes is a pathological condition characterized by relative insulin deficiency, persistent hyperglycemia, and, consequently, diffuse micro- and macrovascular disease. One therapeutic strategy is to amplify insulin-secretion ...
    • Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells 

      Takagi, H; King, GL; Robinson, GS; Ferrara, N; Aiello, Lloyd Paul (Association for Research in Vision and Ophthalmology, 1996)
      PURPOSE: To determine the mechanistic role for adenosine and adenosine receptors in the hypoxic induction of vascular endothelial growth factor (VEGF) in retinal microvascular cells. METHODS: Bovine retinal capillary ...
    • Adenosine signaling promotes hematopoietic stem and progenitor cell emergence 

      Jing, Lili; Tamplin, Owen J.; Chen, Michael J.; Deng, Qing; Patterson, Shenia; Kim, Peter G.; Durand, Ellen M.; McNeil, Ashley; Green, Julie M.; Matsuura, Shinobu; Ablain, Julien; Brandt, Margot K.; Schlaeger, Thorsten M.; Huttenlocher, Anna; Daley, George Q.; Ravid, Katya; Zon, Leonard I. (The Rockefeller University Press, 2015)
      Hematopoietic stem cells (HSCs) emerge from aortic endothelium via the endothelial-to-hematopoietic transition (EHT). The molecular mechanisms that initiate and regulate EHT remain poorly understood. Here, we show that ...
    • Adenosine Transporter ENT4 Is a Direct Target of EWS/WT1 Translocation Product and Is Highly Expressed in Desmoplastic Small Round Cell Tumor 

      Li, Hongjie; Smolen, Gromoslaw Aleksander; Beers, Lisa F.; Xia, Li; Gerald, William; Wang, Joanne; Haber, Daniel Arie; Lee, Sean Bong (Public Library of Science, 2008)
      Background: Desmoplastic Small Round Cell Tumor (DSRCT) is a highly aggressive malignancy that affects mainly adolescents and young adults. A defining characteristic of DSRCT is a specific chromosomal translocation, ...
    • Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo 

      Shu, Yilai; Tao, Yong; Li, Wenyan; Shen, Jun; Wang, Zhengmin; Chen, Zheng-Yi (Hindawi Publishing Corporation, 2016)
      Mammalian inner ear harbors diverse cell types that are essential for hearing and balance. Adenovirus is one of the major vectors to deliver genes into the inner ear for functional studies and hair cell regeneration. To ...
    • Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia 

      Newman, K D; Dunn, Peter Francis; Owens, J W; Schulick, A H; Virmani, R; Sukhova, Galina K.; Libby, Peter; Dichek, D A (American Society for Clinical Investigation, 1995)
      Adenovirus vectors are capable of high efficiency in vivo arterial gene transfer, and are currently in use as therapeutic agents in animal models of vascular disease. However, despite substantial data on the ability of ...
    • Adequacy of Cancer Screening in Adult Women with Congenital Heart Disease 

      Christman, Mitalee P.; Castro-Zarraga, Margarita; DeFaria Yeh, Doreen; Liberthson, Richard R.; Bhatt, Ami B. (Hindawi Publishing Corporation, 2013)
      Adults with congenital heart disease (ACHD) face noncardiac healthcare challenges as the population ages. We assessed whether women with ACHD have comparable cancer screening rates to non-ACHD women in a cardiac practice ...
    • Adequacy of FDA's Response to Mad Cow Disease 

      Cantor, Alison E. (1999)
      This paper will attempt to analyze the history of FDA’s response to the emergence of BSE and whether FDA’s actions were adequate to protect the American public and its food supply.
    • Adequacy of Outpatient Specialty Care Access in Marketplace Plans Under the Affordable Care Act 

      Dorner, Stephen Christopher; Jacobs, Douglas Bernard; Sommers, Benjamin Daniel (American Medical Association (AMA), 2015)
    • Adequate Relief in a Treatment Trial With IBS Patients: A Prospective Assessment 

      Passos, Maria C F; Lembo, Anthony J.; Conboy, Lisa Ann; Kaptchuk, Ted Jack; Kelly, John M; Quilty, Mary T; Kerr, Catherine; Jacobson, Eric Emil; Hu, Rong; Friedlander, Elizabeth; Drossman, Douglas A (Nature Publishing Group, 2009)
      Background: Adequate relief of IBS symptoms (IBS-AR) has been used as a primary endpoint in many randomized controlled trials of IBS and is considered by the Rome III Committee to be an acceptable primary endpoint. However, ...
    • ADHD in girls and boys – gender differences in co-existing symptoms and executive function measures 

      Skogli, Erik Winther; Teicher, Martin H; Andersen, Per Normann; Hovik, Kjell Tore; Øie, Merete (BioMed Central, 2013)
      Background: ADHD is diagnosed and treated more often in males than in females. Research on gender differences suggests that girls may be consistently underidentified and underdiagnosed because of differences in the expression ...
    • Adherence adjustment in the Coronary Drug Project: A call for better per-protocol effect estimates in randomized trials 

