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Now showing items 55894-55913 of 56059
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Y Chromosome Haplogroups and Prostate Cancer in Populations of European and Ashkenazi Jewish Ancestry
(Springer-Verlag, 2012)Genetic variation on the Y chromosome has not been convincingly implicated in prostate cancer risk. To comprehensively analyze the role of inherited Y chromosome variation in prostate cancer risk in individuals of European ... -
Y Chromosome Mediates Ribosomal DNA Silencing and Modulates the Chromatin State in Drosophila
(Proceedings of the National Academy of Sciences, 2012)Although the Drosophila Y chromosome is degenerated, heterochromatic, and contains few genes, increasing evidence suggests that it plays an important role in regulating the expression of numerous autosomal and X-linked ... -
Y Not a Dead End: Epistatic Interactions Between Y-Linked Regulatory Polymorphisms and Genetic Background Affect Global Gene Expression in Drosophila melanogaster
(Genetics Society of America, 2010)The Y chromosome, inherited without meiotic recombination from father to son, carries relatively few genes in most species. This is consistent with predictions from evolutionary theory that nonrecombining chromosomes lack ... -
Y-Chromosome and mtDNA Genetics Reveal Significant Contrasts in Affinities of Modern Middle Eastern Populations with European and African Populations
(Public Library of Science, 2013)The Middle East was a funnel of human expansion out of Africa, a staging area for the Neolithic Agricultural Revolution, and the home to some of the earliest world empires. Post LGM expansions into the region and subsequent ... -
YAP Induces High-Grade Serous Carcinoma in Fallopian Tube Secretory Epithelial Cells
(2015)Accumulating evidence indicates that ovarian high-grade serous carcinoma (HGSC) originates from Fallopian tube secretory epithelial cells (FTSECs). However, the molecular mechanisms underlying the initiation and progression ... -
YAP Regulation of RHO GTPase Activities Controls Epithelial Cell Morphology and Adhesion
(2019-05-15)Yes-Associated Protein 1 (YAP) is the downstream effector of the Hippo pathway. Hippo is a kinase cascade that regulates development and tissue growth through phosphorylation of YAP and regulation of its localization. ... -
Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth
(2016)The Hippo pathway is an important regulator of organ size and tumorigenesis. It is unclear, however, how Hippo signaling provides the cellular building blocks required for rapid growth. Here, we demonstrate that transgenic ... -
YAP Subcellular Localization and Hippo Pathway Transcriptome Analysis in Pediatric Hepatocellular Carcinoma
(Nature Publishing Group, 2016)Pediatric hepatocellular carcinoma (HCC) is a rare tumor which is associated with an extremely high mortality rate due to lack of effective chemotherapy. Recently, the Hippo pathway and its transcriptional co-activator ... -
A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions
(Nature Publishing Group, 2015)The molecular origins of fibrosis affecting multiple tissue beds remain incompletely defined. Previously, we delineated the critical role of the control of extracellular matrix (ECM) stiffening by the mechanosensitive ... -
Yards and Gates: Gender in Harvard and Radcliffe History
(Palgrave MacMillan, 2004) -
Yards and Gates: Gender in Harvard and Radcliffe History [Table of Contents]
(Palgrave Macmillan, 2004) -
Yarrabubba - A Large, Deeply Eroded Impact Structure in the Yilgarn Craton, Western Australia
(Elsevier, 2003)Yarrabubba is a newly discovered impact structure situated within the complex granite^greenstone terrain of the Yilgarn Craton. Shock-metamorphic effects including shatter cones, planar deformation features in quartz grains, ... -
Yasser Elsheshtawy, Temporary Cities: Resisting Transience in Arabia. Review essay by Gareth Doherty.
(International Association for the Study of Traditional Environments (IASTE), 2020-12)“Can transience be inscribed into the built environment, and what tactics are employed by residents to overcome this?” is the central question posed by Yasser Elsheshtawy in Temporary Cities: Resisting Transience in Arabia ... -
YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression
(Oxford University Press, 2016)Stress-induced angiogenin (ANG)-mediated tRNA cleavage promotes a cascade of cellular events that starts with production of tRNA-derived stress-induced RNAs (tiRNAs) and culminates with enhanced cell survival. This stress ... -
The Year in Elections, 2013: The World's Flawed and Failed Contests
(The Electoral Integrity Project, 2014)In many countries, polling day ends with disputes about ballot-box fraud, corruption, and flawed registers. Which claims are accurate? And which are false complaints from sore losers? New evidence gathered by the Electoral ... -
The Year in Elections, 2015: The expert survey on perceptions of electoral integrity.
(The Electoral Integrity Project, Department of Government and International Relations, University of Sydney, 2016-05-20) -
A Year of Teaching with Dialog
(American Philosophical Association, 1994) -
Year of the Titan: Percy Bysshe Shelley and Ancient Poetry
(2018-05-15)“Year of the Titan” examines the life and poetic career of Percy Bysshe Shelley from March 1818 to April 1819—a central turning point. It focuses on the Greek and Latin poetry that Shelley studied while composing Prometheus ... -
Year round measurements of O3 and CO at a rural site near Beijing: variations in their correlations
(Co-Action Publishing, 2010)We examine seasonal variations of carbon monoxide (CO), ozone (O3), and their relationships observed over the course of 3 yr (2005–2007) at Miyun, a rural site 100 km north of Beijing. Monthly mean afternoon mixing ratios ... -
Years of Able Life in Older Persons—The Role of Cardiovascular Imaging and Biomarkers: The Cardiovascular Health Study
(Blackwell Publishing Ltd, 2015)Background: As the U.S. population grows older, there is greater need to examine physical independence. Previous studies have assessed risk factors in relation to either disability or mortality, but an outcome that combines ...