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Now showing items 8359-8378 of 48948
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Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL
(Nature Publishing Group, 2016)Proapoptotic molecules directly targeting the BCL-2 family network are promising anticancer therapeutics, but an understanding of the cellular stress signals that render them effective is still elusive. We show here that ... -
Constrained Bayesian Optimization and Applications
(2015-05-17)Bayesian optimization is an approach for globally optimizing black-box functions that are expensive to evaluate, non-convex, and possibly noisy. Recently, Bayesian optimization has been used with great effectiveness for ... -
Constraining Alternate Models of Black Holes: Type I X‐Ray Bursts on Accreting Fermion‐Fermion and Boson‐Fermion Stars
(American Astronomical Society, 2004)The existence of black holes remains open to doubt until other conceivable options are excluded. With this motivation, we consider a model of a compact star in which most of the mass consists of dark particles of some kind ... -
Constraining Cosmological Parameters Based on Relative Galaxy Ages
(American Astronomical Society, 2002)We propose to use relative galaxy ages as a means of constraining cosmological parameters. By measuring the age difference between two ensembles of passively evolving galaxies at somewhat different redshifts, one could ... -
Constraining Dark Halo Potentials with Tidal Tails
(American Astronomical Society, 1999)We present an extensive parameter survey of the influence of halo mass profiles on the development of tidal tails in interacting disk galaxies. We model the galaxies using a fixed exponential disk with a central bulge and ... -
Constraining Light Colored Particles with Event Shapes
(American Physical Society, 2008)Using recently developed techniques for computing event shapes with Soft-Collinear Effective Theory, LEP event shape data is used to derive strong model-independent bounds on new colored particles. In the effective field ... -
Constraining OCT with Knowledge of Device Design Enables High Accuracy Hemodynamic Assessment of Endovascular Implants
(Public Library of Science, 2016)Background: Stacking cross-sectional intravascular images permits three-dimensional rendering of endovascular implants, yet introduces between-frame uncertainties that limit characterization of device placement and the ... -
Constraining parity violation in gravity with measurements of neutron-star moments of inertia
(American Physical Society, 2010) -
The Constraining Power of International Treaties: Theory and Methods
(Cambridge University Press, 2005)We acknowledge the contribution of von Stein (2005) in calling attention to the very real problem of selection bias in estimating treaty effects. Nonetheless, we dispute both von Stein's theoretical and empirical conclusions. ... -
Constraining primordial black-hole bombs through spectral distortions of the cosmic microwave background
(American Physical Society, 2013)We consider the imprint of super-radiant instabilities of nonevaporating primordial black holes (PBHs) on the spectrum of the cosmic microwave background (CMB). In the radiation-dominated era, PBHs are surrounded by a ... -
Constraining Primordial Gravitational Waves Using Present and Future CMB Experiments
(2019-05-17)Cosmic inflation is our current best theory for what occurred in the universe in the first instances of time. It postulates a brief period of exponential expansion in which quantum fluctuations are magnified to cosmic size ... -
Constraining proposed combinations of ice history and Earth rheology using VLBI determined baseline length rates in North America
(American Geophysical Union, 1993)We predict the present-day rates of change of the lengths of 19 North American baselines due to the glacial isostatic adjustment process. Contrary to previously published research, we find that the three-dimensional motion ... -
Constraining Questions About the Organisation and Representation of Conceptual Knowledge
(Taylor & Francis (Routledge), 2003)In this article we assume a domain-specific organisation of conceptual knowledge and consider two questions: How does this architecture constrain further assumptions that might be made regarding (1) the organisation of ... -
Constraining reionization using 21-cm observations in combination with CMB and Lyα forest data
(Oxford University Press, 2010) -
Constraining Spinning Dust Parameters With the WMAP Five-Year Data
(IOP Publishing, 2009)We characterize spinning dust emission in the warm ionized medium (WIM) by comparing templates of Galactic dust and Hα with the five-year maps from the Wilkinson Microwave Anisotropy Probe (WMAP). The Hα-correlated microwave ... -
Constraining Sub-parsec Binary Supermassive Black Holes in Quasars with Multi-epoch Spectroscopy. I. The General Quasar Population
(American Astronomical Society, 2013)We perform a systematic search for sub-parsec binary supermassive black holes (BHs) in normal broad-line quasars at z < 0.8, using multi-epoch Sloan Digital Sky Survey (SDSS) spectroscopy of the broad H beta line. Our ... -
Constraining Sub-parsec Binary Supermassive Black Holes in Quasars with Multi-epoch Spectroscopy. Ii. The Population with Kinematically Offset Broad Balmer Emission Lines
(American Astronomical Society, 2014)A small fraction of quasars have long been known to show bulk velocity offsets (of a few hundred to thousands of km s(-1)) in the broad Balmer lines with respect to the systemic redshift of the host galaxy. Models to explain ... -
Constraining Subduction Zone Processes Through Local, Regional, and Global Chemical Systematics
(2015-04-08)Subduction zones recycle material from Earth’s surface into the mantle, and are an important means of continent building. The subduction system serves as a stamp, imprinting the distinct chemical characteristics of our ... -
Constraining the Beaming of Gamma-Ray Bursts with Radio Surveys
(American Astronomical Society, 1998)The degree of beaming in gamma-ray bursts (GRBs) is currently unknown. The uncertainty in the gamma-ray-beaming angle, theta(b), leaves the total energy release (proportional to theta(b)(2)) and the event rate per galaxy ... -
Constraining the CMB optical depth through the dispersion measure of cosmological radio transients
(IOP Publishing, 2016)The dispersion measure of extragalactic radio transients, such as of recently discovered Fast Radio Burst FRB150418, can be used to measure the column density of free electrons in the intergalactic medium. The same electrons ...