Now showing items 50344-50363 of 57077

    • T Cell Activation Markers and African Mitochondrial DNA Haplogroups among Non-Hispanic Black Participants in AIDS Clinical Trials Group Study 384 

      Hulgan, Todd; Robbins, Gregory Kimball; Kalams, Spyros A.; Samuels, David C.; Grady, Benjamin; Shafer, Robert; Murdock, Deborah G.; Selph, Doug; Haas, David W.; Pollard, Richard B. (Public Library of Science, 2012)
      Introduction: Mitochondrial function influences T cell dynamics and is affected by mitochondrial DNA (mtDNA) variation. We previously reported an association between African mtDNA haplogroup L2 and less robust CD4 cell ...
    • T Cell Costimulatory and Coinhibitory Pathways in Vascular Inflammatory Diseases 

      Lichtman, Andrew Harry (Frontiers Research Foundation, 2012)
      A broad array of evidence indicates that T lymphocytes make significant contributions to vascular inflammation in the setting of atherosclerotic disease, hypertension, autoimmune vasculitis, and other disorders. Experimental ...
    • T Cell Detection of a B-Cell Tropic Virus Infection: Newly-Synthesised versus Mature Viral Proteins as Antigen Sources for CD4 and CD8 Epitope Display 

      Mackay, Laura K.; Long, Heather M.; Brooks, Jill M.; Taylor, Graham S.; Leung, Carol S.; Chen, Adrienne; Wang, Frederick Chi-Shing; Rickinson, Alan B. (Public Library of Science, 2009)
      Viruses that naturally infect cells expressing both MHC I and MHC II molecules render themselves potentially visible to both CD8+ and CD4+ T cells through the de novo expression of viral antigens. Here we use one such ...
    • T Cell Help Shapes B Cell Tolerance 

      Akama-Garren, Elliot (2023-11-21)
      Maintenance of B cell tolerance allows organisms to defend against pathogens without attacking their own tissues. Loss of B cell tolerance leads to autoimmune disease driven by the accumulation of pathogenic autoantibodies. ...
    • T cell receptor recognition of CD1b presenting a mycobacterial glycolipid 

      Gras, Stephanie; Van Rhijn, Ildiko; Shahine, Adam; Cheng, Tan-Yun; Bhati, Mugdha; Tan, Li Lynn; Halim, Hanim; Tuttle, Kathryn D.; Gapin, Laurent; Le Nours, Jérôme; Moody, D. Branch; Rossjohn, Jamie (Nature Publishing Group, 2016)
      CD1 proteins present microbial lipids to T cells. Germline-encoded mycolyl lipid-reactive (GEM) T cells with conserved αβ T cell receptors (TCRs) recognize CD1b presenting mycobacterial mycolates. As the molecular basis ...
    • T Cell Transcriptomes Describe Patient Subtypes in Systemic Lupus Erythematosus 

      Bradley, Sean J.; Suarez-Fueyo, Abel; Moss, David R.; Kyttaris, Vasileios C.; Tsokos, George C. (Public Library of Science, 2015)
      Background: T cells regulate the adaptive immune response and have altered function in autoimmunity. Systemic Lupus Erythematosus (SLE) has great diversity of presentation and treatment response. Peripheral blood component ...
    • T cell–derived inducible nitric oxide synthase switches off TH17 cell differentiation 

      Yang, Jianjun; Zhang, Ruihua; Lu, Geming; Shen, Yu; Peng, Liang; Zhu, Chen; Cui, Miao; Wang, Weidong; Arnaboldi, Paul; Tang, Meng; Gupta, Monica; Qi, Chen-Feng; Jayaraman, Padmini; Zhu, Hongfa; Jiang, Bo; Chen, Shu-hsia; He, John Cijiang; Ting, Adrian T.; Zhou, Ming-Ming; Kuchroo, Vijay K.; Morse, Herbert C.; Ozato, Keiko; Sikora, Andrew G.; Xiong, Huabao (The Rockefeller University Press, 2013)
      RORγt is necessary for the generation of TH17 cells but the molecular mechanisms for the regulation of TH17 cells are still not fully understood. We show that activation of CD4+ T cells results in the expression of inducible ...
    • T cell–derived interleukin (IL)-21 promotes brain injury following stroke in mice 

      Clarkson, Benjamin D.S.; Ling, Changying; Shi, Yejie; Harris, Melissa G.; Rayasam, Aditya; Sun, Dandan; Salamat, M. Shahriar; Kuchroo, Vijay; Lambris, John D.; Sandor, Matyas; Fabry, Zsuzsanna (The Rockefeller University Press, 2014)
      T lymphocytes are key contributors to the acute phase of cerebral ischemia reperfusion injury, but the relevant T cell–derived mediators of tissue injury remain unknown. Using a mouse model of transient focal brain ischemia, ...
    • T granules in human platelets function in TLR9 organization and signaling 

      Thon, Jonathan N.; Peters, Christopher G.; Machlus, Kellie R.; Aslam, Rukhsana; Rowley, Jesse; Macleod, Hannah; Devine, Matthew T.; Fuchs, Tobias A; Weyrich, Andrew S.; Semple, John W.; Flaumenhaft, Robert C.; Italiano, Joseph E. (The Rockefeller University Press, 2012)
      Human and murine platelets (PLTs) variably express toll-like receptors (TLRs), which link the innate and adaptive immune responses during infectious inflammation and atherosclerotic vascular disease. In this paper, we show ...
    • T Lymphocyte–Endothelial Interactions: Emerging Understanding of Trafficking and Antigen-Specific Immunity 