      Murray, Eleanor Jane; Hernan, Miguel Angel (SAGE Publications, 2016)
      BACKGROUND: In many randomized controlled trials, patients and doctors are more interested in the per-protocol effect than in the intention-to-treat effect. However, valid estimation of the per-protocol effect generally ...
    • Adherence is a multi-dimensional construct in the POUNDS LOST trial 

      Williamson, Donald A.; Anton, Stephen D.; Han, Hongmei; Champagne, Catherine M.; Allen, Ray; LeBlanc, Eric; Ryan, Donna H.; McManus, Katherine; Laranjo, Nancy M; Carey, Vincent James; Loria, Catherine M.; Bray, George A.; Sacks, Frank Martin (Springer Nature, 2009)
      Research on the conceptualization of adherence to treatment has not addressed a key question: Is adherence best defined as being a uni-dimensional or multi-dimensional behavioral construct? The primary aim of this study ...
    • Adherence of hip and knee arthroplasty studies to RSA standardization guidelines: A systematic review 

      Madanat, Rami; Mäkinen, Tatu J; Aro, Hannu T; Bragdon, Charles; Malchau, Henrik (Informa Healthcare, 2014)
      Background and purpose Guidelines for standardization of radiostereometry (RSA) of implants were published in 2005 to facilitate comparison of outcomes between various research groups. In this systematic review, we determined ...
    • Adherence to Antiretroviral Prophylaxis for HIV Prevention: A Substudy Cohort within a Clinical Trial of Serodiscordant Couples in East Africa 

      Haberer, Jessica E.; Baeten, Jared M.; Campbell, James; Wangisi, Jonathan; Katabira, Elly; Ronald, Allan; Tumwesigye, Elioda; Psaros, Christina; Safren, Steven A.; Ware, Norma C.; Thomas, Katherine K.; Donnell, Deborah; Krows, Meighan; Kidoguchi, Lara; Celum, Connie; Bangsberg, David R. (Public Library of Science, 2013)
      Background: Randomized clinical trials of oral antiretroviral pre-exposure prophylaxis (PrEP) for HIV prevention have widely divergent efficacy estimates, ranging from 0% to 75%. These discrepancies are likely due to ...
    • Adherence to healthy lifestyle and risk of gestational diabetes mellitus: prospective cohort study 

      Zhang, Cuilin; Tobias, Deirdre K; Chavarro, Jorge E; Bao, Wei; Wang, Dong; Ley, Sylvia H; Hu, Frank B (BMJ Publishing Group Ltd., 2014)
      Objective: To quantify the association between a combination of healthy lifestyle factors before pregnancy (healthy body weight, healthy diet, regular exercise, and not smoking) and the risk of gestational diabetes. Design: ...
    • Adherence to National Guidelines for Drug Treatment of Suspected Acute Myocardial Infarction 

      McLaughlin, Thomas J.; Soumerai, Stephen Bertram; Willison, Donald J.; Gurwitz, Jerry H.; Borbas, Catherine; Guadagnoli, Edward; McLaughlin, Barbara; Morris, Nora; Cheng, Su-Chun; Hauptman, Paul J.; Antman, Elliott Marshall; Casey, Linda; Asinger, Richard; Gobel, Fredarick (American Medical Association (AMA), 1996)
      Background: Evidence-based guidelines for the treatment of patients with acute myocardial infarction (AMI) have been published and disseminated by the American College of Cardiology and the American Heart Association. Few ...
    • Adherence to physical activity guidelines in older adults, using objectively measured physical activity in a population-based study 

      Jefferis, Barbara J; Sartini, Claudio; Lee, I-Min; Choi, Minkyoung; Amuzu, Antoinette; Gutierrez, Christina; Casas, Juan Pablo; Ash, Sarah; Lennnon, Lucy T; Wannamethee, S Goya; Whincup, Peter H (BioMed Central, 2014)
      Background: Physical activity (PA) levels in older adults decline with age. The prevalence and correlates of adherence to current UK PA guidelines in older adults has not been studied using objectively measured PA, which ...
    • Adherence to Pre-Exposure Prophylaxis for HIV Prevention in a Clinical Setting 

      Montgomery, Madeline C.; Oldenburg, Catherine E.; Nunn, Amy S.; Mena, Leandro; Anderson, Peter; Liegler, Teri; Mayer, Kenneth H.; Patel, Rupa; Almonte, Alexi; Chan, Philip A. (Public Library of Science, 2016)
      Background: The HIV epidemic in the United States (US) disproportionately affects gay, bisexual, and other men who have sex with men (MSM). Pre-exposure prophylaxis (PrEP) using co-formulated tenofovir disoproxil fumarate ...
    • Adherence to the healthy Nordic food index, dietary composition, and lifestyle among Swedish women 

      Roswall, Nina; Eriksson, Ulf; Sandin, Sven; Löf, Marie; Olsen, Anja; Skeie, Guri; Adami, Hans-Olov; Weiderpass, Elisabete (Co-Action Publishing, 2015)
      Background: Studies examining diet scores in relation to health outcomes are gaining ground. Thus, control for dietary factors not part of the score, and lifestyle associated with adherence, is required to allow for a ...