Now showing items 136-155 of 56842

    • 53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks 

      Guirouilh-Barbat, Josée; Gelot, Camille; Xie, Anyong; Dardillac, Elodie; Scully, Ralph; Lopez, Bernard S. (Public Library of Science, 2016)
      DNA double-strand breaks (DSB) are very harmful lesions that can generate genome rearrangements. In this study, we used intrachromosomal reporters to compare both the efficiency and accuracy of end-joining occurring with ...
    • 5mC and 5hmC dynamics during PGC reprogramming and role of Tet1 in female meiosis 

      Yamaguchi, Shinpei; Hong, Kwonho; Liu, Rui; Shen, Li; Inoue, Azusa; Diep, Dinh; Zhang, Kun; Zhang, Yi (BioMed Central, 2013)
    • 5α-reductase Inhibitors and Risk of High-grade or Lethal Prostate Cancer 

      Preston, Mark A.; Wilson, Kathryn; Markt, Sarah C.; Ge, Rongbin; Morash, Christopher; Stampfer, Meir; Loda, Massimo F.; Giovannucci, Edward; Mucci, Lorelei A.; Olumi, Aria F. (American Medical Association, 2014)
    • A 600 kb Deletion Syndrome at 16p11.2 Leads to Energy Imbalance and Neuropsychiatric Disorders 

      Zufferey, Flore; Sherr, Elliott H; Beckmann, Noam D; Hanson, Ellen M.; Maillard, Anne M; Hippolyte, Loyse; Macé, Aurélien; Ferrari, Carina; Kutalik, Zoltán; Andrieux, Joris; Aylward, Elizabeth; Barker, Mandy; Bernier, Raphael; Bouquillon, Sonia; Conus, Philippe; Delobel, Bruno; Faucett, W Andrew; Goin-Kochel, Robin P; Grant, Ellen; Harewood, Louise; Hunter, Jill V; Lebon, Sébastien; Ledbetter, David H; Martin, Christa Lese; Männik, Katrin; Martinet, Danielle; Mukherjee, Pratik; Ramocki, Melissa B; Spence, Sarah J; Steinman, Kyle J; Tjernagel, Jennifer; Spiro, John E; Reymond, Alexandre; Beckmann, Jacques S; Chung, Wendy K; Jacquemont, Sébastien (BMJ Publishing Group, 2012)
      Background: The recurrent ∼600 kb 16p11.2 BP4-BP5 deletion is among the most frequent known genetic aetiologies of autism spectrum disorder (ASD) and related neurodevelopmental disorders. Objective: To define the medical, ...
    • A 65 k.y. Time Series From Sediment-Hosted Glasses Reveals Rapid Transitions in Ocean Ridge Magmas 

      Ferguson, David; Li, Yinqi; Langmuir, Charles; Costa, Kassandra; McManus, Jerry; Huybers, Peter; Corbotte, Suzanne (Geological Society of America, 2017)
      Studies of ocean ridge magmatism have been hampered by the difficulty in constructing time-series data over more than a few thousand years. Sediment rapidly covers newly formed ocean crust, and older rocks, even when ...
    • 6d Conformal matter 

      Del Zotto, Michele; Heckman, Jonathan J.; Tomasiello, Alessandro; Vafa, Cumrun (Springer Verlag, 2015)
      A single M5-brane probing G, an ADE-type singularity, leads to a system which has G x G global symmetry and can be viewed as "bifundamental" (C, C) matter. For the AN series, this leads to the usual notion of bifundamental ...
    • 7 Leadership Blind Spots: Adult Development, Emotional Intelligence, and Leadership Effectiveness Among Biotech R&D Leaders 

      Shiner, Michael (2015-05-15)
      In this multiple-case study of 6 mid-level leaders working in biotech R&D--an archetype of a complex, uncertain, turbulent, and, multidisciplinary 21st-Century workplace--I explore the importance and interaction of mental ...
    • 7T MRI of spinal cord injury 

      Cohen-Adad, J.; Zhao, Wei Chen; Wald, Lawrence Leroy; Oaklander, Anne Louise (Ovid Technologies (Wolters Kluwer Health), 2012)
      A man with 25 years of mild left neck, arm, and leg paresthesias had initial MRI in 1996 identifying a left C3-4 dorsal horn cavernous hemangioma. In 1997, hemorrhage (C3-7) and resection induced left arm > leg proprioceptive ...
    • 8.4 GHz VLBI Observations of SN 2004et in NGC 6946 

      Martí-Vidal, I.; Marcaide, J. M.; Alberdi, A.; Guirado, J. C.; Lara, L.; Pérez-Torres, M. A.; Ros, E.; Argo, M. K.; Beswick, R. J.; Muxlow, T. W. B.; Pedlar, A.; Shapiro, Irwin; Stockdale, C. J.; Sramek, R. A.; Weiler, K. W.; Vinko, J. (EDP Sciences, 2007-05-25)
      We report on 8.4 GHz very-long-baseline-interferometry (VLBI) observations of the type II-P supernova SN2004et in the spiral galaxy NGC 6946, made on 20 February 2005 (151 days after explosion). The Very Large Array (VLA) ...
    • 87 Rare Variants Associated With Blood Pressure in Meta-Analysis of ∼1.32 Million Individuals 

      Feofanova, Elena; Franks, Paul (Ovid Technologies (Wolters Kluwer Health), 2021-04)
      Genetic studies of blood pressure (BP) to date have mainly analysed common variants (minor allele frequency, MAF>0.05). In a meta-analysis of up to >1.3 million participants, we discovered 106 new BP-associated genomic ...
    • 89 Zr-Labeled Dextran Nanoparticles Allow in Vivo Macrophage Imaging 

