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Now showing items 176-195 of 56883
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A Cholera Toxin B-subunit Variant That Binds Ganglioside G M1 but Fails to Induce Toxicity
(American Society for Biochemistry and Molecular Biology, 2001) -
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
(National Academy of Sciences, 2010)Many proteins that respond to DNA damage are recruited to DNA lesions. We used a proteomics approach that coupled isotopic labeling with chromatin fractionation and mass spectrometry to uncover proteins that associate with ... -
A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases
(American Society for Biochemistry and Molecular Biology, 2013)Chrysin (5,7-dihydroxyflavone), a natural flavonoid widely distributed in plants, reportedly has chemopreventive properties against various cancers. However, the anticancer activity of chrysin observed in in vivo studies ... -
A Clinician-administered Severity Rating Scale for Illness Anxiety: Development, Reliability, and Validity of the H-ybocs-m
(2012)Background Clinician-administered measures to assess severity of illness anxiety and response to treatment are few. The authors evaluated a modified version of the hypochondriasis-Y-BOCS (H-YBOCS-M), a 19-item, semistructured, ... -
A Clock-Phased Sigma Factor Cascade Is Required for Global Circadian Transcriptional Rhythms in Cyanobacteria
(2017-09-07)The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 drives oscillations in global mRNA transcript abundances with 24 h periodicity under continuous light conditions. The transcription factor RpaA ... -
A Closer Lens on Gut Health, Stress, Mental Health in the Middle East: A Focus on Kuwait
(2021-11-08)Generalized Anxiety Disorder (GAD), is a highly prevalent and disruptive disorder as it is highly resistant to both pharmacological and psychological treatments (Borkovec et al., 2002), and has a high financial burden on ... -
A Cohort Study of Tumoral LINE-1 Hypomethylation and Prognosis in Colon Cancer
(Oxford University Press, 2008)Genome-wide DNA hypomethylation plays has an important role in genomic instability and colorectal carcinogenesis. However, the relationship between cellular DNA methylation level and patient outcome remains uncertain. Using ... -
A Combinatorial Maf Transcription Factor Code Establishes Synaptic Heterogeneity Critical for Normal Hearing Function
(2023-01-18)Spiral ganglion neuron (SGN) synaptic, functional, and molecular diversity is critical for hearing function. Heterogeneous inner hair cell (IHC)-SGN synapses transduce complex sound information from the ear to the brain. ... -
A Combined Mastery Learning and Flipped-Classroom Approach: The Effect on Self-Assessment of Leadership Skills
(2022-05-12)Abstract Strong leadership is associated with better performance of individuals, teams, and organizations. This project aimed to determine whether a flipped-classroom and mastery-learning curriculum is associated with ... -
A Common 8q24 Variant in Prostate and Breast Cancer from a Large Nested Case-Control Study
(American Association for Cancer Research, 2007)Two recent studies independently identified polymorphisms in the 8q24 region, including a single nucleotide polymorphism (rsl447295), strongly associated with prostate cancer risk. Here, we replicate the overall association ... -
A Comparative Analysis of Engagement Methodologies in Community Resilience Initiatives
(2022-05-12)Millions of dollars, not to mention invaluable community trust and energy, are wasted every year on ineffective community redevelopment programs and projects that fail to live up to their goals due to lack of community ... -
A Comparative Analysis of Incident Reporting Lag Times in Academic Medical Centres in Japan and the USA
(2010)Background Delays in reporting of medical errors may signal deficiencies in the performance of hospital-based incident reporting. We sought to understand the characteristics of hospitals, providers and patient injuries ... -
A Comparative Analysis of Socially Responsible Investment (SRI) Funds: How Sustainable Are SRI Funds?
(2018-04-01)Between 2012 and 2014, socially responsible investments (SRI) grew by 76%, with over $6.5 trillion now being held in managed SRI assets (Schueth et al., 2014). This remarkable growth accentuates the blossoming interest ... -
A Comparative Analysis of the Transmission and “Translation” of Tibetan Buddhist Teachings in the American Context
(2021-05-18)In the history of the transmission and adoption of the practice of Tibetan Buddhism in the American context, two teachers from the Kagyu tradition, His Holiness the Sixteenth Karmapa Rangjung Rigpe Dorje (Rang byung Rig ... -
A Comparative Framework for Building Life Cycle Embodied Carbon Emissions Databases and Its Application for Public Databases
(2022-06-08)Data availability and accuracy are some of the main obstacles to calculating the life-cycle embodied carbon emissions in buildings. There have been several studies to assess life cycle assessment (LCA) databases in the ... -
A Comparative Study of Bishop Joseph Butler and Wang Yang-ming's Conception of Conscience
This dissertation is a comparative study of the Anglican Bishop Joseph Butler's (1692-1752 AD) and the Neo-Confucianist Wang Yang-ming's (1472-1529 AD) conception of conscience (or in Wang's terminology, liang-chih. ... -
A Comparison of Co-stimulatory HVEM Domains in Second Generation CAR-T Cells
(2022-10-05)Chimeric antigen receptor T cells (CAR-T) are T cells that have been genetically modified to express a receptor that recognizes a specific target molecule. When T cells bind to their target molecule, usually a surface ... -
A Comparison of Different Methods for Evaluating Diet, Physical Activity, and Long-Term Weight Gain in 3 Prospective Cohort Studies
(Oxford University Press, 2015)Background: The insidious pace of long-term weight gain (similar to 1 lb/y or 0.45 kg/y) makes it difficult to study in trials; long-term prospective cohorts provide crucial evidence on its key contributors. Most previous ... -
A Comparison of Heritability Maps of Cortical Surface Area and Thickness and the Influence of Adjustment for Whole Brain Measures: A Magnetic Resonance Imaging Twin Study
(BMC, 2012)Understanding the genetic and environmental contributions to measures of brain structure such as surface area and cortical thickness is important for a better understanding of the nature of brain-behavior relationships and ...