Now showing items 56893-56912 of 57074

    • Y Chromosome Haplogroups and Prostate Cancer in Populations of European and Ashkenazi Jewish Ancestry 

      Wang, Zhaoming; Parikh, Hemang; Jia, Jinping; Yeager, Meredith; Jacobs, Kevin B.; Hutchinson, Amy; Burdett, Laurie; Ghosh, Arpita; Thun, Michael J.; Gapstur, Susan M.; Virtamo, Jarmo; Albanes, Demetrius; Cancel-Tassin, Geraldine; Valeri, Antoine; Cussenot, Olivier; Offit, Kenneth; Dutra-Clarke, Ana; Kirchhoff, Tomas; Alavanja, Michael; Freeman, Laura B.; Koutros, Stella; Hoover, Robert; Berndt, Sonja I.; Hayes, Richard B.; Agalliu, Ilir; Burk, Robert D.; Wacholder, Sholom; Thomas, Gilles; Amundadottir, Laufey; Myers, Timothy; Giovannucci, Edward L.; Ma, Jing; Stampfer, Meir; Gaziano, John Michael; Hunter, David J.; Diver, W. Ryan (Springer-Verlag, 2012)
      Genetic variation on the Y chromosome has not been convincingly implicated in prostate cancer risk. To comprehensively analyze the role of inherited Y chromosome variation in prostate cancer risk in individuals of European ...
    • Y Chromosome Mediates Ribosomal DNA Silencing and Modulates the Chromatin State in Drosophila 

      Zhou, Jun; Sackton, Timothy; Martinsen, Lene; Silva, Bernardo Lemos; Eickbush, Thomas H.; Hartl, Daniel L. (Proceedings of the National Academy of Sciences, 2012)
      Although the Drosophila Y chromosome is degenerated, heterochromatic, and contains few genes, increasing evidence suggests that it plays an important role in regulating the expression of numerous autosomal and X-linked ...
    • Y Not a Dead End: Epistatic Interactions Between Y-Linked Regulatory Polymorphisms and Genetic Background Affect Global Gene Expression in Drosophila melanogaster 

      Jiang, Pan-Pan Xueke; Hartl, Daniel L.; Silva, Bernardo Lemos (Genetics Society of America, 2010)
      The Y chromosome, inherited without meiotic recombination from father to son, carries relatively few genes in most species. This is consistent with predictions from evolutionary theory that nonrecombining chromosomes lack ...
    • Y-Chromosome and mtDNA Genetics Reveal Significant Contrasts in Affinities of Modern Middle Eastern Populations with European and African Populations 

      Badro, Danielle A.; Douaihy, Bouchra; Haber, Marc; Youhanna, Sonia C.; Salloum, Angélique; Ghassibe-Sabbagh, Michella; Johnsrud, Brian; Khazen, Georges; Matisoo-Smith, Elizabeth; Soria-Hernanz, David F.; Wells, R. Spencer; Tyler-Smith, Chris; Platt, Daniel E.; Zalloua, Pierre A. (Public Library of Science, 2013)
      The Middle East was a funnel of human expansion out of Africa, a staging area for the Neolithic Agricultural Revolution, and the home to some of the earliest world empires. Post LGM expansions into the region and subsequent ...
    • Yamanashi Now: From Iconic Relic to Urban Incubator 

      Guo, Wentao (2023-01-05)
      In 1966, Kenzo Tange devised a powerful apparatus of disseminating mass media, Yamanashi Broadcasting and Press Center. A concrete innovation and an urban fragment, the Yamanashi Building applied the joint-core system that ...
    • YAP Induces High-Grade Serous Carcinoma in Fallopian Tube Secretory Epithelial Cells 

      Hua, Guohua; Lv, Xiangmin; He, Chunbo; Remmenga, Steven W.; Rodabough, Kerry J.; Dong, Jixin; Yang, Liguo; Lele, Subodh M.; Yang, Peixin; Zhou, Jin; Karst, Alison; Drapkin, Ronny I.; Davis, John S.; Wang, Cheng (2015)
      Accumulating evidence indicates that ovarian high-grade serous carcinoma (HGSC) originates from Fallopian tube secretory epithelial cells (FTSECs). However, the molecular mechanisms underlying the initiation and progression ...
    • Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth 

      Cox, Andrew G.; Hwang, Katie L.; Brown, Kristin K.; Evason, Kimberley; Beltz, Sebastian; Tsomides, Allison; O'Connor, Keelin; Galli, Giorgio G.; Yimlamai, Dean; Chhangawala, Sagar; Yuan, Min; Lien, Evan C.; Wucherpfennig, Julia; Nissim, Sahar; Minami, Akihiro; Cohen, David E.; Camargo, Fernando D.; Asara, John M.; Houvras, Yariv; Stainier, Didier Y.R.; Goessling, Wolfram (2016)
      The Hippo pathway is an important regulator of organ size and tumorigenesis. It is unclear, however, how Hippo signaling provides the cellular building blocks required for rapid growth. Here, we demonstrate that transgenic ...
    • YAP Subcellular Localization and Hippo Pathway Transcriptome Analysis in Pediatric Hepatocellular Carcinoma 

