Browsing by Title
Now showing items 176-195 of 58461
-
a Case Study on the Decision-Making Behind the Development of Linezolid, Daptomycin, and Lysobactin.
(2020-03-02)After the "golden era" of antibiotic discovery in the 1950' and 1960's pharmaceutical companies failed to discover novel antibiotic classes leading them to abandon research in spite of the growing threat of antibiotic ... -
A case-control study of GST polymorphisms and arsenic related skin lesions
(BMC, 2007)Background: Polymorphisms in GSTT1, GSTM1 and GSTP1 impact detoxification of carcinogens by GSTs and have been reported to increase susceptibility to environmentally related health outcomes. Individual factors in arsenic ... -
A cell wall damage response mediated by a sensor kinase/response regulator pair enables beta-lactam tolerance
(National Academy of Sciences, 2016)The bacterial cell wall is critical for maintenance of cell shape and survival. Following exposure to antibiotics that target enzymes required for cell wall synthesis, bacteria typically lyse. Although several cell envelope ... -
A Chandra Observation of the Globular Cluster Terzan 1: The Neutron Star X‐Ray Transient X1732−304 in Quiescence
(American Astronomical Society, 2002) -
A CHANDRA X-RAY OBSERVATORY STUDY OF PSR J1740-5340 AND CANDIDATE MILLISECOND PULSARS IN THE GLOBULAR CLUSTER NGC 6397
(American Astronomical Society, 2010) -
A Chandra X-Ray study of the dense globular cluster Terzan 5
(American Astronomical Society, 2003)We report a Chandra ACIS-I observation of the dense globular cluster Terzan 5. The previously known transient low-mass X-ray binary (LMXB) EXO 1745-248 in the cluster entered a rare high state during our 2000 August ... -
A Chandra X‐Ray Study of the Globular Cluster M80
(American Astronomical Society, 2003) -
A Characteristic Division Between the Fueling of Quasars and Seyferts: Five Simple Tests
(American Astronomical Society, 2009)Given the existence of the M-BH-sigma relation, models of self-regulated black hole (BH) growth require both a fuel supply and concomitant growth of the host bulge to deepen the central potential, or else the system will ... -
A Chemical Biology Approach Towards Targeting Understudied Lipid Kinases in Cancer and Ebola
(2019-05-18)Cellular processes are orchestrated in an intricate and highly coordinated fashion in order to facilitate proper metabolism, cell cycle progression, gene expression, and ultimately survival. Phosphoinositides, lipid moieties ... -
A Chemical Biology Platform to Develop Small Molecule Probes for Bromodomains
(2017-05-16)Bromodomain epigenetic reader proteins play crucial roles in the pathogenesis of diseases ranging from inflammation to cancer. Small molecule inihibitors have engendered a nuanced understanding of the role of BET subfamily ... -
A Chemical Odor Map in Cortex
(2017-09-08)Odorous molecules trigger specific percepts. Appropriate assignment of odorants to corresponding percepts relies on the brain’s ability to both discriminate distinct odorants, as well as generalize odorants that share ... -
A Chimeric Protein of Simian Immunodeficiency Virus Envelope Glycoprotein gp140 and Escherichia coli Aspartate Transcarbamoylase
(American Society for Microbiology, 2004)The envelope glycoproteins of the human immunodeficiency virus and the related simian immunodeficiency virus (SIV) mediate viral entry into host cells by fusing viral and target cell membranes. We have reported expression, ... -
A Cholera Toxin B-subunit Variant That Binds Ganglioside G M1 but Fails to Induce Toxicity
(American Society for Biochemistry and Molecular Biology, 2001) -
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
(National Academy of Sciences, 2010)Many proteins that respond to DNA damage are recruited to DNA lesions. We used a proteomics approach that coupled isotopic labeling with chromatin fractionation and mass spectrometry to uncover proteins that associate with ... -
A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases
(American Society for Biochemistry and Molecular Biology, 2013)Chrysin (5,7-dihydroxyflavone), a natural flavonoid widely distributed in plants, reportedly has chemopreventive properties against various cancers. However, the anticancer activity of chrysin observed in in vivo studies ... -
A Classy Affair: Modeling Course Enrollment Prediction
(2020-06-18)The problem of course enrollment prediction has many implications in the determination of university policy. Namely, logistic concerns around course planning cause many universities, Harvard among them, to consider moving ... -
A Clinician-administered Severity Rating Scale for Illness Anxiety: Development, Reliability, and Validity of the H-ybocs-m
(2012)Background Clinician-administered measures to assess severity of illness anxiety and response to treatment are few. The authors evaluated a modified version of the hypochondriasis-Y-BOCS (H-YBOCS-M), a 19-item, semistructured, ... -
A Clock-Phased Sigma Factor Cascade Is Required for Global Circadian Transcriptional Rhythms in Cyanobacteria
(2017-09-07)The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 drives oscillations in global mRNA transcript abundances with 24 h periodicity under continuous light conditions. The transcription factor RpaA ... -
A Closer Lens on Gut Health, Stress, Mental Health in the Middle East: A Focus on Kuwait
(2021-11-08)Generalized Anxiety Disorder (GAD), is a highly prevalent and disruptive disorder as it is highly resistant to both pharmacological and psychological treatments (Borkovec et al., 2002), and has a high financial burden on ... -
A Coherence of Incoherences: Graeco-Arabic Philosophy and the Fifteenth-Century Ottoman Synthesis of Philosophy With Sharia
(2019-09-11)The fifteenth-century Ottoman world was a dynamic seedbed of philosophical and theological debates and was particularly marked by numerous adjudications produced by certain celebrated scholars who synthesized different ...