      Carman, Christopher V.; Martinelli, Roberta (Frontiers Media S.A., 2015)
      Antigen-specific immunity requires regulated trafficking of T cells in and out of diverse tissues in order to orchestrate lymphocyte development, immune surveillance, responses, and memory. The endothelium serves as a ...
    • T-Branes and Monodromy 

      Cecotti, Sergio; Cordova, Clay Alexander; Heckman, Jonathan; Vafa, C. (Springer Verlag, 2011)
      We introduce T-branes, or "triangular branes," which are novel non-abelian bound states of branes characterized by the condition that on some loci, their matrix of normal deformations, or Higgs field, is upper triangular. ...
    • T-cell co-stimulatory blockade in kidney transplantation: back to the bench 

      Riella, Leonardo V; Sayegh, Mohamed H (Nature Publishing Group, 2011)
      It is believed that blocking positive T-cell co-stimulatory pathways should lead to long-term graft acceptance. Despite the exciting initial achievements in experimental animal models, targeting co-stimulatory pathways has ...
    • T-Cell Non-Hodgkin Lymphomas: Spectrum of Disease and the Role of Imaging in the Management of Common Subtypes 

      Park, Hye Sun; McIntosh, Lacey; Braschi-Amirfarzan, Marta; Shinagare, Atul B.; Krajewski, Katherine M. (The Korean Society of Radiology, 2017)
      T-cell non-Hodgkin lymphomas (NHLs) are biologically diverse, uncommon malignancies characterized by a spectrum of imaging findings according to subtype. The purpose of this review is to describe the common subtypes of ...
    • T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation 

      Feng, Hui; Stachura, David L.; White, Richard; Gutierrez, Alejandro; Zhang, Lu; Sanda, Takaomi; Jette, Cicely A.; Testa, Joseph R.; Neuberg, Donna S.; Langenau, David M.; Kutok, Jeffery Lorne; Zon, Leonard Ira; Traver, David; Fleming, Mark Daniel; Kanki, John P.; Look, A. Thomas (Elsevier BV, 2010)
      The molecular events underlying the progression of T-lymphoblastic lymphoma (T-LBL) to acute T-lymphoblastic leukemia (T-ALL) remain elusive. In our zebrafish model, concomitant overexpression of bcl-2 with Myc accelerated ...
    • T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy 

      Sackstein, Robert; Schatton, Tobias; Barthel, Steven (Springer Science and Business Media LLC, 2017-03-27)
      Advances in cancer immunotherapy have offered new hope for patients with metastatic disease. This unfolding success story has been exemplified by a growing arsenal of novel immunotherapeutics, including blocking antibodies ...
    • T1 measurements identify extracellular volume expansion in a genotyped hypertrophic cardiomyopathy population with and without left ventricular hypertrophy 

      Abbasi, Siddique Akbar; Shah, Ravi Vikram; Neilan, Tomas G; Heydari, Bobby; Chen, Yucheng; Jerosch-Herold, Michael; Kwong, Raymond Yan-Kit; Ho, Carolyn Yung (BioMed Central, 2013)
    • T1- vs. T2-based MRI measures of spinal cord volume in healthy subjects and patients with multiple sclerosis 

      Kim, Gloria; Khalid, Fariha; Oommen, Vinit V.; Tauhid, Shahamat; Chu, Renxin; Horsfield, Mark A.; Healy, Brian C.; Bakshi, Rohit (BioMed Central, 2015)
      Background: The reliable and efficient measurement of spinal cord atrophy is of growing interest in monitoring disease progression in multiple sclerosis (MS). Methods: We compared T1- and T2-weighted MRI for measuring ...
    • The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1 

      Boada-Romero, Emilio; Serramito-Gómez, Inmaculada; Sacristán, María P.; Boone, David L.; Xavier, Ramnik J.; Pimentel-Muiños, Felipe X. (Nature Publishing Group, 2016)
      A coding polymorphism of human ATG16L1 (rs2241880; T300A) increases the risk of Crohn's disease and it has been shown to enhance susceptibility of ATG16L1 to caspase cleavage. Here we show that T300A also alters the ability ...
    • Tabasco: Diagnóstico Industrial 

      Barrios, Douglas; Ramos, Johanna; Tapia, Jorge Andres; Grisanti, Ana (Center for International Development at Harvard University, 2018-09)
      En este estudio se consideraron los productos priorizados en el Reporte de Complejidad Económica de Tabasco y se procedió a evaluar su potencial a partir de un conjunto de consideraciones de mercado. Luego, se agregó el ...
    • Tabasco: Growth Diagnostic 

      Barrios, Douglas; Ramos, Johanna; Tapia, Jorge Andres; Grisanti, Ana; Obach, Juan (Center for International Development at Harvard University, 2018-09)
      Since 2003, the GDP per capita of Tabasco has consistently figured among the 4 largest in the country. However, this level of economic activity has not translated into an equally favorable performance in other social welfare ...