      LaQuaglia, Michael J.; Grijalva, James L.; Mueller, Kaly A.; Perez-Atayde, Antonio R.; Kim, Heung Bae; Sadri-Vakili, Ghazaleh; Vakili, Khashayar (Nature Publishing Group, 2016)
      Pediatric hepatocellular carcinoma (HCC) is a rare tumor which is associated with an extremely high mortality rate due to lack of effective chemotherapy. Recently, the Hippo pathway and its transcriptional co-activator ...
    • YAP-Dependent Proliferation by a Small Molecule Targeting Annexin A2 

      Shalhout, Sophia; Yang, Peng-Yu; Grzelak, Edyta M.; Nutsch, Kayla; Shao, Sida; Zambaldo, Claudio; Iaconelli, Jonathan; Ibrahim, Lara; Stanton, Caroline; Chadwick, Stormi R.; Chen, Emily; DeRan, Michael; Li, Sijia; Hull, Mitchell; Wu, Xu; Chatterjee, Arnab K.; Shen, Weijun; Camargo, Fernando; Schultz, Peter; Bollong, Michael J. (Springer Science and Business Media LLC, 2021-03-15)
      The transcriptional coactivator YAP orchestrates a pro-proliferative transcriptional program that controls the fate of somatic stem cells and the regenerative responses of certain tissues. As such, agents that activate YAP ...
    • A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions 

      Bertero, Thomas; Cottrill, Katherine A.; Annis, Sofia; Bhat, Balkrishen; Gochuico, Bernadette R.; Osorio, Juan C.; Rosas, Ivan; Haley, Kathleen J.; Corey, Kathleen E.; Chung, Raymond T.; Nelson Chau, B.; Chan, Stephen Y. (Nature Publishing Group, 2015)
      The molecular origins of fibrosis affecting multiple tissue beds remain incompletely defined. Previously, we delineated the critical role of the control of extracellular matrix (ECM) stiffening by the mechanosensitive ...
    • Yards and Gates: Gender in Harvard and Radcliffe History 

      Ulrich, Laurel Thatcher (Palgrave MacMillan, 2004)
    • Yards and Gates: Gender in Harvard and Radcliffe History [Table of Contents] 

      Ulrich, Laurel Thatcher (Palgrave Macmillan, 2004)
    • Yarrabubba - A Large, Deeply Eroded Impact Structure in the Yilgarn Craton, Western Australia 

      Macdonald, Francis Alexander; Bunting, John A.; Cina, Sara E. (Elsevier, 2003)
      Yarrabubba is a newly discovered impact structure situated within the complex granite^greenstone terrain of the Yilgarn Craton. Shock-metamorphic effects including shatter cones, planar deformation features in quartz grains, ...
    • Yasser Elsheshtawy, Temporary Cities: Resisting Transience in Arabia. Review essay by Gareth Doherty. 

      Doherty, Gareth (International Association for the Study of Traditional Environments (IASTE), 2020-12)
      “Can transience be inscribed into the built environment, and what tactics are employed by residents to overcome this?” is the central question posed by Yasser Elsheshtawy in Temporary Cities: Resisting Transience in Arabia ...
    • YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression 

      Lyons, Shawn M.; Achorn, Chris; Kedersha, Nancy L.; Anderson, Paul J.; Ivanov, Pavel (Oxford University Press, 2016)
      Stress-induced angiogenin (ANG)-mediated tRNA cleavage promotes a cascade of cellular events that starts with production of tRNA-derived stress-induced RNAs (tiRNAs) and culminates with enhanced cell survival. This stress ...
    • YE DEJI ABEBA NEGN: Sonic Floral Imaginaries in Addis Ababa, Ethiopia 

      Ewunnet, Olani (2022-06-08)
      Ye Deji Abeba Negn: Sonic Floral Imaginaries in Addis Ababa, Ethiopia, illustrates and creates new sonics in Ethiopian floral imagination. Composed as a series of essays, graphic scores, and sound works, the thesis examines ...
    • The Year in Elections, 2013: The World's Flawed and Failed Contests 

      Norris, Pippa; Frank, Richard W.; Martinez i Coma, Ferran (The Electoral Integrity Project, 2014)
      In many countries, polling day ends with disputes about ballot-box fraud, corruption, and flawed registers. Which claims are accurate? And which are false complaints from sore losers? New evidence gathered by the Electoral ...
    • The Year in Elections, 2015: The expert survey on perceptions of electoral integrity. 

      Norris, Pippa; Martinez i Coma, Ferran; Nai, Alessandro; Gromping, Max (The Electoral Integrity Project, Department of Government and International Relations, University of Sydney, 2016-05-20)
    • A Year of Being With 

      Luo, Maisie
      Luo's paintings, poetry, and videos envision the possibility of forming compassionate and intimate interspecies relationships in our current climate. Reflecting on the idea of "being with" animals, Luo captures the beauty ...