      Keliher, Edmund J.; Yoo, Jeongsoo; Nahrendorf, Matthias; Lewis, Jason S.; Marinelli, Brett; Newton, Andita; Pittet, Mikael J.; Weissleder, Ralph (American Chemical Society, 2011)
      Tissue macrophages play a critical role both in normal physiology and in disease states. However, because of a lack of specific imaging agents, we continue to have a poor understanding of their absolute numbers, flux rates, ...
    • The 8q24 Cancer Risk Variant Rs6983267 Shows Long-Range Interaction With MYC in Colorectal Cancer 

      Pomerantz, Mark; Ahmadiyeh, Nasim; Jia, Li; Herman, Paula; Verzi, Michael; Doddapaneni, Harshavardhan; Beckwith, Christine A.; Chan, Jennifer A.; Hills, Adam; Davis, Matt; Yao, Keluo; Kehoe, Sarah M.; Lenz, Heinz-Josef; Haiman, Christopher A.; Yan, Chunli; Henderson, Brian E.; Frenkel, Baruch; Barretina, Jordi; Bass, Adam; Tabernero, Josep; Baselga, Jose; Regan, Meredith; Manak, J. Robert; Shivdasani, Ramesh; Coetzee, Gerhard A.; Freedman, Matthew (Springer Science and Business Media LLC, 2009-06-28)
      An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with ...
    • The 8th Annual Computational and Systems Neuroscience (Cosyne) Meeting 

      Histed, Mark; Pillow, Jonathan W (BioMed Central, 2011)
    • 8th international conference on management and rehabilitation of chronic respiratory failure: the long summaries – part 1 

      Ambrosino, Nicolino; Casaburi, Richard; Chetta, Alfredo; Clini, Enrico; Donner, Claudio F.; Dreher, Michael; Goldstein, Roger; Jubran, Amal; Nici, Linda; Owen, Caroline A.; Rochester, Carolyn; Tobin, Martin J.; Vagheggini, Guido; Vitacca, Michele; ZuWallack, Richard (BioMed Central, 2015)
      This paper summarizes the Part 1 of the proceedings of the 8th International Conference on Management and Rehabilitation of Chronic Respiratory Failure, held in Pescara, Italy, on 7 and 8 May, 2015. It summarizes the ...
    • 8th International conference on management and rehabilitation of chronic respiratory failure: the long summaries – part 2 

      Ambrosino, Nicolino; Casaburi, Richard; Chetta, Alfredo; Clini, Enrico; Donner, Claudio F.; Dreher, Michael; Goldstein, Roger; Jubran, Amal; Nici, Linda; Owen, Caroline A.; Rochester, Carolyn; Tobin, Martin J.; Vagheggini, Guido; Vitacca, Michele; ZuWallack, Richard (BioMed Central, 2015)
      This paper summarizes the Part 2 of the proceedings of the 8th International Conference on Management and Rehabilitation of Chronic Respiratory Failure, held in Pescara, Italy, on 7 and 8 May, 2015. It summarizes the ...
    • 8th International conference on management and rehabilitation of chronic respiratory failure: the long summaries – Part 3 

      Ambrosino, Nicolino; Casaburi, Richard; Chetta, Alfredo; Clini, Enrico; Donner, Claudio F.; Dreher, Michael; Goldstein, Roger; Jubran, Amal; Nici, Linda; Owen, Caroline A.; Rochester, Carolyn; Tobin, Martin J.; Vagheggini, Guido; Vitacca, Michele; ZuWallack, Richard (BioMed Central, 2015)
      This paper summarizes the Part 3 of the proceedings of the 8th International Conference on Management and Rehabilitation of Chronic Respiratory Failure, held in Pescara, Italy, on 7 and 8 May, 2015. It summarizes the ...
    • 9-Genes Reinforce the Phylogeny of Holometabola and Yield Alternate Views on the Phylogenetic Placement of Strepsiptera 

      McKenna, Duane D; Farrell, Brian Dorsey (Public Library of Science, 2010)
      Background: The extraordinary morphology, reproductive and developmental biology, and behavioral ecology of twisted wing parasites (order Strepsiptera) have puzzled biologists for centuries. Even today, the phylogenetic ...
    • 90 Reasons to Consider Cellular Agriculture 

      Gasteratos, Kristopher (2019)
      90 Reasons is a list of prospective benefits cellular agriculture may offer upon global-scale introduction this century.
    • A 12-Residue-long Polyleucine Tail Is Sufficient to Anchor Synaptobrevin to the Endoplasmic Reticulum Membrane 

      Whitley, Paul; Grahn, Elin; Kutay, Ulrike; Rapoport, Tom A.; von Heijne, Gunnar (American Society for Biochemistry and Molecular Biology, 1996)
    • A 15.65-solar-mass black hole in an eclipsing binary in the nearby spiral galaxy M 33 

      Orosz, Jerome A.; McClintock, Jeffrey E.; Narayan, Ramesh; Bailyn, Charles D.; Hartman, Joel D.; Macri, Lucas; Liu, Jiefeng; Pietsch, Wolfgang; Remillard, Ronald A.; Shporer, Avi; Mazeh, Tsevi (Nature Research (part of Springer Nature), 2007)
      Stellar-mass black holes are found in X-ray-emitting binary systems, where their mass can be determined from the dynamics of their companion stars(1-3). Models of stellar evolution have difficulty producing black holes in ...