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Now showing items 8345-8364 of 47511
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Contribution of PDZD8 to Stabilization of the Human Immunodeficiency Virus (HIV-1) Capsid
(2014-02-25)Following human immunodeficiency virus (HIV-1) entry into the host cell, the viral capsid gradually disassembles in a process called uncoating. A proper rate of uncoating is important for reverse transcription of the HIV-1 ... -
Contribution of Preventable Acute Care Spending to Total Spending for High-cost Medicare Patients
(2013)Importance A small proportion of patients account for the majority of US health care spending, and understanding patterns of spending among this cohort is critical to reducing health care costs. The degree to which preventable ... -
Contribution of Selection for Protein Folding Stability in Shaping the Patterns of Polymorphisms in Coding Regions
(Oxford University Press, 2013)The patterns of polymorphisms in genomes are imprints of the evolutionary forces at play in nature. In particular, polymorphisms have been extensively used to infer the fitness effects of mutations and their dynamics of ... -
The contribution of sleep problems to academic and psychosocial functioning
(Wiley, 2014-01-28)The current study examined the concurrent and longitudinal relations among sleep problems with academic and psychosocial functioning in a prospective cohort study, the Tucson Children’s Assessment of Sleep Apnea study ... -
Contribution of socioeconomic factors to the variation in body-mass index in 58 low-income and middle-income countries: an econometric analysis of multilevel data
(Elsevier BV, 2018)Background Most epidemiological studies have not simultaneously quantified variance in health within and between populations. We aimed to estimate the extent to which basic socioeconomic factors contribute to variation ... -
The Contribution of Spatial and Temporal Molecular Networks in the Induction of Long-term Memory and Its Underlying Synaptic Plasticity
(2016)The ability to form long-lasting memories is critical to survival and thus is highly conserved across the animal kingdom. By virtue of its complexity, this same ability is vulnerable to disruption by a wide variety of ... -
Contributions of Electron Microscopy to Understand Secretion of Immune Mediators by Human Eosinophils
(Cambridge University Press (CUP), 2010)Mechanisms governing secretion of proteins underlie the biologic activities and functions of human eosinophils, leukocytes of the innate immune system, involved in allergic, inflammatory, and immunoregulatory responses. ... -
Contributions of integrin-linked kinase to breast cancer metastasis and tumourigenesis
(Blackwell Publishing Ltd, 2008)Abstract Metastasis contributes to more than 90% of mortality in breast cancer. Critical stages in the development of aggressive breast cancer include growth of the primary tumours, and their abilities to spread to distant ... -
Contributions of Mamu-A*01 Status and TRIM5 Allele Expression, But Not CCL3L Copy Number Variation, to the Control of SIVmac251 Replication in Indian-Origin Rhesus Monkeys
(Public Library of Science, 2010)CCL3 is a ligand for the HIV-1 co-receptor CCR5. There have recently been conflicting reports in the literature concerning whether CCL3-like gene (CCL3L) copy number variation (CNV) is associated with resistance to HIV-1 ... -
Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip
(National Academy of Sciences, 2016)A human gut-on-a-chip microdevice was used to coculture multiple commensal microbes in contact with living human intestinal epithelial cells for more than a week in vitro and to analyze how gut microbiome, inflammatory ... -
Contributions of the Hadley and Ferrel Circulations to the Energetics of the Atmosphere over the past 32-years
(American Meteorological Society, 2014)The Hadley system provides an example of a thermally direct circulation, the Ferrel system in contrast an example of a thermally indirect circulation. In this study, we develop an approach to investigate the key thermodynamic ... -
Contributions of the mother–infant relationship to dissociative, borderline, and conduct symptoms in young adulthood
(Wiley, 2008)Recent high-risk longitudinal studies have documented a unique contribution of the quality of the early mother–child relationship to diverse forms of psychopathology in young adulthood, even with family economic status, ... -
Contributions of the RhoGEF activity of p210 BCR/ABL to disease progression
(2014)We have previously identified a tyrosine kinase-independent, guanine nucleotide exchange factor (GEF) activity that is contained within the region of p210 BCR/ABL that distinguishes it from p190 BCR/ABL. In the current ... -
Contributions to Evolutionary Dynamics and Causal Inference
(2018-05-11)In this dissertation, we investigate topics in two different quantitative disciplines, both of which have profound impact in biomedical sciences. The first area is evolutionary dynamical systems to model biological systems; ... -
Contributions to Imputation Methods Based on Ranks and to Treatment Selection Methods in Personalized Medicine
(2013-02-14)The chapters of this thesis focus two different issues that arise in clinical trials and propose novel methods to address them. The first issue arises in the analysis of data with non-ignorable missing observations. The ... -
Contributions to Semiparametric Methods for Incomplete Data
(2017-05-10)Abstract Chapter 1: The effect of treatment on the treated (ETT) is a common parameter of interest in causal inference. Identification of ETT typically relies on an assumption of no unobserved confounding. When information ... -
Contrived Threats v. Uncontrived Warnings: A General Solution to the Puzzles of Contractual Duress, Unconstitutional Conditions, and Blackmail
(University of Chicago Press, 2015)Contractual duress, unconstitutional conditions, and blackmail have long been puzzling. The puzzle is why these doctrines sometimes condemn threatening lawful action to induce agreements, but sometimes do not. This article ... -
Control algorithm for multiscale flow simulations of water
(American Physical Society, 2009)We present a multiscale algorithm to couple atomistic water models with continuum incompressible flow simulations via a Schwarz domain decomposition approach. The coupling introduces an inhomogeneity in the description of ... -
Control and Function of Arm Swing in Human Walking and Running
(The Company of Biologists, 2009)We investigated the control and function of arm swing in human walking and running to test the hypothesis that the arms act as passive mass dampers powered by movement of the lower body, rather than being actively driven ... -
Control and local measurement of the spin chemical potential in a magnetic insulator
(American Association for the Advancement of Science (AAAS), 2017-07-13)The spin chemical potential characterizes the tendency of spins to diffuse. Probing this quantity could provide insight into materials such as magnetic insulators and spin liquids and aid optimization of spintronic devices. ...